Meds A-Z
Pergolide Mesylate
Detailed information about Pergolide Mesylate
Pet Owner Quick Guide
Start here: what this medicine is for, what it does, and when it's usually needed.
Usually used for:
For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in horses.
What it does:
For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing's Disease) in horses. For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equin...
When it's needed:
Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of per...
Call your vet sooner if you notice:
- Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.
Commonly reported reactions:
- (1 reports)
- (1 reports)
- (1 reports)
What to ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Pergolide Mesylate
Drug type: Generic ingredient • Branded profile • FDA branded products available
Species: Both
Manufacturer: MSK
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200823 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141331 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source
Warnings / Contraindications
Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.
- High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Tap or hover a reaction to see what it means in plain language.
Most Reported Reactions
| Reaction | Cases | Species | Serious cases |
|---|---|---|---|
| 1 | Dog | 0 | |
| 1 | Dog | 0 | |
| 1 | Cat | 0 | |
| 1 | Dog | 0 | |
| 1 | Dog | 0 | |
| 1 | Dog | 0 | |
| 1 | Dog | 0 | |
| 1 | Dog | 0 |
Species coverage: Dog (20) Cat (12)
View detailed reaction table
| Reaction | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|
| Dog | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Dog | Unknown | - | - |
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-020401
Storage & Handling
No storage/handling guidance is linked yet.
Documents
Official label facts are separated from secondary summaries.
Official documents: 4 • Secondary summaries: 0
- A-200823-Q-0001-OT-AA_foi.pdf · FOI
- Zygolide® · SPL
- UCM280354.pdf · FOI
- Prascend® · SPL
No source yet.
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/17829 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/18159/Zygolide%C2%AE · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/890 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2215/Prascend%C2%AE · document · SPL
Promotional Materials (Marketing)
This content is marketing material and not clinical guidance.
No marketing assets are linked yet.
No source yet.
Technical appendix (vet reference)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
- Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
-
Animal Drugs @ FDA:
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Applications/products are imported from FDA export data.
-
Animal Drugs @ FDA previews:
Source FDA
| Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed Feb 9, 2026, 3:14 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
- Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation. (Contraindication, High)
Identifiers & Packages
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 58597-8072-1 | 58597 | - | |
| 58597-8072-2 | 58597 | - | |
| 58597-8072-4 | 58597 | - | |
| 58597-8072-6 | 58597 | - | |
| 62991-2528-1 | 62991 | - | |
| 62991-2528-2 | 62991 | - | |
| 62991-2528-3 | 62991 | - | |
| 62991-2528-5 | 62991 | - | |
| 62991-2528-6 | 62991 | - | |
| 62991-2528-7 | 62991 | - | |
| 62991-2528-8 | 62991 | - | |
| 73377-297-01 | 73377 | - | |
| 73377-297-02 | 73377 | - | |
| 73377-297-03 | 73377 | - | |
| 73377-297-04 | 73377 | - | |
| 83251-004-00 | 83251 | - |
Enriched Documents
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
-
A-200823-Q-0001-OT-AA_foi.pdf
• FOI summary • Official
• Jan. 8, 2026
FDA FOI summary for application 200823
-
UCM280354.pdf
• FOI summary • Official
• June 1, 2016
FDA FOI summary for application 141331
Data Sources & Revision History
Every non-trivial field is expected to include provenance and update timestamps.
- contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, o… (Official, 2026-02-12)
- side_effects: Top reported reactions (openFDA): Accidental exposure, Emesis, Vomiting, Emesis (multiple), Lethargy (see also Central nervous system depression in 'Neurologic… (Official, 2026-02-12)
- usage: For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing's Disease) in horses. For the control of clinical signs… (Official, 2026-02-12)
- side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
Official sponsor/proprietary-name/application-status records linked by active ingredient.
| Product | Sponsor | Application | Status | Published |
|---|---|---|---|---|
|
Zygolide®
RX
Pergolide mesylate
Tablet
• Oral
|
Dechra Veterinary Products LLC | ANADA 200-823 | Approved | Jan 8, 2026 |
|
Prascend®
RX
Pergolide mesylate
Tablet
• Oral
|
Boehringer lngelheim Animal Health USA, Inc. | NADA 141-331 | Approved | Jun 1, 2016 |
Data source: FDA Animal Drugs @ FDA (public search export).
What It's For (FDA Label Highlights)
Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.
Composition / specifications
For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in horses.
Administer orally at a starting dose of 2 mcg/kg once daily. Dosage may be adjusted to effect, not to exceed 4 mcg/kg daily.
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Official Documents (FDA)
Direct links to FDA-hosted PDFs and SPL packages (when available).
-
Summary
For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing's Disease) in horses.
- Zygolide® (ZIP)
FDA page: Open in Animal Drugs @ FDA
-
FOI UCM280354.pdf
Summary
For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in horses.
- Prascend® (ZIP)
FDA page: Open in Animal Drugs @ FDA
Usage
For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing's Disease) in horses. For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in horses.
Source: FDA Animal Drugs @ FDA • Reference
Contraindications
Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.
Side Effects
No approved side-effect narrative is linked yet.
openFDA reaction signals are available for Dog 8 and Cat 6 (view top reported reactions).
Top Reported Reactions (openFDA)
Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Dog, Dog (unknown), Unknown, 22.68 kilogram • Drug: MSK, Tablet, Oral, Dose: 0.50 Milligram per animal • Reactions: Vomiting, Shaking, Vomiting, Accidental exposure • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-020401
- Serious AE: No
- Treated For AE: No
- Sex: Unknown
- Weight: 22.680 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 0.50 Milligram per animal
Dog, Shepherd Dog - Australian, Male, 5 year, 22.68 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal • Reactions: Vomiting bile, Tiredness (lethargy), Nausea, Tachypnoea • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-020364
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 5.00 Year
- Weight: 22.680 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 1 tablet per animal
Dog, Rottweiler, Female, 7.5 month, 27.216 kilogram • Drug: MSK, Tablet, Oral • Reactions: Vomiting • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-011484
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 7.50 Month
- Weight: 27.216 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
Dog, Dog (unknown), Unknown • Drug: MSK, Tablet, Oral, Dose: 0.50 tablet per animal • Reactions: Dry heaving, Chattering of teeth • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2024-US-077604
- Serious AE: No
- Treated For AE: No
- Sex: Unknown
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 0.50 tablet per animal
Dog, Dog (unknown), Unknown • Drug: MSK, Tablet, Oral • Reactions: Syncope • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2024-US-068793
- Serious AE: No
- Treated For AE: No
- Sex: Unknown
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
Cat, Domestic Shorthair, Female, 4.082 kilogram • Drug: MSK, Tablet, Oral, Dose: 0.50 tablet per animal • Reactions: Third eyelid protrusion, Hyperthermia • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2024-US-030123
- Serious AE: No
- Treated For AE: Yes
- Sex: Female
- Weight: 4.082 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 0.50 tablet per animal
Cat, Domestic Shorthair, Male, 2 year, 6.804 kilogram • Drug: MSK, Tablet, Oral, Dose: 0.07 Milligram per kilogram, Frequency: 1 per day • Reactions: Hallucination, Hyperexcitation, Anxiety, Dilated pupils • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2024-US-002644
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 2.00 Year
- Weight: 6.804 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 0.07 Milligram per kilogram
- Frequency: 1 per day
Cat, Domestic Shorthair, Male, 1 year, 4.99 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 Milligram per animal • Reactions: Third eyelid protrusion • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2018-US-047691
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 1.00 Year
- Weight: 4.990 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 1 Milligram per animal
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.
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