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Capromorelin

Detailed information about Capromorelin

Official label facts Owner quick guide first Marketing clearly labeled
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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

For appetite stimulation in dogs.

What it does:

For appetite stimulation in dogs. For management of weight loss in cats with chronic kidney disease.

When it's needed:

The safe use of ENTYCE has not been evaluated in dogs used for breeding or pregnant or lactating bitches.

Call your vet sooner if you notice:

  • The safe use of ENTYCE has not been evaluated in dogs used for breeding or pregnant or lactating bitches.

Commonly reported reactions:

  • (2 reports)
  • (2 reports)
  • (1 reports)

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
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Capromorelin

Capromorelin

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: MSK

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: MSK
Form: Oral Solution
Identifiers:
NADA: 141457 NADA: 141536 NDC Package: 58198-5535-1 NDC Package: 58198-5535-2 NDC Package: 58198-5535-3 NDC Package: 58198-5545-1 NDC Product: 58198
Source metadata:

Warnings / Contraindications

The safe use of ENTYCE has not been evaluated in dogs used for breeding or pregnant or lactating bitches.

  • High: The safe use of ENTYCE has not been evaluated in dogs used for breeding or pregnant or lactating bitches.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
9
Species represented
2
Most Reported Reactions
Reaction Cases Species Serious cases
2 Cat, Dog 0
2 Cat, Dog 0
1 Dog 1
1 Cat 1
1 Dog 1
1 Dog 1
1 Cat 1
1 Cat 1

Species coverage: Cat (20) Dog (12)

View detailed reaction table
Reaction Species Seriousness Frequency Reports
Cat Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Dog Serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Cat Serious - 1
Cat Non-serious - 1
Dog Serious - 1
Dog Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Dog Non-serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Cat Non-serious - 1
Source metadata:

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 4 • Secondary summaries: 0

Official label facts
Secondary summaries

No source yet.

Source metadata:

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.
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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: ENTYCE™ Elura™
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat, Dog
Rx/OTC: RX
Form/route: Oral Solution • Oral
Applications: NADA 141-457 • NADA 141-536
Documents: 2 (FOI: 2) • SPL: 2 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 56 • Cat 56 • View
Case summaries: 10 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: N18.9
Chronic kidney disease, unspecified

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • The safe use of ENTYCE has not been evaluated in dogs used for breeding or pregnant or lactating bitches. (Contraindication, High)
Top reaction signals
Adipsia (1) Administration error NOS (1) Anorexia (1) Anorexia (1) Behavioural disorder NOS (1) Bradycardia (1) Circling - behavioural disorder (see also Neurological disorders) (1) Corneal ulcer (1) Death (1) Death by euthanasia (1) Decreased appetite (1) Diarrhoea (1) Elevated blood urea nitrogen (BUN) (1) Elevated creatinine (1) Fever (1) Gall bladder & bile duct disorder NOS (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141457 NADA: 141536 NDC Package: 58198-5535-1 NDC Package: 58198-5535-2 NDC Package: 58198-5535-3 NDC Package: 58198-5545-1 NDC Product: 58198
Package NDC Product NDC Form / Route Status
58198-5535-1 58198 -
58198-5535-2 58198 -
58198-5535-3 58198 -
58198-5545-1 58198 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 5 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: The safe use of ENTYCE has not been evaluated in dogs used for breeding or pregnant or lactating bitches. (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Vomiting, Death by euthanasia, Lethargy (see also Central nervous system depression in 'Neurological'), Lack of efficacy - NO… (Official, 2026-02-12)
  • usage: For appetite stimulation in dogs. For management of weight loss in cats with chronic kidney disease. (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
ENTYCE™
RX
Capromorelin
Oral Solution • Oral
Label highlights
Official documents
Elanco US Inc. NADA 141-457 Approved Nov 19, 2020
Elura™
RX
Capromorelin
Oral Solution • Oral
Label highlights
Official documents
Elanco US Inc. NADA 141-536 Approved Oct 16, 2020

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of solution contains 30 milligrams (mg) capromorelin.
Dogs
Indication
For appetite stimulation in dogs.
Dosage
Administer 3 mg/kg once daily by mouth.
Limitations
The safe use of ENTYCE has not been evaluated in dogs used for breeding or pregnant or lactating bitches.

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
20 mg/mL flavored oral solution
Cats
Indication

For management of weight loss in cats with chronic kidney disease.

Dosage

2 mg/kg once daily

Limitations

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

For appetite stimulation in dogs. For management of weight loss in cats with chronic kidney disease.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

The safe use of ENTYCE has not been evaluated in dogs used for breeding or pregnant or lactating bitches.

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 56 and Cat 56 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog
Digestive
Vomiting (90) Diarrhea (69) Loss of appetite (3) Loss of appetite (3) Loss of appetite (3) Loss of appetite (3) Loss of appetite (3) Loss of appetite (3) Vomiting (3) Vomiting (3) Vomiting (3) Vomiting (3) Vomiting (3) Vomiting (3)
Neurologic
Tiredness (lethargy) (78) Tiredness (lethargy) (52) Tiredness (lethargy) (3) Tiredness (lethargy) (3) Tiredness (lethargy) (3) Tiredness (lethargy) (3) Tiredness (lethargy) (3) Tiredness (lethargy) (3)
Effectiveness
Lack of efficacy - NOS (73) Lack of efficacy - NOS (4) Lack of efficacy - NOS (4) Lack of efficacy - NOS (4) Lack of efficacy - NOS (4) Lack of efficacy - NOS (4) Lack of efficacy - NOS (4)
Other
Death by euthanasia (82) Not eating (72) UNPALATABLE (52) Not eating (5) Not eating (5) Not eating (5) Not eating (5) Not eating (5) Not eating (5) Elevated creatinine (3) Elevated creatinine (3) Elevated creatinine (3) Elevated creatinine (3) Elevated creatinine (3) Elevated creatinine (3) Hyperphosphataemia (3) Hyperphosphataemia (3) Hyperphosphataemia (3) Hyperphosphataemia (3) Hyperphosphataemia (3) Hyperphosphataemia (3) Azotaemia (2) Azotaemia (2) Azotaemia (2) Azotaemia (2) Azotaemia (2) Azotaemia (2)
Cat
Digestive
Drooling (43) Vomiting (43)
Neurologic
Tiredness (lethargy) (42) Tiredness (lethargy) (21) Tiredness (lethargy) (3) Tiredness (lethargy) (3) Tiredness (lethargy) (3) Tiredness (lethargy) (3) Tiredness (lethargy) (3) Tiredness (lethargy) (3)
Other
Bradycardia (46) Death by euthanasia (28) Hypotension (27) Decreased heart rate (20) Bradycardia (2) Bradycardia (2) Bradycardia (2) Bradycardia (2) Bradycardia (2) Bradycardia (2) Hypotension (2) Hypotension (2) Hypotension (2) Hypotension (2) Hypotension (2) Hypotension (2) Increased respiratory rate (2) Increased respiratory rate (2) Increased respiratory rate (2) Increased respiratory rate (2) Increased respiratory rate (2) Increased respiratory rate (2) Not eating (2) Not eating (2) Not eating (2) Not eating (2) Not eating (2) Not eating (2) Vocalisation (2) Vocalisation (2) Vocalisation (2) Vocalisation (2) Vocalisation (2) Vocalisation (2) Adipsia (1) Adipsia (1) Adipsia (1) Adipsia (1) Adipsia (1) Adipsia (1) Administration error NOS (1) Administration error NOS (1) Administration error NOS (1) Administration error NOS (1) Administration error NOS (1) Administration error NOS (1)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Alaskan Malamute, Male, 9.5 year, 45.35 kilogram • Drug: MSK, Solution, Oral, Dose: 2.20 mL per animal, Frequency: 1 per day • Reactions: Lack of efficacy - NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055798
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 9.50 Year
  • Weight: 45.350 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Dose: 2.20 mL per animal
  • Frequency: 1 per day
Reactions Reported:
Lack of efficacy - NOS
Outcomes: Outcome Unknown

Dog, Shar Pei, Female, 5 year, 16.23 kilogram • Drug: MSK, Solution, Oral, Dose: 1.70 mL per animal • Reactions: Neuromuscular disorder NOS, Unsteady gait, Nystagmus, Circling - behavioural disorder, Not himself/herself • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055976
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 5.00 Year
  • Weight: 16.230 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Dose: 1.70 mL per animal
Reactions Reported:
Neuromuscular disorder NOS Unsteady gait Nystagmus Circling - behavioural disorder Not himself/herself
Outcomes: Recovered/Normal

Dog, Chihuahua, Female, 16 year, 3.12 kilogram • Drug: MSK, Solution, Oral • Reactions: Reduced responses, Elevated creatinine, Corneal ulcer, Sleepiness - systemic disorder, Elevated blood urea nitrogen… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055817
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 16.00 Year
  • Weight: 3.120 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
Reactions Reported:
Reduced responses Elevated creatinine Corneal ulcer Sleepiness - systemic disorder Elevated blood urea nitrogen Lack of efficacy - NOS Hyperphosphataemia
Outcomes: Ongoing

Dog, Dog (unknown), Male • Drug: MSK, Solution, Oral • Reactions: Increased appetite • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055935
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
Reactions Reported:
Increased appetite
Outcomes: Outcome Unknown

Dog, Dachshund (unspecified), Male, 14 year, 9.25 kilogram • Drug: MSK, Solution, Oral, Dose: 1 mL per animal • Reactions: Unwell, Loss of appetite, Malaise, Whining, Drooling… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055407
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 14.00 Year
  • Weight: 9.250 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Dose: 1 mL per animal
Reactions Reported:
Unwell Loss of appetite Malaise Whining Drooling Lack of efficacy - NOS
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Female, 4.5 year, 4.39 kilogram • Drug: MSK, Solution, Oral • Reactions: Tiredness (lethargy), Not eating • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-054125
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 4.50 Year
  • Weight: 4.390 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
Reactions Reported:
Tiredness (lethargy) Not eating
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 8 year, 5.7 kilogram • Drug: MSK, Solution, Oral • Reactions: Tiredness (lethargy), Not eating, Gall bladder & bile duct disorder NOS, Pancreas disorder, Not himself/herself… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-053793
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.00 Year
  • Weight: 5.700 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
Reactions Reported:
Tiredness (lethargy) Not eating Gall bladder & bile duct disorder NOS Pancreas disorder Not himself/herself Weight gain
Outcomes: Ongoing

Cat, Cat (other), Unknown, 2.39 kilogram • Drug: MSK, Solution, Oral, Dose: 2.70 mL per animal • Reactions: Bradycardia, Increased respiratory rate, Hypotension, Vocalisation • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054818
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Unknown
  • Weight: 2.390 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Dose: 2.70 mL per animal
Reactions Reported:
Bradycardia Increased respiratory rate Hypotension Vocalisation
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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