Meds A-Z

Protamine Zinc Recombinant Human Insulin

Detailed information about Protamine Zinc Recombinant Human Insulin

Official label facts Owner quick guide first Marketing clearly labeled

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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

Use this medication only when your veterinarian confirms it matches your pet's condition.

What it does:

Use this medication only when your veterinarian confirms it matches your pet's condition.

When it's needed:

Use this medication only when your veterinarian confirms it matches your pet's condition.

Commonly reported reactions:

(2 reports)
(1 reports)
(1 reports)

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Protamine Zinc Recombinant Human Insulin

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Species: Both

Manufacturer: MSK

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both

Manufacturer: MSK

Form: No source yet

Identifiers:

NDC Package: 0010-4499-01 NDC Package: 0010-4499-02 NDC Product: 0010

Source metadata: No source yet.

Warnings / Contraindications

No contraindication summary is linked yet.

No owner-focused warning rows are linked yet.

Source metadata: No source yet.

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals

Reported cases

Serious reports

Species represented

Most Reported Reactions

Cases	Species	Serious cases
2	Cat, Dog	0
1	Cat	1
1	Cat	1
1	Dog	1
1	Dog	1
1	Cat	1
1	Cat	1
1	Cat	1

Species coverage: Cat (23) Dog (9)

View detailed reaction table

Species	Seriousness	Frequency	Reports
Dog	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Cat	Non-serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Cat	Non-serious	-	1
Dog	Non-serious	-	1
Cat	Non-serious	-	1
Cat	Serious	-	1
Cat	Non-serious	-	1
Cat	Serious	-	1
Cat	Non-serious	-	1
Cat	Non-serious	-	1
Cat	Non-serious	-	1
Dog	Unknown	-	-
Cat	Unknown	-	-
Cat	Unknown	-	-
Cat	Unknown	-	-
Cat	Unknown	-	-
Cat	Unknown	-	-
Cat	Unknown	-	-
Dog	Unknown	-	-
Dog	Unknown	-	-

Source metadata:

https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-052644

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

No linked label PDFs or safety notices yet.

Official label facts

No source yet.

Secondary summaries

No source yet.

Source metadata: No source yet.

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.

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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness

Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:03 AM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC

Official (FDA)

Identity: Generic ingredient • No FDA branded products linked

No official FDA brand rows linked yet for this ingredient.

Case-reported brands (openFDA): MSK

Catalog species: Both

Safety (openFDA)

Top reactions: Dog 32 • Cat 56 • View

Case summaries: 10 (showing 8) • View

openFDA reports are unverified and do not prove causation.

Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

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Top reaction signals

Death (1) Death by euthanasia (1) Elevated alanine aminotransferase (ALT) (1) Elevated total bilirubin (1) Emesis (multiple) (1) Granuloma (1) Haemangiosarcoma (1) Hypochloraemia (1) Hypoglycaemia (1) Hypokalaemia (1) Hyponatremia (1) Hypophosphataemia (1) Lack of efficacy (bacteria) - Leptospira (1) Lack of efficacy (bacteria) - NOS (1) Lack of efficacy - NOS (1) Lack of efficacy - NOS (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers

NDC Package: 0010-4499-01 NDC Package: 0010-4499-02 NDC Product: 0010

Package NDC	Product NDC	Form / Route	Status
0010-4499-01	0010		-
0010-4499-02	0010		-

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 1 Clinical 0 Manufacturer 0 Marketing 0

Current Field Facts

side_effects: Top reported reactions (openFDA): Lack of efficacy - NOS, INEFFECTIVE, GLYCEMIC CONTROL, Hypoglycaemia, Vomiting, Death, Lethargy (see also Central nervous sys… (Official, 2026-02-12)

Recent Revisions

side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

No linked FDA product applications are available for this ingredient yet.

Usage

No approved usage text is linked yet for this ingredient.

Catalog species: Both
Safety reports available: 10 openFDA case summaries (view)

Contraindications

No approved contraindication text is linked yet. Review FDA label highlights and openFDA safety reports before making treatment decisions.

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 32 and Cat 56 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog

Digestive

Vomiting (11) Loss of appetite (6)

Neurologic

Tiredness (lethargy) (7)

Effectiveness

Lack of efficacy - NOS (114) Lack of efficacy (bacteria) - Leptospira (1) Lack of efficacy (bacteria) - Leptospira (1) Lack of efficacy (bacteria) - Leptospira (1) Lack of efficacy (bacteria) - Leptospira (1) Lack of efficacy (bacteria) - Leptospira (1) Lack of efficacy (bacteria) - Leptospira (1) Lack of efficacy (bacteria) - NOS (1) Lack of efficacy (bacteria) - NOS (1) Lack of efficacy (bacteria) - NOS (1) Lack of efficacy (bacteria) - NOS (1) Lack of efficacy (bacteria) - NOS (1) Lack of efficacy (bacteria) - NOS (1)

Other

INEFFECTIVE, GLYCEMIC CONTROL (64) Hypoglycaemia (21) Death (7) Death by euthanasia (6) Death (1) Death (1) Death (1) Death (1) Death (1) Death (1) Granuloma (1) Granuloma (1) Granuloma (1) Granuloma (1) Granuloma (1) Granuloma (1)

Cat

Digestive

Vomiting (56) Diarrhea (21) Vomiting (1) Vomiting (1) Vomiting (1) Vomiting (1) Vomiting (1) Vomiting (1)

Neurologic

Tiredness (lethargy) (38)

Effectiveness

Lack of efficacy - NOS (173)

Other

INEFFECTIVE, GLYCEMIC CONTROL (303) Hypoglycaemia (140) INEFFECTIVE, LOSS OF EFFECT (59) Death by euthanasia (54) Urinary tract disorder NOS (2) Urinary tract disorder NOS (2) Urinary tract disorder NOS (2) Urinary tract disorder NOS (2) Urinary tract disorder NOS (2) Urinary tract disorder NOS (2) Death by euthanasia (1) Death by euthanasia (1) Death by euthanasia (1) Death by euthanasia (1) Death by euthanasia (1) Death by euthanasia (1) Elevated alanine aminotransferase (1) Elevated alanine aminotransferase (1) Elevated alanine aminotransferase (1) Elevated alanine aminotransferase (1) Elevated alanine aminotransferase (1) Elevated alanine aminotransferase (1) Elevated total bilirubin (1) Elevated total bilirubin (1) Elevated total bilirubin (1) Elevated total bilirubin (1) Elevated total bilirubin (1) Elevated total bilirubin (1) Haemangiosarcoma (1) Haemangiosarcoma (1) Haemangiosarcoma (1) Haemangiosarcoma (1) Haemangiosarcoma (1) Haemangiosarcoma (1) Hypochloraemia (1) Hypochloraemia (1) Hypochloraemia (1) Hypochloraemia (1) Hypochloraemia (1) Hypochloraemia (1) Hypokalaemia (1) Hypokalaemia (1) Hypokalaemia (1) Hypokalaemia (1) Hypokalaemia (1) Hypokalaemia (1)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Shorthair, Male, 15 year, 6.622 kilogram • Drug: MSK, Suspension, Subcutaneous, Dose: 2 [iU] per animal, Frequency: 12 per hour • Reactions: Vocalisation, Vomiting, Tiredness (lethargy), Urinary tract disorder NOS • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-054382
Serious AE: No
Treated For AE: Yes
Sex: Male
Age: 15.00 Year
Weight: 6.622 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Subcutaneous
Form: Suspension
Dose: 2 [iU] per animal
Frequency: 12 per hour

Reactions Reported:

Vocalisation Vomiting Tiredness (lethargy) Urinary tract disorder NOS

Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Female, 12 year, 8.074 kilogram • Drug: MSK, Injection, solution, Subcutaneous • Reactions: Underdose, Haemangiosarcoma, Urinary tract disorder NOS • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-053444
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 12.00 Year
Weight: 8.074 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Subcutaneous
Form: Injection, solution

Reactions Reported:

Underdose Haemangiosarcoma Urinary tract disorder NOS

Outcomes: Ongoing

Dog, Pinscher - Miniature, Female, 13 year, 4.037 kilogram • Drug: MSK, Suspension, Unknown • Reactions: Lack of efficacy (bacteria) - Leptospira, Death, Granuloma, Lack of efficacy (bacteria) - NOS • Outcome: Died

Report ID: USA-USFDACVM-2025-US-052644
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 13.00 Year
Weight: 4.037 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Form: Suspension

Reactions Reported:

Lack of efficacy (bacteria) - Leptospira Death Granuloma Lack of efficacy (bacteria) - NOS

Outcomes: Died

Cat, Maine Coon, Male, 10 year, 4.944 kilogram • Drug: MSK, Suspension, Unknown, Dose: 0.61 [iU] per kilogram • Reactions: Elevated total bilirubin, Low serum alkaline phosphatase, Elevated alanine aminotransferase, Hyponatremia, Hypokalaemia… • Outcome: Euthanized

Report ID: USA-USFDACVM-2025-US-052205
Serious AE: Yes
Treated For AE: Yes
Sex: Male
Age: 10.00 Year
Weight: 4.944 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Form: Suspension
Dose: 0.61 [iU] per kilogram

Reactions Reported:

Elevated total bilirubin Low serum alkaline phosphatase Elevated alanine aminotransferase Hyponatremia Hypokalaemia Hypochloraemia Hypophosphataemia Death by euthanasia

Outcomes: Euthanized

Cat, Domestic Shorthair, Male, 10 year, 5.67 kilogram • Drug: MSK, Suspension, Subcutaneous, Dose: 0.88 [iU] per kilogram, Frequency: 12 per hour • Reactions: Lack of efficacy - NOS • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-049903
Serious AE: No
Treated For AE: No
Sex: Male
Age: 10.00 Year
Weight: 5.670 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Subcutaneous
Form: Suspension
Dose: 0.88 [iU] per kilogram
Frequency: 12 per hour

Reactions Reported:

Lack of efficacy - NOS

Outcomes: Outcome Unknown

Cat, Cat (unknown), Male, 11 year, 4.536 kilogram • Drug: MSK, Suspension, Unknown, Dose: 0.60 [iU] per kilogram, Frequency: 12 per hour • Reactions: Vomiting, Partial anorexia, Lack of efficacy - NOS • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-049447
Serious AE: No
Treated For AE: No
Sex: Male
Age: 11.00 Year
Weight: 4.536 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Form: Suspension
Dose: 0.60 [iU] per kilogram
Frequency: 12 per hour

Reactions Reported:

Vomiting Partial anorexia Lack of efficacy - NOS

Outcomes: Outcome Unknown

Dog, Schnauzer (unspecified), Unknown • Drug: MSK, Suspension, Unknown, Dose: 0.40 [iU] per kilogram • Reactions: Lack of efficacy - NOS • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-049309
Serious AE: No
Treated For AE: No
Sex: Unknown

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Form: Suspension
Dose: 0.40 [iU] per kilogram

Reactions Reported:

Lack of efficacy - NOS

Outcomes: Outcome Unknown

Dog, Dog (unknown), Unknown • Drug: MSK, Suspension, Unknown • Reactions: Lack of efficacy - NOS • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-039089
Serious AE: No
Treated For AE: No
Sex: Unknown

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Form: Suspension

Reactions Reported:

Lack of efficacy - NOS

Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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Medical Disclaimer: The medication details provided on PetWisePlus are for informational purposes only and are not a substitute for professional veterinary advice. Always consult your veterinarian about your pet's specific needs.

Protamine Zinc Recombinant Human Insulin

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