Meds A-Z

Dexmedetomidine

Detailed information about Dexmedetomidine

Official label facts Owner quick guide first Marketing clearly labeled

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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures.

What it does:

When it's needed:

Call your vet sooner if you notice:

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue. Federal law (USA) restricts this drug to use by or on the order of a licensed veterinarian.

Commonly reported reactions:

(2 reports)
(2 reports)
(2 reports)

What to ask your vet today:

Is this medicine the right fit for my pet’s current symptoms?
Which warning signs mean I should call back right away?
How should I handle missed doses or refusal to take the medicine?

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Dexmedetomidine

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: MSK

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both

Manufacturer: MSK

Form: Injectable Solution, Liquid (Solution), Oromucosal Gel, Sterile Injectable Solution, Sterile Solution

Identifiers:

ANADA: 200573 ANADA: 200699 ANADA: 200735 ANADA: 200752 ANADA: 200824 NADA: 141267 NADA: 141456 NDC Package: 11695-6967-1 NDC Package: 17033-005-10 NDC Package: 46066-088-13 NDC Package: 54771-1050-1 NDC Package: 54771-2805-1 NDC Package: 54771-2806-1 NDC Package: 64189-8502-0 NDC Package: 64189-8502-1 NDC Package: 68504-006-10 NDC Package: 69043-038-10 NDC Package: 86101-061-41 NDC Package: 86136-105-31 NDC Product: 11695

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200699 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200824 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue. Federal law (USA) restricts this drug to use by or on the order of a licensed veterinarian.

High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue. Federal law (USA) restricts this drug to use by or on the order of a licensed veterinarian.

Source metadata:

https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals

Reported cases

Serious reports

Species represented

Most Reported Reactions

Cases	Species	Serious cases
2	Cat, Dog	2
2	Cat, Dog	2
2	Cat, Dog	2
2	Cat, Dog	1
1	Dog	1
1	Dog	1
1	Dog	1
1	Dog	1

Species coverage: Dog (24) Cat (8)

View detailed reaction table

Species	Seriousness	Frequency	Reports
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Cat	Non-serious	-	1
Cat	Non-serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Cat	Non-serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1

Source metadata:

https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-055759

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 18 • Secondary summaries: 0

Official label facts

FOI Summary oA 200-699 Approved March 11, 2021.pdf · FOI
DEXVETRA™ · SPL
FOI Summary oA 200-824 Approved September 19, 2025.pdf · FOI
Dexmedetomidine Hydrochloride · SPL
FOI Summary oA 200-752 Approved July 6, 2023.pdf · FOI
DexmedVet™ · SPL
FOI Summary oA 200-735 Approved January 13, 2023.pdf · FOI
Dexmedetomidine Hydrochloride · SPL
UCM436647.pdf · FOI
Dexmedesed® · SPL
UCM475135.pdf · FOI
CIS SILEO N141456G0022-2.pdf · Labeling
PI SILEO N141456G0022.pdf · Labeling
SILEO® · SPL
UCM504535.pdf · FOI
ucm062318.pdf · FOI
ucm062316.pdf · FOI
Dexdomitor® · SPL

Secondary summaries

No source yet.

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/10554 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/10614/DEXVETRA%E2%84%A2 · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/17446 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/17786/Dexmedetomidine%20Hydrochloride · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/14234 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/14472/DexmedVet%E2%84%A2 · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/13374 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/13531/Dexmedetomidine%20Hydrochloride · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1250 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2332/Dexmedesed%C2%AE · document · SPL

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.

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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness

Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:03 AM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC

Official (FDA)

Identity: Generic ingredient • FDA branded products available

Official FDA brands: DEXVETRA™ Dexdomitor® DexmedVet™ Dexmedesed® Dexmedetomidine Hydrochloride SILEO®

Case-reported brands (openFDA): MSK

Catalog species: Both • FDA-labeled species: Cat, Dog

Rx/OTC: RX

Form/route: Injectable Solution, Liquid (Solution), Oromucosal Gel, Sterile Injectable Solution, Sterile Solution • Intramuscular, Intravenous, Oromucosal

Applications: ANADA 200-699 • ANADA 200-824 • ANADA 200-752 • ANADA 200-735 • ANADA 200-573 • NADA 141-456 • NADA 141-267

NDC: Packages 11695-6967-1 64189-8502-0 64189-8502-1 68504-006-10 • Products 11695 64189 64189 68504

Documents: 11 (FOI: 9) • SPL: 7 • Label highlights • Official documents

Safety (openFDA)

Top reactions: Dog 56 • Cat 56 • View

Case summaries: 10 (showing 8) • View

openFDA reports are unverified and do not prove causation.

Explore

Related conditions: Shock (hypovolemic, septic, cardiogenic, anaphylactic)

Linked using: Fda_Label (0.95)

Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue. Federal law (USA) restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)

Top reaction signals

Acid-base disorder (1) Anorexia (1) Application site pain (1) Arthritis (1) Bacterial skin infection NOS (1) Cardiac arrest (1) Death (1) Death (1) Death by euthanasia (1) Dyspnoea (1) Elevated serum alkaline phosphatase (ALP) (1) Enamel disorder (1) Eosinophilia (1) General pain (see other SOCs for specific pain) (1) Hyperactivity (1) Hyperglycaemia (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers

Package NDC	Product NDC	Status
11695-6967-1	11695	-
17033-005-10	17033	-
46066-088-13	46066	-
54771-1050-1	54771	-
54771-2805-1	54771	-
54771-2806-1	54771	-
64189-8502-0	64189	-
64189-8502-1	64189	-
68504-006-10	68504	-
69043-038-10	69043	-
86101-061-41	86101	-
86136-105-31	86136	-

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

FOI Summary oA 200-699 Approved March 11, 2021.pdf • FOI summary • Official • Jan. 8, 2026
FDA FOI summary for application 200699
FOI Summary oA 200-824 Approved September 19, 2025.pdf • FOI summary • Official • Oct. 1, 2025
FDA FOI summary for application 200824
FOI Summary oA 200-752 Approved July 6, 2023.pdf • FOI summary • Official • Aug. 1, 2023
FDA FOI summary for application 200752
FOI Summary oA 200-735 Approved January 13, 2023.pdf • FOI summary • Official • Feb. 1, 2023
FDA FOI summary for application 200735
UCM436647.pdf • FOI summary • Official • Dec. 16, 2021
FDA FOI summary for application 200573
PI SILEO N141456G0022.pdf • Official label • Official • May 17, 2021
FDA official labeling for application 141456
CIS SILEO N141456G0022-2.pdf • Official label • Official • May 17, 2021
FDA official labeling for application 141456
UCM475135.pdf • FOI summary • Official • May 17, 2021
FDA FOI summary for application 141456
ucm062316.pdf • FOI summary • Official • June 1, 2016
FDA FOI summary for application 141267
ucm062318.pdf • FOI summary • Official • June 1, 2016
FDA FOI summary for application 141267
UCM504535.pdf • FOI summary • Official • June 1, 2016
FDA FOI summary for application 141267

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 14 Clinical 0 Manufacturer 0 Marketing 0

Current Field Facts

contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use DEXDOMITOR in dogs or cats with cardiovascular disease, respir… (Official, 2026-02-12)
side_effects: Top reported reactions (openFDA): Lack of efficacy - NOS, Vomiting, Injection site swelling, Death, Bradycardia, Diarrhoea. (Official, 2026-02-12)
usage: For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. For use a… (Official, 2026-02-12)

Recent Revisions

side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product	Sponsor	Application	Status	Published
DEXVETRA™ RX Dexmedetomidine hydrochloride Injectable Solution • Intravenous, Intramuscular Label highlights Official documents	Parnell Technologies Pty. Ltd.	ANADA 200-699	Approved	Jan 8, 2026
Dexmedetomidine Hydrochloride RX Dexmedetomidine hydrochloride Sterile Injectable Solution • Intravenous, Intramuscular Label highlights Official documents	Felix Pharmaceuticals Pvt. Ltd.	ANADA 200-824	Approved	Oct 1, 2025
DexmedVet™ RX Dexmedetomidine hydrochloride Sterile Injectable Solution • Intramuscular, Intravenous Label highlights Official documents	Cronus Pharma Specialities India Private Ltd.	ANADA 200-752	Approved	Aug 1, 2023
Dexmedetomidine Hydrochloride RX Dexmedetomidine hydrochloride Injectable Solution • Intravenous, Intramuscular Label highlights Official documents	ZYVET AH, Inc.	ANADA 200-735	Approved	Feb 1, 2023
Dexmedesed® RX Dexmedetomidine hydrochloride Sterile Solution • Intramuscular, Intravenous Label highlights Official documents	Dechra Veterinary Products LLC	ANADA 200-573	Approved	Dec 16, 2021
SILEO® RX Dexmedetomidine Oromucosal Gel • Oromucosal Label highlights Official documents	Orion Corp.	NADA 141-456	Approved	May 17, 2021
Dexdomitor® RX Dexmedetomidine hydrochloride Liquid (Solution) • Intravenous, Intramuscular Label highlights Official documents	Orion Corp.	NADA 141-267	Approved	Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied

Composition / specifications

0.5 mg/mL

Dogs

Indication

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures.

Dosage

Administer 375 micrograms (mcg) per square meter (/m2) of body surface area by intravenous injection or 500 mcg/m2 of body surface area by intramuscular injection.

Limitations

Indication

For use as a preanesthetic to general anesthesia.

Dosage

Administer 125 mcg/m2 of body surface area or 375 mcg/m2 of body surface area by intramuscular injection.

Limitations

Cats

Indication

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures; and as a preanesthetic to general anesthesia.

Dosage

40 mcg/kg by intramuscular injection

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications

0.5 mg/mL

Dogs

Indication

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures.

Dosage

Administer 375 micrograms (µg) per square meter (/m2) of body surface area by intravenous injection or 500 µg/m2 of body surface area by intramuscular injection.

Limitations

Indication

For use as a preanesthetic to general anesthesia.

Dosage

Administer 125 µg/m2 of body surface area or 375 µg/m2 of body surface area by intramuscular injection.

Limitations

Cats

Indication

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures; and as a preanesthetic to general anesthesia.

Dosage

40 µg/killogram by intramuscular injection.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied

Composition / specifications

0.5 mg/mL

Dogs

Indication

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. It is also indicated for use as a preanesthetic to general anesthesia.

Dosage

Sedation and Analgesia: 500 mcg/m2 intramuscularly (IM) or 375 mcg/m2 intravenously (IV). Preanesthesia: 125 or 375 mcg/m2 IM.

Limitations

Cats

Indication

Dosage

Sedation, Analgesia and Preanesthesia: 40 mcg/kg IM.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied

Composition / specifications

0.5 mg/mL

Dogs

Indication

Dosage

Sedation and Analgesia: 500 mcg/m2 intramuscularly (IM) or 375 mcg/m2 intravenously (IV). Preanesthesia: 125 or 375 mcg/m2 IM.

Limitations

Cats

Indication

Dosage

Sedation, Analgesia and Preanesthesia: 40 mcg/kg intramuscularly (IM)

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied

Composition / specifications

0.5 mg/mL

Indication

Dosage

For sedative and analgesic administer 375 mcg/m2 by intravenous (IV) injection or 500 mcg/m2 by intramuscular (IM) injection; for preanesthesia administer 125 or 375 mcg/m2 by IM injection

Limitations

Indication

For use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. Dexmedetomidine HCl is also indicated for use as a preanesthetic to general anesthesia in dogs and cats

Dosage

For sedation, analgesia, or preanesthesia administer 40 mcg/kg IM

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied

Composition / specifications

Each mL contains 0.09 mg dexmedetomidine (equivalent to 0.1 mg dexmedetomidine hydrochloride)

Dogs

Indication

For the treatment of noise aversion in dogs.

Dosage

Administer onto the oral mucosa between the dog’s cheek and gum at the dose of 125 micrograms per square meter.

Limitations

Federal law (USA) restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied

Composition / specifications

Each mL contains 0.5 mg dexmedetomidine hydrochloride

Cats

Indication

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures.

Dosage

40 mcg/kg by intramuscular (IM) injection.

Limitations

Indication

For use as a preanesthetic to general anesthesia.

Dosage

40 mcg/kg by intramuscular (IM) injection.

Limitations

Dogs

Indication

For use as a sedative and analgesic in dogs to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures.

Dosage

Administer 500 mcg/m2 intramuscularly (IM) or 375 mcg/m2 of body surface area by intravenous (IV) injection. Note that the mcg/kg dosage decreases as body weight increases.

Limitations

Indication

For use as a preanesthetic to general anesthesia.

Dosage

Administer 125 mcg/m2 of body surface area or 375 mcg/m2 of body surface area by intramuscular injection. Note that the mcg/kg dosage decreases as body weight increases.

Limitations

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents

FOI FOI Summary oA 200-699 Approved March 11, 2021.pdf

Summary

For use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. It is also indicated for use as a preanesthetic to general anesthesia in dogs and cats.

SPL Packages

DEXVETRA™ (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI FOI Summary oA 200-824 Approved September 19, 2025.pdf

Summary

For use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. It is also indicated for use as a preanesthetic to general anesthesia in dogs and cats.

SPL Packages

Dexmedetomidine Hydrochloride (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI FOI Summary oA 200-752 Approved July 6, 2023.pdf

Summary

For use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. It is also indicated for use as a preanesthetic to general anesthesia in dogs and cats.

SPL Packages

DexmedVet™ (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI FOI Summary oA 200-735 Approved January 13, 2023.pdf

Summary

For use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. It is also indicated for use as a preanesthetic to general anesthesia in dogs and cats.

SPL Packages

Dexmedetomidine Hydrochloride (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM436647.pdf

Summary

For use as a sedative and analgesic in dogs and cats to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. Dexmedetomidine HCl is also indicated for use as a preanesthetic to general anesthesia in dogs and cats.

SPL Packages

Dexmedesed® (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM475135.pdf

Summary

For the treatment of noise aversion in dogs.
Labeling CIS SILEO N141456G0022-2.pdf
Labeling PI SILEO N141456G0022.pdf

SPL Packages

SILEO® (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM504535.pdf

Summary

This supplement provides for a new indication for use as a preanesthetic to general anesthesia in cats.
FOI ucm062318.pdf

Summary

The effect of the supplement is to add an indication for its use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures in cats.
FOI ucm062316.pdf

Summary

DEXDOMITOR is indicated for use as a sedative and analgesic in dogs to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. DEXDOMITOR is also indicated for use as a preanesthetic to general anesthesia

SPL Packages

Dexdomitor® (ZIP)

FDA page: Open in Animal Drugs @ FDA

Usage

For use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures. For use as a preanesthetic to general anesthesia. For use as a sedative and analgesic in dogs to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 56 and Cat 56 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog

Digestive

Vomiting (130) Diarrhea (92) Drooling (2) Drooling (2) Drooling (2) Drooling (2) Drooling (2) Drooling (2) Vomiting (2) Vomiting (2) Vomiting (2) Vomiting (2)

Skin & allergy

Injection site swelling (118)

Neurologic

Tiredness (lethargy) (73)

Effectiveness

Lack of efficacy - NOS (295) Lack of efficacy - NOS (2) Lack of efficacy - NOS (2)

Other

Death (97) Bradycardia (92) Not eating (67) Death (3) Death (3) Death (3) Death (3) Death (3) Regurgitation (3) Regurgitation (3) Regurgitation (3) Regurgitation (3) Regurgitation (3) Regurgitation (3) Bacterial skin infection NOS (2) Bacterial skin infection NOS (2) Bacterial skin infection NOS (2) Bacterial skin infection NOS (2) Bacterial skin infection NOS (2) Bacterial skin infection NOS (2) Bradycardia (2) Bradycardia (2) Bradycardia (2) Bradycardia (2) Bradycardia (2) Bradycardia (2) Death (2) Elevated serum alkaline phosphatase (2) Elevated serum alkaline phosphatase (2) Elevated serum alkaline phosphatase (2) Elevated serum alkaline phosphatase (2) Elevated serum alkaline phosphatase (2) Elevated serum alkaline phosphatase (2) Trouble breathing (dyspnea) (2) Trouble breathing (dyspnea) (2) Trouble breathing (dyspnea) (2) Trouble breathing (dyspnea) (2) Trouble breathing (dyspnea) (2) Trouble breathing (dyspnea) (2)

Cat

Digestive

Loss of appetite (63)

Behavior

Behavioral disorder (unspecified) (119) Behavioral disorder (unspecified) (2) Behavioral disorder (unspecified) (2) Behavioral disorder (unspecified) (2) Behavioral disorder (unspecified) (2) Behavioral disorder (unspecified) (2) Behavioral disorder (unspecified) (2)

Effectiveness

Lack of efficacy - NOS (90)

Other

Death (109) Not eating (96) Hyperactivity (79) Dilated pupils (77) Dysphoria (72) Hyperactivity (4) Hyperactivity (4) Hyperactivity (4) Hyperactivity (4) Hyperactivity (4) Hyperactivity (4) Intentional misuse (3) Intentional misuse (3) Intentional misuse (3) Intentional misuse (3) Intentional misuse (3) Intentional misuse (3) Anaphylaxis (2) Anaphylaxis (2) Anaphylaxis (2) Anaphylaxis (2) Death (2) Death (2) Death (2) Death (2) Mydriasis (2) Mydriasis (2) Mydriasis (2) Mydriasis (2) Mydriasis (2) Mydriasis (2) Not eating (2) Not eating (2) Not eating (2) Not eating (2) Not eating (2) Not eating (2) Open mouth breathing (2) Open mouth breathing (2) Open mouth breathing (2) Open mouth breathing (2) Open mouth breathing (2) Open mouth breathing (2) Polyphagia (2) Polyphagia (2) Anaphylaxis (1) Anaphylaxis (1)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Shorthair, Male, 5 year, 8.61 kilogram • Drug: MSK, Unknown • Reactions: Hyperthermia, Hyperactivity • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-055972
Serious AE: No
Treated For AE: No
Sex: Male
Age: 5.00 Year
Weight: 8.610 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown

Reactions Reported:

Hyperthermia Hyperactivity

Outcomes: Ongoing

Dog, ['Shepherd Dog - German', 'Dog (unknown)'], Female, 2.5 year • Drug: MSK, Intramuscular, Dose: 0.29 mL per animal • Reactions: Neutropenia, Eosinophilia, Lymphocytosis, Enamel disorder, Tooth disorder • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-055809
Serious AE: Yes
Treated For AE: No
Sex: Female
Age: 2.50 Year

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Intramuscular
Dose: 0.29 mL per animal

Reactions Reported:

Neutropenia Eosinophilia Lymphocytosis Enamel disorder Tooth disorder

Outcomes: Outcome Unknown

Cat, Domestic Mediumhair, Female, 19 week, 2.06 kilogram • Drug: MSK, Unknown • Reactions: Sleepiness - neurological disorder, Temporary blindness, Tiredness (lethargy), Reduced responses, Mydriasis… • Outcome: Euthanized

Report ID: USA-USFDACVM-2025-US-055689
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 19.00 Week
Weight: 2.060 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown

Reactions Reported:

Sleepiness - neurological disorder Temporary blindness Tiredness (lethargy) Reduced responses Mydriasis Death by euthanasia

Outcomes: Euthanized

Cat, Cat (unknown), Female, 4.05 kilogram • Drug: MSK, Injection, Unknown, Dose: 0.03 Milligram per kilogram • Reactions: Hyperglycaemia • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-054116
Serious AE: No
Treated For AE: No
Sex: Female
Weight: 4.050 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Form: Injection
Dose: 0.03 Milligram per kilogram

Reactions Reported:

Hyperglycaemia

Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 13 year, 6.804 kilogram • Drug: MSK, Injection, Intramuscular, Dose: 5 Microgram per kilogram • Reactions: Nausea, Prolonged one stage prothrombin time, Prolonged activated partial thrombin time, Cardiac arrest, Death • Outcome: Died

Report ID: USA-USFDACVM-2025-US-055853
Serious AE: Yes
Treated For AE: Yes
Sex: Male
Age: 13.00 Year
Weight: 6.804 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Intramuscular
Form: Injection
Dose: 5 Microgram per kilogram

Reactions Reported:

Nausea Prolonged one stage prothrombin time Prolonged activated partial thrombin time Cardiac arrest Death

Outcomes: Died

Dog, ['Crossbred Canine/dog', 'Retriever - Labrador', 'Poodle - Medium size'], Female, 3 year, 12.338 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy - NOS, Rubbing, Application site pain • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-056018
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 3.00 Year
Weight: 12.338 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown

Reactions Reported:

Lack of efficacy - NOS Rubbing Application site pain

Outcomes: Ongoing

Dog, Dog (unknown), Male, 10 year, 32.659 kilogram • Drug: MSK, Unknown • Reactions: Mass NOS, Lymph node abscess, Lymphadenopathy, Tachycardia, Drooling… • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-055759
Serious AE: Yes
Treated For AE: No
Sex: Male
Age: 10.00 Year
Weight: 32.659 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown

Reactions Reported:

Mass NOS Lymph node abscess Lymphadenopathy Tachycardia Drooling Elevated serum alkaline phosphatase Monocytosis Neutrophilia Leucocytosis NOS Acid-base disorder Musculoskeletal disorder NOS Luxation/subluxation Arthritis Muscle tremor Tachypnoea Trouble breathing (dyspnea) Bacterial skin infection NOS Trauma NOS Hyperthermia Loss of appetite Oedema NOS Tiredness (lethargy) General pain

Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 16 year, 4.36 kilogram • Drug: MSK, Solution, Intramuscular, Dose: 0.0050 Milligram per kilogram • Reactions: Lack of efficacy - NOS • Outcome: Recovered/Normal

Report ID: USA-USFDACVM-2025-US-055487
Serious AE: Yes
Treated For AE: Yes
Sex: Male
Age: 16.00 Year
Weight: 4.360 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Intramuscular
Form: Solution
Dose: 0.0050 Milligram per kilogram

Reactions Reported:

Lack of efficacy - NOS

Outcomes: Recovered/Normal

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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Medical Disclaimer: The medication details provided on PetWisePlus are for informational purposes only and are not a substitute for professional veterinary advice. Always consult your veterinarian about your pet's specific needs.

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