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Progesterone

Detailed information about Progesterone

Official label facts Owner quick guide first Marketing clearly labeled
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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

For increased rate of weight gain in beef calves 45 days of age and older and weighing up to 400 lbs. This implant is not approved for repeated implantation (reimplantation) with this or any other cattle ear implant as s...

What it does:

For increased rate of weight gain in growing beef steers fed in confinement for slaughter in a reimplantation program where SYNOVEX® C or SYNOVEX® S is the first implant and a SYNOVEX® S implant is administered approxima...

When it's needed:

For use in suckling beef calves (at least 45 days of age) up to 400 pounds of body weight. For subcutaneous ear implantation, one dose per animal. Do not use in bull calves intended for reproduction. Safety and effective...

Call your vet sooner if you notice:

  • For use in suckling beef calves (at least 45 days of age) up to 400 pounds of body weight. For subcutaneous ear implantation, one dose per animal. Do not use in bull calves intended for reproduction. Safety and effectiveness have not been established in veal calves. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal. This product is approved for concurrent use of dinoprost solution on day 7 of the 7-day administration period when used for the following indications: For synchronization of estrus in lactating dairy cows. Do not use in animals with abnormal, immature, or infected genital tracts; or in dairy cows that are fewer than 40 days postpartum for synchronization of estrus or synchronization of the return to estrus; or in anestrous lactating dairy cows less than 42 days or greater than 78 days postpartum for induction of estrous cycles. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility. Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations. Do not use in animals with abnormal, immature, or infected genital tracts; or in dairy cows that are fewer than 40 days postpartum for synchronization of estrus or synchronization of the return to estrus; or in anestrous lactating dairy cows less than 42 days or greater than 78 days postpartum for induction of estrous cycles. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations..

Commonly reported reactions:

  • (1 reports)

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
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Progesterone

Progesterone

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Zoetis Inc.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Zoetis Inc.
Form: Implant, Implant (Pellet), Insert, Solid Matrix
Identifiers:
NADA: 110315 NADA: 141200 NADA: 141302 NADA: 9576 NDC Package: 54771-1533-1 NDC Package: 54771-3902-1 NDC Package: 54771-3903-1 NDC Package: 54771-3903-2 NDC Package: 54771-5207-1 NDC Package: 58198-0507-2 NDC Package: 58198-0792-1 NDC Package: 62157-485-01 NDC Package: 73309-381-01 NDC Package: 73377-133-01 NDC Package: 73377-160-01 NDC Package: 73377-160-02 NDC Package: 73377-160-03 NDC Package: 77382-0200-1 NDC Product: 54771 NDC Product: 58198
Source metadata:

Warnings / Contraindications

For use in suckling beef calves (at least 45 days of age) up to 400 pounds of body weight. For subcutaneous ear implantation, one dose per animal. Do not use in bull calves intended for reproduction. Safety and effectiveness have not been established in veal calves. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal. This product is approved for concurrent use of dinoprost solution on day 7 of the 7-day administration period when used for the following indications: For synchronization of estrus in lactating dairy cows. Do not use in animals with abnormal, immature, or infected genital tracts; or in dairy cows that are fewer than 40 days postpartum for synchronization of estrus or synchronization of the return to estrus; or in anestrous lactating dairy cows less than 42 days or greater than 78 days postpartum for induction of estrous cycles. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility. Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations. Do not use in animals with abnormal, immature, or infected genital tracts; or in dairy cows that are fewer than 40 days postpartum for synchronization of estrus or synchronization of the return to estrus; or in anestrous lactating dairy cows less than 42 days or greater than 78 days postpartum for induction of estrous cycles. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations..

  • High: For use in suckling beef calves (at least 45 days of age) up to 400 pounds of body weight. For subcutaneous ear implantation, one dose per animal. Do not use in bull calves intended for reproduction. Safety and effectiveness have not been established in veal calves. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal. This product is approved for concurrent use of dinoprost solution on day 7 of the 7-day administration period when used for the following indications: For synchronization of estrus in lactating dairy cows. Do not use in animals with abnormal, immature, or infected genital tracts; or in dairy cows that are fewer than 40 days postpartum for synchronization of estrus or synchronization of the return to estrus; or in anestrous lactating dairy cows less than 42 days or greater than 78 days postpartum for induction of estrous cycles. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility. Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations. Do not use in animals with abnormal, immature, or infected genital tracts; or in dairy cows that are fewer than 40 days postpartum for synchronization of estrus or synchronization of the return to estrus; or in anestrous lactating dairy cows less than 42 days or greater than 78 days postpartum for induction of estrous cycles. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations..
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
2
Reported cases
1
Serious reports
0
Species represented
1
Most Reported Reactions
Reaction Cases Species Serious cases
1 Dog 0
0 Dog 0

Species coverage: Dog (2)

View detailed reaction table
Reaction Species Seriousness Frequency Reports
Dog Non-serious - 1
Dog Unknown - -
Source metadata:

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 27 • Secondary summaries: 0

Official label facts
Secondary summaries

No source yet.

Source metadata:

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.
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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 9, 2026, 3:15 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:22 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Component™ E-C with Tylan™ Component™ E-S with Tylan™ Component™ E-C EAZI-BREED™ CIDR® Cattle Insert EAZI-BREED™ CIDR® Sheep Insert SYNOVEX® S SYNOVEX® C
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Beef calves at least 45 days old and up to 400 lbs of body weight, Beef cows and beef heifers (female breeding stock), Dairy cows and heifers (female breeding stock), Growing beef steers fed in confinement for slaughter, Sheep
Rx/OTC: OTC, RX
Form/route: Implant, Implant (Pellet), Insert, Solid Matrix • Intravaginal, Subcutaneous
Applications: NADA 110-315 • NADA 9576 • NADA 141-200 • NADA 141-302
Documents: 20 (FOI: 12) • SPL: 7 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 1 • Cat 0 • View
Case summaries: 1 (showing 1) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • For use in suckling beef calves (at least 45 days of age) up to 400 pounds of body weight. For subcutaneous ear implantation, one dose per animal. Do not use in bull calves intended for reproduction. Safety and effectiveness have not been established in veal calves. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal. This product is approved for concurrent use of dinoprost solution on day 7 of the 7-day administration period when used for the following indications: For synchronization of estrus in lactating dairy cows. Do not use in animals with abnormal, immature, or infected genital tracts; or in dairy cows that are fewer than 40 days postpartum for synchronization of estrus or synchronization of the return to estrus; or in anestrous lactating dairy cows less than 42 days or greater than 78 days postpartum for induction of estrous cycles. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility. Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations. Do not use in animals with abnormal, immature, or infected genital tracts; or in dairy cows that are fewer than 40 days postpartum for synchronization of estrus or synchronization of the return to estrus; or in anestrous lactating dairy cows less than 42 days or greater than 78 days postpartum for induction of estrous cycles. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations.. (Contraindication, High)
Top reaction signals
Behavioural disorder NOS (1) Behavioural disorder NOS (reports: 1, since 2016-02-12) (0)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 110315 NADA: 141200 NADA: 141302 NADA: 9576 NDC Package: 54771-1533-1 NDC Package: 54771-3902-1 NDC Package: 54771-3903-1 NDC Package: 54771-3903-2 NDC Package: 54771-5207-1 NDC Package: 58198-0507-2 NDC Package: 58198-0792-1 NDC Package: 62157-485-01 NDC Package: 73309-381-01 NDC Package: 73377-133-01 NDC Package: 73377-160-01 NDC Package: 73377-160-02 NDC Package: 73377-160-03 NDC Package: 77382-0200-1 NDC Product: 54771 NDC Product: 58198 NDC Product: 62157 NDC Product: 73309 NDC Product: 73377 NDC Product: 77382
Package NDC Product NDC Form / Route Status
54771-1533-1 54771 -
54771-3902-1 54771 -
54771-3903-1 54771 -
54771-3903-2 54771 -
54771-5207-1 54771 -
58198-0507-2 58198 -
58198-0792-1 58198 -
62157-485-01 62157 -
73309-381-01 73309 -
73377-133-01 73377 -
73377-160-01 73377 -
73377-160-02 73377 -
73377-160-03 73377 -
77382-0200-1 77382 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • N110315_Supp_04-05-1990.pdf • FOI summary • Official • July 3, 2024
    FDA FOI summary for application 110315
  • N110315_Supp_01-22-1997.pdf • FOI summary • Official • July 3, 2024
    FDA FOI summary for application 110315
  • ucm064925.pdf • FOI summary • Official • July 3, 2024
    FDA FOI summary for application 110315
  • ucm064927.pdf • FOI summary • Official • July 3, 2024
    FDA FOI summary for application 110315
  • N009576_Supp_08_19_1994.pdf • FOI summary • Official • June 15, 2023
    FDA FOI summary for application 9576
  • UCM440503.pdf • FOI summary • Official • June 15, 2023
    FDA FOI summary for application 9576
  • ucm049523.pdf • FOI summary • Official • June 15, 2023
    FDA FOI summary for application 9576
  • ucm117628.pdf • FOI summary • Official • March 2, 2021
    FDA FOI summary for application 141200
  • ucm117632.pdf • FOI summary • Official • March 2, 2021
    FDA FOI summary for application 141200
  • UCM235348.pdf • FOI summary • Official • March 2, 2021
    FDA FOI summary for application 141200
  • UCM388266.pdf • FOI summary • Official • March 2, 2021
    FDA FOI summary for application 141200
  • UCM190797.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 141302

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 15 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: For use in suckling beef calves (at least 45 days of age) up to 400 pounds of body weight. For subcutaneous ear implantation, one dose per animal. Do not use i… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Behavioural disorder NOS. (Official, 2026-02-12)
  • usage: For increased rate of weight gain in growing beef steers fed in confinement for slaughter in a reimplantation program where SYNOVEX® C or SYNOVEX® S is the fir… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Component™ E-C with Tylan™ Component™ E-S with Tylan™ Component™ E-C
RX
Estradiol Benzoate Progesterone Tylosin Tartrate
Implant • Subcutaneous
Label highlights
Official documents
Elanco US Inc. NADA 110-315 Approved Jul 3, 2024
SYNOVEX® S SYNOVEX® C
OTC
Estradiol Benzoate Progesterone
Implant (Pellet) • Subcutaneous
Label highlights
Official documents
Zoetis Inc. NADA 9576 Approved Jun 15, 2023
EAZI-BREED™ CIDR® Cattle Insert
OTC
Progesterone
Insert • Intravaginal
Label highlights
Official documents
Zoetis Inc. NADA 141-200 Approved Mar 2, 2021
EAZI-BREED™ CIDR® Sheep Insert
OTC
Progesterone
Solid Matrix • Intravaginal
Label highlights
Official documents
Zoetis Inc. NADA 141-302 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Beef calves at least 45 days old and up to 400 lbs of body weight
Composition / specifications
Each implant consists of 100 mg progesterone, 10 mg estradiol benzoate, and 20 mg tylosin tartrate.
Beef calves 45 days of age and older and weighing up to 400 lbs
Indication

For increased rate of weight gain in beef calves 45 days of age and older and weighing up to 400 lbs. This implant is not approved for repeated implantation (reimplantation) with this or any other cattle ear implant as safety and effectiveness has not been evaluated.

Dosage

Administer one implant containing 100 mg progesterone, 10 mg estradiol benzoate, and 29 mg tylosin tartrate (5 pellets) to each calf by subcutaneous implantation in the middle-third of the ear

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Beef calves at least 45 days old and up to 400 lbs of body weight • Growing beef steers fed in confinement for slaughter
Composition / specifications
Contains 100 mg progesterone and 10 mg estradiol benzoate per implant. Each implant consists of 4 pellets.
Beef calves 45 days of age and older and weighing up to 400 lbs. and Growing beef steers fed in confinement for slaughter.
Indication

For increased rate of weight gain in growing beef steers fed in confinement for slaughter in a reimplantation program where SYNOVEX® C or SYNOVEX® S is the first implant and a SYNOVEX® S implant is administered approximately 70 days later. Other than ad described on labeling, this implant is not approved for repeated implantation (reimplantation) with any other cattle ear implant in growing beef steers fed in confinement for slaughter as safety and effectiveness have not been evaluated. Do not use in beef calves less than 2 months of age, dairy calves, and veal calves because effectiveness and safety have not been evaluated. Do not use in animals intended for subsequent breeding, or in dairy cows.

Dosage

For increased rate of weight gain in beef calves 45 days of age and older and weighing up to 400 lbs: Administer one implant containing 100 mg progesterone and 10 mg estradiol benzoate (4 pellets) to each steer by subcutaneous implantation in the middle third of the ear. For increased rate of weight gain in growing beef steers fed in confinement for slaughter in a reimplantation program where SYNOVEX® C or SYNOVEX® S is the first implant and a SYNOVEX® S implant is administered approximately 70 days later: Administer one implant containing 100 mg progesterone and 10 mg estradiol benzoate (4 pellets) or one implant containing 200 mg progesterone and 20 mg estradiol benzoate (8 pellets) and administer one implant containing 200 mg progesterone and 20 mg estradiol benzoate (pellets) on approximately day 70 following initial implantation.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Beef cows and beef heifers (female breeding stock) • Dairy cows and heifers (female breeding stock)
Composition / specifications
Each insert contains 1.38 grams of progesterone in molded silicone over a nylon spine.
Lactating Dairy Cows
Indication
For synchronization of estrus in lactating dairy cows.
Dosage
Administer one intravaginal insert per animal for 7 days. Administer 25 milligrams dinoprost (5 milliliters of 5 milligrams per milliliter solution) as a single intramuscular injection insert removal, on Day 7 of the 7 day administration period.
Limitations
This product is approved for concurrent use of dinoprost solution on day 7 of the 7-day administration period when used for the following indications:  For synchronization of estrus in lactating dairy cows. Do not use in animals with abnormal, immature, or infected genital tracts; or in dairy cows that are fewer than 40 days postpartum for synchronization of estrus or synchronization of the return to estrus; or in anestrous lactating dairy cows less than 42 days or greater than 78 days postpartum for induction of estrous cycles. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility. Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations.
Indication
For induction of estrous cycles in anestrous lactating dairy cows.
Dosage
Administer one intravaginal insert per anestrous cow and remove 7 days later.
Limitations
Do not use in animals with abnormal, immature, or infected genital tracts; or in dairy cows that are fewer than 40 days postpartum for synchronization of estrus or synchronization of the return to estrus; or in anestrous lactating dairy cows less than 42 days or greater than 78 days postpartum for induction of estrous cycles. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations..
Indication
For synchronization of the return to estrus in lactating dairy cows inseminated at the immediately preceding estrus.
Dosage

Administer one intravaginal insert per animal 14 +/- 1 days after insemination. Remove intravaginal insert 7 days later.

Limitations
Do not use in animals with abnormal, immature, or infected genital tracts; or in dairy cows that are fewer than 40 days postpartum for synchronization of estrus or synchronization of the return to estrus; or in anestrous lactating dairy cows less than 42 days or greater than 78 days postpartum for induction of estrous cycles. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations..
Suckled Beef Cows, Replacement Beef and Dairy Heifers
Indication
For the advancement of first pubertal estrus in replacement beef heifers.
Dosage
Administer one intravaginal insert per animal for 7 days.  Administer 25 milligrams dinoprost (5 milliliters of 5 milligrams per milliliter solution) as a single intramuscular injection one day prior to insert removal, on Day 6 of the 7 day administration period.
Limitations
Do not use in animals with abnormal, immature, or infected genital tracts; or in beef cows that are fewer than 20 days postpartum; or in beef or dairy heifers of insufficient size or age for breeding. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility. This product is approved with the concurrent use of dinoprost solution on day 6 of the 7-day administration period when used for indications: For synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, for advancement of first postpartum estrus in suckled beef cows, and for the advancement of first pubertal estrus in replacement beef heifers. Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations.
Indication
For synchronization of estrus in suckled beef cows and replacement beef and dairy heifers.
Dosage
Administer one intravaginal insert per animal for 7 days.  Administer 25 milligrams dinoprost (5 milliliters of 5 milligrams per milliliter solution) as a single intramuscular injection one day prior to insert removal, on Day 6 of the 7 day administration period.
Limitations
Do not use in animals with abnormal, immature, or infected genital tracts; or in beef cows that are fewer than 20 days postpartum; or in beef or dairy heifers of insufficient size or age for breeding. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility. This product is approved with the concurrent use of dinoprost solution on day 6 of the 7-day administration period when used for indications: For synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, for advancement of first postpartum estrus in suckled beef cows, and for the advancement of first pubertal estrus in replacement beef heifers. Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations.
Indication
For advancement of first postpartum estrus in suckled beef cows.
Dosage
Administer one intravaginal insert per animal for 7 days.  Administer 25 milligrams dinoprost (5 milliliters of 5 milligrams per milliliter solution) as a single intramuscular injection one day prior to insert removal, on Day 6 of the 7 day administration period.
Limitations
Do not use in animals with abnormal, immature, or infected genital tracts; or in beef cows that are fewer than 20 days postpartum; or in beef or dairy heifers of insufficient size or age for breeding. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility. This product is approved with the concurrent use of dinoprost solution on day 6 of the 7-day administration period when used for indications: For synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, for advancement of first postpartum estrus in suckled beef cows, and for the advancement of first pubertal estrus in replacement beef heifers. Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations.

FDA page: Open in Animal Drugs @ FDA

Species: Sheep, Breeding
Composition / specifications
Each insert contains 0.3 gram progesterone in molded silicone over a flexible nylon spine.
Sheep (Ewes)
Indication
For induction of estrus in ewes (sheep) during seasonal anestrus.
Dosage
One insert per ewe for five days.
Limitations
DO NOT USE in ewes with abnormal, immature or infected genital tracts, in ewes that have never lambed, or an insert more than once. To prevent the potential transmission of venereal and blood borne diseases the EAZI-BREED CIDR Sheep Insert should be disposed after a single use.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary
    This supplement provides for addition to the labeling of the statements “A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.” to the warning section and “Do not use in veal calves. Effectiveness and animal safety in veal calves have not been established.” immediately following the label indications.
  • Summary
    Component® E-S with Tylan®: For increased rate of weight gain and improved feed efficiency in steers weighing 400 lbs or more.
  • Summary

    This supplement provides for the deletion of the present labeling limitation against the use of Implus-C in heifer (suckling beef) calves intended for reproduction.

  • Summary

    This supplement provides for the use of CALF-oid in suckling beef calves (at least 45 days of age) up to 400 lbs. of bodyweight.

  • EA 110-315
  • FONSI 110-315
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    This supplement provides for addition to the labeling of the statements “A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.” to the warning section and “Do not use in veal calves. Effectiveness and animal safety in veal calves have not been established.” immediately following the label indications.
  • Summary
    This supplement provides for the implantation of Synovex C in steers fed in confinement for slaughter when used as part of a reimplant program where Synovex S is implanted at approximately day 70 after the initial implantation of Synovex C.
  • Summary

    This supplement provides for reimplantation of Synovex® S at approximately day 70 in steers fed in confinement for slaughter for additional improvement in rate of weight gain.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    This supplement provides for the addition of a new indication for induction of estrous cycles in anestrous lactating dairy cows.
  • Summary
    This supplement provides for the concurrent administration of progesterone solid matrix and dinoprost tromethamine for synchronization of estrus in lactating dairy cows.
  • Summary
    For synchronization of the return to estrus in lactating dairy cows inseminated at the immediately preceding estrus
  • Summary
    1. Synchronization of estrus in suckled beef cows, and replacement beef and dairy heifers. 2. Advancement of first postpartum estrus in suckled beef cows. 3. Advancement of first pubertal estrus in replacement beef heifers.
  • EA 141-200
  • FONSI 141-200
  • EA 141-200
  • FONSI 141-200
  • EA 141-200
  • FONSI 141-200
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For induction of estrus in ewes (sheep) during seasonal anestrus.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

For increased rate of weight gain in growing beef steers fed in confinement for slaughter in a reimplantation program where SYNOVEX® C or SYNOVEX® S is the first implant and a SYNOVEX® S implant is administered approximately 70 days later. Other than ad described on labeling, this implant is not approved for repeated implantation (reimplantation) with any other cattle ear implant in growing beef steers fed in confinement for slaughter as safety and effectiveness have not been evaluated. Do not use in beef calves less than 2 months of age, dairy calves, and veal calves because effectiveness and safety have not been evaluated. Do not use in animals intended for subsequent breeding, or in dairy cows. For increased rate of weight gain in growing beef steers fed in confinement for slaughter in a reimplantation program where SYNOVEX® C or SYNOVEX® S is the first implant and a SYNOVEX® S implant is administered approximately 70 days later. Other than as described on labeling, this implant is not approved for repeated implantation (reimplantation) with any other cattle ear implant in growing beef steers fed in confinement for slaughter as safety and effectiveness have not been evaluated. Do not use in beef calves less than 2 months of age, dairy calves, and veal calves because effectiveness and safety have not been evaluated. Do not use in animals intended for subsequent breeding, or in dairy cows. For increased rate of weight gain in beef calves 45 days of age and older and weighing up to 400 lbs. This implant is not approved for repeated implantation (reimplantation) with this or any other cattle ear implant as safety and effectiveness has not been evaluated.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

For use in suckling beef calves (at least 45 days of age) up to 400 pounds of body weight. For subcutaneous ear implantation, one dose per animal. Do not use in bull calves intended for reproduction. Safety and effectiveness have not been established in veal calves. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal. This product is approved for concurrent use of dinoprost solution on day 7 of the 7-day administration period when used for the following indications: For synchronization of estrus in lactating dairy cows. Do not use in animals with abnormal, immature, or infected genital tracts; or in dairy cows that are fewer than 40 days postpartum for synchronization of estrus or synchronization of the return to estrus; or in anestrous lactating dairy cows less than 42 days or greater than 78 days postpartum for induction of estrous cycles. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility. Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations. Do not use in animals with abnormal, immature, or infected genital tracts; or in dairy cows that are fewer than 40 days postpartum for synchronization of estrus or synchronization of the return to estrus; or in anestrous lactating dairy cows less than 42 days or greater than 78 days postpartum for induction of estrous cycles. Do not use an insert more than once. To prevent the potential transmission of venereal and blood borne diseases, the inserts should be disposed after a single use. Administration of vaginal inserts for periods greater than 7 days may result in reduced fertility Product labeling shall bear the following warnings: "Avoid contact with skin by wearing protective gloves when handling inserts. Store used (removed) inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, State, and Federal regulations..

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 1 and Cat 0 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog
Behavior
Behavioral disorder (unspecified) (1)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Retriever - Labrador, Male, 3 year, 45.359 kilogram • Drug: MSK, Insert, Oral • Reactions: Behavioral disorder (unspecified) • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2018-US-026397
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 3.00 Year
  • Weight: 45.359 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Insert
Reactions Reported:
Behavioral disorder (unspecified)
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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This medication has not been reviewed by a veterinarian yet.