Meds A-Z
Sevoflurane
Detailed information about Sevoflurane
Pet Owner Quick Guide
Start here: what this medicine is for, what it does, and when it's usually needed.
Usually used for:
For induction and maintenance of general anesthesia in dogs.
What it does:
SevoFlo is indicated for induction and maintenance of general anesthesia in dogs. For induction and maintenance of general anesthesia in dogs.
When it's needed:
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilat...
Call your vet sooner if you notice:
- Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Commonly reported reactions:
- (1 reports)
- (1 reports)
- (1 reports)
What to ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Sevoflurane
Drug type: Generic ingredient • Branded profile • FDA branded products available
Species: Both
Manufacturer: MSK
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200830 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200438 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source
Warnings / Contraindications
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Tap or hover a reaction to see what it means in plain language.
Most Reported Reactions
| Reaction | Cases | Species | Serious cases |
|---|---|---|---|
| 1 | Cat | 1 | |
| 1 | Dog | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Cat | 1 | |
| 1 | Dog | 1 |
Species coverage: Cat (17) Dog (15)
View detailed reaction table
| Reaction | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Serious | - | 1 |
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-055950
Storage & Handling
No storage/handling guidance is linked yet.
Documents
Official label facts are separated from secondary summaries.
Official documents: 8 • Secondary summaries: 0
- FOI Summary oA 200-830 Approved January 30, 2026.pdf · FOI
- Sevoflurane · SPL
- ucm061373.pdf · FOI
- Petrem® · SPL
- UCM202417.pdf · FOI
- Sevospire™ · SPL
- ucm117135.pdf · FOI
- SevoFlo® · SPL
No source yet.
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/17972 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/18331/Sevoflurane · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1164 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/174/Petrem%C2%AE · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1181 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2577/Sevospire%E2%84%A2 · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/635 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1386/SevoFlo%C2%AE · document · SPL
Promotional Materials (Marketing)
This content is marketing material and not clinical guidance.
No marketing assets are linked yet.
No source yet.
Technical appendix (vet reference)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
- Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
-
Animal Drugs @ FDA:
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Applications/products are imported from FDA export data.
-
Animal Drugs @ FDA previews:
Source FDA
| Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:04 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC
Diagnosis-code mappings are not available for this medication yet.
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
- Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Identifiers & Packages
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 11695-0505-2 | 11695 | - | |
| 13985-711-25 | 13985 | - | |
| 17033-092-25 | 17033 | - | |
| 46066-116-04 | 46066 | - | |
| 54771-5458-2 | 54771 | - | |
| 66794-018-10 | 66794 | - | |
| 66794-018-25 | 66794 | - | |
| 68504-011-01 | 68504 | - |
Enriched Documents
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
-
FOI Summary oA 200-830 Approved January 30, 2026.pdf
• FOI summary • Official
• Feb. 2, 2026
FDA FOI summary for application 200830
-
ucm061373.pdf
• FOI summary • Official
• March 14, 2024
FDA FOI summary for application 200438
-
UCM202417.pdf
• FOI summary • Official
• Oct. 14, 2022
FDA FOI summary for application 200467
-
ucm117135.pdf
• FOI summary • Official
• June 1, 2016
FDA FOI summary for application 141103
Data Sources & Revision History
Every non-trivial field is expected to include provenance and update timestamps.
- contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and fac… (Official, 2026-02-12)
- side_effects: Top reported reactions (openFDA): Vomiting, Death, Lethargy (see also Central nervous system depression in 'Neurological'), Bradycardia, Diarrhoea, Lack of eff… (Official, 2026-02-12)
- usage: SevoFlo is indicated for induction and maintenance of general anesthesia in dogs. For induction and maintenance of general anesthesia in dogs. (Official, 2026-02-12)
- side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
Official sponsor/proprietary-name/application-status records linked by active ingredient.
| Product | Sponsor | Application | Status | Published |
|---|---|---|---|---|
|
Sevoflurane
RX
Sevoflurane
Liquid
• Inhalation
|
Parnell Technologies Pty. Ltd. | ANADA 200-830 | Approved | Feb 2, 2026 |
|
Petrem®
RX
Sevoflurane
Liquid (Solution)
• Inhalation
|
Piramal Pharma Ltd. | ANADA 200-438 | Approved | Mar 14, 2024 |
|
Sevospire™
RX
Sevoflurane
Liquid
• Inhalation
|
Dechra Veterinary Products LLC | ANADA 200-467 | Approved | Oct 14, 2022 |
|
SevoFlo®
RX
Sevoflurane
Liquid
• Inhalation
|
Zoetis Inc. | NADA 141-103 | Approved | Jun 1, 2016 |
Data source: FDA Animal Drugs @ FDA (public search export).
What It's For (FDA Label Highlights)
Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.
Composition / specifications
For induction and maintenance of general anesthesia in dogs.
For induction of surgical anesthesia: up to 7 percent sevoflurane. For maintenance of surgical anesthesia: 3.7 to 4percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication.
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
Official Documents (FDA)
Direct links to FDA-hosted PDFs and SPL packages (when available).
-
Summary
For induction and maintenance of general anesthesia in dogs.
- Sevoflurane (ZIP)
FDA page: Open in Animal Drugs @ FDA
-
FOI ucm061373.pdf
Summary
PETREM is indicated for induction and maintenance of general anesthesia in dogs.
- Petrem® (ZIP)
FDA page: Open in Animal Drugs @ FDA
-
FOI UCM202417.pdf
Summary
For induction and maintenance of general anesthesia in dogs.
- Sevospire™ (ZIP)
FDA page: Open in Animal Drugs @ FDA
-
FOI ucm117135.pdf
Summary
For induction and maintenance of general anesthesia.
- SevoFlo® (ZIP)
FDA page: Open in Animal Drugs @ FDA
Usage
SevoFlo is indicated for induction and maintenance of general anesthesia in dogs. For induction and maintenance of general anesthesia in dogs.
Source: FDA Animal Drugs @ FDA • Reference
Contraindications
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Side Effects
No approved side-effect narrative is linked yet.
openFDA reaction signals are available for Dog 56 and Cat 8 (view top reported reactions).
Top Reported Reactions (openFDA)
Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Dog, ['Dachshund - Standard Long-haired', 'Dog (unknown)'], Female, 12 year, 5.942 kilogram • Drug: MSK, Unassigned, Respiratory (Inhalation) • Reactions: Localised pain NOS, Intervertebral disc disease, Excessive chewing, licking and/or grooming, Skin necrosis, Reddening of the skin… • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-054276
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 12.00 Year
- Weight: 5.942 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Respiratory (Inhalation)
- Form: Unassigned
Dog, ['Dog (unknown)', 'Poodle (unspecified)'], Male, 8 month, 21.863 kilogram • Drug: MSK, Solution, Unknown • Reactions: Hyperthermia, Tachycardia, Abnormal electrocardiogram, Tachypnoea • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-055950
- Serious AE: No
- Treated For AE: Yes
- Sex: Male
- Age: 8.00 Month
- Weight: 21.863 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Solution
Dog, Dog (unknown), Male, 10 year, 32.659 kilogram • Drug: MSK, Solution, Unknown • Reactions: Mass NOS, Lymph node abscess, Lymphadenopathy, Tachycardia, Drooling… • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-055759
- Serious AE: Yes
- Treated For AE: No
- Sex: Male
- Age: 10.00 Year
- Weight: 32.659 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Solution
Dog, Dachshund (unspecified), Male, 7 year, 5.443 kilogram • Drug: MSK, Solution, Unknown • Reactions: Allergic oedema • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-054215
- Serious AE: No
- Treated For AE: Yes
- Sex: Male
- Age: 7.00 Year
- Weight: 5.443 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Solution
Dog, Dog (unknown), Unknown • Drug: MSK, Unknown • Reactions: Regurgitation, Death, Trouble breathing (dyspnea) • Outcome: Died
- Report ID: GBR-USFDACVM-2025-GB-000059
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Unknown
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Cat, Domestic Shorthair, Male, 2.83 year, 5.77 kilogram • Drug: MSK, Respiratory (Inhalation) • Reactions: Application site ulcer, Increased red blood cell count, Application site scab, Disorder of red blood cell NOS, Application site bleeding… • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-045337
- Serious AE: No
- Treated For AE: Yes
- Sex: Male
- Age: 2.83 Year
- Weight: 5.770 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Respiratory (Inhalation)
Cat, Domestic Longhair, Male, 12.72 year, 4.87 kilogram • Drug: MSK, Unknown • Reactions: Not eating, Dilated pupils, Pacing, Hiding, Fear/fearful • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-044676
- Serious AE: No
- Treated For AE: Yes
- Sex: Male
- Age: 12.72 Year
- Weight: 4.870 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Cat, Domestic Shorthair, Male, 9 year, 5.443 kilogram • Drug: MSK, Respiratory (Inhalation) • Reactions: Swelling NOS, Defect Unknown/Not Specified, Hypersensitivity reaction • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-038490
- Serious AE: No
- Treated For AE: Yes
- Sex: Male
- Age: 9.00 Year
- Weight: 5.443 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Respiratory (Inhalation)
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.
Share Your Thoughts
Let others know your experience or advice regarding this medication.
This medication has not been reviewed by a veterinarian yet.