Meds A-Z
Metronidazole
Detailed information about Metronidazole
Pet Owner Quick Guide
Start here: what this medicine is for, what it does, and when it's usually needed.
Usually used for:
For the treatment of Giardia duodenalis infection in dogs.
What it does:
Antibiotic/antiprotozoal used for certain GI infections and inflammation.
When it's needed:
Use caution with liver disease. Avoid overdosing.
Call your vet sooner if you notice:
- Use caution with liver disease. Avoid overdosing.
Commonly reported reactions:
- (2 reports)
- (2 reports)
- (2 reports)
What to ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Metronidazole
Drug type: Generic ingredient • Branded profile • FDA branded products available
Species: Both
Manufacturer: MSK
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141572 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source
Warnings / Contraindications
Use caution with liver disease. Avoid overdosing.
- High: Use caution with liver disease. Avoid overdosing.
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Tap or hover a reaction to see what it means in plain language.
Most Reported Reactions
| Reaction | Cases | Species | Serious cases |
|---|---|---|---|
| 2 | Cat, Dog | 1 | |
| 2 | Cat, Dog | 1 | |
| 2 | Cat, Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 |
Species coverage: Dog (18) Cat (14)
View detailed reaction table
| Reaction | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 |
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-055801
Storage & Handling
Store at room temperature.
Documents
Official label facts are separated from secondary summaries.
Official documents: 2 • Secondary summaries: 0
- N-141572-G-0006-OT-AA_foi.pdf · FOI
- AYRADIA™ · SPL
No source yet.
Promotional Materials (Marketing)
This content is marketing material and not clinical guidance.
No marketing assets are linked yet.
No source yet.
Technical appendix (vet reference)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
- Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 7:40 PM UTC
-
Animal Drugs @ FDA:
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Applications/products are imported from FDA export data.
-
Animal Drugs @ FDA previews:
Source FDA
| Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:02 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:19 AM UTC
Diagnosis-code mappings are not available for this medication yet.
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
- Use caution with liver disease. Avoid overdosing. (Contraindication, High)
Identifiers & Packages
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 17163-015-16 | 17163 | - | |
| 17163-016-17 | 17163 | - | |
| 43457-537-25 | 43457 | - | |
| 46144-602-01 | 46144 | - | |
| 51311-034-10 | 51311 | - | |
| 51311-034-30 | 51311 | - | |
| 53745-016-01 | 53745 | - | |
| 53745-016-02 | 53745 | - | |
| 55999-081-12 | 55999 | - | |
| 55999-081-15 | 55999 | - | |
| 55999-081-18 | 55999 | - | |
| 55999-081-56 | 55999 | - | |
| 55999-081-57 | 55999 | - | |
| 62157-529-01 | 62157 | - | |
| 63732-2047-9 | 63732 | - | |
| 73309-199-01 | 73309 | - | |
| 86184-255-01 | 86184 | - |
Enriched Documents
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
-
N-141572-G-0006-OT-AA_foi.pdf
• FOI summary • Official
• March 26, 2024
FDA FOI summary for application 141572
Data Sources & Revision History
Every non-trivial field is expected to include provenance and update timestamps.
- storage_handling: Store at room temperature. (Clinical, 2026-02-12)
- contraindications: Use caution with liver disease. Avoid overdosing. (Official, 2026-02-12)
- side_effects: GI upset. High doses can cause neurologic signs (ataxia, tremors). (Official, 2026-02-12)
- usage: Antibiotic/antiprotozoal used for certain GI infections and inflammation. (Official, 2026-02-12)
- side_effects updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
Official sponsor/proprietary-name/application-status records linked by active ingredient.
| Product | Sponsor | Application | Status | Published |
|---|---|---|---|---|
|
AYRADIA™
RX
Metronidazole
Suspension
• Oral
|
Virbac AH, Inc. | NADA 141-572 | Approved | Mar 26, 2024 |
Data source: FDA Animal Drugs @ FDA (public search export).
What It's For (FDA Label Highlights)
Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.
Composition / specifications
For the treatment of Giardia duodenalis infection in dogs.
25 mg/kg (11.3 mg/lb) of body weight, using the supplied syringe, twice daily for five consecutive days
FDA page: Open in Animal Drugs @ FDA
Official Documents (FDA)
Direct links to FDA-hosted PDFs and SPL packages (when available).
-
Summary
For the treatment of Giardia duodenalis infection in dogs.
- AYRADIA™ (ZIP)
FDA page: Open in Animal Drugs @ FDA
Usage
Antibiotic/antiprotozoal used for certain GI infections and inflammation.
Source: FDA Animal Drugs @ FDA • Reference
Contraindications
Use caution with liver disease. Avoid overdosing.
Side Effects
GI upset. High doses can cause neurologic signs (ataxia, tremors).
Source: FDA openFDA • Reference
Top Reported Reactions (openFDA)
Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Dog, Shar Pei, Female, 5 year, 16.23 kilogram • Drug: MSK, Unknown • Reactions: Neuromuscular disorder NOS, Unsteady gait, Nystagmus, Circling - behavioural disorder, Not himself/herself • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-055976
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 5.00 Year
- Weight: 16.230 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, Crossbred Canine/dog, Female, 10.75 year, 31.7 kilogram • Drug: MSK, Unknown • Reactions: Walking difficulty, Weakness • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-054932
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 10.75 Year
- Weight: 31.700 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, Terrier - Bull - American Pit, Male, 14 year, 24.494 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Stiff gait, Cognitive disorder NOS, Malaise, Vomiting, Diarrhea… • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-055236
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Male
- Age: 14.00 Year
- Weight: 24.494 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Unassigned
Cat, Domestic Mediumhair, Female, 13 year, 2.858 kilogram • Drug: MSK, Oral • Reactions: Tiredness (lethargy), Unresponsive to stimuli, Not eating, Not drinking, Hiding… • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-055801
- Serious AE: No
- Treated For AE: Yes
- Sex: Female
- Age: 13.00 Year
- Weight: 2.858 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
Dog, Terrier - Bull, Male, 10 year, 32.38 kilogram • Drug: MSK, Unknown • Reactions: Elevated alanine aminotransferase, Diarrhea, Elevated serum alkaline phosphatase, Elevated gamma-glutamyl transferase, Abnormal ultrasound finding… • Outcome: Euthanized
- Report ID: USA-USFDACVM-2025-US-054535
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Male
- Age: 10.00 Year
- Weight: 32.380 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, ['Mountain Dog - Bernese', 'Poodle (unspecified)'], Female, 6.5 month, 3.7 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Sleepiness - systemic disorder, Barking, Inappropriate urination, Agitation, Decreased appetite • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-055655
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 6.50 Month
- Weight: 3.700 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Unassigned
Cat, Domestic Shorthair, Female, 11 year, 2.33 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy - NOS, Ketosis • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-053010
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 11.00 Year
- Weight: 2.330 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Cat, Domestic Longhair, Male, 12 year, 6.44 kilogram • Drug: MSK, Unknown • Reactions: Diarrhea, Itching • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-054223
- Serious AE: No
- Treated For AE: Yes
- Sex: Male
- Age: 12.00 Year
- Weight: 6.440 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
Store at room temperature.
Share Your Thoughts
Let others know your experience or advice regarding this medication.
This medication has not been reviewed by a veterinarian yet.