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Meds A-Z

Flunixin Meglumine

Detailed information about Flunixin Meglumine

Official label facts Owner quick guide first Marketing clearly labeled
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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

For treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica , Pasteurella multocida , Histophilus somni , and Mycoplasma bovis , and control of BRD-associated pyrexia in beef and non-lactatin...

What it does:

For alleviation of inflammation and pain associated with musculoskeletal disorders, and alleviation of visceral pain associated with colic. For control of pyrexia associated with bovine respiratory disease, acute bovine...

When it's needed:

Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter for human consumption within 4 days of last treatment. A withdrawal period h...

Call your vet sooner if you notice:

  • Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter for human consumption within 4 days of last treatment. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. Do not use in dry dairy cows. Milk that has been taken during treatment and for 36 hours after the last treatment must not be used for food. Approved only for intravenous administration in cattle. Intramuscular administration has resulted in violative residues in the edible tissues of cattle sent to slaughter. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Swine must not be slaughtered for human consumption within 12 days of last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Commonly reported reactions:

  • (2 reports)
  • (1 reports)
  • (1 reports)

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
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Flunixin Meglumine

Flunixin Meglumine

Drug type: Generic ingredient • Branded profile FDA branded products available

Species: Both

Manufacturer: Intervet, Inc.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Intervet, Inc.
Form: Injectable Solution, Liquid (Solution), Paste, Top Dressing In Feed
Identifiers:
ANADA: 200061 ANADA: 200124 ANADA: 200142 ANADA: 200387 ANADA: 200476 ANADA: 200489 ANADA: 200581 ANADA: 200781 ANADA: 200791 ANADA: 200828 NADA: 101479 NADA: 106616 NADA: 137409 NADA: 141299 NADA: 141312 NDC Package: 0061-0214-02 NDC Package: 0061-0851-03 NDC Package: 0061-0851-04 NDC Package: 0061-4305-01 NDC Package: 0061-4305-02
Source metadata:

Warnings / Contraindications

Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter for human consumption within 4 days of last treatment. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. Do not use in dry dairy cows. Milk that has been taken during treatment and for 36 hours after the last treatment must not be used for food. Approved only for intravenous administration in cattle. Intramuscular administration has resulted in violative residues in the edible tissues of cattle sent to slaughter. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Swine must not be slaughtered for human consumption within 12 days of last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter for human consumption within 4 days of last treatment. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. Do not use in dry dairy cows. Milk that has been taken during treatment and for 36 hours after the last treatment must not be used for food. Approved only for intravenous administration in cattle. Intramuscular administration has resulted in violative residues in the edible tissues of cattle sent to slaughter. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Swine must not be slaughtered for human consumption within 12 days of last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
26
Species represented
2
Most Reported Reactions
Reaction Cases Species Serious cases
2 Cat, Dog 2
1 Dog 1
1 Cat 1
1 Dog 1
1 Dog 1
1 Dog 1
1 Dog 1
1 Dog 1

Species coverage: Dog (25) Cat (7)

View detailed reaction table
Reaction Species Seriousness Frequency Reports
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Non-serious - 1
Dog Serious - 1
Dog Non-serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Non-serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Non-serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Non-serious - 1
Dog Serious - 1
Cat Serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Non-serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Source metadata:

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 45 • Secondary summaries: 0

Secondary summaries

No source yet.

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.
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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 9, 2026, 3:15 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Banamine® Banamine®-S Banamine® Granules Banamine® Paste Flu-Nix™ Flunazine® Flunazine®-S Flunazine™ Flunine-S™ Flunine™ Flunixin Injection - S Flunixin Meglumine Injection Flunixin Meglumine Solution Hexasol® Injection Resflor GOLD® nixiFLOR™
Case-reported brands (openFDA): MSK
Catalog species: Both FDA-labeled species: Beef, Beef And Dairy, Beef And Non-Lactating Dairy, Calves, Dairy, Horse, No Use Class Stated Or Implied, No use class stated or implied
Rx/OTC: RX
Form/route: Injectable Solution, Liquid (Solution), Paste, Top Dressing In Feed Intramuscular, Intravenous, Oral, Subcutaneous
Applications: ANADA 200-828 • ANADA 200-489 • ANADA 200-791 • NADA 137-409 • NADA 141-299 • ANADA 200-781 • ANADA 200-476 • ANADA 200-061 • NADA 101-479 • NADA 141-312 • ANADA 200-581 • ANADA 200-387 • ANADA 200-142 • ANADA 200-124 • NADA 106-616
Documents: 29 (FOI: 23) • SPL: 16 Label highlights Official documents
Safety (openFDA)
Top reactions: Dog 8 Cat 8 View
Case summaries: 6 (showing 6) View
openFDA reports are unverified and do not prove causation.

Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)

Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter for human consumption within 4 days of last treatment. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. Do not use in dry dairy cows. Milk that has been taken during treatment and for 36 hours after the last treatment must not be used for food. Approved only for intravenous administration in cattle. Intramuscular administration has resulted in violative residues in the edible tissues of cattle sent to slaughter. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Swine must not be slaughtered for human consumption within 12 days of last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Abnormal radiograph finding (1) Adipsia (1) Anaphylaxis (1) Anorexia (1) Bloody diarrhoea (1) Claw / hoof / nail disorder NOS (1) Death (1) Decreased red blood cell count (1) Dehydration (1) Diarrhoea (1) Distension of abdomen (1) Ear infection NOS (1) Elevated alanine aminotransferase (ALT) (1) Elevated liver enzymes (1) Elevated total bilirubin (1) Febrile (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200061 ANADA: 200124 ANADA: 200142 ANADA: 200387 ANADA: 200476 ANADA: 200489 ANADA: 200581 ANADA: 200781 ANADA: 200791 ANADA: 200828 NADA: 101479 NADA: 106616 NADA: 137409 NADA: 141299 NADA: 141312 NDC Package: 0061-0214-02 NDC Package: 0061-0851-03 NDC Package: 0061-0851-04 NDC Package: 0061-4305-01 NDC Package: 0061-4305-02 NDC Package: 0061-4305-03 NDC Package: 0061-4363-01 NDC Package: 0061-4363-02 NDC Package: 0061-4363-03
Package NDC Product NDC Form / Route Status
0061-0214-02 0061 -
0061-0851-03 0061 -
0061-0851-04 0061 -
0061-4305-01 0061 -
0061-4305-02 0061 -
0061-4305-03 0061 -
0061-4363-01 0061 -
0061-4363-02 0061 -
0061-4363-03 0061 -
11695-7021-1 11695 -
11695-7021-2 11695 -
13985-018-02 13985 -
13985-018-04 13985 -
13985-707-15 13985 -
23243-0120-4 23243 -
23243-0120-5 23243 -
46066-008-02 46066 -
46066-008-04 46066 -
46066-102-03 46066 -
46066-102-04 46066 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • FOI Summary oA 200-828 Approved January 9, 2026.pdf • FOI summary • Official • Feb. 3, 2026
    FDA FOI summary for application 200828
  • A-200489-C-0073-NL-AA_PI_2.pdf • Official label • Official • Dec. 16, 2025
    FDA official labeling for application 200489
  • UCM210561.pdf • FOI summary • Official • Dec. 16, 2025
    FDA FOI summary for application 200489
  • FOI Summary oA 200-791 Approved April 3 2025_ceg_ef.pdf • FOI summary • Official • June 3, 2025
    FDA FOI summary for application 200791
  • N-137409-C-0125-NL-AA_PI.pdf • Official label • Official • Feb. 24, 2025
    FDA official labeling for application 137409
  • UCM203309.pdf • FOI summary • Official • Aug. 6, 2024
    FDA FOI summary for application 141299
  • UCM231147.pdf • FOI summary • Official • Aug. 6, 2024
    FDA FOI summary for application 141299
  • A-200781-C-0017-NL-AA_PI.pdf • Official label • Official • July 16, 2024
    FDA official labeling for application 200781
  • FOI Summary oA 200-781 Approved May 16, 2024.pdf • FOI summary • Official • July 16, 2024
    FDA FOI summary for application 200781
  • A-200476-R-0049-CS-AA_PI.pdf • Official label • Official • Aug. 21, 2023
    FDA official labeling for application 200476
  • UCM181537.pdf • FOI summary • Official • Aug. 21, 2023
    FDA FOI summary for application 200476
  • A200061_Orig_09_11_1996.pdf • FOI summary • Official • June 1, 2022
    FDA FOI summary for application 200061
  • ucm061576.pdf • FOI summary • Official • June 1, 2022
    FDA FOI summary for application 200061
  • UCM241575.pdf • FOI summary • Official • June 1, 2022
    FDA FOI summary for application 200061
  • 353.pdf • FOI summary • Official • May 3, 2022
    FDA FOI summary for application 101479
  • ucm064907.pdf • FOI summary • Official • May 3, 2022
    FDA FOI summary for application 101479
  • ucm064910.pdf • FOI summary • Official • May 3, 2022
    FDA FOI summary for application 101479
  • ucm064912.pdf • FOI summary • Official • May 3, 2022
    FDA FOI summary for application 101479
  • UCM243040.pdf • FOI summary • Official • March 4, 2022
    FDA FOI summary for application 141312
  • UCM421903.pdf • FOI summary • Official • Oct. 2, 2018
    FDA FOI summary for application 200581
  • ucm061339.pdf • FOI summary • Official • Oct. 2, 2018
    FDA FOI summary for application 200387
  • A200387_Supp_12_18_2008.pdf • FOI summary • Official • Oct. 2, 2018
    FDA FOI summary for application 200387
  • A200142_Orig_09_25_1995.pdf • FOI summary • Official • July 28, 2017
    FDA FOI summary for application 200142
  • A200124_Org_9_25_1995.pdf • FOI summary • Official • May 16, 2017
    FDA FOI summary for application 200124
  • ucm061590.pdf • FOI summary • Official • May 16, 2017
    FDA FOI summary for application 200124
  • ucm061738.pdf • FOI summary • Official • May 16, 2017
    FDA FOI summary for application 200124
  • ucm061593.pdf • FOI summary • Official • May 16, 2017
    FDA FOI summary for application 200124

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 30 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter for human consu… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Vomiting, Death, Diarrhoea, Elevated total bilirubin, Lack of efficacy - NOS, Lethargy (see also Central nervous system depre… (Official, 2026-02-12)
  • usage: For alleviation of inflammation and pain associated with musculoskeletal disorders, and alleviation of visceral pain associated with colic. For control of pyre… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
nixiFLOR™
RX
Florfenicol Flunixin Meglumine
Injectable Solution Subcutaneous
Parnell Technologies Pty. Ltd. ANADA 200-828 Approved Feb 3, 2026
Flunazine®-S
RX
Flunixin Meglumine
Injectable Solution Intramuscular
Bimeda Animal Health Limited ANADA 200-489 Approved Dec 16, 2025
Flunine-S™
RX
Flunixin Meglumine
Injectable Solution Intramuscular
Cronus Pharma Specialities India Private Ltd. ANADA 200-791 Approved Jun 3, 2025
Banamine® Paste
RX
Flunixin Meglumine
Paste Oral
Intervet, Inc. NADA 137-409 Approved Feb 24, 2025
Resflor GOLD®
RX
Florfenicol Flunixin Meglumine
Injectable Solution Subcutaneous
Intervet, Inc. NADA 141-299 Approved Aug 6, 2024
Flunine™
RX
Flunixin Meglumine
Injectable Solution Intramuscular, Intravenous
Cronus Pharma Specialities India Private Ltd. ANADA 200-781 Approved Jul 16, 2024
Flunixin Injection - S
RX
Flunixin Meglumine
Liquid (Solution) Intramuscular
Norbrook Laboratories, Ltd. ANADA 200-476 Approved Aug 21, 2023
Flu-Nix™
RX
Flunixin Meglumine
Liquid (Solution) Intramuscular, Intravenous
Huvepharma EOOD ANADA 200-061 Approved Jun 1, 2022
Banamine® Banamine®-S
RX
Flunixin Meglumine
Injectable Solution Intravenous, Intramuscular
Intervet, Inc. NADA 101-479 Approved May 3, 2022
Hexasol® Injection
RX
Flunixin Meglumine Oxytetracycline
Liquid (Solution) Intramuscular, Subcutaneous
Norbrook Laboratories, Ltd. NADA 141-312 Approved Mar 4, 2022
Flunazine®
RX
Flunixin Meglumine
Paste Oral
Bimeda Animal Health Limited ANADA 200-581 Approved Oct 2, 2018
Flunazine™
RX
Flunixin Meglumine
Liquid (Solution) Intravenous, Intramuscular
Bimeda Animal Health Limited ANADA 200-387 Approved Oct 2, 2018
Flunixin Meglumine Solution
RX
Flunixin Meglumine
Liquid (Solution) Intramuscular, Intravenous
Zoetis Inc. ANADA 200-142 Approved Jul 28, 2017
Flunixin Meglumine Injection
RX
Flunixin Meglumine
Liquid (Solution) Intravenous, Intramuscular
Elanco US Inc. ANADA 200-124 Approved May 16, 2017
Banamine® Granules
RX
Flunixin Meglumine
Top Dressing In Feed Oral
Intervet, Inc. NADA 106-616 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Beef And Non-Lactating Dairy
Composition / specifications
300 mg florfenicol and 16.5 mg flunixin (as flunixin meglumine) per mL
Beef and non-lactating dairy cattle
Indication

For treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis, and control of BRD-associated pyrexia in beef and non-lactating dairy cattle.

Dosage

40 mg florfenicol/kg body weight (BW) and 2.2 mg flunixin/kg BW (equivalent to 2 mL/15 kg BW or 6 mL/100 lbs) once, by subcutaneous injection.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: No use class stated or implied
Composition / specifications
Each milliliter contains flunixin meglumine equivalent to 50 mg of flunixin.
Swine
Indication
For the control of pyrexia associated with swine respiratory disease.
Dosage
Administer 2.2 mg/kg (1 mg/lb; 2 mL per 100 lbs) body weight as a single intramuscular administration. The injection should be given only in the neck musculature with a maximum of 10 mL per site.
Limitations
For intramuscular use in swine. Not tor use in breeding swine.

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
50 mg flunixin (equivalent to 83 mg flunixin meglumine) per mL
Swine
Indication

For the control of pyrexia associated with swine respiratory disease

Dosage

2.2 mg/kg (1 mg/lb; 2 mL per 100 lbs) body weight given by a single intramuscular administration. The injection should be given only in the neck musculature with a maximum of 10 mL per site.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production
Composition / specifications
Each 30-gram syringe contains flunixin meglumine equivalent to 1,500 milligrams of flunixin.
Horses
Indication
For alleviation of inflammation and pain associated with musculoskeletal disorders.
Dosage
0.5 milligram of flunixin per pound of body weight daily.
Limitations

For oral use only. Treatment should not exceed 5 consecutive days. The effect of this drug on pregnancy has not been determined. Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Beef • Dairy, non-lactating
Composition / specifications
300 mg florfenicol and 16.5 mg flunixin as flunixin meglumine
Cattle (Beef and Non-Lactating Dairy)
Indication
For the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis, and control of BRD-associated pyrexia in beef and non lactating dairy cattle.
Dosage

Administer once by subcutaneous injection at a dose rate of 40 mg florfenicol/kg body weight and 2.2 mg flunixin/kg body weight (6 mL/100 lb).

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dairy, excluding dry cows • No Use Class Stated Or Implied
Composition / specifications
50 mg/mL
Horses
Indication

For the alleviation of inflammation and pain associated with musculoskeletal disorders in the horse. It is also recommended for the alleviation of visceral pain associated with colic in the horse.

Dosage

The recommended dose for musculoskeletal disorders is 0.5 mg per pound (1 mL/100 lbs) of body weight once daily. Treatment may be given by intravenous or intramuscular injection and repeated for up to 5 days. The recommended dose for the alleviation of pain associated with equine colic is 0.5 mg per pound of body weight. Intravenous administration is recommended for prompt relief. Treatment may be repeated when signs of colic recur.

Limitations
Cattle
Indication

For the control of pyrexia associated with bovine respiratory disease, endotoxemia and acute bovine mastitis. It is also indicated for the control of inflammation in endotoxemia.

Dosage

The recommended dose for control of pyrexia associated with bovine respiratory disease and endotoxemia and control of inflammation in endotoxemia, is 1.1 to 2.2 mg/kg (0.5 to 1 mg/lb; 1 to 2 mL per 100 lbs) of body weight given by slow intravenous administration either once a day as a single dose or divided into two doses administered at 12-hour intervals for up to 3 days. The total daily dose should not exceed 2.2 mg/kg (1.0 mg/lb) of body weight. Avoid rapid intravenous administration of the drug. The recommended dose for acute bovine mastitis is 2.2 mg/kg (1 mg/lb; 2 mL per 100 lbs) of body weight given once by intravenous administration.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: No use class stated or implied
Label highlights
Indication
For the control of pyrexia associated with swine respiratory disease.
Dosage
The recommended dose for swine is 2.2 mg/kg (1 mg/lb; 2 mL per 100 lbs) body weight given by a single intramuscular administration. The injection should be given only in the neck musculature with a maximum of 10 mL per site
Limitations
Not for use in breeding swine. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production • Beef And Dairy
Composition / specifications
Each mL contains flunixin meglumine equivalent to 50 mg flunixin.
Horses
Indication
For alleviation of inflammation and pain associated with musculoskeletal disorders and alleviation of visceral pain associated with colic.
Dosage
0.5 mg per pound of body weight per day, intravenously or intramuscularly, for up to 5 days.
Limitations
Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cattle (Beef and dairy)
Indication
For control of pyrexia associated with bovine respiratory disease, endotoxemia, and acute bovine mastitis. It is also indicated for the control of inflammation in endotoxemia.
Dosage
1.1 to 2.2 mg/kilogram (0.5 to 1.0 mg/lb) of body weight per day, as a single dose or divided into 2 doses administered at 12-hour intervals, intravenously, for up to 3 days.
Limitations
Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production • Beef, excluding breeding bulls • Dairy, excluding dry dairy cows and breeding bulls • Calves, excluding veal calves
Composition / specifications
The drug contains 50 milligrams of flunixin per milliliter of aqueous solution.
Horses
Indication

For alleviation of inflammation and pain associated with musculoskeletal disorders, and alleviation of visceral pain associated with colic.

Dosage

0.5 mg per pound of body weight per day, intravenously or intramuscularly, for up to 5 days.

Limitations
Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cattle
Indication

For control of pyrexia associated with bovine respiratory disease, acute bovine mastitis, and endotoxemia. Also indicated for control of inflammation in endotoxemia.

Dosage

1. 1 to 2.2 mg/kilogram (0.5 to 1.0 mg/lb) of body weight per day, as a single dose or divided into 2 doses administered at 12-hour intervals, intravenously, for up to 3 days (control of pyrexia associated with bovine respiratory disease and endotoxemia and control of inflammation in endotoxemia).

2. 2mg/kg (1.0 mg/lb) of body weight given once by intravenous administration for control of pyrexia associated with acute bovine mastitis.

Limitations

Do not slaughter for human consumption within 4 days of last treatment. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. Do not use in dry dairy cows. Milk that has been taken during treatment and for 36 hours after the last treatment must not be used for food. Approved only for intravenous administration in cattle. Intramuscular administration has resulted in violative residues in the edible tissues of cattle sent to slaughter. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Beef • Dairy, non-lactating
Composition / specifications
300 mg oxytetracycline and 20 mg flunixin base as flunixin meglumine per mL.
Cattle (Beef, Non-Lactating Dairy, Calves, Yearlings)
Indication
For the treatment of bacterial pneumonia associated with Pasteurella spp. and for the control of associated pyrexia in beef and non-lactating dairy cattle
Dosage
Administer once as an intramuscular or subcutaneous injection of 1 mL per 22 pounds (lb) body weight (BW) (13.6 mg oxytetracycline and 0.9 mg flunixin per lb BW) where retreatment of calves and yearlings for bacterial pneumonia is impractical due to husbandry conditions, such as cattle on range, or where their repeated restraint is inadvisable
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. For intramuscular or subcutaneous use in beef and non-lactating dairy cattle, calves and yearlings. Not for use in female dairy cattle 20 months of age or older, including dry dairy cows, bulls intended for breeding, and calves intended to be processed for veal. Do not use in animals showing hypersensitivity to either flunixin meglumine or oxytetracycline.

FDA page: Open in Animal Drugs @ FDA

Species: No Use Class Stated Or Implied
Composition / specifications
30 grams of paste contains flunixin meglumine equivalent to 1,500 mg of flunixin.
Label highlights
Indication
For the alleviation of inflammation and pain associated with musculoskeletal disorders in the horse
Dosage
0.5 mg per pound of body weight per day for up to 5 days
Limitations
For oral use in horses only. Treatment should not exceed 5 consecutive days. The effect of flunixin meglumine on pregnancy has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian

FDA page: Open in Animal Drugs @ FDA

Species: Beef And Dairy • No Use Class Stated Or Implied
Composition / specifications
<span style="font-size: 10.5pt; font-family: Verdana; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-bidi-font-family: 'Times New Roman'">Each mL of solution contains flunixin meglumine equivalent to 50 mg flunixin.</span>
Cattle
Indication
For the control of pyrexia associated with bovine respiratory disease, endotoxemia, and acute bovine mastitis.
Dosage
1.1 to 2.2 mg/kg (0.5 to 1 mg/lb; 1 to 2 mL per 100 lbs) body weight given by slow intravenous administration, either once a day as a single dose, or divided into two doses at 12-hour intervals for up to 3 days; for control of pyrexia associated with bovine respiratory disease and endotoxemia and control of inflammation in endotoxemia. 2.2 mg/kg (1.0 mg/lb; 2 mL per 100 lbs) of body weight given once by intravenous administration for acute bovine mastitis.
Limitations
The total daily dose should not exceed 2.2 mg/kg (1.0 mg/lb) of body weight. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in calves to be processed for veal. Do not use in dry dairy cows.
Horses
Indication
For the alleviation of inflammation and pain associated with musculoskeletal disorders, and alleviation of visceral pain associated with colic.
Dosage
0.5 mg per pound of body weight per day, intravenously or intramuscularly, for up to 5 days.
Limitations
Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production
Composition / specifications
The drug contains 50 milligrams of flunixin per milliliter of aqueous solution.
Horses
Indication
For alleviation of inflammation and pain associated with musculoskeletal disorders, and alleviation of pain associated with colic.
Dosage
0.5 mg per pound (/lb) of body weight per day, intravenously or intramuscularly, for up to 5 days.
Limitations
Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Beef And Dairy • No Use Class Stated Or Implied
Composition / specifications
<pre><span style="font-size: 10.5pt; font-family: Verdana; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-bidi-font-family: 'Times New Roman'">Each mL of solution contains flunixin meglumine equivalent to 50 mg flunixin. </span></pre><p>&nbsp;
Horses
Indication
For the alleviation of inflammation and pain associated with musculoskeletal disorders, and alleviation of visceral pain associated with colic.
Dosage
0.5 mg per pound of body weight once daily, intravenously or intramuscularly, for up to 5 days.
Limitations
Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cattle
Indication
For control of pyrexia associated with acute bovine mastitis.
Dosage
2.2 mg/kg (1.0 mg/lb; 2 mL per 100 lb) of body weight given once by intravenous administration.
Limitations
Do not use in calves to be processed for veal. Do not use in dry dairy cows. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Indication
For control of pyrexia associated with bovine respiratory disease and endotoxemia. Also indicated for the control of inflammation in endotoxemia.
Dosage
1.1 to 2.2 mg/kg (0.5 to 1.0 mg/lb; 1 to 2 mL per 100 lb) of body weight per day, as a single dose or divided into 2 doses administered at 12-hour intervals, intravenously, for up to 3 days.
Limitations
Do not use in calves to be processed for veal. Do not use in dry dairy cows. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production
Composition / specifications
Each 10-gram packet contains flunixin meglumine equivalent to 250 milligrams of flunixin.
Horses
Indication
For alleviation of inflammation and pain associated with musculoskeletal disorders in the horse.
Dosage
0.5 milligram of flunixin per pound of body weight (one packet per 500 pounds) per day.
Limitations
Administer daily dose for up to 5 days by sprinkling on small amount of feed. The effect of this drug on pregnancy has not been determined. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary

    For treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis, and control of BRD-associated pyrexia in beef and non-lactating dairy cattle.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    This supplement provides for the addition of Mycoplasma bovis to the list of target pathogens for the treatment of BRD and control of BRD-associated pyrexia indication.
  • Summary
    For the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni, and control of BRD-associated pyrexia in beef and non-lactating dairy cattle.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    Horse: For the alleviation of inflammation and pain associated with musculoskeletal disorders in the horse. It is also recommended for the alleviation of visceral pain associated with colic in the horse.
    Cattle: For the control of pyrexia associated with bovine respiratory disease, endotoxemia and acute bovine mastitis. It is also indicated for the control of inflammation in endotoxemia.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    This supplement provides for a change in proprietary name and the addition of the lactating dairy cattle indication, “For the control of pyrexia associated with acute bovine mastitis.”

  • Summary
    This supplement provides for the addition of a claim for intravenous use in beef cattle and nonlactating dairy cattle to the labeling of the approved product Flunixin Meglumine Solution. The exclusivity period protecting this claim for the pioneer product expired on May 6, 2001.
  • Summary

    For the alleviation of inflammation and pain associated with musculoskeletal disorders in horses. It is also recommended for the alleviation of visceral pain associated with colic in horses.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    This supplement allows for use in swine for the control of pyrexia associated with swine respiratory disease. This product has been approved for beef and lactating dairy cattle and horses.
  • Summary
    This supplement allows for use in lactating dairy cattle for the existing indications of “the control of pyrexia associated with bovine respiratory disease and endotoxemia and for the control of inflammation in endotoxemia.” Additionally, it allows for a new indication “for the control of pyrexia associated with acute bovine mastitis” and it establishes a tolerance for residues of flunixin in milk.
  • Summary
    This supplement provides for an additional statement added to the Precaution section of the labeling and a heading change on the label from Warning to Adverse Reactions to the previously approved product labeling for BANAMINE® Injectable Solution.
  • FOI 353.pdf
    Summary

    This supplement provides for the additional species, cattle, to be added to the previously approved product, BANAMINE® Injectable Solution.

  • EA 101-479
  • FONSI 101-479
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For the treatment of bacterial pneumonia associated with Pasteurella spp. and for the control of associated pyrexia in beef and non-lactating dairy cattle.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For the alleviation of inflammation and pain associated with musculoskeletal disorders in the horse.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    The supplement requests the addition of a new indication, "for the control of pyrexia associated with acute bovine mastitis", that is no longer protected by marketing exclusivity.

  • Summary

    Horse: recommended for the alleviation of inflammation and pain associated with musculoskeletal disorders in the horse. It is also recommended for the alleviation of visceral pain associated with colic in the horse.
    Cattle: indicated for the control of pyrexia associated with bovine respiratory disease and endotoxemia. Flunixin Meglumine Injection is also indicated for the control of inflammation in endotoxemia.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    For the alleviation of inflammation and pain associated with musculoskeletal disorders in horses. It is also recommended for the alleviation of visceral pain associated with colic in horses.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    The effect of this supplement is to allow for the addition of a new indication, “for the control of pyrexia associated with acute bovine mastitis”, that is no longer protected by marketing exclusivity.
  • Summary
    This supplement provides the addition of lactating dairy cattle to the existing claim allowing for the control of pyrexia associated with bovine respiratory disease and endotoxemia and for the control of inflammation in endotoxemia. The addition of lactating dairy cattle to the pioneer labeling was approved on August 19, 2004, and was not protected by exclusivity.
  • Summary
    The supplement provides revised labeling with the addition of a new species, cattle, to the previously approved generic product for horses only.
  • Summary

    For the alleviation of inflammation and pain associated with musculoskeletal disorders in the horse. It is also recommended for the alleviation of visceral pain associated with colic in the horse.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

For alleviation of inflammation and pain associated with musculoskeletal disorders, and alleviation of visceral pain associated with colic. For control of pyrexia associated with bovine respiratory disease, acute bovine mastitis, and endotoxemia. Also indicated for control of inflammation in endotoxemia. For the control of pyrexia associated with swine respiratory disease.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not slaughter for human consumption within 4 days of last treatment. A withdrawal period has not been established for use in preruminating calves. Do not use in calves to be processed for veal. Do not use in dry dairy cows. Milk that has been taken during treatment and for 36 hours after the last treatment must not be used for food. Approved only for intravenous administration in cattle. Intramuscular administration has resulted in violative residues in the edible tissues of cattle sent to slaughter. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Swine must not be slaughtered for human consumption within 12 days of last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 8 and Cat 8 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog
Digestive
Vomiting (5) Diarrhea (2)
Neurologic
Tiredness (lethargy) (2)
Effectiveness
Lack of efficacy - NOS (2)
Other
Death (2) Elevated total bilirubin (2) Abnormal radiograph finding (1) Anaphylaxis (1)
Cat
Digestive
Loss of appetite (1)
Neurologic
Tiredness (lethargy) (1)
Effectiveness
Lack of efficacy (ectoparasite) - tick NOS (1)
Other
Adipsia (1) Febrile (1) Leucopenia NOS (1) Reluctant to move (1) Third eyelid protrusion (1)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Griffon - French Wire-haired Pointing, Female, 23 month, 15.4 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy - NOS, Other abnormal test result NOS, Elevated total bilirubin, Decreased red blood cell count, Ear infection NOS… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2023-US-062807
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 23.00 Month
  • Weight: 15.400 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Lack of efficacy - NOS Other abnormal test result NOS Elevated total bilirubin Decreased red blood cell count Ear infection NOS Vomiting
Outcomes: Outcome Unknown

Dog, ['Retriever - Labrador', 'Dog (unknown)'], Female, 3 year, 18.824 kilogram • Drug: MSK, Injection, solution, Unknown • Reactions: Vomiting, Weakness, Diarrhea, Haemorrhagic diarrhoea, Anaphylaxis… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2023-US-009609
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 3.00 Year
  • Weight: 18.824 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Injection, solution
Reactions Reported:
Vomiting Weakness Diarrhea Haemorrhagic diarrhoea Anaphylaxis Elevated liver enzymes Elevated total bilirubin
Outcomes: Recovered/Normal

Cat, Siamese, Male, 7 year, 6.804 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Tiredness (lethargy), Third eyelid protrusion, Loss of appetite, Adipsia, Lack of efficacy (ectoparasite) - tick NOS… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2020-US-020224
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 7.00 Year
  • Weight: 6.804 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Tiredness (lethargy) Third eyelid protrusion Loss of appetite Adipsia Lack of efficacy (ectoparasite) - tick NOS Vomiting Reluctant to move Febrile Leucopenia NOS
Outcomes: Ongoing

Dog, Ridgeback - Rhodesian, Male, 6 year, 32.749 kilogram • Drug: MSK, Liquid, Unknown • Reactions: Shaking, Panting, Tiredness (lethargy), Proprioception deficit, Dehydration… • Outcome: Died

  • Report ID: USA-USFDACVM-2019-US-026054
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 6.00 Year
  • Weight: 32.749 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Liquid
Reactions Reported:
Shaking Panting Tiredness (lethargy) Proprioception deficit Dehydration Elevated alanine aminotransferase Vomiting Polydipsia Bloody diarrhoea Vomiting Hypothermia Tiredness (lethargy) Death
Outcomes: Died

Dog, Retriever - Labrador, Female, 2 year, 34.927 kilogram • Drug: MSK, Intramuscular, Dose: 0.70 mL per unknown, Frequency: 5 per month • Reactions: Not eating, Tiredness (lethargy), Vomiting, Surgical site disorder, Distension of abdomen… • Outcome: Died

  • Report ID: USA-USFDACVM-2019-US-025839
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 2.00 Year
  • Weight: 34.927 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Dose: 0.70 mL per unknown
  • Frequency: 5 per month
Reactions Reported:
Not eating Tiredness (lethargy) Vomiting Surgical site disorder Distension of abdomen Abnormal radiograph finding Intestinal perforation Peritonitis Death
Outcomes: Died

Dog, Spaniel - Springer English, Male, 2 year • Drug: MSK, Intravenous, Dose: 4 Milligram per unknown • Reactions: Lack of efficacy - NOS, Claw / hoof / nail disorder NOS • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2018-US-021211
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 2.00 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intravenous
  • Dose: 4 Milligram per unknown
Reactions Reported:
Lack of efficacy - NOS Claw / hoof / nail disorder NOS
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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