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Meds A-Z

Xylazine

Detailed information about Xylazine

Official label facts Owner quick guide first Marketing clearly labeled
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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

To produce sedation, as an analgesic, and as a preanesthetic to local anesthesia. To produce sedation, accompanied by a shorter period of analgesia. May be used to calm and facilitate handling of fractious animals for di...

What it does:

To produce sedation, as an analgesic, and as a preanesthetic to local or general anesthesia. To produce sedation, as an analgesic, and as a preanesthetic to local anesthesia. To produce sedation, accompanied by a shorter...

When it's needed:

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption. Do not use in domestic food-producing animals. Do not use in Cervidae less than 1...

Call your vet sooner if you notice:

  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption. Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.

Commonly reported reactions:

  • (2 reports)
  • (1 reports)
  • (1 reports)

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
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Xylazine

Xylazine

Drug type: Generic ingredient • Branded profile FDA branded products available

Species: Both

Manufacturer: MSK

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: MSK
Form: Injectable Solution, Liquid (Solution)
Identifiers:
ANADA: 200088 ANADA: 200139 ANADA: 200184 ANADA: 200529 NADA: 139236 NADA: 140442 NADA: 47955 NADA: 47956 NDC Package: 11695-4024-1 NDC Package: 17033-099-05 NDC Package: 58597-8582-6 NDC Package: 58597-8582-8 NDC Package: 62157-373-01 NDC Package: 62157-374-01 NDC Package: 62991-1624-2 NDC Package: 62991-1624-3 NDC Package: 62991-1624-4 NDC Package: 63537-0091-5 NDC Package: 63537-0092-9 NDC Package: 64189-9001-0
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption. Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption. Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
31
Species represented
2
Most Reported Reactions
Reaction Cases Species Serious cases
2 Cat, Dog 2
1 Dog 1
1 Dog 1
1 Dog 1
1 Dog 1
1 Dog 1
1 Dog 1
1 Dog 1

Species coverage: Dog (25) Cat (7)

View detailed reaction table
Reaction Species Seriousness Frequency Reports
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Non-serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Source metadata:

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 18 • Secondary summaries: 0

Secondary summaries

No source yet.

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.
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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Anased® Chanazine® Rompun® Injectable (100 mg) Rompun® Injectable (20 mg) Sedazine™ XylaMed™ Xylazine HCl Injection AnaSed® Equine Injection
Case-reported brands (openFDA): MSK
Catalog species: Both FDA-labeled species: Cat, Dog, Elk, Fallow Deer, Horse, Mule Deer, No Use Class Stated Or Implied, Sika Deer, White-Tailed Deer
Rx/OTC: RX
Form/route: Injectable Solution, Liquid (Solution) Intramuscular, Intravenous, Subcutaneous
Applications: ANADA 200-088 • NADA 140-442 • NADA 139-236 • NADA 47956 • ANADA 200-529 • NADA 47955 • ANADA 200-139 • ANADA 200-184
Documents: 9 (FOI: 9) • SPL: 9 Label highlights Official documents
Safety (openFDA)
Top reactions: Dog 56 Cat 8 View
Case summaries: 10 (showing 8) View
openFDA reports are unverified and do not prove causation.

Explore
Related conditions: Pain (acute, chronic)
Linked using: Fda_Label (0.95)

Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption. Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season. (Contraindication, High)
Top reaction signals
Abdominal pain (1) Abnormal radiograph finding (1) Abnormal ultrasound finding (1) Arched back (1) Cyanosis (1) Death (1) Death (1) Difficulty standing (1) Elevated renal parameters (1) Emesis (1) Excitation (1) Fluid in abdomen NOS (1) Gastric ulcer (1) Hind limb paralysis (1) Hyperaemic mucosae (1) Hyperthermia (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200088 ANADA: 200139 ANADA: 200184 ANADA: 200529 NADA: 139236 NADA: 140442 NADA: 47955 NADA: 47956 NDC Package: 11695-4024-1 NDC Package: 17033-099-05 NDC Package: 58597-8582-6 NDC Package: 58597-8582-8 NDC Package: 62157-373-01 NDC Package: 62157-374-01 NDC Package: 62991-1624-2 NDC Package: 62991-1624-3 NDC Package: 62991-1624-4 NDC Package: 63537-0091-5 NDC Package: 63537-0092-9 NDC Package: 64189-9001-0 NDC Package: 64189-9001-1 NDC Package: 64189-9001-2 NDC Package: 64189-9001-3 NDC Package: 64189-9002-0
Package NDC Product NDC Form / Route Status
11695-4024-1 11695 -
17033-099-05 17033 -
58597-8582-6 58597 -
58597-8582-8 58597 -
62157-373-01 62157 -
62157-374-01 62157 -
62991-1624-2 62991 -
62991-1624-3 62991 -
62991-1624-4 62991 -
63537-0091-5 63537 -
63537-0092-9 63537 -
64189-9001-0 64189 -
64189-9001-1 64189 -
64189-9001-2 64189 -
64189-9001-3 64189 -
64189-9002-0 64189 -
64189-9002-1 64189 -
64189-9002-2 64189 -
64189-9002-3 64189 -
69043-043-05 69043 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • A200088_Org_2_24_1994.pdf • FOI summary • Official • May 12, 2025
    FDA FOI summary for application 200088
  • UCM539440.pdf • FOI summary • Official • Feb. 26, 2025
    FDA FOI summary for application 140442
  • UCM474107.pdf • FOI summary • Official • June 13, 2024
    FDA FOI summary for application 139236
  • UCM508360.pdf • FOI summary • Official • June 13, 2024
    FDA FOI summary for application 139236
  • UCM508357.pdf • FOI summary • Official • June 13, 2024
    FDA FOI summary for application 139236
  • ucm069889.pdf • FOI summary • Official • June 13, 2024
    FDA FOI summary for application 139236
  • UCM396610.pdf • FOI summary • Official • Feb. 27, 2023
    FDA FOI summary for application 200529
  • A200139_Orig_05_16_1995.pdf • FOI summary • Official • July 28, 2017
    FDA FOI summary for application 200139
  • A200184_Org_7_12_1996.pdf • FOI summary • Official • May 22, 2017
    FDA FOI summary for application 200184

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 12 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption. Do not use in domest… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Death, Lack of efficacy - NOS, Vomiting, Death by euthanasia, Hives (see also 'Skin'), INEFFECTIVE, ANESTHESIA. (Official, 2026-02-12)
  • usage: To produce sedation, as an analgesic, and as a preanesthetic to local or general anesthesia. To produce sedation, as an analgesic, and as a preanesthetic to lo… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Sedazine™
RX
Xylazine Hydrochloride
Liquid (Solution) Intramuscular, Intravenous
Boehringer lngelheim Animal Health USA Inc. ANADA 200-088 W May 12, 2025
Xylazine HCl Injection AnaSed® Equine Injection
RX
Xylazine Hydrochloride
Injectable Solution Intramuscular, Intravenous
Cronus Pharma Specialities India Private Ltd. NADA 140-442 Approved Feb 26, 2025
Anased®
RX
Xylazine Hydrochloride
Liquid (Solution) Subcutaneous, Intramuscular, Intravenous
Cronus Pharma Specialities India Private Ltd. NADA 139-236 Approved Jun 13, 2024
Rompun® Injectable (100 mg)
RX
Xylazine Hydrochloride
Liquid (Solution) Intramuscular, Intravenous, Subcutaneous
Dechra, Ltd. NADA 47956 Approved Nov 29, 2023
XylaMed™
RX
Xylazine
Injectable Solution
Bimeda Animal Health Limited ANADA 200-529 Approved Feb 27, 2023
Rompun® Injectable (20 mg)
RX
Xylazine Hydrochloride
Liquid (Solution) Intravenous, Intramuscular, Subcutaneous
Dechra, Ltd. NADA 47955 Approved Oct 28, 2021
Chanazine®
RX
Xylazine Hydrochloride
Liquid (Solution) Intravenous, Intramuscular
Chanelle Pharmaceuticals Manufacturing Ltd. ANADA 200-139 Approved Jul 28, 2017
Chanazine®
RX
Xylazine Hydrochloride
Liquid (Solution) Subcutaneous, Intramuscular, Intravenous
Chanelle Pharmaceuticals Manufacturing Ltd. ANADA 200-184 Approved May 22, 2017

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Horse, Not For Meat Production • Fallow Deer, Excluding Use For Food • Elk, Excluding Use For Food • Mule Deer, Excluding Use For Food • Sika Deer, Excluding Use For Food • White-Tailed Deer, Excluding Use For Food
Composition / specifications
Each milliliter of solution contains xylazine hydrochloride equivalent to 100 milligrams xylazine or 300 milligrams xylazine.
Mule deer (Odocoileus hemionus), sika deer (Cervus nippon), and white-tailed deer (Odocoileus virginianus)
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local anesthesia. To produce sedation, accompanied by a shorter period of analgesia. May be used to calm and facilitate handling of fractious animals for diagnostic procedures, for minor surgical procedures, for therapeutic medication for sedation and relief of pain following injury or surgery, and as a preanesthetic to local anesthetic. At the recommended dosages, can be used in conjunction with local anesthetics, such as procaine or lidocaine.
Dosage
Administer intramuscularly, by hand syringe, or by syringe dart, in the heavy muscles of the croup or shoulder 1 to 2 milligrams per pound.
Limitations
Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.
Elk (Cervus canadensis)
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local anesthesia. To produce sedation, accompanied by a shorter period of analgesia. May be used to calm and facilitate handling of fractious animals for diagnostic procedures, for minor surgical procedures, for therapeutic medication for sedation and relief of pain following injury or surgery, and as a preanesthetic to local anesthetic. At the recommended dosages, can be used in conjunction with local anesthetics, such as procaine or lidocaine.
Dosage
Administer intramuscularly, by hand syringe, or by syringe dart, in the heavy muscles of the croup or shoulder 0.25 to 0.5 milligrams per pound of body weight.
Limitations
Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.
Fallow deer (Dama dama)
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local anesthesia. To produce sedation, accompanied by a shorter period of analgesia. May be used to calm and facilitate handling of fractious animals for diagnostic procedures, for minor surgical procedures, for therapeutic medication for sedation and relief of pain following injury or surgery, and as a preanesthetic to local anesthetic. At the recommended dosages, can be used in conjunction with local anesthetics, such as procaine or lidocaine.
Dosage
Administer intramuscularly, by hand syringe, or by syringe dart, in the heavy muscles of the croup or shoulder 2 to 4 milligrams per pound.
Limitations
Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.
Horses
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local or general anesthesia
Dosage
0.5 milligrams per pound intravenously or 1.0 milligram per pound intramuscularly.
Limitations
Not for use in horses intended for food..

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production
Composition / specifications
Each milliliter of solution contains xylazine hydrochloride equivalent to 100 milligrams of xylazine .
Horses
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local or general anesthesia.
Dosage
0.5 milligrams per pound intravenously or 1.0 milligrams per pound intramuscularly.
Limitations

Do not use in horses intended for human consumption.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Horse, Not For Meat Production • Cat, No Use Class Stated Or Implied • Fallow Deer, Excluding Use For Food • Elk, Excluding Use For Food • Mule Deer, Excluding Use For Food • Sika Deer, Excluding Use For Food • White-Tailed Deer, Excluding Use For Food
Composition / specifications
Each milliliter of solution contains xylazine hydrochloride equivalent to: 1) 20 milligrams xylazine, 2) 100 milligrams xylazine or 3) 300 milligrams xylazine.
Dogs
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local or general anesthesia.
Dosage
0.5 milligrams per pound intravenously or 1.0 milligram per pound intramuscularly.
Limitations
Horses
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local or general anesthesia.
Dosage
0.5 milligrams per pound intravenously or 1.0 milligram per pound intramuscularly.
Limitations
Not for use in horses intended for food.
Mule deer (Odocoileus hemionus), sika deer (Cervus nippon), and white-tailed deer (Odocoileus virginianus)
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local anesthesia. To produce sedation, accompanied by a shorter period of analgesia. May be used to calm and facilitate handling of fractious animals for diagnostic procedures, for minor surgical procedures, for therapeutic medication for sedation and relief of pain following injury or surgery, and as a preanesthetic to local anesthetic. At the recommended dosages, can be used in conjunction with local anesthetics, such as procaine or lidocaine.
Dosage
Administer intramuscularly, by hand syringe, or by syringe dart, in the heavy muscles of the croup or shoulder 1 to 2 milligrams per pound.
Limitations
Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.
Elk (Cervus canadensis)
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local anesthesia. To produce sedation, accompanied by a shorter period of analgesia. May be used to calm and facilitate handling of fractious animals for diagnostic procedures, for minor surgical procedures, for therapeutic medication for sedation and relief of pain following injury or surgery, and as a preanesthetic to local anesthetic. At the recommended dosages, can be used in conjunction with local anesthetics, such as procaine or lidocaine.
Dosage
Administer intramuscularly, by hand syringe, or by syringe dart, in the heavy muscles of the croup or shoulder 0.25 to 0.5 milligrams per pound of body weight.
Limitations
Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.
Cats
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local or general anesthesia.
Dosage
0.5 milligrams per pound intravenously or 1.0 milligram per pound intramuscularly.
Limitations
Fallow deer (Dama dama)
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local anesthesia. To produce sedation, accompanied by a shorter period of analgesia. May be used to calm and facilitate handling of fractious animals for diagnostic procedures, for minor surgical procedures, for therapeutic medication for sedation and relief of pain following injury or surgery, and as a preanesthetic to local anesthetic. At the recommended dosages, can be used in conjunction with local anesthetics, such as procaine or lidocaine.
Dosage
Administer intramuscularly, by hand syringe, or by syringe dart, in the heavy muscles of the croup or shoulder 2 to 4 milligrams per pound.
Limitations
Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production • Fallow Deer, Excluding Use For Food • Elk, Excluding Use For Food • Mule Deer, Excluding Use For Food • Sika Deer, Excluding Use For Food • White-Tailed Deer, Excluding Use For Food
Composition / specifications
Each milliliter of solution contains xylazine hydrochloride equivalent to 100 milligrams xylazine
Horses
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local or general anesthesia.
Dosage
0.5 milligrams per pound intravenously or 1.0 milligram per pound intramuscularly.
Limitations

Do not use in horses intended for human consumption.

Fallow deer (Dama dama)
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local anesthesia. To produce sedation, accompanied by a shorter period of analgesia. May be used to calm and facilitate handling of fractious animals for diagnostic procedures, for minor surgical procedures, for therapeutic medication for sedation and relief of pain following injury or surgery, and as a preanesthetic to local anesthetic. At the recommended dosages, can be used in conjunction with local anesthetics, such as procaine or lidocaine.
Dosage
Administer intramuscularly, by hand syringe, or by syringe dart, in the heavy muscles of the croup or shoulder 2 to 4 milligrams per pound.
Limitations
Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.
Mule deer (Odocoileus hemionus), sika deer (Cervus nippon), and white-tailed deer (Odocoileus virginianus)
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local anesthesia. To produce sedation, accompanied by a shorter period of analgesia. May be used to calm and facilitate handling of fractious animals for diagnostic procedures, for minor surgical procedures, for therapeutic medication for sedation and relief of pain following injury or surgery, and as a preanesthetic to local anesthetic. At the recommended dosages, can be used in conjunction with local anesthetics, such as procaine or lidocaine.
Dosage
Administer intramuscularly, by hand syringe, or by syringe dart, in the heavy muscles of the croup or shoulder 1 to 2 milligrams per pound.
Limitations
Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.
Elk (Cervus canadensis)
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local anesthesia. To produce sedation, accompanied by a shorter period of analgesia. May be used to calm and facilitate handling of fractious animals for diagnostic procedures, for minor surgical procedures, for therapeutic medication for sedation and relief of pain following injury or surgery, and as a preanesthetic to local anesthetic. At the recommended dosages, can be used in conjunction with local anesthetics, such as procaine or lidocaine.
Dosage
Administer intramuscularly, by hand syringe, or by syringe dart, in the heavy muscles of the croup or shoulder 0.25 to 0.5 milligrams per pound of body weight.
Limitations
Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.

FDA page: Open in Animal Drugs @ FDA

Species: No Use Class Stated Or Implied • Fallow Deer, Excluding Use For Food • Mule Deer, Excluding Use For Food • Sika Deer, Excluding Use For Food • White-Tailed Deer, Excluding Use For Food
<strong>Horses:</strong><br />
Indication
Dosage
Intravenously-0.5 mL/100 lbs body weight (0.5 mg/lb)
Intramuscularly-1.0 mL/100 lbs body weight (1.0 mg/lb)
Following injection of XYLAMED, the animal should be allowed to rest quietly until the full effect has been reached.
These dosages produce sedation which is usually maintained for 1 to 2 hours, and analgesia which lasts for 15 to 30 minutes.
2. Preanesthetic to Local Anesthesia:
XYLAMED at the recommended dosages can be used in conjunction with local anesthetics, such as procaine or lidocaine.
3. Preanesthetic to General Anesthesia:
XYLAMED at the recommended dosage rates, produces an additive effect to central nervous system depressants such as pentobarbital sodium, thiopental sodium and thiamylal sodium. Therefore, the dosage of such compounds should be reduced and administered to the desired effect. In general, only 1/3 to ½ of the calculated dosage of the barbiturates will be needed to produce a surgical plane of anesthesia. Post-anesthetic or emergence excitement has not been observed in animals preanesthetized with XYLAMED.
XylaMed™ has been used successfully as a preanesthetic agent for pentobarbital sodium, thiopental sodium, thiamylal sodium, nitrous oxide, ether, halothane, glyceryl guaiacolate, and methoxyflurane anesthesia.
Limitations
<strong>Cervidae:</strong><br />
Indication
XYLAMED should be used in horses and Cervidae (Fallow Deer, Mule Deer, Sika Deer, White-Tailed Deer, and Elk) when it is desirable to produce a state of sedation accompanied by a shorter period of analgesia.
Horses: XYLAMED has been used successfully as follows:
1. Diagnostic procedures-oral and ophthalmic examinations, abdominal palpation, rectal palpation, vaginal examination, catheterization of the bladder and radiographic examinations.
2. Orthopedic procedures, such as application of casting materials and splints.
3. Dental procedures.
4. Minor surgical procedures of short duration such as debridement, removal of cutaneous neoplasms and suturing of lacerations.
5. To calm and facilitate handling of fractious animals.
6. Therapeutic medication for sedation and relief of pain following injury or surgery.
7. Major surgical procedures:
a. When used as a preanesthetic to general anesthesia.
b. When used in conjunction with local anesthetics.
Cervidae: XYLAMED may be used for the following:
1. To calm and facilitate handling of fractious animals.
2. Diagnostic procedures.
3. Minor surgical procedures.
4. Therapeutic medication for sedation and relief of pain following injury or surgery.
5. As a preanesthetic to local anesthesia.
XYLAMED at the recommended dosages can be used in conjunction with local anesthetics, such as procaine or lidocaine.
Dosage
Administer intramuscularly, by either hand syringe or syringe dart, in the heavy muscles of the croup or shoulder.
Dosage Range:
Fallow Deer (Dama dama)-2.0 to 4.0 mL/100 lbs body weight (2.0 to 4.0 mg/lb).
Mule Deer (Odocoileus hemionus)-1.0 to 2.0 mL/100 lbs body weight (1.0 to 2.0 mg/lb).
Sika Deer (Cervus nippon)-1.0 to 2.0 mL/100 lbs body weight (1.0 to 2.0 mg/lb).
White-Tailed Deer (Odocoileus virginianus)-1.0 to 2.0 mL/100 lbs body weight (1.0 to 2.0 mg/lb).
Elk (Cervus canadensis)-0.25 to 0.5 mL/100 lbs body weight (0.25 to 0.5 mg/lb).
Following injection of XYLAMED the animal should be allowed to rest quietly until the full effect has been reached.
These dosages produce sedation which is usually maintained for 1 to 2 hours and analgesia which lasts for 15 to 30 minutes
Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of solution contains xylazine hydrochloride equivalent to 20 milligrams xylazine.
Cats
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local or general anesthesia.
Dosage
0.5 milligrams per pound intravenously or 1.0 milligram per pound intramuscularly.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local or general anesthesia.
Dosage
0.5 milligrams per pound intravenously or 1.0 milligram per pound intramuscularly.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production • Fallow Deer, Excluding Use For Food • Elk, Excluding Use For Food • Mule Deer, Excluding Use For Food • Sika Deer, Excluding Use For Food • White-Tailed Deer, Excluding Use For Food
Composition / specifications
Each milliliter of solution contains xylazine hydrochloride equivalent to 100 milligrams xylazine or 300 milligrams xylazine.
Mule deer (Odocoileus hemionus), sika deer (Cervus nippon), and white-tailed deer (Odocoileus virginianus)
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local anesthesia. To produce sedation, accompanied by a shorter period of analgesia. May be used to calm and facilitate handling of fractious animals for diagnostic procedures, for minor surgical procedures, for therapeutic medication for sedation and relief of pain following injury or surgery, and as a preanesthetic to local anesthetic. At the recommended dosages, can be used in conjunction with local anesthetics, such as procaine or lidocaine.
Dosage
Administer intramuscularly, by hand syringe, or by syringe dart, in the heavy muscles of the croup or shoulder 1 to 2 milligrams per pound.
Limitations
Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.
Fallow deer (Dama dama)
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local anesthesia. To produce sedation, accompanied by a shorter period of analgesia. May be used to calm and facilitate handling of fractious animals for diagnostic procedures, for minor surgical procedures, for therapeutic medication for sedation and relief of pain following injury or surgery, and as a preanesthetic to local anesthetic. At the recommended dosages, can be used in conjunction with local anesthetics, such as procaine or lidocaine.
Dosage
Administer intramuscularly, by hand syringe, or by syringe dart, in the heavy muscles of the croup or shoulder 2 to 4 milligrams per pound.
Limitations
Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.
Elk (Cervus canadensis)
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local anesthesia. To produce sedation, accompanied by a shorter period of analgesia. May be used to calm and facilitate handling of fractious animals for diagnostic procedures, for minor surgical procedures, for therapeutic medication for sedation and relief of pain following injury or surgery, and as a preanesthetic to local anesthetic. At the recommended dosages, can be used in conjunction with local anesthetics, such as procaine or lidocaine.
Dosage
Administer intramuscularly, by hand syringe, or by syringe dart, in the heavy muscles of the croup or shoulder 0.25 to 0.5 milligrams per pound of body weight.
Limitations
Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.
Horses
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local or general anesthesia.
Dosage
0.5 milligrams per pound intravenously or 1.0 milligram per pound intramuscularly.
Limitations
Not for use in horses intended for food.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of solution contains xylazine hydrochloride equivalent to 20 milligrams xylazine.
Dogs
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local or general anesthesia.
Dosage
0.5 milligrams per pound intravenously or 1.0 milligram per pound intramuscularly.
Limitations
Cats
Indication
To produce sedation, as an analgesic, and as a preanesthetic to local or general anesthesia.
Dosage
0.5 milligrams per pound intravenously or 1.0 milligram per pound intramuscularly.
Limitations

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary

    Sedazine (xylazine) should be used in horses and Cervidae when it is desirable to produce a state of sedation accompanied by a shorter period of analgesia.

    Horses: Sedazine has been used successfully as follows:

    1. Diagnostic procedures -- oral and opthalmic examinations, abdominal palpation, rectal palpation, vaginal examination, catheterization of the bladder and radiographic examinations.
    2. Orthopedic procedures, such as application of casting materials and splints.
    3. Dental procedures.
    4. Minor surgical procedures of short duration such as debridement, removal of cutaneous neoplasms and suturing of lacerations.
    5. To calm and facilitate handling of fractious animals.
    6. Therapeutic medication for sedation and relief of pain following injury or surgery.
    7. Major surgical procedures 

    • When used as a preanesthetic to general anesthesia.
    • When used in conjunction with local anesthetics.

    Cervidae: Sedazine may be used for the following:To calm and facilitate the handling of fractious animals.
    1. Diagnostic procedures.
    2. Minor surgical procedures.
    3. Therapeutic medication for sedation and relief of pain following injury or surgery.
    4. As a preanesthetic to local anesthesia. Sedazine at the recommended dosages can be used in conjunction with local anesthetics, such as procain or lidocaine.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    Xylazine HCl Injection should be used in horses when it is desirable to produce a state of sedation. It has been successfully used when conducting various diagnostic, orthopedic and dental procedures and for minor surgical procedures of short duration. It may also be used as a preanesthetic to local or general anesthesia.

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    This supplement provides for a 300 mg/mL xylazine concentration, in addition to the approved concentration of 100 mg/mL for Cervidae.
  • Summary
    This supplement provides for modification of the labeling to include use of AnaSed® 20 mg/mL in cats.
  • Summary
    This supplement provides for modification of the labeling to include use of AnaSed; 100 mg/mL in Fallow Deer, Mule Deer, Sika Deer, White-tailed Deer, and Elk.
  • Summary
    Supplement provides for use of the product in an additional species (dog).
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    XYLAMED should be used in horses and Cervidae (Fallow Deer, Mule Deer, Sika Deer, White-Tailed Deer, and Elk) when it is desirable to produce a state of sedation accompanied by a shorter period of analgesia. 
    Horses: XYLAMED has been used successfully as follows:
    1. Diagnostic procedures-oral and ophthalmic examinations, abdominal palpation, rectal palpation, vaginal examination, catheterization of the bladder and radiographic examinations.
    2. Orthopedic procedures, such as application of casting materials and splints.
    3. Dental procedures.
    4. Minor surgical procedures of short duration such as debridement, removal of cutaneous neoplasms and suturing of lacerations.
    5. To calm and facilitate handling of fractious animals.
    6. Therapeutic medication for sedation and relief of pain following injury or surgery.
    7. Major surgical procedures:
    a. When used as a preanesthetic to general anesthesia.
    b. When used in conjunction with local anesthetics.
    Cervidae: XYLAMED may be used for the following:
    1. To calm and facilitate handling of fractious animals.
    2. Diagnostic procedures.
    3. Minor surgical procedures.
    4. Therapeutic medication for sedation and relief of pain following injury or surgery.
    5. As a preanesthetic to local anesthesia.
    XYLAMED at the recommended dosages can be used in conjunction with local anesthetics, such as procaine or lidocaine..

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    Chanazine (xylazine) should be used in horses and Cervidae when it is desirable to produce a state of sedation accompanied by a shorter period of analgesia.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    Chanazine (xylazine) should be used in dogs and cats when it is desirable to produce a state of sedation accompanied by a shorter period of analgesia. Xylazine has been used successfully as follows:

    Diagnostic procedures - examination of mouth and ears, abdominal palpation, rectal palpation, vaginal examination, catheterization of the bladder and radiographic examinations.

    Orthopedic procedures, such as application of casting materials and splints.

    Dental procedures.

    Minor surgical procedures of short duration such as debridement, removal of cutaneous neoplasms and suturing of lacerations.

    To calm and facilitate restraint of fractious animals.

    Therapeutic medication for sedation and relief of pain following injury or surgery.

    Major surgical procedures:

    When used as a preanesthetic to general anesthesia.

    When used in conjunction with local anesthetics.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

To produce sedation, as an analgesic, and as a preanesthetic to local or general anesthesia. To produce sedation, as an analgesic, and as a preanesthetic to local anesthesia. To produce sedation, accompanied by a shorter period of analgesia. May be used to calm and facilitate handling of fractious animals for diagnostic procedures, for minor surgical procedures, for therapeutic medication for sedation and relief of pain following injury or surgery, and as a preanesthetic to local anesthetic. At the recommended dosages, can be used in conjunction with local anesthetics, such as procaine or lidocaine. To produce sedation, as an analgesic, and as a preanesthetic to local or general anesthesia

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption. Do not use in domestic food-producing animals. Do not use in Cervidae less than 15 days before or during the hunting season.

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 56 and Cat 8 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog
Digestive
Vomiting (6) Nausea (4) Vomiting (1) Vomiting (1) Vomiting (1) Vomiting (1) Vomiting (1) Vomiting (1)
Skin & allergy
Hives (4)
Neurologic
Tiredness (lethargy) (4)
Effectiveness
Lack of efficacy - NOS (7)
Other
Death (9) Death by euthanasia (5) INEFFECTIVE, ANESTHESIA (4) Abdominal pain (1) Abdominal pain (1) Abdominal pain (1) Abdominal pain (1) Abdominal pain (1) Abdominal pain (1) Abnormal ultrasound finding (1) Abnormal ultrasound finding (1) Abnormal ultrasound finding (1) Abnormal ultrasound finding (1) Abnormal ultrasound finding (1) Abnormal ultrasound finding (1) Death (1) Death (1) Death (1) Death (1) Death (1) Death (1) Fluid in abdomen NOS (1) Fluid in abdomen NOS (1) Fluid in abdomen NOS (1) Fluid in abdomen NOS (1) Fluid in abdomen NOS (1) Fluid in abdomen NOS (1) Gastric ulcer (1) Gastric ulcer (1) Gastric ulcer (1) Gastric ulcer (1) Gastric ulcer (1) Gastric ulcer (1) Hyperthermia (1) Hyperthermia (1) Hyperthermia (1) Hyperthermia (1) Hyperthermia (1) Hyperthermia (1) Malaise (1) Malaise (1) Malaise (1) Malaise (1) Malaise (1) Malaise (1)
Cat
Neurologic
Unsteady walking (ataxia) (4)
Behavior
Behavioral disorder (unspecified) (6)
Effectiveness
Lack of efficacy - NOS (7)
Other
Death (10) Not eating (5) Elevated blood urea nitrogen (4) Hypothermia (4) Medication error NOS (4)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Sheepdog - Old English (Bobtail), Male, 4 year, 37.8 kilogram • Drug: MSK, Unknown • Reactions: Malaise, Gastric ulcer, Peritonitis, Fluid in abdomen NOS, Fluid in abdomen NOS… • Outcome: Euthanized

  • Report ID: DEU-USFDACVM-2025-DE-000039
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 4.00 Year
  • Weight: 37.800 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Malaise Gastric ulcer Peritonitis Fluid in abdomen NOS Fluid in abdomen NOS Abdominal pain Vomiting Abnormal ultrasound finding Death Hyperthermia
Outcomes: Euthanized

Cat, ['Domestic Shorthair', 'Domestic Shorthair', 'Domestic Shorthair', 'Domestic Shorthair'], Mixed, 2 year, 8.63 kilogram • Drug: MSK, Intramuscular, Dose: 5.50 Milligram per kilogram • Reactions: Death • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-049619
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Mixed
  • Age: 2.00 Year
  • Weight: 8.630 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Dose: 5.50 Milligram per kilogram
Reactions Reported:
Death
Outcomes: Died

Cat, Domestic Shorthair, Male, 8 month • Drug: MSK, Unassigned, Intramuscular • Reactions: Death, Medication error NOS • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-021420
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.00 Month
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Unassigned
Reactions Reported:
Death Medication error NOS
Outcomes: Died

Cat, Domestic Shorthair, Female, 5 year, 7.112 kilogram • Drug: MSK, Unassigned, Intramuscular • Reactions: Cyanosis, Death, Medication error NOS • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-019865
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 5.00 Year
  • Weight: 7.112 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Unassigned
Reactions Reported:
Cyanosis Death Medication error NOS
Outcomes: Died

Cat, Domestic Shorthair, Male, 5 year • Drug: MSK, Unassigned, Intramuscular • Reactions: Death, Medication error NOS • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-019864
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 5.00 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Unassigned
Reactions Reported:
Death Medication error NOS
Outcomes: Died

Cat, Domestic Shorthair, Female, 8.5 year, 3.084 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Otitis NOS, Hind limb paralysis, Urinary retention, Abnormal radiograph finding, Intentional misuse • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-012093
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 8.50 Year
  • Weight: 3.084 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Otitis NOS Hind limb paralysis Urinary retention Abnormal radiograph finding Intentional misuse
Outcomes: Ongoing

Dog, 5 year, 7 kilogram • Drug: MSK, Injection, solution • Reactions: Excitation • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2024-US-070765
  • Serious AE: No
  • Treated For AE: No
  • Age: 5.00 Year
  • Weight: 7.000 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Form: Injection, solution
Reactions Reported:
Excitation
Outcomes: Recovered/Normal

Dog, ['Coonhound (unspecified)', 'Dog (unknown)'], Male, 8.5 year, 29.483 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Reluctant to move, Limb weakness, Walking difficulty, Knuckling, Paraparesis… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2024-US-028777
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.50 Year
  • Weight: 29.483 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Reluctant to move Limb weakness Walking difficulty Knuckling Paraparesis Proprioception loss Myelopathy NOS Arched back Difficulty standing
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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