Meds A-Z
Prednisolone
Detailed information about Prednisolone
Pet Owner Quick Guide
Start here: what this medicine is for, what it does, and when it's usually needed.
Usually used for:
Antipruritic : Trimeprazine with Prednisolone is recommended for the relief of itching regardless of cause. Its usefulness has been demonstrated for the relief of itching and the reduction of inflammation commonly associ...
What it does:
The drug is indicated in the treatment of dogs for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylit...
When it's needed:
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinica...
Call your vet sooner if you notice:
- Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered late in pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Commonly reported reactions:
- (2 reports)
- (2 reports)
- (1 reports)
What to ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Prednisolone
Drug type: Generic ingredient • Branded profile • FDA branded products available
Species: Both
Manufacturer: Zoetis Inc.
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200784 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/11403 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source
Warnings / Contraindications
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered late in pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered late in pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Tap or hover a reaction to see what it means in plain language.
Most Reported Reactions
| Reaction | Cases | Species | Serious cases |
|---|---|---|---|
| 2 | Cat, Dog | 1 | |
| 2 | Cat, Dog | 0 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 |
Species coverage: Dog (18) Cat (14)
View detailed reaction table
| Reaction | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 |
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-055886
Storage & Handling
No storage/handling guidance is linked yet.
Documents
Official label facts are separated from secondary summaries.
Official documents: 30 • Secondary summaries: 0
- FOI Summary oA 200-784 Approved June 20, 2024.pdf · FOI
- Trimeprazine with Prednisolone · SPL
- Medrol® Tablets · SPL
- Methylprednisolene Tablets · SPL
- Temaril-P® Tablets · SPL
- Hydeltrone Ointment · SPL
- Hydeltrone-TBA Suspension · SPL
- Depo-Medrol® · SPL
- Prednis-A-Vet Injection · SPL
- Methylprednisolone Acetate Inj. · SPL
- N140921_Supp_11_20_1997.pdf · FOI
- UCM478245.pdf · FOI
- PrednisTab® · SPL
- Chlorasone Ophthalmic Ointment · SPL
- Cortaba® Tablets · SPL
- Delta Albaplex® 3x Tablets · SPL
- Delta Albaplex® Tablets · SPL
- Liquichlor with Cerumene · SPL
- Liquisone F with Cerumene · SPL
- Meticortelone Acetate · SPL
- Neo-Delta Cortef® Sterile Solution · SPL
- Neo-Delta-Cortef® with Tetracaine Ointment · SPL
- Optisone · SPL
- Prednisolone Aqueous Suspension · SPL
- Prednisolone Sodium Succinate for Injection · SPL
- Solu-Delta Cortef® Sterile Powder · SPL
- UCM202424.pdf · FOI
- Surolan® · SPL
- Temaril-P® Spansule Capsule No. 2 · SPL
- Temaril-P® Spansule Capsule No. 1 · SPL
No source yet.
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/15546 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/15806/Trimeprazine%20with%20Prednisolone · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/675/Medrol%C2%AE%20Tablets · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2153/Methylprednisolene%20Tablets · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/711/Temaril-P%C2%AE%20Tablets · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/677/Hydeltrone%20Ointment · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/660/Hydeltrone-TBA%20Suspension · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/703/Depo-Medrol%C2%AE · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1604/Prednis-A-Vet%20Injection · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/522/Methylprednisolone%20Acetate%20Inj. · document · SPL
Promotional Materials (Marketing)
This content is marketing material and not clinical guidance.
No marketing assets are linked yet.
No source yet.
Technical appendix (vet reference)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
- Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
-
Animal Drugs @ FDA:
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Applications/products are imported from FDA export data.
-
Animal Drugs @ FDA previews:
Source FDA
| Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:03 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Feb 12, 2026, 10:43 PM UTC
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
- Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered late in pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Identifiers & Packages
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 11695-4469-1 | 11695 | - | |
| 11695-4470-1 | 11695 | - | |
| 11695-7043-1 | 11695 | - | |
| 11695-7043-2 | 11695 | - | |
| 11789-248-10 | 11789 | - | |
| 11789-249-10 | 11789 | - | |
| 50989-163-53 | 50989 | - | |
| 50989-286-52 | 50989 | - | |
| 54771-1613-1 | 54771 | - | |
| 54771-1614-1 | 54771 | - | |
| 54771-3547-1 | 54771 | - | |
| 54771-8550-1 | 54771 | - | |
| 54771-8550-2 | 54771 | - | |
| 57319-441-16 | 57319 | - | |
| 58198-0813-1 | 58198 | - | |
| 58198-0813-2 | 58198 | - | |
| 62157-152-01 | 62157 | - | |
| 62157-413-01 | 62157 | - | |
| 62157-414-01 | 62157 | - | |
| 69043-042-10 | 69043 | - |
Enriched Documents
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
-
FOI Summary oA 200-784 Approved June 20, 2024.pdf
• FOI summary • Official
• July 1, 2024
FDA FOI summary for application 200784
-
UCM478245.pdf
• FOI summary • Official
• May 17, 2017
FDA FOI summary for application 140921
-
N140921_Supp_11_20_1997.pdf
• FOI summary • Official
• May 17, 2017
FDA FOI summary for application 140921
-
UCM202424.pdf
• FOI summary • Official
• June 1, 2016
FDA FOI summary for application 141298
Data Sources & Revision History
Every non-trivial field is expected to include provenance and update timestamps.
- contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug … (Official, 2026-02-12)
- side_effects: Top reported reactions (openFDA): Loss of hearing, Vomiting, Deafness, Lack of efficacy - NOS, Lethargy (see also Central nervous system depression in 'Neurolo… (Official, 2026-02-12)
- usage: The drug is indicated in the treatment of dogs for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoske… (Official, 2026-02-12)
- side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
Official sponsor/proprietary-name/application-status records linked by active ingredient.
| Product | Sponsor | Application | Status | Published |
|---|---|---|---|---|
|
Trimeprazine with Prednisolone
RX
Prednisolone Trimeprazine Tartrate
Tablet
• Oral
|
ZYVET AH, Inc. | ANADA 200-784 | Approved | Jul 1, 2024 |
|
Medrol® Tablets
RX
Methylprednisolone
Tablet
• Oral
|
Zoetis Inc. | NADA 11403 | Approved | Feb 23, 2024 |
|
Methylprednisolene Tablets
RX
Methylprednisolone
Tablet
• Oral
|
Cronus Pharma Specialities India Private Ltd. | NADA 135-771 | Approved | Nov 24, 2023 |
|
Temaril-P® Tablets
RX
Prednisolone Trimeprazine Tartrate
Tablet
• Oral
|
Zoetis Inc. | NADA 12437 | Approved | Jun 7, 2023 |
|
Hydeltrone Ointment
RX
Neomycin Sulfate Prednisolone Sodium Phosphate
Ointment
• Ophthalmic, Topical
|
Boehringer lngelheim Animal Health USA Inc. | NADA 11437 | W | May 3, 2023 |
|
Hydeltrone-TBA Suspension
RX
Prednisolone Tertiary Butylacetate
Liquid (Suspension)
• Intrasynovial, Intramuscular
|
Boehringer lngelheim Animal Health USA Inc. | NADA 11080 | W | May 3, 2023 |
|
Depo-Medrol®
RX
Methylprednisolone Acetate
Liquid (Suspension)
• Intramuscular, Intrasynovial
|
Zoetis Inc. | NADA 12204 | Approved | Dec 7, 2021 |
|
Prednis-A-Vet Injection
RX
Prednisolone Sodium Phosphate
Liquid (Solution)
• Intravenous
|
Bimeda Animal Health Limited | NADA 98288 | Approved | Oct 2, 2018 |
|
Methylprednisolone Acetate Inj.
RX
Methylprednisolone Acetate
Liquid (Suspension)
• Intramuscular, Intrasynovial
|
Cronus Pharma Specialities India Private Ltd. | NADA 136-212 | Approved | Feb 1, 2018 |
|
PrednisTab®
RX
Prednisolone
Tablet
• Oral
|
Lloyd, Inc. | NADA 140-921 | Approved | May 17, 2017 |
|
Chlorasone Ophthalmic Ointment
RX
Chloramphenicol Prednisolone Acetate
Ointment
• Ophthalmic
|
Evsco Pharmaceuticals, An Affiliate of IGI, Inc. | NADA 65259 | W | Jun 1, 2016 |
|
Cortaba® Tablets
RX
Acetylsalicylic Acid Methylprednisolone
Tablet
• Oral
|
Zoetis Inc. | NADA 11700 | Approved | Jun 1, 2016 |
|
Delta Albaplex® 3x Tablets Delta Albaplex® Tablets
RX
Novobiocin Sodium Prednisolone Tetracycline Hydrochloride
Tablet
• Oral
|
Zoetis Inc. | NADA 65090 | Approved | Jun 1, 2016 |
|
Liquichlor with Cerumene
RX
Chloramphenicol Prednisolone Squalene Tetracaine
|
Evsco Pharmaceuticals, An Affiliate of IGI, Inc. | NADA 55005 | W | Jun 1, 2016 |
|
Liquisone F with Cerumene
RX
Hexamethyltetracosane Neomycin Sulfate Prednisolone Tetracaine
Liquid (Suspension)
• Topical
|
Evsco Pharmaceuticals, An Affiliate of IGI, Inc. | NADA 32322 | W | Jun 1, 2016 |
|
Meticortelone Acetate
RX
Prednisolone Acetate
Liquid (Suspension)
• Intramuscular, Intra-Articular
|
Intervet, Inc. | NADA 10312 | Approved | Jun 1, 2016 |
|
Neo-Delta Cortef® Sterile Solution
RX
Neomycin Sulfate Prednisolone Acetate
Liquid (Suspension)
• Ophthalmic
|
Zoetis Inc. | NADA 91534 | Approved | Jun 1, 2016 |
|
Neo-Delta-Cortef® with Tetracaine Ointment
RX
Neomycin Sulfate Prednisolone Acetate Tetracaine Hydrochloride
Liquid (Suspension)
• Ophthalmic
|
Zoetis Inc. | NADA 11703 | Approved | Jun 1, 2016 |
|
Optisone
RX
Neomycin Sulfate Prednisolone Acetate
Ointment
• Ophthalmic
|
Evsco Pharmaceuticals, An Affiliate of IGI, Inc. | NADA 45288 | W | Jun 1, 2016 |
|
Prednisolone Aqueous Suspension
RX
Prednisolone Acetate
|
Akorn, Inc. | NADA 12444 | W | Jun 1, 2016 |
|
Prednisolone Sodium Succinate for Injection
RX
Prednisolone Sodium Succinate
|
Watson Laboratories, Inc. | NADA 117-973 | W | Jun 1, 2016 |
|
Solu-Delta Cortef® Sterile Powder
RX
Prednisolone Sodium Succinate
Liquid
• Intravenous, Intramuscular
|
Zoetis Inc. | NADA 11593 | Approved | Jun 1, 2016 |
|
Surolan®
RX
Miconazole Nitrate Polymyxin B Sulfate Prednisolone Acetate
Liquid (Suspension)
• Otic
|
Elanco US Inc. | NADA 141-298 | Approved | Jun 1, 2016 |
|
Temaril-P® Spansule Capsule No. 2 Temaril-P® Spansule Capsule No. 1
RX
Prednisolone Trimeprazine Tartrate
Capsule
• Oral
|
Zoetis Inc. | NADA 35161 | Approved | Jun 1, 2016 |
Data source: FDA Animal Drugs @ FDA (public search export).
What It's For (FDA Label Highlights)
Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.
Composition / specifications
Antipruritic: Trimeprazine with Prednisolone is recommended for the relief of itching regardless of cause. Its usefulness has been demonstrated for the relief of itching and the reduction of inflammation commonly associated with most skin disorders of dogs such as the eczema caused by internal disorders, otitis, and dermatitis (allergic, parasitic, pustular, and nonspecific). It often relieves pruritis which does not respond to other therapy.
Antitussive: Trimeprazine with Prednisolone has been found to be effective therapy and adjunctive therapy in various cough conditions of dogs. Therefore, in addition to its antipruritic action, Trimeprazine with Prednisolone is recommended for the treatment of “kennel cough” or tracheobronchitis, bronchitis including all allergic bronchitis, and infections and coughs of nonspecific origin. (Coughs due to cardiac insufficiency would not be expected to respond to Trimeprazine with Prednisolone therapy).
The drug is administered orally at an initial dosage level of 1/2 tablet twice daily to dogs weighing up to 10 pounds, one tablet twice daily to dogs weighing 11 to 20 pounds, two tablets twice daily to dogs weighing 21 to 40 pounds, and three tablets twice daily to dogs weighing over 40 pounds. After 4 days, the dosage is reduced to approximately 1/2 the initial dosage or to an amount just sufficient to maintain remission of symptoms. Dosages in individual cases may vary and should be adjusted until proper response is obtained.
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
Hazardous for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis. Systemic therapy with methylprednisolone is contraindicated in animals with arrested tuberculosis, peptic ulcer, acute psychoses, corneal ulcer, and cushingoid syndrome. The presence of diabetes, osteoporosis, chronic psychotic reactions, predisposition to thrombophlebitis, hypertension, congestive heart failure, renal insufficiency and active tuberculosis necessitates carefully controlled use. Some of the above conditions occur only rarely in dogs and cats but should be kept in mind. Antiinflammatory action of corticosteroids may mask signs of infection.
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
The drug is administered orally to dogs for the relief of itching regardless of cause; reduction of inflammation commonly associated with most skin disorders of dogs such as eczema, caused by internal disorders, otitis, and dermatitis, (allergic, parasitic, pustular, and nonspecific). It is also used in dogs as adjunctive therapy in various cough conditions including treatment of “kennel cough” or tracheobronchitis, bronchitis including allergic bronchitis, infections and coughs of nonspecific origin. The product may also be administered to dogs suffering from acute or chronic bacterial infections provided the infection is controlled by appropriate antibiotic or chemotherapeutic agents.
Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
Not for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis. Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis, peptic ulcer, and Cushing's syndrome. The presence of active tuberculosis, diabetes mellitus, osteoporosis, renal insufficiency, predisposition to thrombophlebitis, hypertension, or congestive heart failure necessitates carefully controlled use of corticosteroids. Intrasynovial, intratendinous or other injections of corticosteroids for local effect are contraindicated in the presence of acute infectious conditions. Exacerbation of pain, further loss of joint motion, with fever and malaise following injection may indicate that the condition has become septic. Appropriate antibacterial therapy should be instituted immediately.
Not for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis. Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis, peptic ulcer, and Cushing's syndrome. The presence of active tuberculosis, diabetes mellitus, osteoporosis, renal insufficiency, predisposition to thrombophlebitis, hypertension, or congestive heart failure necessitates carefully controlled use of corticosteroids. Intrasynovial, intratendinous or other injections of corticosteroids for local effect are contraindicated in the presence of acute infectious conditions. Exacerbation of pain, further loss of joint motion, with fever and malaise following injection may indicate that the condition has become septic. Appropriate antibacterial therapy should be instituted immediately.
Not for human use. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis. Systemic therapy with methylprednisolone acetate, as with other corticoids, is contraindicated in animals with arrested tuberculosis, peptic ulcer, and Cushing's syndrome. The presence of active tuberculosis, diabetes mellitus, osteoporosis, renal insufficiency, predisposition to thrombophlebitis, hypertension, or congestive heart failure necessitates carefully controlled use of corticosteroids. Intrasynovial, intratendinous or other injections of corticosteroids for local effect are contraindicated in the presence of acute infectious conditions. Exacerbation of pain, further loss of joint motion, with fever and malaise following injection may indicate that the condition has become septic. Appropriate antibacterial therapy should be instituted immediately.
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Official Documents (FDA)
Direct links to FDA-hosted PDFs and SPL packages (when available).
-
Summary
Antipruritic: Trimeprazine with Prednisolone is recommended for the relief of itching regardless of cause. Its usefulness has been demonstrated for the relief of itching and the reduction of inflammation commonly associated with most skin disorders of dogs such as the eczema caused by internal disorders, otitis, and dermatitis (allergic, parasitic, pustular, and nonspecific). It often relieves pruritis which does not respond to other therapy.
Antitussive: Trimeprazine with Prednisolone has been found to be effective therapy and adjunctive therapy in various cough conditions of dogs. Therefore, in addition to its antipruritic action, Trimeprazine with Prednisolone is recommended for the treatment of "kennel cough" or tracheobronchitis, bronchitis including all allergic bronchitis, and infections and coughs of nonspecific origin. (Coughs due to cardiac insufficiency would not be expected to respond to Trimeprazine with Prednisolone therapy).
FDA page: Open in Animal Drugs @ FDA
- Medrol® Tablets (ZIP)
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
- Temaril-P® Tablets (ZIP)
FDA page: Open in Animal Drugs @ FDA
- Hydeltrone Ointment (ZIP)
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
- Depo-Medrol® (ZIP)
FDA page: Open in Animal Drugs @ FDA
- Prednis-A-Vet Injection (ZIP)
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
-
Summary
Provides for a new 20 mg tablet size.
-
FOI UCM478245.pdf
Summary
PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various collagen, dermal, allergic, ocular, otic, and musculoskeletal conditions known to be responsive to the anti-inflammatory corticosteroids.
- PrednisTab® (ZIP)
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
- Cortaba® Tablets (ZIP)
FDA page: Open in Animal Drugs @ FDA
- Delta Albaplex® 3x Tablets (ZIP)
- Delta Albaplex® Tablets (ZIP)
FDA page: Open in Animal Drugs @ FDA
- Liquichlor with Cerumene (ZIP)
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
- Meticortelone Acetate (ZIP)
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
- Optisone (ZIP)
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
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FOI UCM202424.pdf
Summary
For the treatment of canine otitis externa associated with susceptible strains of yeast ( Malassezia pachydermatis) and bacteria ( Staphylococcus pseudintermedius)
- Surolan® (ZIP)
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
Usage
The drug is indicated in the treatment of dogs for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition. The drug is indicated in the treatment of cats for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition. The drug is indicated in the treatment of horses for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition.
Source: FDA Animal Drugs @ FDA • Reference
Contraindications
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered late in pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Side Effects
No approved side-effect narrative is linked yet.
openFDA reaction signals are available for Dog 56 and Cat 56 (view top reported reactions).
Top Reported Reactions (openFDA)
Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Dog, Lhasa Apso, Female, 10.92 year, 11.16 kilogram • Drug: MSK, Unknown • Reactions: Diarrhea, Oral mass • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-056010
- Serious AE: No
- Treated For AE: Yes
- Sex: Female
- Age: 10.92 Year
- Weight: 11.160 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, ['Retriever - Golden', 'Poodle (unspecified)'], Male, 3 year, 31.75 kilogram • Drug: MSK, Suspension, Intraocular • Reactions: Squinting, Eye irritation, Medication error NOS • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-055998
- Serious AE: No
- Treated For AE: Yes
- Sex: Male
- Age: 3.00 Year
- Weight: 31.750 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Intraocular
- Form: Suspension
Cat, Domestic Shorthair, Male, 12 year, 10.43 kilogram • Drug: MSK, Unknown • Reactions: Weight loss, Vomiting, Decreased appetite, Hard stool • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-055784
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 12.00 Year
- Weight: 10.430 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Cat, Domestic Longhair, Male, 15 year, 4.19 kilogram • Drug: MSK, Unknown • Reactions: Vomiting • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-056003
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 15.00 Year
- Weight: 4.190 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, Shih Tzu, Female, 13 year, 6.623 kilogram • Drug: MSK, Oral, Dose: 5 Milligram per animal, Frequency: 1 per day • Reactions: Erythema, Behavioral disorder (unspecified), Weight loss, Bumps on skin, Skin sore… • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-055886
- Serious AE: No
- Treated For AE: Yes
- Sex: Female
- Age: 13.00 Year
- Weight: 6.623 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Dose: 5 Milligram per animal
- Frequency: 1 per day
Dog, Terrier - West Highland White, Male, 12 year, 9.52 kilogram • Drug: MSK, Suspension, Auricular (Otic), Dose: 1 dose per animal • Reactions: Deafness • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-055789
- Serious AE: Yes
- Treated For AE: No
- Sex: Male
- Age: 12.00 Year
- Weight: 9.520 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Auricular (Otic)
- Form: Suspension
- Dose: 1 dose per animal
Dog, Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog), Female, 2 year, 16.965 kilogram • Drug: MSK, Unknown • Reactions: Other abnormal test result NOS, Skin irritation, Skin inflammation NOS, Hives, Pustules • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-054907
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 2.00 Year
- Weight: 16.965 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Cat, Domestic Shorthair, Female, 8 year, 3.629 kilogram • Drug: MSK, Unknown, Dose: 0.50 mL per dose, Frequency: 24 per hour • Reactions: Oral bleeding, Haemorrhage NOS, Food refusal, Cardiac arrest, Death… • Outcome: Died
- Report ID: USA-USFDACVM-2025-US-055214
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 8.00 Year
- Weight: 3.629 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Dose: 0.50 mL per dose
- Frequency: 24 per hour
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.
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This medication has not been reviewed by a veterinarian yet.