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Pyriproxyfen

Detailed information about Pyriproxyfen

Official label facts Owner quick guide first Marketing clearly labeled
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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

Use this medication only when your veterinarian confirms it matches your pet's condition.

What it does:

Use this medication only when your veterinarian confirms it matches your pet's condition.

When it's needed:

Use this medication only when your veterinarian confirms it matches your pet's condition.

Commonly reported reactions:

  • (1 reports)
  • (1 reports)
  • (1 reports)

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
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Pyriproxyfen

Pyriproxyfen

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Species: Both

Manufacturer: MSK

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: MSK
Form: No source yet
Identifiers:

No source yet.

Source metadata: No source yet.

Warnings / Contraindications

No contraindication summary is linked yet.

No owner-focused warning rows are linked yet.

Source metadata: No source yet.

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
22
Species represented
2
Most Reported Reactions
Reaction Cases Species Serious cases
1 Dog 1
1 Dog 1
1 Dog 1
1 Dog 1
1 Dog 1
1 Cat 1
1 Dog 1
1 Dog 1

Species coverage: Dog (21) Cat (11)

View detailed reaction table
Reaction Species Seriousness Frequency Reports
Cat Non-serious - 1
Dog Non-serious - 1
Cat Serious - 1
Dog Non-serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Serious - 1
Cat Non-serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Non-serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Non-serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Non-serious - 1
Dog Serious - 1
Cat Non-serious - 1
Dog Serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Source metadata:

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

No linked label PDFs or safety notices yet.

Official label facts

No source yet.

Secondary summaries

No source yet.

Source metadata: No source yet.

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.
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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 36 • Cat 44 • View
Case summaries: 10 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Administration error NOS (1) Alopecia local (1) Behavioural disorder NOS (1) Biting - pruritus (see also Behavioural disorders) (1) Blood in vomit (1) Bloody diarrhoea (1) Chattering of teeth (1) Cough, hacking (1) Death (1) Dental calculus (1) Diarrhoea (1) Digestive tract hypomotility (1) Drooling (1) Gastritis (1) Gastroenteritis (1) Gut sounds increased (1)

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 1 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (ectoparasite) - flea, Pruritus, Vomiting, Lethargy (see also Central nervous system depression in 'Neurolog… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

No linked FDA product applications are available for this ingredient yet.

Usage

No approved usage text is linked yet for this ingredient.

  • Catalog species: Both
  • Safety reports available: 10 openFDA case summaries (view)

Contraindications

No approved contraindication text is linked yet. Review FDA label highlights and openFDA safety reports before making treatment decisions.

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 36 and Cat 44 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog
Digestive
Vomiting (78) Diarrhea (55) Loss of appetite (34)
Skin & allergy
Itching (98) Alopecia local (1) Alopecia local (1) Alopecia local (1) Alopecia local (1) Biting - pruritus (1) Biting - pruritus (1) Biting - pruritus (1) Biting - pruritus (1) Itching (1) Itching (1) Itching (1) Itching (1)
Neurologic
Tiredness (lethargy) (74) Seizure NOS (47)
Behavior
Behavioral disorder (unspecified) (52)
Effectiveness
Lack of efficacy (ectoparasite) - flea (223) Lack of efficacy (ectoparasite) - flea (2) Lack of efficacy (ectoparasite) - flea (2) Lack of efficacy (ectoparasite) - flea (2) Lack of efficacy (ectoparasite) - flea (2)
Other
Hot spot (1) Hot spot (1) Hot spot (1) Hot spot (1) Self trauma (1) Self trauma (1) Self trauma (1) Self trauma (1) Skin sore (1) Skin sore (1) Skin sore (1) Skin sore (1)
Cat
Digestive
Vomiting (23)
Skin & allergy
Itching (92) Hair loss at application site (19) Localised hair loss (1) Localised hair loss (1) Localised hair loss (1) Localised hair loss (1) Localised hair loss (1) Localised hair loss (1) Localised itching (1) Localised itching (1) Localised itching (1) Localised itching (1) Localised itching (1) Localised itching (1)
Neurologic
Tiredness (lethargy) (35)
Behavior
Behavioral disorder (unspecified) (47)
Effectiveness
Lack of efficacy (ectoparasite) - flea (128) Lack of efficacy (endoparasite) - tapeworm (33)
Other
Hiding (19) Rubbing (1) Rubbing (1) Rubbing (1) Rubbing (1) Rubbing (1) Rubbing (1) Skin discolouration NOS (1) Skin discolouration NOS (1) Skin discolouration NOS (1) Skin discolouration NOS (1) Skin discolouration NOS (1) Skin discolouration NOS (1) Skin lesion NOS (1) Skin lesion NOS (1) Skin lesion NOS (1) Skin lesion NOS (1) Skin lesion NOS (1) Skin lesion NOS (1) Skin sore (1) Skin sore (1) Skin sore (1) Skin sore (1) Skin sore (1) Skin sore (1)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Cat (unknown), Female, 16 year • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Localised itching, Rubbing, Skin discolouration NOS, Skin lesion NOS, Skin sore… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-053922
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 16.00 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
Reactions Reported:
Localised itching Rubbing Skin discolouration NOS Skin lesion NOS Skin sore Localised hair loss
Outcomes: Outcome Unknown

Dog, Dog (unknown), Male, 3 year, 9.525 kilogram • Drug: MSK, Unassigned, Topical, Dose: 1 dose per animal, Frequency: 1 per month • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-047850
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 3.00 Year
  • Weight: 9.525 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Unassigned
  • Dose: 1 dose per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Dog, ['Retriever - Labrador', 'Dog (unknown)'], Unknown, 4 year, 24.94 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Hot spot, Skin sore, Itching, Self trauma, Alopecia local… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-048328
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Unknown
  • Age: 4.00 Year
  • Weight: 24.940 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
Reactions Reported:
Hot spot Skin sore Itching Self trauma Alopecia local Lack of efficacy (ectoparasite) - flea Biting - pruritus
Outcomes: Ongoing

Dog, Retriever - Chesapeake Bay, Female, 5.83 year, 20.77 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Seizure NOS, Overdose • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-046457
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 5.83 Year
  • Weight: 20.770 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
Reactions Reported:
Seizure NOS Overdose
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Male, 8 year, 7.26 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Lack of efficacy (endoparasite) - tapeworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-047725
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 8.00 Year
  • Weight: 7.260 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
Reactions Reported:
Lack of efficacy (endoparasite) - tapeworm
Outcomes: Outcome Unknown

Dog, Brittany, Female, 7 year, 20.41 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal, Frequency: 1 per month • Reactions: Vomiting • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-046584
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 20.410 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
  • Frequency: 1 per month
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal

Dog, Retriever - Labrador, Female, 8 year, 28.12 kilogram • Drug: MSK, Solution, Topical • Reactions: Vomiting, Not eating, Tiredness (lethargy), Pancreatitis NOS, Lack of efficacy (endoparasite) - roundworm NOS… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-045276
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 8.00 Year
  • Weight: 28.120 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
Reactions Reported:
Vomiting Not eating Tiredness (lethargy) Pancreatitis NOS Lack of efficacy (endoparasite) - roundworm NOS Other abnormal test result NOS Shaking Non-regenerative anaemia Pale mucous membrane Diarrhea Gastroenteritis Bloody diarrhoea Gastritis Blood in vomit Trembling Mucous stool Hives Hypoalbuminaemia Gut sounds increased Tense abdomen Digestive tract hypomotility Skin scab Dental calculus Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Cat, Domestic Longhair, Male, 11 year, 5.44 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal, Frequency: 1 per month • Reactions: Death • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-042915
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 11.00 Year
  • Weight: 5.440 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 dose per animal
  • Frequency: 1 per month
Reactions Reported:
Death
Outcomes: Died

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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