Meds A-Z
Doxycycline
Detailed information about Doxycycline
Pet Owner Quick Guide
Start here: what this medicine is for, what it does, and when it's usually needed.
Usually used for:
DOXIROBE Gel is indicated for the treatment and control of periodontal disease in dogs.
What it does:
Tetracycline antibiotic used for a variety of infections (often tick-borne diseases in dogs).
When it's needed:
Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.
Call your vet sooner if you notice:
- Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.
Commonly reported reactions:
- (2 reports)
- (2 reports)
- (2 reports)
What to ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Doxycycline
Drug type: Generic ingredient • Branded profile • FDA branded products available
Species: Both
Manufacturer: MSK
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141082 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source
Warnings / Contraindications
Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.
- High: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Tap or hover a reaction to see what it means in plain language.
Most Reported Reactions
| Reaction | Cases | Species | Serious cases |
|---|---|---|---|
| 2 | Cat, Dog | 2 | |
| 2 | Cat, Dog | 2 | |
| 2 | Cat, Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Dog | 1 |
Species coverage: Cat (17) Dog (15)
View detailed reaction table
| Reaction | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 |
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-047564
Storage & Handling
Store at room temperature; protect from moisture.
Documents
Official label facts are separated from secondary summaries.
Official documents: 2 • Secondary summaries: 0
- UCM437264.pdf · FOI
- Doxirobe™ Gel · SPL
No source yet.
Promotional Materials (Marketing)
This content is marketing material and not clinical guidance.
No marketing assets are linked yet.
No source yet.
Technical appendix (vet reference)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
- Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 7:40 PM UTC
-
Animal Drugs @ FDA:
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Applications/products are imported from FDA export data.
-
Animal Drugs @ FDA previews:
Source FDA
| Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:02 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:19 AM UTC
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
- Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Contraindication, High)
Identifiers & Packages
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 17163-017-16 | 17163 | - | |
| 43457-541-25 | 43457 | - | |
| 46144-604-01 | 46144 | - | |
| 54771-5193-1 | 54771 | - | |
| 58645-005-01 | 58645 | - | |
| 62157-482-01 | 62157 | - | |
| 62157-538-01 | 62157 | - | |
| 62157-816-01 | 62157 | - | |
| 73377-033-01 | 73377 | - | |
| 73377-033-02 | 73377 | - | |
| 73377-033-03 | 73377 | - |
Enriched Documents
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
-
UCM437264.pdf
• FOI summary • Official
• June 1, 2016
FDA FOI summary for application 141082
Data Sources & Revision History
Every non-trivial field is expected to include provenance and update timestamps.
- storage_handling: Store at room temperature; protect from moisture. (Clinical, 2026-02-12)
- contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Official, 2026-02-12)
- side_effects: GI upset; photosensitivity. (Official, 2026-02-12)
- usage: Tetracycline antibiotic used for a variety of infections (often tick-borne diseases in dogs). (Official, 2026-02-12)
- side_effects updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
Official sponsor/proprietary-name/application-status records linked by active ingredient.
| Product | Sponsor | Application | Status | Published |
|---|---|---|---|---|
|
Doxirobe™ Gel
RX
Doxycycline Hyclate
Liquid
• Subgingival
|
Zoetis Inc. | NADA 141-082 | Approved | Jun 1, 2016 |
Data source: FDA Animal Drugs @ FDA (public search export).
What It's For (FDA Label Highlights)
Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Official Documents (FDA)
Direct links to FDA-hosted PDFs and SPL packages (when available).
-
FOI UCM437264.pdf
Summary
The Heska Periodontal Disease Therapeutic is indicated for the treatment and control of periodontal disease in dogs.
- Doxirobe™ Gel (ZIP)
FDA page: Open in Animal Drugs @ FDA
Usage
Tetracycline antibiotic used for a variety of infections (often tick-borne diseases in dogs).
Source: FDA Animal Drugs @ FDA • Reference
Contraindications
Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.
Side Effects
GI upset; photosensitivity.
Source: FDA openFDA • Reference
Top Reported Reactions (openFDA)
Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Dog, ['Retriever - Labrador', 'Dog (unknown)'], Male, 11 year, 29.3 kilogram • Drug: MSK, Unknown • Reactions: Excessive thirst, Increased drinking • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-054420
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 11.00 Year
- Weight: 29.300 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, Mastiff (unspecified), Male, 5.5 year, 90.26 kilogram • Drug: MSK, Unknown • Reactions: Regenerative anaemia, Tiredness (lethargy), Localised oedema, Uncomfortable, Lack of efficacy - NOS… • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-054417
- Serious AE: No
- Treated For AE: Yes
- Sex: Male
- Age: 5.50 Year
- Weight: 90.260 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, Dog (other), Female, 4 year, 33.29 kilogram • Drug: MSK, Unknown • Reactions: Facial paralysis, Facial palsy • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-056006
- Serious AE: Yes
- Treated For AE: No
- Sex: Female
- Age: 4.00 Year
- Weight: 33.290 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, Chihuahua, Female, 2 year, 5.534 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Injection site pain, Injection site swelling • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-054500
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 2.00 Year
- Weight: 5.534 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Unassigned
Dog, Dachshund - Miniature, Female, 12 year, 5.443 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Arthritis, Tiredness (lethargy), Decreased red blood cell count, Death by euthanasia, Pale mucous membrane… • Outcome: Euthanized
- Report ID: USA-USFDACVM-2025-US-053358
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 12.00 Year
- Weight: 5.443 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Unassigned
Cat, Domestic Longhair, Male, 15 year, 6.8 kilogram • Drug: MSK, Solution/drops, Oral, Dose: 0.60 mL per animal, Frequency: 24 per hour • Reactions: Unsteady walking (ataxia), Stiffness NOS • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-052743
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 15.00 Year
- Weight: 6.800 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Solution/drops
- Dose: 0.60 mL per animal
- Frequency: 24 per hour
Cat, Domestic Shorthair, Female, 16 year • Drug: MSK, Unknown • Reactions: Ketosis, Hyperglycaemia • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-048331
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 16.00 Year
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Cat, Domestic Mediumhair, Male, 16.5 year, 2.948 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Digestive tract disorder NOS, Gagging, Tongue disorder NOS, Weight loss, Tiredness (lethargy)… • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-047609
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Male
- Age: 16.50 Year
- Weight: 2.948 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Unassigned
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
Store at room temperature; protect from moisture.
Share Your Thoughts
Let others know your experience or advice regarding this medication.
This medication has not been reviewed by a veterinarian yet.