Meds A-Z
Ilunocitinib
Detailed information about Ilunocitinib
Pet Owner Quick Guide
Start here: what this medicine is for, what it does, and when it's usually needed.
Usually used for:
For the control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
What it does:
For the control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
When it's needed:
For the control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
Commonly reported reactions:
- (1 reports)
- (1 reports)
- (1 reports)
What to ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Ilunocitinib
Drug type: Generic ingredient • Branded profile • FDA branded products available
Species: Both
Manufacturer: MSK
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141585 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source
Warnings / Contraindications
No contraindication summary is linked yet.
No owner-focused warning rows are linked yet.
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Tap or hover a reaction to see what it means in plain language.
Most Reported Reactions
| Reaction | Cases | Species | Serious cases |
|---|---|---|---|
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 0 | |
| 1 | Dog | 0 | |
| 1 | Dog | 0 |
Species coverage: Dog (32)
View detailed reaction table
| Reaction | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - |
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-055555
Storage & Handling
No storage/handling guidance is linked yet.
Documents
Official label facts are separated from secondary summaries.
Official documents: 3 • Secondary summaries: 0
No source yet.
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/17467 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/15865 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/16205/Zenrelia%E2%84%A2 · document · SPL
Promotional Materials (Marketing)
This content is marketing material and not clinical guidance.
No marketing assets are linked yet.
No source yet.
Technical appendix (vet reference)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
- Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
-
Animal Drugs @ FDA:
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Applications/products are imported from FDA export data.
-
Animal Drugs @ FDA previews:
Source FDA
| Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:04 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Feb 12, 2026, 10:44 PM UTC
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
Identifiers & Packages
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 58198-5536-1 | 58198 | - | |
| 58198-5536-2 | 58198 | - | |
| 58198-5536-3 | 58198 | - | |
| 58198-5537-1 | 58198 | - | |
| 58198-5537-2 | 58198 | - | |
| 58198-5537-3 | 58198 | - | |
| 58198-5538-1 | 58198 | - | |
| 58198-5538-2 | 58198 | - | |
| 58198-5538-3 | 58198 | - | |
| 58198-5539-1 | 58198 | - | |
| 58198-5539-2 | 58198 | - | |
| 58198-5539-3 | 58198 | - |
Enriched Documents
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
-
FOI Summary oN 141-585 Approved September 19, 2024.pdf
• FOI summary • Official
• Oct. 1, 2025
FDA FOI summary for application 141585
-
FOI Summary sN 141-585 Approved September 19, 2025.pdf
• FOI summary • Official
• Oct. 1, 2025
FDA FOI summary for application 141585
Data Sources & Revision History
Every non-trivial field is expected to include provenance and update timestamps.
- side_effects: Top reported reactions (openFDA): Lack of efficacy - NOS, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Leucopeni… (Official, 2026-02-12)
- usage: For the control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. (Official, 2026-02-12)
- side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
Official sponsor/proprietary-name/application-status records linked by active ingredient.
| Product | Sponsor | Application | Status | Published |
|---|---|---|---|---|
|
Zenrelia™
RX
Ilunocitinib
Tablet
• Oral
|
Elanco US Inc. | NADA 141-585 | Approved | Oct 1, 2025 |
Data source: FDA Animal Drugs @ FDA (public search export).
What It's For (FDA Label Highlights)
Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.
Composition / specifications
For the control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
Administer orally 0.27 to 0.36 mg ilunocitinib/lb (0.6 to 0.8 mg ilunocitinib/kg) body weight, once daily, with or without food.
FDA page: Open in Animal Drugs @ FDA
Official Documents (FDA)
Direct links to FDA-hosted PDFs and SPL packages (when available).
-
Summary
This supplement provides for revisions to the boxed warning and Animal Safety Warnings.
-
Summary
For the control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
- Zenrelia™ (ZIP)
FDA page: Open in Animal Drugs @ FDA
Usage
For the control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
Source: FDA Animal Drugs @ FDA • Reference
Contraindications
No approved contraindication text is linked yet. Review FDA label highlights and openFDA safety reports before making treatment decisions.
Side Effects
No approved side-effect narrative is linked yet.
openFDA reaction signals are available for Dog 56 and Cat 0 (view top reported reactions).
Top Reported Reactions (openFDA)
Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Dog, Lhasa Apso, Female, 10.92 year, 11.16 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal, Frequency: 1 per day • Reactions: Diarrhea, Oral mass • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-056010
- Serious AE: No
- Treated For AE: Yes
- Sex: Female
- Age: 10.92 Year
- Weight: 11.160 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 1 tablet per animal
- Frequency: 1 per day
Dog, Pit Bull, Male, 8 year, 24.86 kilogram • Drug: MSK, Tablet, Oral, Dose: 2 tablet per animal, Frequency: 1 per day • Reactions: Unable to jump, Muscle weakness NOS • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-055968
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 8.00 Year
- Weight: 24.860 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 2 tablet per animal
- Frequency: 1 per day
Dog, Sheepdog - Shetland, Female, 4.5 year, 9 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal, Frequency: 1 per day • Reactions: Inappropriate urination, Polyuria • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-055980
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 4.50 Year
- Weight: 9.000 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 1 tablet per animal
- Frequency: 1 per day
Dog, ['Dachshund - Standard Long-haired', 'Dog (unknown)'], Male, 12 year, 8.936 kilogram • Drug: MSK, Tablet, Oral • Reactions: Fever, Panting, Swollen limb, Localised pain NOS, Paralysis NOS • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-055637
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Male
- Age: 12.00 Year
- Weight: 8.936 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
Dog, Retriever - Labrador, Male, 8 year, 24.94 kilogram • Drug: MSK, Tablet, Oral, Frequency: 1 per day • Reactions: Diarrhea • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-055970
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 8.00 Year
- Weight: 24.940 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Frequency: 1 per day
Dog, Pit Bull, Female, 5 year, 49 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal, Frequency: 1 per day • Reactions: Cough, hacking, Not eating • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-055555
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 5.00 Year
- Weight: 49.000 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 1 tablet per animal
- Frequency: 1 per day
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.
Share Your Thoughts
Let others know your experience or advice regarding this medication.
This medication has not been reviewed by a veterinarian yet.