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Fluralaner

Detailed information about Fluralaner

Official label facts Owner quick guide first Marketing clearly labeled
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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment of infections with intestinal roundworm ( Toxocara cati ; 4th stage larvae, immature adults and adults) and hookworm ( Ancylosto...

What it does:

Bravecto® kills adult fleas and is indicated for the treatment and prevention of flea infestations ( Ctenocephalides felis ), and the treatment and control of tick infestations [ Ixodes scapularis (black-legged tick), De...

When it's needed:

For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment of infections with intestinal roundworm ( Toxocara cati ; 4th stage larvae, immature adults and adults) and hookworm ( Ancylosto...

Commonly reported reactions:

  • (2 reports)
  • (2 reports)
  • (2 reports)

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
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Fluralaner

Fluralaner

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Intervet, Inc.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Intervet, Inc.
Form: Chewable Tablets, Concentrated Solution, Powder for extended-release injectable suspension, Solution, Topical Solution
Identifiers:
NADA: 141426 NADA: 141459 NADA: 141518 NADA: 141532 NADA: 141599 NADA: 141607 NADA: 141617 NDC Package: 0061-1438-02 NDC Package: 0061-1440-01 NDC Package: 0061-1440-02 NDC Package: 0061-1442-01 NDC Package: 0061-1442-02 NDC Package: 0061-1442-03 NDC Package: 0061-4340-01 NDC Package: 0061-4341-01 NDC Package: 0061-4342-01 NDC Package: 0061-4343-01 NDC Package: 0061-4344-01 NDC Package: 0061-4366-01 NDC Package: 0061-4367-01
Source metadata:

Warnings / Contraindications

No contraindication summary is linked yet.

No owner-focused warning rows are linked yet.

Source metadata: No source yet.

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
15
Species represented
2
Most Reported Reactions
Reaction Cases Species Serious cases
2 Cat, Dog 1
2 Cat, Dog 1
2 Cat, Dog 1
1 Dog 1
1 Dog 1
1 Dog 1
1 Dog 1
1 Dog 1

Species coverage: Dog (23) Cat (9)

View detailed reaction table
Reaction Species Seriousness Frequency Reports
Dog Non-serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Dog Serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Dog Serious - 1
Dog Non-serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Non-serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Non-serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Dog Serious - 1
Dog Non-serious - 1
Dog Non-serious - 1
Dog Non-serious - 1
Dog Serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Dog Serious - 1
Source metadata:

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 19 • Secondary summaries: 0

Official label facts
Secondary summaries

No source yet.

Source metadata:

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.
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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:03 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 12, 2026, 10:42 PM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: BRAVECTO® BRAVECTO® 1-MONTH BRAVECTO® PLUS BRAVECTO® QUANTUM Bravecto® Exzolt™ Exzolt™ Cattle-CA1
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Beef calves 2 months of age and older, Cat, Dog, Layers, Replacement dairy heifers under 20 months of age, Replacements
Rx/OTC: RX
Form/route: Chewable Tablets, Concentrated Solution, Powder for extended-release injectable suspension, Solution, Topical Solution • Oral, Subcutaneous, Topical
Applications: NADA 141-518 • C 141-617 • NADA 141-599 • NADA 141-607 • NADA 141-426 • NADA 141-459 • NADA 141-532
Documents: 12 (FOI: 12) • SPL: 7 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 56 • Cat 20 • View
Case summaries: 11 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: B74.8 ICD10_CM: B88.1
Other filariases

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Abnormal radiograph finding (1) Abrasion (1) Allergic pruritus (1) Anaemia NOS (1) Application site hair loss (1) Ataxia (1) Ataxia (1) Coprophagia (1) Death by euthanasia (1) Decreased drinking (1) Decreased haematocrit (1) Decreased haemoglobin (1) Decreased mean corpuscular haemoglobin concentration (MCHC) (1) Decreased red blood cell count (1) Difficulty standing (1) Disorder of red blood cell NOS (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141426 NADA: 141459 NADA: 141518 NADA: 141532 NADA: 141599 NADA: 141607 NADA: 141617 NDC Package: 0061-1438-02 NDC Package: 0061-1440-01 NDC Package: 0061-1440-02 NDC Package: 0061-1442-01 NDC Package: 0061-1442-02 NDC Package: 0061-1442-03 NDC Package: 0061-4340-01 NDC Package: 0061-4341-01 NDC Package: 0061-4342-01 NDC Package: 0061-4343-01 NDC Package: 0061-4344-01 NDC Package: 0061-4366-01 NDC Package: 0061-4367-01 NDC Package: 0061-4368-01 NDC Package: 0061-4370-01 NDC Package: 0061-5500-02 NDC Package: 0061-5501-02
Package NDC Product NDC Form / Route Status
0061-1438-02 0061 -
0061-1440-01 0061 -
0061-1440-02 0061 -
0061-1442-01 0061 -
0061-1442-02 0061 -
0061-1442-03 0061 -
0061-4340-01 0061 -
0061-4341-01 0061 -
0061-4342-01 0061 -
0061-4343-01 0061 -
0061-4344-01 0061 -
0061-4366-01 0061 -
0061-4367-01 0061 -
0061-4368-01 0061 -
0061-4370-01 0061 -
0061-5500-02 0061 -
0061-5501-02 0061 -
0061-5502-02 0061 -
0061-5503-02 0061 -
0061-5504-02 0061 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 14 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (endoparasite) - heartworm, Lethargy (see also Central nervous system depression in 'Neurological'… (Official, 2026-02-12)
  • usage: Bravecto® kills adult fleas and is indicated for the treatment and prevention of flea infestations ( Ctenocephalides felis ), and the treatment and control of … (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
BRAVECTO® PLUS
RX
Fluralaner Moxidectin
Solution • Topical
Label highlights
Official documents
Intervet, Inc. NADA 141-518 Approved Feb 2, 2026
Exzolt™ Cattle-CA1
RX
Fluralaner
Topical Solution • Topical
Label highlights
Official documents
Intervet, Inc. C 141-617 Approved Jan 27, 2026
BRAVECTO® QUANTUM
RX
Fluralaner
Powder for extended-release injectable suspension • Subcutaneous
Label highlights
Official documents
Intervet, Inc. NADA 141-599 Approved Jul 31, 2025
Exzolt™
RX
Fluralaner
Concentrated Solution • Oral
Label highlights
Official documents
Intervet, Inc. NADA 141-607 Approved Jul 31, 2025
Bravecto®
RX
Fluralaner
Chewable Tablets • Oral
Label highlights
Official documents
Intervet, Inc. NADA 141-426 Approved Jan 13, 2025
BRAVECTO®
RX
Fluralaner
Solution • Topical
Label highlights
Official documents
Intervet, Inc. NADA 141-459 Approved Jan 13, 2025
BRAVECTO® 1-MONTH
RX
Fluralaner
Chewable Tablets • Oral
Label highlights
Official documents
Intervet, Inc. NADA 141-532 Approved Jan 13, 2025

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter contains 280 mg of fluralaner and 14 mg of moxidectin
Cats
Indication

For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment of infections with intestinal roundworm (Toxocara cati; 4th stage larvae, immature adults and adults) and hookworm (Ancylostoma tubaeforme; 4th stage larvae, immature adults and adults). Kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), Haemaphysalis longicornis (Asian longhorned tick), and Amblyomma maculatum (Gulf Coast tick)] for 2 months in cats and kittens 6 months of age and older and weighing 2.6 lb or greater.

Dosage

Administer topically as a single dose every 2 months to provide a minimum dose of 18.2 mg/lb (40 mg/kg) fluralaner and 0.9 mg/lb (2 mg/kg) moxidectin.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Replacement dairy heifers under 20 months of age • Beef calves 2 months of age and older
Composition / specifications
Each milliliter of solution contains 50 milligrams of fluralaner
Beef cattle 2 months of age and older and replacement dairy heifers less than 20 months of age
Indication

For the prevention and treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) and treatment and control of cattle fever tick (Rhipicephalus microplus) in beef cattle 2 months of age and older and replacement dairy heifers less than 20 months of age.

Dosage

2.5 milligrams per kilogram (1.13 milligram per one pound) body weight.

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
Each mL of constituted suspension contains 150 mg fluralaner
Dogs
Indication

Kills adult fleas and for the treatment and prevention of flea infestations (Ctenocephalides felis); for the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 months in dogs and puppies 6 months of age and older; and for the treatment and control of Amblyomma americanum (lone star tick) infestations for 8 months in dogs and puppies 6 months of age and older.

Dosage

Administer as a single subcutaneous dose every 12 months or every 8 months in the case of potential exposure to Amblyomma americanum ticks. The subcutaneous dose volume is 0.1 mL of the constituted suspension/kg body weight (0.045 mL per pound (/lb)). This volume provides a dose of 15 mg fluralaner per kilogram body weight (6.8 mg/lb).

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Layers • Replacements
Composition / specifications
10 mg fluralaner/mL
Chickens, laying hens and replacement chickens
Indication

For the treatment and control of northern fowl mites (Ornithonyssus sylviarum).

Dosage

Administer orally to chickens via the drinking water as 2 single doses spaced 7 days apart, with each dose consumed over a period of 6 to 24 hours. Each dose is 0.5 mg fluralaner/kg (0.227 mg/lb) body weight, equivalent to 0.05 mL fluralaner oral solution/kg body weight (0.023 mL/lb).

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains 112.5, 250, 500, 1000, or 1400 mg fluralaner.
Dogs (Dogs and Puppies 6 Months and Older)
Indication

Bravecto® kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (Asian longhorned tick)] for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater.

Bravecto® is also indicated for the treatment and control of Amblyomma americanum (lone star tick) infestations for 8 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater.

Dosage
May be administered every 8 weeks in case of potential exposure to Amblyomma americanum ticks.
Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter contains 280 mg fluralaner.
Cats
Indication

Kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of Ixodes scapularis (black-legged tick) infestations for 12 weeks in cats and kittens 6 months of age and older, and weighing 2.6 lb or greater. It is also indicated for the treatment and control of Dermacentor variabilis (American dog tick) infestations for 8 weeks in cats and kittens 6 months of age and older, and weighing 2.6 lb or greater.

For the treatment and control of Haemaphysalis longicornis (Asian longhorned tick) infestations for 12 weeks in cats and kittens 6 months of age, and older and weighing 2.6 pounds or greater.

Dosage

Administer topically as a single dose every 12 weeks according to the label dosage schedule to provide a minimum dose of 18.2 mg/lb (40 mg/ kg) body weight. May be administered every 8 weeks in case of potential exposure to Dermacentor variabilis ticks.

Limitations
Dogs
Indication

Kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick),and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. It is also indicated for the treatment and control of Amblyomma americanum (lone star tick) infestations for 8 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater.

Dosage

Administer topically as a single dose every 12 weeks according to the label dosage schedule to provide a minimum dose of 11.4 mg/lb (25 mg/ kg) body weight. May be administered every 8 weeks in case of potential exposure to Amblyomma americanum ticks.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet (“chew”) contains 45, 100, 200, 400, or 560 mg of fluralaner
Dogs
Indication

BRAVECTO® 1- MONTH kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), Rhipicephalus sanguineus (brown dog tick) and Haemaphysalis longicornis (Asian longhorned tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater.

BRAVECTO® 1-MONTH is also indicated for the treatment and control of Amblyomma americanum (lone star tick) infestations for one month in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater.

Dosage

Administer orally as a single dose monthly to provide a minimum dose of 4.5 mg/lb (10 mg/kg) fluralaner. Administer with food.

Limitations

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary

    This supplement provides for the addition of the indication for the treatment and control of Amblyomma maculatum (Gulf Coast tick) infestations for 2 months in cats and kittens 6 months of age and older and weighing 2.6 pounds or greater.


  • Summary

    This supplement provides for the addition of the indication for the treatment and control of Haemaphysalis longicornis (Asian longhorned tick) infestations for 2 months in cats and kittens 6 months of age and older and weighing 2.6 pounds or greater.

  • Summary

    For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment of infections with intestinal roundworm (Toxocara cati, 4th stage larvae, immature adults, and adults) and hookworm (Ancylostoma tubaeforme, 4th stage larvae, immature adults, and adults); kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations (Ixodes scapularis (black-legged tick) and Dermacentor variabilis (American dog tick)) for 2 months in cats and kittens 6 months of age and older and weighing 2.6 lb or greater.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    For the prevention and treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) and treatment and control of cattle fever tick (Rhipicephalus microplus) in beef cattle 2 months of age and older and replacement dairy heifers less than 20 months of age.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    Kills adult fleas and for the treatment and prevention of flea infestations (Ctenocephalides felis); for the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 months in dogs and puppies 6 months of age and older; and for the treatment and control of Amblyomma americanum (lone star tick) infestations for 8 months in dogs and puppies 6 months of age and older.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    This supplement provides for the addition of the indication for the treatment and control of Haemaphysalis longicornis (Asian longhorned tick) infestations for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater.

  • Summary

    BRAVECTO kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater.

    BRAVECTO is also indicated for the treatment and control of Amblyomma americanum (lone star tick) infestations for 8 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    This supplement provides for the addition of the indication for the treatment and control of Haemaphysalis longicornis (Asian longhorned tick) infestations for 12 weeks in cats and kittens 6 months of age and older, and weighing 2.6 pounds or greater.

  • Summary
    BRAVECTO® kills adult fleas and is indicated for the treatment and prevention of flea infestations ( Ctenocephalides felis) and the treatment and control of tick infestations [ Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 lb or greater. BRAVECTO® is also indicated for the treatment and control of Ambloyomma americanum (lone star tick) infestations for 8 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. BRAVECTO® kills adult fleas and is indicated for the treatment and prevention of flea infestations ( Ctenocephalides felis) and the treatment and control of Ixodes scapularis (black-legged tick) infestations for 12 weeks in cats and kittens 6 months of age and older, and weighing 2.6 lb or greater. BRAVECTO® is also indicated for the treatment and control of Dermacentor variabilis (American dog tick) infestations for 8 weeks in cats and kittens 6 months of age and older, and weighing 2.6 lb or greater.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    This supplement provides for the addition of the indication for the treatment and control of Haemaphysalis longicornis (Asian longhorned tick) infestations for one month in dogs and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater.

  • Summary

    Kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick) and Rhipicephalus sanguineus (brown dog tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater.

    It is also indicated for the treatment and control of Amblyomma americanum (lone star tick) infestations for one month in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

Bravecto® kills adult fleas and is indicated for the treatment and prevention of flea infestations ( Ctenocephalides felis ), and the treatment and control of tick infestations [ Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (Asian longhorned tick)] for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. Bravecto® is also indicated for the treatment and control of Amblyomma americanum (lone star tick) infestations for 8 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. Kills adult fleas and is indicated for the treatment and prevention of flea infestations ( Ctenocephalides felis ) and the treatment and control of Ixodes scapularis (black-legged tick) infestations for 12 weeks in cats and kittens 6 months of age and older, and weighing 2.6 lb or greater. It is also indicated for the treatment and control of Dermacentor variabilis (American dog tick) infestations for 8 weeks in cats and kittens 6 months of age and older, and weighing 2.6 lb or greater. For the treatment and control of Haemaphysalis longicornis (Asian longhorned tick) infestations for 12 weeks in cats and kittens 6 months of age, and older and weighing 2.6 pounds or greater. Kills adult fleas and is indicated for the treatment and prevention of flea infestations ( Ctenocephalides felis ) and the treatment and control of tick infestations [ Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick),and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. It is also indicated for the treatment and control of Amblyomma americanum (lone star tick) infestations for 8 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

No approved contraindication text is linked yet. Review FDA label highlights and openFDA safety reports before making treatment decisions.

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 56 and Cat 20 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog
Digestive
Vomiting (765) Diarrhea (263) Vomiting (7) Vomiting (7) Vomiting (7) Vomiting (7) Vomiting (7) Vomiting (7) Diarrhea (4) Diarrhea (4) Diarrhea (4) Diarrhea (4) Diarrhea (4) Diarrhea (4) Drooling (3) Drooling (3) Drooling (3) Drooling (3) Drooling (3)
Neurologic
Tiredness (lethargy) (304) Seizure NOS (158) Seizure NOS (5) Seizure NOS (5) Seizure NOS (5) Seizure NOS (5) Seizure NOS (5) Seizure NOS (5) Tiredness (lethargy) (4) Tiredness (lethargy) (4) Tiredness (lethargy) (4) Tiredness (lethargy) (4) Tiredness (lethargy) (4) Tiredness (lethargy) (4)
Effectiveness
Lack of efficacy (endoparasite) - heartworm (429) Lack of efficacy (endoparasite) - heartworm (6) Lack of efficacy (endoparasite) - heartworm (6) Lack of efficacy (endoparasite) - heartworm (6) Lack of efficacy (endoparasite) - heartworm (6) Lack of efficacy (endoparasite) - heartworm (6) Lack of efficacy (endoparasite) - heartworm (6)
Other
Other abnormal test result NOS (177) Not eating (121) Weight loss (112) Fever (6) Fever (6) Fever (6) Fever (6) Fever (6) Fever (6) Tachycardia (4) Tachycardia (4) Tachycardia (4) Tachycardia (4) Tachycardia (4) Tachycardia (4) Elevated serum alkaline phosphatase (3)
Cat
Digestive
Vomiting (27) Loss of appetite (16)
Skin & allergy
Hair loss at application site (11)
Neurologic
Tiredness (lethargy) (25) Unsteady walking (ataxia) (12)
Other
Weight loss (20) Other abnormal test result NOS (13) Death (12) General illness (1) General illness (1) General illness (1) General illness (1) General illness (1) General illness (1) Intentional misuse (1) Intentional misuse (1) Intentional misuse (1) Intentional misuse (1) Intentional misuse (1) Intentional misuse (1)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Shepherd Dog - German, Male, 5.8 year, 40.82 kilogram • Drug: MSK, Tablet, Unknown • Reactions: Sneezing, Listless, Not eating, Reduced responses, Difficulty standing… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055636
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 5.80 Year
  • Weight: 40.820 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Tablet
Reactions Reported:
Sneezing Listless Not eating Reduced responses Difficulty standing Falling Polyuria Decreased drinking Fever Tachycardia Tachypnoea Weight loss Stress leukogram Neutrophilia Monocytosis Eosinopenia Elevated globulins Abnormal radiograph finding Hepatomegaly Proprioception deficit Muscle atrophy Pain NOS
Outcomes: Ongoing

Dog, Corgi (unspecified), Female, 3 year, 11.793 kilogram • Drug: MSK, Unassigned, Subcutaneous • Reactions: Vomiting, Allergic pruritus, Swollen lip, Hives • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055192
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 3.00 Year
  • Weight: 11.793 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Unassigned
Reactions Reported:
Vomiting Allergic pruritus Swollen lip Hives
Outcomes: Ongoing

Dog, Retriever - Labrador, Male, 3 year, 36.832 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Itchy skin • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055024
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 3.00 Year
  • Weight: 36.832 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Itchy skin
Outcomes: Ongoing

Dog, Pointing Dog - Hungarian Short-haired (Vizsla), Female, 7 year, 25 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy (bacteria) - Borrelia, Disorientation, Urination, Spondylosis, Foaming at the mouth… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055629
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 25.000 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Lack of efficacy (bacteria) - Borrelia Disorientation Urination Spondylosis Foaming at the mouth Seizure NOS
Outcomes: Outcome Unknown

Dog, Retriever - Labrador, Female, 6 year, 44.905 kilogram • Drug: MSK, Unknown • Reactions: Abrasion, Laceration, Death by euthanasia, Lack of efficacy (endoparasite) - heartworm • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2025-US-055794
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 6.00 Year
  • Weight: 44.905 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Abrasion Laceration Death by euthanasia Lack of efficacy (endoparasite) - heartworm
Outcomes: Euthanized

Dog, Dog (other), Male, 13.41 year, 16.33 kilogram • Drug: MSK, Unknown, Frequency: 1 per month • Reactions: Pale mucous membrane, Weakness, Unsteady walking (ataxia), Elevated creatinine, Tachycardia… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-056007
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 13.41 Year
  • Weight: 16.330 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Frequency: 1 per month
Reactions Reported:
Pale mucous membrane Weakness Unsteady walking (ataxia) Elevated creatinine Tachycardia Decreased haematocrit Disorder of red blood cell NOS Decreased mean corpuscular haemoglobin concentration Lack of efficacy - NOS Shallow breathing Low platelet count Decreased haemoglobin Elevated blood urea nitrogen Lymphopenia Decreased red blood cell count Hyperglycaemia Abnormal radiograph finding Neutrophilia Vomiting bile Tiredness (lethargy)
Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 10 year, 3.18 kilogram • Drug: MSK, Solution, Topical • Reactions: General illness, Intentional misuse • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-051529
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 10.00 Year
  • Weight: 3.180 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
Reactions Reported:
General illness Intentional misuse
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Female, 5 year, 4.536 kilogram • Drug: MSK, Topical, Dose: 1 dose per animal • Reactions: Tiredness (lethargy) • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-032290
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 5.00 Year
  • Weight: 4.536 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Dose: 1 dose per animal
Reactions Reported:
Tiredness (lethargy)
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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