Meds A-Z
Milbemycin Oxime + Lufenuron
Detailed information about Milbemycin Oxime + Lufenuron
Pet Owner Quick Guide
Start here: what this medicine is for, what it does, and when it's usually needed.
Usually used for:
Use this medication only when your veterinarian confirms it matches your pet's condition.
What it does:
Use this medication only when your veterinarian confirms it matches your pet's condition.
When it's needed:
Use this medication only when your veterinarian confirms it matches your pet's condition.
Commonly reported reactions:
- (1 reports)
- (1 reports)
- (1 reports)
What to ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Milbemycin Oxime + Lufenuron
Drug type: Generic ingredient • Generic profile • No FDA branded products linked
Species: Both
Manufacturer: MSK
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
No source yet.
Warnings / Contraindications
No contraindication summary is linked yet.
No owner-focused warning rows are linked yet.
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Tap or hover a reaction to see what it means in plain language.
Most Reported Reactions
| Reaction | Cases | Species | Serious cases |
|---|---|---|---|
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 0 | |
| 1 | Dog | 0 | |
| 1 | Dog | 0 | |
| 1 | Dog | 0 | |
| 1 | Dog | 0 | |
| 1 | Dog | 0 |
Species coverage: Dog (32)
View detailed reaction table
| Reaction | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - |
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-045280
Storage & Handling
No storage/handling guidance is linked yet.
Documents
Official label facts are separated from secondary summaries.
No linked label PDFs or safety notices yet.
No source yet.
No source yet.
Promotional Materials (Marketing)
This content is marketing material and not clinical guidance.
No marketing assets are linked yet.
No source yet.
Technical appendix (vet reference)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
- Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:04 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Diagnosis-code mappings are not available for this medication yet.
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
Data Sources & Revision History
Every non-trivial field is expected to include provenance and update timestamps.
- side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Vomiting, Diarrhoea, Lethargy (see also Central nervous system depression in 'Ne… (Official, 2026-02-12)
- side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
No linked FDA product applications are available for this ingredient yet.
Usage
No approved usage text is linked yet for this ingredient.
- Catalog species: Both
- Safety reports available: 5 openFDA case summaries (view)
Contraindications
No approved contraindication text is linked yet. Review FDA label highlights and openFDA safety reports before making treatment decisions.
Side Effects
No approved side-effect narrative is linked yet.
openFDA reaction signals are available for Dog 26 and Cat 0 (view top reported reactions).
Top Reported Reactions (openFDA)
Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Dog, ['Beagle', 'Dog (unknown)'], Female, 1.5 year, 6.4 kilogram • Drug: MSK, Oral, Frequency: 1 per month • Reactions: Other abnormal test result NOS • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-055808
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 1.50 Year
- Weight: 6.400 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Frequency: 1 per month
Dog, Bulldog - French, Male, 5 year, 12.7 kilogram • Drug: MSK, Unknown • Reactions: Rash, Eye inflamed • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-051885
- Serious AE: No
- Treated For AE: Yes
- Sex: Male
- Age: 5.00 Year
- Weight: 12.700 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, Shepherd Dog - German, Female, 9 year, 37.285 kilogram • Drug: MSK, Unknown • Reactions: Cutaneous haemangiosarcoma, Death • Outcome: Died
- Report ID: USA-USFDACVM-2025-US-045280
- Serious AE: Yes
- Treated For AE: No
- Sex: Female
- Age: 9.00 Year
- Weight: 37.285 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, Maltese, Female, 3 year, 4.08 kilogram • Drug: MSK, Unknown • Reactions: Diarrhea, Itching, Hair loss NOS, Vomiting, Scratching… • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-045182
- Serious AE: No
- Treated For AE: Yes
- Sex: Female
- Age: 3.00 Year
- Weight: 4.080 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, Shepherd Dog - Belgian Malinois, Male, 8 year, 21.773 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-042291
- Serious AE: No
- Treated For AE: Yes
- Sex: Male
- Age: 8.00 Year
- Weight: 21.773 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.
Share Your Thoughts
Let others know your experience or advice regarding this medication.
This medication has not been reviewed by a veterinarian yet.