Meds A-Z

Toceranib Phosphate

Detailed information about Toceranib Phosphate

Official label facts Owner quick guide first Marketing clearly labeled

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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

For the treatment of Patnaik grade II or III, recurrent, cutaneous mast cell tumors with or without regional lymph node involvement in dogs.

What it does:

For the treatment of Patnaik grade II or III, recurrent, cutaneous mast cell tumors with or without regional lymph node involvement in dogs.

When it's needed:

For oral use in dogs only. Do not use in dogs used for breeding, or for pregnant or lactating bitches. Do not split tablets. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Call your vet sooner if you notice:

For oral use in dogs only. Do not use in dogs used for breeding, or for pregnant or lactating bitches. Do not split tablets. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Commonly reported reactions:

(2 reports)
(2 reports)
(1 reports)

What to ask your vet today:

Is this medicine the right fit for my pet’s current symptoms?
Which warning signs mean I should call back right away?
How should I handle missed doses or refusal to take the medicine?

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Toceranib Phosphate

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: MSK

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both

Manufacturer: MSK

Form: Tablet

Identifiers:

NADA: 141295 NDC Package: 54771-1690-1 NDC Package: 54771-1691-1 NDC Package: 54771-1692-1 NDC Package: 71052-210-10 NDC Package: 71052-210-25 NDC Package: 72969-072-10 NDC Package: 73309-089-01 NDC Package: 73309-089-02 NDC Package: 73309-089-03 NDC Package: 73377-156-01 NDC Package: 73377-156-02 NDC Package: 82774-003-01 NDC Package: 82774-003-02 NDC Package: 86032-034-01 NDC Package: 86197-007-01 NDC Product: 54771 NDC Product: 71052 NDC Product: 72969 NDC Product: 73309

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141295 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source

Warnings / Contraindications

High: For oral use in dogs only. Do not use in dogs used for breeding, or for pregnant or lactating bitches. Do not split tablets. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Source metadata:

https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals

Reported cases

Serious reports

Species represented

Most Reported Reactions

Cases	Species	Serious cases
2	Cat, Dog	2
2	Cat, Dog	2
1	Dog	1
1	Dog	1
1	Dog	1
1	Dog	1
1	Dog	1
1	Dog	1

Species coverage: Dog (19) Cat (13)

View detailed reaction table

Species	Seriousness	Frequency	Reports
Cat	Non-serious	-	1
Cat	Serious	-	1
Cat	Non-serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Dog	Non-serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1

Source metadata:

https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-021348

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 4 • Secondary summaries: 0

Official label facts

Secondary summaries

No source yet.

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/860 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadLabeling/887 · document · Labeling
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadLabeling/888 · document · Labeling
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2033/Palladia%C2%AE · document · SPL

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.

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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness

Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:04 AM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:21 AM UTC

Official (FDA)

Identity: Generic ingredient • FDA branded products available

Official FDA brands: Palladia®

Case-reported brands (openFDA): MSK

Catalog species: Both • FDA-labeled species: Dog

Rx/OTC: RX

Form/route: Tablet • Oral

Applications: NADA 141-295

Documents: 3 (FOI: 1) • SPL: 1 • Label highlights • Official documents

Safety (openFDA)

Top reactions: Dog 56 • Cat 8 • View

Case summaries: 10 (showing 8) • View

openFDA reports are unverified and do not prove causation.

Explore

Related conditions: Mast Cell Tumor (MCT)

Linked using: Fda_Label (0.95)

Diagnosis Codes

ICD10_CM: C96.A

Mast cell neoplasm

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points

For oral use in dogs only. Do not use in dogs used for breeding, or for pregnant or lactating bitches. Do not split tablets. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)

Top reaction signals

Abdominal mass (1) Anorexia (1) Appetite loss (1) Asystole (1) Bloody stool (1) Cardiorespiratory arrest (1) Cellulitis (1) Chronic renal failure (1) Coma (1) Convulsion (1) Cyanotic mucous membranes (1) Death (1) Death (1) Death by euthanasia (1) Decreased red blood cell count (1) Diarrhoea (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers

Package NDC	Product NDC	Status
54771-1690-1	54771	-
54771-1691-1	54771	-
54771-1692-1	54771	-
71052-210-10	71052	-
71052-210-25	71052	-
72969-072-10	72969	-
73309-089-01	73309	-
73309-089-02	73309	-
73309-089-03	73309	-
73377-156-01	73377	-
73377-156-02	73377	-
82774-003-01	82774	-
82774-003-02	82774	-
86032-034-01	86032	-
86197-007-01	86197	-

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

PALLADIA N141295C0016.pdf • Official label • Official • May 17, 2021
FDA official labeling for application 141295
PALLADIA N141295C0016.pdf • Official label • Official • May 17, 2021
FDA official labeling for application 141295
UCM164091.pdf • FOI summary • Official • May 17, 2021
FDA FOI summary for application 141295

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 6 Clinical 0 Manufacturer 0 Marketing 0

Current Field Facts

contraindications: For oral use in dogs only. Do not use in dogs used for breeding, or for pregnant or lactating bitches. Do not split tablets. Federal (USA) law restricts this d… (Official, 2026-02-12)
side_effects: Top reported reactions (openFDA): Diarrhoea, Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), Anorexia, Neutropenia, Leucopen… (Official, 2026-02-12)
usage: For the treatment of Patnaik grade II or III, recurrent, cutaneous mast cell tumors with or without regional lymph node involvement in dogs. (Official, 2026-02-12)

Recent Revisions

side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product	Sponsor	Application	Status	Published
Palladia® RX Toceranib Phosphate Tablet • Oral Label highlights Official documents	Zoetis Inc.	NADA 141-295	Approved	May 17, 2021

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, No Use Class Stated Or Implied

Composition / specifications

Each tablet contains 10, 15, or 50 mg toceranib as toceranib phosphate.

Dogs

Indication

For the treatment of Patnaik grade II or III, recurrent, cutaneous mast cell tumors with or without regional lymph node involvement in dogs.

Dosage

Administer an initial dosage of 3.25 mg/kg (1.48 mg/lb) body weight, orally every other day.

Limitations

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents

FOI UCM164091.pdf

Summary

For the treatment of Patnaik grade II or III, recurrent, cutaneous mast cell tumors with or without regional lymph node involvement in dogs.
Labeling PALLADIA N141295C0016.pdf
Labeling PALLADIA N141295C0016.pdf

SPL Packages

Palladia® (ZIP)

FDA page: Open in Animal Drugs @ FDA

Usage

For the treatment of Patnaik grade II or III, recurrent, cutaneous mast cell tumors with or without regional lymph node involvement in dogs.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 56 and Cat 8 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog

Digestive

Diarrhea (108) Vomiting (80) Loss of appetite (43) Decreased appetite (36)

Neurologic

Tiredness (lethargy) (47) Convulsion (1) Convulsion (1) Convulsion (1) Convulsion (1) Convulsion (1) Convulsion (1)

Other

Neutropenia (41) Leucopenia NOS (37) Lameness (36) Asystole (1) Asystole (1) Asystole (1) Asystole (1) Asystole (1) Asystole (1) Cardiorespiratory arrest (1) Cardiorespiratory arrest (1) Cardiorespiratory arrest (1) Cardiorespiratory arrest (1) Cardiorespiratory arrest (1) Cardiorespiratory arrest (1) Cellulitis (1) Cellulitis (1) Cellulitis (1) Cellulitis (1) Cellulitis (1) Cellulitis (1) Coma (1) Coma (1) Coma (1) Coma (1) Coma (1) Coma (1) Cyanotic mucous membranes (1) Cyanotic mucous membranes (1) Cyanotic mucous membranes (1) Cyanotic mucous membranes (1) Cyanotic mucous membranes (1) Cyanotic mucous membranes (1) Death (1) Death (1) Death (1) Death (1) Death (1) Death (1) Dilated pupils (1) Dilated pupils (1) Dilated pupils (1) Dilated pupils (1) Dilated pupils (1) Dilated pupils (1)

Cat

Digestive

Vomiting (14) Loss of appetite (8) Diarrhea (5)

Effectiveness

Lack of efficacy - NOS (4)

Other

Death by euthanasia (5) Weight loss (5) Anaemia NOS (4) Death (3)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Boxer (German Boxer), Female, 2.3 year, 28.7 kilogram • Drug: MSK, Tablet, Oral, Dose: 15 Milligram per dose, Frequency: 48 per hour • Reactions: Death, Injection site discharge NOS, Swollen limb, Pain NOS, Not eating… • Outcome: Died

Report ID: USA-USFDACVM-2025-US-055852
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 2.30 Year
Weight: 28.700 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Tablet
Dose: 15 Milligram per dose
Frequency: 48 per hour

Reactions Reported:

Death Injection site discharge NOS Swollen limb Pain NOS Not eating Not drinking Uncomfortable Elevated temperature Increased heart rate Increased respiratory rate Pitting oedema Injection site skin discolouration Injection site serosanguinous discharge Injection site reaction NOS Wound Cellulitis Local skin slough Convulsion Cardiorespiratory arrest Panting Fixed pupil Dilated pupils Cyanotic mucous membranes Coma Neurological signs NOS Premature ventricular contractions Ventricular fibrillation Asystole

Outcomes: Died

Dog, Terrier - Scottish, Female, 9.5 year, 10.28 kilogram • Drug: MSK, Unknown • Reactions: Mammary gland neoplasm NOS, Low platelet count, Nausea, Leucopenia NOS, Neutropenia… • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-049474
Serious AE: Yes
Treated For AE: No
Sex: Female
Age: 9.50 Year
Weight: 10.280 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown

Reactions Reported:

Mammary gland neoplasm NOS Low platelet count Nausea Leucopenia NOS Neutropenia Lung nodule NOS

Outcomes: Outcome Unknown

Dog, Bulldog - English, Male, 7 year, 27.216 kilogram • Drug: MSK, Tablet, Oral • Reactions: Tremors, Diarrhea • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-043938
Serious AE: Yes
Treated For AE: Yes
Sex: Male
Age: 7.00 Year
Weight: 27.216 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Tablet

Reactions Reported:

Tremors Diarrhea

Outcomes: Ongoing

Dog, Bulldog - French, Male, 12 year, 11.34 kilogram • Drug: MSK, Tablet, Oral, Dose: 25 Milligram per animal • Reactions: Bloody stool, Intentional misuse • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-043858
Serious AE: Yes
Treated For AE: Yes
Sex: Male
Age: 12.00 Year
Weight: 11.340 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Tablet
Dose: 25 Milligram per animal

Reactions Reported:

Bloody stool Intentional misuse

Outcomes: Ongoing

Dog, Pug, Female, 4 year, 9.072 kilogram • Drug: MSK, Tablet, Unknown, Dose: 25 Milligram per animal • Reactions: Vomiting • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-041014
Serious AE: No
Treated For AE: No
Sex: Female
Age: 4.00 Year
Weight: 9.072 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Form: Tablet
Dose: 25 Milligram per animal

Reactions Reported:

Vomiting

Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 20 year, 3.4 kilogram • Drug: MSK, Unknown • Reactions: Digestive tract neoplasm NOS, Eye neoplasm NOS, Not eating, Not drinking, Death by euthanasia… • Outcome: Euthanized

Report ID: USA-USFDACVM-2025-US-036809
Serious AE: Yes
Treated For AE: No
Sex: Male
Age: 20.00 Year
Weight: 3.400 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown

Reactions Reported:

Digestive tract neoplasm NOS Eye neoplasm NOS Not eating Not drinking Death by euthanasia Swollen lymph node Metastatic neoplasia Elevated renal parameters

Outcomes: Euthanized

Cat, Cat (other), Male • Drug: MSK, Tablet, Oral • Reactions: Decreased red blood cell count, Gut pain, Weakness, Loss of appetite, Vocalisation… • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-022668
Serious AE: Yes
Treated For AE: Yes
Sex: Male

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Tablet

Reactions Reported:

Decreased red blood cell count Gut pain Weakness Loss of appetite Vocalisation Digestive tract disorder NOS Intentional misuse

Outcomes: Outcome Unknown

Cat, Mixed (Cat), Mixed, 6 year • Drug: MSK, Tablet, Oral • Reactions: Tiredness (lethargy), Loss of appetite, Neutropenia, Vomiting, Diarrhea… • Outcome: Died

Report ID: USA-USFDACVM-2025-US-021212
Serious AE: Yes
Treated For AE: No
Sex: Mixed
Age: 6.00 Year

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Tablet

Reactions Reported:

Tiredness (lethargy) Loss of appetite Neutropenia Vomiting Diarrhea Chronic renal failure Pulmonary metastases Death

Outcomes: Died

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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Medical Disclaimer: The medication details provided on PetWisePlus are for informational purposes only and are not a substitute for professional veterinary advice. Always consult your veterinarian about your pet's specific needs.

Toceranib Phosphate

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