Meds A-Z
Amoxicillin-Clavulanate
Detailed information about Amoxicillin-Clavulanate
Pet Owner Quick Guide
Start here: what this medicine is for, what it does, and when it's usually needed.
Usually used for:
Antibiotic combination used for susceptible bacterial infections (often skin, soft tissue, dental, urinary).
What it does:
Antibiotic combination used for susceptible bacterial infections (often skin, soft tissue, dental, urinary).
When it's needed:
Avoid in pets with known penicillin allergy. Use caution with severe kidney disease.
Call your vet sooner if you notice:
- Avoid in pets with known penicillin allergy. Use caution with severe kidney disease.
Commonly reported reactions:
- (1 reports)
- (1 reports)
- (1 reports)
What to ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Amoxicillin-Clavulanate
Drug type: Generic ingredient • Generic profile • No FDA branded products linked
Species: Both
Manufacturer: Zoetis
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
No source yet.
Warnings / Contraindications
Avoid in pets with known penicillin allergy. Use caution with severe kidney disease.
- High: Avoid in pets with known penicillin allergy. Use caution with severe kidney disease.
- https://animaldrugsatfda.fda.gov · safety_warning · Medication contraindications
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Tap or hover a reaction to see what it means in plain language.
Most Reported Reactions
| Reaction | Cases | Species | Serious cases |
|---|---|---|---|
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 |
Species coverage: Dog (32)
View detailed reaction table
| Reaction | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 |
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-054707
Storage & Handling
Store at room temperature; follow label directions for liquid suspensions.
Documents
Official label facts are separated from secondary summaries.
No linked label PDFs or safety notices yet.
No source yet.
No source yet.
Promotional Materials (Marketing)
This content is marketing material and not clinical guidance.
No marketing assets are linked yet.
No source yet.
Technical appendix (vet reference)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
- Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 7:40 PM UTC
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:01 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:19 AM UTC
Diagnosis-code mappings are not available for this medication yet.
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
- Avoid in pets with known penicillin allergy. Use caution with severe kidney disease. (Contraindication, High)
Data Sources & Revision History
Every non-trivial field is expected to include provenance and update timestamps.
- contraindications: Avoid in pets with known penicillin allergy. Use caution with severe kidney disease. (Clinical, 2026-02-12)
- overdose_info: Mild overdose may cause more pronounced GI symptoms; extreme overdose could lead to kidney damage or neurologic effects. Supportive care is recommended. (Clinical, 2026-02-12)
- storage_handling: Store at room temperature; follow label directions for liquid suspensions. (Clinical, 2026-02-12)
- usage: Antibiotic combination used for susceptible bacterial infections (often skin, soft tissue, dental, urinary). (Clinical, 2026-02-12)
- side_effects: GI upset (vomiting/diarrhea), decreased appetite. Rare: allergic reaction. (Official, 2026-02-12)
- side_effects updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
No linked FDA product applications are available for this ingredient yet.
Usage
Antibiotic combination used for susceptible bacterial infections (often skin, soft tissue, dental, urinary).
Contraindications
Avoid in pets with known penicillin allergy. Use caution with severe kidney disease.
Side Effects
GI upset (vomiting/diarrhea), decreased appetite. Rare: allergic reaction.
Source: FDA openFDA • Reference
Top Reported Reactions (openFDA)
Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Dog, Weimaraner, Female, 16 month, 28.1 kilogram • Drug: MSK, Oral, Dose: 375 Milligram per animal, Frequency: 12 per hour • Reactions: Injection site swelling, Hyperactivity, Abnormal cytology, Injection site skin change NOS, Local swelling… • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-054707
- Serious AE: Yes
- Treated For AE: No
- Sex: Female
- Age: 16.00 Month
- Weight: 28.100 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Dose: 375 Milligram per animal
- Frequency: 12 per hour
Dog, Corgi (unspecified), Female, 5 year, 13.154 kilogram • Drug: MSK, Oral • Reactions: Decreased appetite, Myocarditis, Heart failure, Cardiac disorder NOS, Abnormal ultrasound finding… • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-011542
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 5.00 Year
- Weight: 13.154 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
Dog, Corgi (unspecified), Female, 5 year, 13.154 kilogram • Drug: MSK, Oral • Reactions: Decreased appetite, Decreased activity, Injection site pain, Injection site swelling, Dysphagia… • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-008900
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 5.00 Year
- Weight: 13.154 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
Dog, ['Boxer (German Boxer)', 'Mastiff (unspecified)'], Male, 6 year, 40.823 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Tiredness (lethargy), Decreased appetite, Elevated alanine aminotransferase, Lymphocytosis, Monocytosis… • Outcome: Euthanized
- Report ID: USA-USFDACVM-2024-US-073827
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Male
- Age: 6.00 Year
- Weight: 40.823 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Unassigned
Dog, Bulldog - French, Female, 5 year, 12.247 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Fever, Agitation, Vomiting, Inappropriate defecation, Uncomfortable… • Outcome: Died
- Report ID: USA-USFDACVM-2024-US-054007
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 5.00 Year
- Weight: 12.247 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Unassigned
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
Mild overdose may cause more pronounced GI symptoms; extreme overdose could lead to kidney damage or neurologic effects. Supportive care is recommended.
Storage & Handling
Store at room temperature; follow label directions for liquid suspensions.
Share Your Thoughts
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This medication has not been reviewed by a veterinarian yet.