Skip to main content

Need urgent help? Start triage first, then route to emergency care.

Meds A-Z

Furosemide

Detailed information about Furosemide

Official label facts Owner quick guide first Marketing clearly labeled
Showing simplified owner view. Switch to Vet View for full technical detail.

Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

For treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.

What it does:

Diuretic used to manage fluid overload (commonly in heart failure).

When it's needed:

Use caution with dehydration, kidney disease, or electrolyte imbalances.

Call your vet sooner if you notice:

  • Use caution with dehydration, kidney disease, or electrolyte imbalances.

Commonly reported reactions:

  • (2 reports)
  • (2 reports)
  • (1 reports)

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Talk to a Vet / Find a Vet Near You
Image coming soon
Furosemide

Furosemide

Drug type: Generic ingredient • Branded profile FDA branded products available

Species: Both

Manufacturer: Intervet, Inc.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Intervet, Inc.
Form: Liquid, Liquid (Solution), Powder, Syrup, Tablet
Identifiers:
ANADA: 200293 ANADA: 200373 ANADA: 200382 ANADA: 200759 NADA: 102380 NADA: 118550 NADA: 125329 NADA: 127034 NADA: 129034 NADA: 131538 NADA: 131806 NADA: 34478 NADA: 34621 NADA: 45188 NDC Package: 0010-6737-01 NDC Package: 0010-6738-01 NDC Package: 0010-6739-01 NDC Package: 11695-0090-5 NDC Package: 11695-0091-5 NDC Package: 11695-0092-1
Source metadata:

Warnings / Contraindications

Use caution with dehydration, kidney disease, or electrolyte imbalances.

  • High: Use caution with dehydration, kidney disease, or electrolyte imbalances.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
28
Species represented
2
Most Reported Reactions
Reaction Cases Species Serious cases
2 Cat, Dog 2
2 Cat, Dog 1
1 Cat 1
1 Dog 1
1 Dog 1
1 Dog 1
1 Cat 1
1 Cat 1

Species coverage: Dog (19) Cat (13)

View detailed reaction table
Reaction Species Seriousness Frequency Reports
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Cat Non-serious - 1
Dog Serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Non-serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Dog Non-serious - 1
Dog Non-serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Serious - 1
Source metadata:

Storage & Handling

Store at room temperature.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 18 • Secondary summaries: 0

Secondary summaries

No source yet.

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.
Talk to a Vet / Find a Vet Near You
Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 7:40 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:19 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Disal® Disal® Injection Furos-A-Vet Furosemide Injection 5% Furosemide Syrup 1% Furosemide Tablets Lasix® Packets Lasix® Syrup 1% Salix® Salix® Tablets
Case-reported brands (openFDA): MSK
Catalog species: Both FDA-labeled species: Cat, Cows, Dog, Horse, No Use Class Stated Or Implied
Rx/OTC: RX
Form/route: Liquid, Liquid (Solution), Powder, Syrup, Tablet Intramuscular, Intravenous, Oral
Applications: ANADA 200-759 • NADA 34478 • NADA 118-550 • NADA 127-034 • NADA 129-034 • NADA 131-538 • ANADA 200-293 • ANADA 200-373 • ANADA 200-382 • NADA 125-329 • NADA 131-806 • NADA 45188 • NADA 102-380 • NADA 34621
Documents: 4 (FOI: 4) • SPL: 14 Label highlights Official documents
Safety (openFDA)
Top reactions: Dog 56 Cat 56 View
Case summaries: 10 (showing 8) View
openFDA reports are unverified and do not prove causation.

Explore
Related conditions: Ascites (hepatic) Dehydration
Linked using: Fda_Label (0.95), Fda_Label (0.95)

Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Use caution with dehydration, kidney disease, or electrolyte imbalances. (Contraindication, High)
Top reaction signals
Anorexia (1) Appetite disorder NOS (1) Ataxia (1) Behavioural disorder NOS (1) Cardiac arrest (1) Cognitive disorder NOS (1) Congestive heart failure (1) Cough (1) Cough (1) Deafness (1) Death (1) Death by euthanasia (1) Decreased appetite (1) Decreased blood urea nitrogen (BUN) or creatinine (1) Dehydration (1) Elevated blood urea nitrogen (BUN) (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200293 ANADA: 200373 ANADA: 200382 ANADA: 200759 NADA: 102380 NADA: 118550 NADA: 125329 NADA: 127034 NADA: 129034 NADA: 131538 NADA: 131806 NADA: 34478 NADA: 34621 NADA: 45188 NDC Package: 0010-6737-01 NDC Package: 0010-6738-01 NDC Package: 0010-6739-01 NDC Package: 11695-0090-5 NDC Package: 11695-0091-5 NDC Package: 11695-0092-1 NDC Package: 11695-2222-2 NDC Package: 13985-303-60 NDC Package: 13985-581-10 NDC Package: 13985-585-50
Package NDC Product NDC Form / Route Status
0010-6737-01 0010 -
0010-6738-01 0010 -
0010-6739-01 0010 -
11695-0090-5 11695 -
11695-0091-5 11695 -
11695-0092-1 11695 -
11695-2222-2 11695 -
13985-303-60 13985 -
13985-581-10 13985 -
13985-585-50 13985 -
13985-586-12 13985 -
57926-463-30 57926 -
57926-464-31 57926 -
57926-465-01 57926 -
58829-303-60 58829 -
73309-064-01 73309 -
73309-064-02 73309 -
73377-163-01 73377 -
73377-163-03 73377 -
86117-016-12 86117 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 7 Clinical 1 Manufacturer 0 Marketing 0
Current Field Facts
  • storage_handling: Store at room temperature. (Clinical, 2026-02-12)
  • contraindications: Use caution with dehydration, kidney disease, or electrolyte imbalances. (Official, 2026-02-12)
  • side_effects: Increased urination, dehydration, electrolyte changes. (Official, 2026-02-12)
  • usage: Diuretic used to manage fluid overload (commonly in heart failure). (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Furosemide Tablets
RX
Furosemide
Tablet Oral
ZYVET AH, Inc. ANADA 200-759 Approved Jul 31, 2025
Salix®
RX
Furosemide
Liquid (Solution) Intravenous, Intramuscular
Intervet, Inc. NADA 34478 Approved Feb 25, 2025
Furos-A-Vet
RX
Furosemide
Liquid (Solution) Intramuscular, Intravenous
Bimeda Animal Health Limited NADA 118-550 Approved Oct 2, 2018
Disal® Injection
RX
Furosemide
Liquid (Solution) Intramuscular, Intravenous
Boehringer lngelheim Animal Health USA, Inc. NADA 127-034 Approved Nov 13, 2017
Disal®
RX
Furosemide
Tablet Oral
Boehringer lngelheim Animal Health USA, Inc. NADA 129-034 Approved Jun 1, 2016
Disal®
RX
Furosemide
Liquid (Solution) Intravenous, Intramuscular
Boehringer lngelheim Animal Health USA, Inc. NADA 131-538 Approved Jun 1, 2016
Furosemide Injection 5%
RX
Furosemide
Liquid (Solution) Intravenous, Intramuscular
Elanco US Inc. ANADA 200-293 Approved Jun 1, 2016
Furosemide Syrup 1%
RX
Furosemide
Syrup Oral
First Priority, Inc. ANADA 200-373 Approved Jun 1, 2016
Furosemide Syrup 1%
RX
Furosemide
Liquid Oral
Cronus Pharma Specialities India Private Ltd. ANADA 200-382 Approved Jun 1, 2016
Furosemide Tablets
RX
Furosemide
Bolar Pharmaceutical Co., Inc. NADA 125-329 W Jun 1, 2016
Furosemide Tablets
RX
Furosemide
Tablet Oral
Teva Animal Health, Inc. NADA 131-806 W Jun 1, 2016
Lasix® Packets
RX
Furosemide
Powder Oral
Intervet, Inc. NADA 45188 Approved Jun 1, 2016
Lasix® Syrup 1%
RX
Furosemide
Syrup Oral
Intervet, Inc. NADA 102-380 Approved Jun 1, 2016
Salix® Tablets
RX
Furosemide
Tablet Oral
Intervet, Inc. NADA 34621 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Composition / specifications
12.5 mg or 50 mg furosemide/tablet
Dogs and cats
Indication

For treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.

Dosage

1 to 2 mg/lb body weight (approximately 2.5 to 5 mg/kg). The lower dosage is suggested for cats. Administer once or twice daily at 6 to 8 hour intervals either orally, intravenously, or intramuscularly.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Horse, Not For Meat Production • Cows • Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of sterile solution contains 50 milligrams of furosemide diethanolamine.
Cattle
Indication
It is used for the treatment of physiological parturient edema of the mammary gland and associated structures.
Dosage
The drug is administered intramuscularly or intravenously at a dosage of 500 milligrams per animal once daily or 250 milligrams per animal twice daily at 12-hour intervals, treatment not to exceed 48 hours post parturition.
Limitations
Milk taken during treatment and for 48 hours (four milkings) after the last treatment must not be used for food. Cattle must not be slaughtered for food within 48 hours following last treatment. The drug if given in excessive amounts may result in dehydration and electrolyte imbalance. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
It is used for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
Dosage
The drug is administered intramuscularly or intravenously at a dosage of 12.5 to 25 milligrams per 10 pounds of body weight; once or twice daily after a 6- to 8-hour interval. The dosage should be adjusted to the individual animal's response. In refractory or severe edematous cases the dosage may be doubled or increased by increments of 1 milligram per pound of body weight to establish the effective dose. The established effective dose should be administered once or twice daily on an intermittent daily schedule. Diuretic therapy should be discontinued after reduction of edema, or when necessary, maintained after determining a programmed dosage schedule to prevent recurrence.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cats
Indication
It is used for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
Dosage
The drug is administered intramuscularly or intravenously at a dosage of 12.5 to 25 milligrams per 10 pounds of body weight; once or twice daily after a 6- to 8-hour interval. The lower dosage is suggested for cats. The dosage should be adjusted to the individual animal's response. In refractory or severe edematous cases the dosage may be doubled or increased by increments of 1 milligram per pound of body weight to establish the effective dose. The established effective dose should be administered once or twice daily on an intermittent daily schedule. Diuretic therapy should be discontinued after reduction of edema, or when necessary, maintained after determining a programmed dosage schedule to prevent recurrence.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Horses
Indication
For the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency, and acute noninflammatory tissue edema.
Dosage
250 to 500 mg/animal once or twice daily, intramuscularly or intravenously.
Limitations
Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production
Composition / specifications
Each milliliter of sterile solution contains 50 milligrams of furosemide diethanolamine.
Horses
Indication
It is used for treatment of acute noninflammatory tissue edema.
Dosage
Administer intramuscularly or intravenously at 0.5 milligram per pound of body weight (1.0 milligram per kilogram); once or twice daily at 6-to 8-hour intervals.
Limitations
Do not use in horses intended for food. The dosage should be adjusted to the individual's response. In refractory or severe edematous cases, the dosage may be doubled or increased by increments of 1 milligram per pound of body weight to establish the effective dose. The established effective dose should be administered once or twice daily on an intermittent daily schedule, i.e., every other day or 2 to 4 consecutive days weekly. Concurrent therapy for treatment of systemic conditions causing edema (pulmonary congestion, ascites, cardiac insufficiency) should be instituted.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production
Composition / specifications
Each milliliter of sterile solution contains 50 milligrams of furosemide monoethanolamine.
Horses
Indication
It is used for treatment of acute noninflammatory tissue edema.
Dosage
Administer intramuscularly or intravenously at 0.5 milligram per pound of body weight (1.0 milligram per kilogram); once or twice daily at 6- to 8-hour intervals.
Limitations
Do not use in horses intended for food. The dosage should be adjusted to the individual's response. In refractory or severe edematous cases, the dosage may be doubled or increased by increments of 1 milligram per pound of body weight to establish the effective dose. The established effective dose should be administered once or twice daily on an intermittent daily schedule, i.e., every other day or 2 to 4 consecutive days weekly. Concurrent therapy for treatment of systemic conditions causing edema (pulmonary congestion, ascites, cardiac insufficiency) should be instituted.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each tablet contains 12.5 or 50 milligrams furosemide.
Dogs
Indication
For treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
Dosage
1 to 2 milligrams per pound of body weight, once or twice daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cats
Indication
For treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
Dosage
1 to 2 milligrams per pound of body weight, once or twice daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Horse, Not For Meat Production
Composition / specifications
Each milliliter of sterile solution contains 50 milligrams of furosemide monoethanolamine.
Dogs
Indication
It is used for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
Dosage
The drug is administered intramuscularly or intravenously at a dosage of 12.5 to 25 milligrams per 10 pounds of body weight; once or twice daily after a 6- to 8-hour interval.

Indications: It is used for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.

Limitations
The dosage should be adjusted to the individual animal's response. In refractory or severe edematous cases the dosage may be doubled or increased by increments of 1 milligram per pound of body weight to establish the effective dose. The established effective dose should be administered once or twice daily on an intermittent daily schedule. Diuretic therapy should be discontinued after reduction of edema, or when necessary, maintained after determining a programmed dosage schedule to prevent recurrence.
Horses
Indication
For treatment of acute noninflammatory tissue edema.
Dosage
0.5 mg/lb body weight once or twice daily, intramuscularly or intravenously.
Limitations
Do not use in horses intended for human consumption. The dosage should be adjusted to the individual animal's response. In refractory or severe edematous cases the dosage may be doubled or increased by increments of 0.5 milligram per pound of body weight to establish the effective dose. The established effective dose should be administered once or twice daily on an intermittent daily schedule. Diuretic therapy should be discontinued after reduction of edema, or when necessary, maintained after determining a programmed dosage schedule to prevent recurrence.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Horse, Not For Meat Production • No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of sterile solution contains 50 milligrams of furosemide diethanolamine.
Horses
Indication
It is used for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
Dosage
Administer intramuscularly or intravenously at 250 to 500 milligrams per animal once or twice daily.
Limitations
Do not use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cattle
Indication
It is used for the treatment of physiological parturient edema of the mammary gland and associated structures.
Dosage
500 milligrams per animal once daily, intramuscularly or intravenously; or 250 milligrams per animal twice daily at 12-hour intervals, intramuscularly or intravenously.
Limitations
Treatment not to exceed 48 hours post-parturition. Milk taken during treatment and for 48 hours (four milkings) after the last treatment must not be used for food. Cattle must not be slaughtered for food within 48 hours following last treatment.
Dogs
Indication
It is used for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
Dosage
1.25 to 2.5 mg per pound (/lb) body weight once or twice daily, intramuscularly or intravenously.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cats
Indication
It is used for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
Dosage
1.25 to 2.5 mg per pound (/lb) body weight once or twice daily, intramuscularly or intravenously.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of syrup contains 10 milligrams furosemide.
Dogs
Indication
For treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
Dosage
1 to 2 milligrams per pound of body weight, once or twice daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of syrup contains 10 milligrams furosemide.
Dogs
Indication
For treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
Dosage
1 to 2 milligrams per pound of body weight, once or twice daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each tablet contains 12.5 or 50 milligrams furosemide.
Dogs
Indication
For treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
Dosage
1 to 2 milligrams per pound of body weight, once or twice daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: No Use Class Stated Or Implied
Composition / specifications
Each bolus or packet of powder contains 2 grams furosemide.
Cattle (dairy)
Indication
For treatment of physiological parturient edema of the mammary gland and associated structures.
Dosage
1 to 2 milligram per pound body weight using powder, or one 2-gram bolus per animal, per day.
Limitations
Treatment not to exceed 48 hours post-parturition. Milk taken during treatment and for 48 hours after the last treatment must not be used for food. Cattle must not be slaughtered for food within 48 hours following last treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each milliliter of syrup contains 10 milligrams furosemide.
Dogs
Indication
For treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
Dosage
1 to 2 milligrams per pound of body weight, once or twice daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cows • Cat, No Use Class Stated Or Implied
Composition / specifications
Each tablet contains 12.5 or 50 milligrams furosemide.
Cats
Indication
For treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
Dosage
1 to 2 milligrams per pound of body weight, once or twice daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
For treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
Dosage
1 to 2 milligrams per pound of body weight, once or twice daily.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    Diuretic-saluretic for prompt relief of edema.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    A diuretic-saluretic for oral use alone or in combination with Furosemide Injection in the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    A diuretic-saluretic for oral use alone or in combination with furosemide Injection in the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

Diuretic used to manage fluid overload (commonly in heart failure).

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Use caution with dehydration, kidney disease, or electrolyte imbalances.

Side Effects

Increased urination, dehydration, electrolyte changes.

Source: FDA openFDA • Reference

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog
Digestive
Vomiting (149) Diarrhea (110) Loss of appetite (68) Decreased appetite (3) Decreased appetite (3) Decreased appetite (3) Decreased appetite (3) Decreased appetite (3) Decreased appetite (3)
Neurologic
Tiredness (lethargy) (113) Seizure NOS (82) Tiredness (lethargy) (7) Tiredness (lethargy) (7) Tiredness (lethargy) (7) Tiredness (lethargy) (7) Tiredness (lethargy) (7) Tiredness (lethargy) (7)
Behavior
Behavioral disorder (unspecified) (3) Behavioral disorder (unspecified) (3) Behavioral disorder (unspecified) (3) Behavioral disorder (unspecified) (3) Behavioral disorder (unspecified) (3) Behavioral disorder (unspecified) (3)
Other
Death (120) Death by euthanasia (117) Cough (69) Cough (5) Cough (5) Cough (5) Cough (5) Cough (5) Cough (5) Not eating (4) Not eating (4) Not eating (4) Not eating (4) Not eating (4) Not eating (4) Death by euthanasia (3) Death by euthanasia (3) Death by euthanasia (3) Death by euthanasia (3) Death by euthanasia (3) Death by euthanasia (3) Other abnormal test result NOS (3) Other abnormal test result NOS (3) Other abnormal test result NOS (3) Other abnormal test result NOS (3) Other abnormal test result NOS (3) Other abnormal test result NOS (3) Abnormal radiograph finding (2) Abnormal radiograph finding (2) Abnormal radiograph finding (2) Abnormal radiograph finding (2) Abnormal radiograph finding (2) Abnormal radiograph finding (2)
Cat
Digestive
Vomiting (26) Loss of appetite (18) Decreased appetite (1) Decreased appetite (1) Decreased appetite (1) Decreased appetite (1) Decreased appetite (1) Decreased appetite (1) Nausea (1) Nausea (1) Nausea (1) Nausea (1)
Neurologic
Tiredness (lethargy) (24) Tiredness (lethargy) (2) Tiredness (lethargy) (2) Tiredness (lethargy) (1) Tiredness (lethargy) (1) Tiredness (lethargy) (1) Tiredness (lethargy) (1)
Other
Death (33) Death by euthanasia (27) Abnormal radiograph finding (20) Tachypnoea (18) Hiding (17) Cough (2) Cough (2) Cardiac arrest (1) Cardiac arrest (1) Cardiac arrest (1) Cardiac arrest (1) Cardiac arrest (1) Cardiac arrest (1) Congestive heart failure (1) Congestive heart failure (1) Cough (1) Cough (1) Cough (1) Cough (1) Death (1) Death (1) Death (1) Death (1) Death (1) Death (1) Death by euthanasia (1) Death by euthanasia (1) Death by euthanasia (1) Death by euthanasia (1) Death by euthanasia (1) Death by euthanasia (1) Foaming at the mouth (1) Foaming at the mouth (1) Foaming at the mouth (1) Foaming at the mouth (1) Foaming at the mouth (1) Foaming at the mouth (1)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Ragdoll, Female, 2 year, 4.3 kilogram • Drug: MSK, Oral, Dose: 1.14 Milligram per kilogram, Frequency: 12 per hour • Reactions: Cough • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055590
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 2.00 Year
  • Weight: 4.300 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Dose: 1.14 Milligram per kilogram
  • Frequency: 12 per hour
Reactions Reported:
Cough
Outcomes: Recovered/Normal

Dog, Spitz - German Pomeranian, Male, 13 year, 7.257 kilogram • Drug: MSK, Tablet, Oral, Frequency: 1 per day • Reactions: Deafness, Sleepiness - systemic disorder, Not eating, Behavioral disorder (unspecified), Lack of efficacy - NOS • Outcome: Recovered with Sequela

  • Report ID: USA-USFDACVM-2025-US-055953
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 13.00 Year
  • Weight: 7.257 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Frequency: 1 per day
Reactions Reported:
Deafness Sleepiness - systemic disorder Not eating Behavioral disorder (unspecified) Lack of efficacy - NOS
Outcomes: Recovered with Sequela

Dog, Chihuahua, Female, 12.2 year, 3.901 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Vomiting, Underdose, Hypothermia, Unsteady walking (ataxia), Dehydration… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054506
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 12.20 Year
  • Weight: 3.901 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Vomiting Underdose Hypothermia Unsteady walking (ataxia) Dehydration Tiredness (lethargy) Loss of appetite Leucocytosis NOS Neutrophilia Increased band neutrophilia Monocytosis Thrombocytosis Elevated blood urea nitrogen Decreased blood urea nitrogen (BUN) or creatinine Other abnormal test result NOS
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 13 year, 6.804 kilogram • Drug: MSK, Unassigned, Intravenous, Dose: 1 Milligram per kilogram • Reactions: Nausea, Prolonged one stage prothrombin time, Prolonged activated partial thrombin time, Cardiac arrest, Death • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-055853
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 13.00 Year
  • Weight: 6.804 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intravenous
  • Form: Unassigned
  • Dose: 1 Milligram per kilogram
Reactions Reported:
Nausea Prolonged one stage prothrombin time Prolonged activated partial thrombin time Cardiac arrest Death
Outcomes: Died

Dog, Chihuahua, Male, 19 year, 3.13 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Overdose, Tiredness (lethargy) • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055295
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 19.00 Year
  • Weight: 3.130 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Overdose Tiredness (lethargy)
Outcomes: Ongoing

Dog, Beagle, Male, 15 year, 12.61 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Cognitive disorder NOS, Pacing, Partial deafness, Impaired vision, Behavioral disorder (unspecified)… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054448
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 15.00 Year
  • Weight: 12.610 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Cognitive disorder NOS Pacing Partial deafness Impaired vision Behavioral disorder (unspecified) Cough Appetite disorder NOS Tiredness (lethargy)
Outcomes: Ongoing

Dog, Retriever - Labrador, Female, 10 year, 24.63 kilogram • Drug: MSK • Reactions: Lack of efficacy (bacteria) - Anaplasma, Lack of efficacy (bacteria) - Borrelia • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055732
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 10.00 Year
  • Weight: 24.630 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
Reactions Reported:
Lack of efficacy (bacteria) - Anaplasma Lack of efficacy (bacteria) - Borrelia
Outcomes: Ongoing

Cat, Ragdoll, Female, 2 year, 4.3 kilogram • Drug: MSK, Oral, Dose: 1.14 Milligram per kilogram, Frequency: 12 per hour • Reactions: Foaming at the mouth • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-053844
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 2.00 Year
  • Weight: 4.300 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Dose: 1.14 Milligram per kilogram
  • Frequency: 12 per hour
Reactions Reported:
Foaming at the mouth
Outcomes: Recovered/Normal

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

Store at room temperature.

Share Your Thoughts

Let others know your experience or advice regarding this medication.

This medication has not been reviewed by a veterinarian yet.