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Selamectin

Detailed information about Selamectin

Official label facts Owner quick guide first Marketing clearly labeled
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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

revolution® PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis , the treatment and control of roundworm ( Toxocara cati ) and intestinal hookworm ( Ancylostoma tubaeforme ) infections...

What it does:

Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the preventionand control of flea infestations ( Ctenocephalides felis ), prevention of heartworm disease caused by Dir...

When it's needed:

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

Call your vet sooner if you notice:

  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

Commonly reported reactions:

  • (1 reports)
  • (1 reports)
  • (1 reports)

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
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Selamectin

Selamectin

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: MSK

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: MSK
Form: Liquid, Topical Solution
Identifiers:
ANADA: 200663 ANADA: 200670 ANADA: 200673 ANADA: 200696 ANADA: 200769 NADA: 141152 NADA: 141502 NDC Package: 13985-966-15 NDC Package: 13985-966-45 NDC Package: 13985-966-60 NDC Package: 13985-967-12 NDC Package: 13985-967-20 NDC Package: 13985-967-30 NDC Package: 13985-967-60 NDC Package: 20076-0000-3 NDC Package: 20076-0000-4 NDC Package: 50989-317-99 NDC Package: 50989-318-99 NDC Package: 50989-319-99 NDC Package: 50989-320-99
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
13
Serious reports
5
Species represented
2
Most Reported Reactions
Reaction Cases Species Serious cases
1 Dog 1
1 Cat 1
1 Cat 1
1 Dog 1
1 Cat 1
1 Dog 0
1 Cat 0
1 Cat 0

Species coverage: Cat (27) Dog (5)

View detailed reaction table
Reaction Species Seriousness Frequency Reports
Cat Serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Dog Non-serious - 1
Dog Serious - 1
Cat Non-serious - 1
Cat Serious - 1
Cat Non-serious - 1
Cat Serious - 1
Cat Non-serious - 1
Dog Serious - 1
Dog Non-serious - 1
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Source metadata:

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 28 • Secondary summaries: 0

Official label facts
Secondary summaries

No source yet.

Source metadata:

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.
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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:19 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Revolt® Revolution® SENERGY™ SelaSpot™ Selamectin Selarid® revolution® PLUS
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: 6 weeks of age and older, 8 weeks of age and older, Cat, Dog
Rx/OTC: RX
Form/route: Liquid, Topical Solution • Topical
Applications: NADA 141-502 • ANADA 200-769 • ANADA 200-670 • ANADA 200-663 • ANADA 200-673 • NADA 141-152 • ANADA 200-696
NDC: Packages 20076-0000-3 20076-0000-4 86117-064-01 86117-064-02 86117-064-03 86117-064-04 • Products 20076 20076 86117 86117 86117 86117
Documents: 21 (FOI: 11) • SPL: 7 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 56 • Cat 56 • View
Case summaries: 10 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: B74.8 ICD10_CM: B86 ICD10_CM: B88.1
Other filariases

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals. (Contraindication, High)
Top reaction signals
Abnormal cytology (1) Application site alopecia (1) Application site lesion (1) Intentional misuse (1) Lack of efficacy (ectoparasite) - flea (1) Lack of efficacy (endoparasite) - hookworm (1) Lack of efficacy (endoparasite) - tapeworm (1) Pruritus (1) Recovery prolonged (1) Skin scab (1) Slow heart rate (1) Tremor (1) Underdose (1) Anorexia (reports: 351, since 2016-02-12) (0) Application site alopecia (reports: 894, since 2016-02-12) (0) Application site hair loss (reports: 1547, since 2016-02-12) (0)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200663 ANADA: 200670 ANADA: 200673 ANADA: 200696 ANADA: 200769 NADA: 141152 NADA: 141502 NDC Package: 13985-966-15 NDC Package: 13985-966-45 NDC Package: 13985-966-60 NDC Package: 13985-967-12 NDC Package: 13985-967-20 NDC Package: 13985-967-30 NDC Package: 13985-967-60 NDC Package: 20076-0000-3 NDC Package: 20076-0000-4 NDC Package: 50989-317-99 NDC Package: 50989-318-99 NDC Package: 50989-319-99 NDC Package: 50989-320-99 NDC Package: 50989-321-99 NDC Package: 50989-322-99 NDC Package: 50989-323-99 NDC Package: 50989-324-99
Package NDC Product NDC Form / Route Status
13985-966-15 13985 -
13985-966-45 13985 -
13985-966-60 13985 -
13985-967-12 13985 -
13985-967-20 13985 -
13985-967-30 13985 -
13985-967-60 13985 -
20076-0000-3 20076 -
20076-0000-4 20076 -
50989-317-99 50989 -
50989-318-99 50989 -
50989-319-99 50989 -
50989-320-99 50989 -
50989-321-99 50989 -
50989-322-99 50989 -
50989-323-99 50989 -
50989-324-99 50989 -
51072-097-01 51072 -
51072-097-02 51072 -
51072-097-03 51072 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 24 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals. (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (ectoparasite) - flea, Lack of efficacy (endoparasite) - heartworm, Vomiting, Lethargy (see also Central ner… (Official, 2026-02-12)
  • usage: Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the preventionand control of flea infestations ( Ctenoceph… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
revolution® PLUS
RX
Sarolaner Selamectin
Topical Solution • Topical
Label highlights
Official documents
Zoetis Inc. NADA 141-502 Approved Dec 2, 2024
Selamectin
RX
Selamectin
Topical Solution • Topical
Label highlights
Official documents
ZYVET AH, Inc. ANADA 200-769 Approved Feb 1, 2024
SENERGY™
RX
Selamectin
Topical Solution • Topical
Label highlights
Official documents
Virbac AH, Inc. ANADA 200-670 Approved Oct 24, 2023
Selarid®
RX
Selamectin
Topical Solution • Topical
Label highlights
Official documents
Norbrook Laboratories, Ltd. ANADA 200-663 Approved Sep 7, 2023
Revolt®
RX
Selamectin
Topical Solution • Topical
Label highlights
Official documents
Aurora Pharmaceutical, Inc. ANADA 200-673 Approved Jun 7, 2021
Revolution®
RX
Selamectin
Liquid • Topical
Label highlights
Official documents
Zoetis Inc. NADA 141-152 Approved May 17, 2021
SelaSpot™
RX
Selamectin
Topical Solution • Topical
Label highlights
Official documents
Bimeda Animal Health Limited ANADA 200-696 Approved May 17, 2021

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
60 mg/mL selamectin; 10 mg/mL sarolaner
Cats
Indication

revolution® PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis, the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections, and the treatment and control of ear mite (Otodectes cynotis) infestations. revolution® PLUS kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated cat, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Ixodes scapularis (black-legged tick) for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

Dosage

The recommended minimum dosage is 2.7 mg selamectin per pound (6.0 mg/kg) of body weight in combination with 0.45 mg sarolaner per pound (1.0 mg/kg) of body weight administered monthly.


Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
60 mg/mL and 120 mg/mL
Dogs (6 Weeks of Age or Older)
Indication

Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.
.

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations
Cats (8 Weeks of Age and Older)
Indication

Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: 6 weeks of age and older • 8 weeks of age and older
Composition / specifications
60 mg/mL and 120 mg/mL
Dogs
Indication

Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations
Cats
Indication

Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: 6 weeks of age and older • 8 weeks of age and older
Composition / specifications
60 mg/mL and 120 mg/mL
Dogs 6 weeks of age and older
Indication

Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and treatment and control of ear mite (Otodectes cynotis) infestations. Treatment and control of sarcoptic mange (Sarcoptes scabiei) and control of tick infestations due to Dermacentor variabilis.

Dosage

2.7 milligrams of selamectin, topically, per pound (6 milligrams per kilogram) of body weight.

Limitations
Cats 8 weeks of age and older
Indication

Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and treatment and control of ear mite (Otodectes cynotis) infestations. Treatment and control of intestinal hookworm (Ancylostoma tubaeforme) and roundworm (Toxocara cati) infections.

Dosage

2.7 milligrams of selamectin, topically, per pound (6 milligrams per kilogram) of body weight.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: 6 weeks of age and older • 8 weeks of age and older
Composition / specifications
60 mg/mL or 120 mg/mL
Dogs
Indication

Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations
Cats
Indication

Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
60 or 120 mg/mL selamectin.
Cats (8 Weeks of Age and Older)
Indication

Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the preventionand control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilariaimmitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolution is also indicatedfor the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme)infections in cats.

Dosage
The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.
Dogs (6 Weeks of Age or Older)
Indication

Revolution kills adult fleas and prevents flea eggs from hatching for one month andis indicated for the prevention and control of flea infestations (Ctenocephalidesfelis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment andcontrol of ear mite (Otodectes cynotis) infestations. Revolution also is indicated forthe treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the controlof tick infestations due to Dermacentor variabilis.

Dosage
The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
60 mg/mL and 120 mg/mL
Dogs
Indication

In dogs six weeks of age or older, kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.

Dosage

Administer topically 2.7 mg of selamectin per pound (6 mg per kilogram) of body weight.

Limitations
Cats
Indication

In cats eight weeks of age and older, kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

Dosage

Administer topically 2.7 mg of selamectin per pound (6 mg per kilogram) of body weight.

Limitations

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary

    This supplement provides for the addition of the indication for the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated cat for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

  • Summary

    This supplement provides for the addition of the indication for the treatment and control of tick infestations with Amblyomma americanum (lone star tick) for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

  • Summary

    revolution® PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. revolution® PLUS kills adult fleas (Ctenocephalides felis)and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations with Ixodes scapularis (black-legged tick), Amblyomma maculatum (Gulf Coast tick) and Dermacentor variabilis (American dog tick), the treatment and control of ear mite (Otodectes cynotis) infestations, and the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

     Selamectin is recommended for use in dogs six weeks of age or older and cats eight weeks of age and older for the following parasites and indications:

    Dogs: Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.

    Cats: Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    Recommended for use in dogs six weeks of age or older and cats eight weeks of age and older for the following parasites and indications:


    Dogs: Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.


    Cats: Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and treatment and control of ear mite (Otodectes cynotis) infestations. Treatment and control of sarcoptic mange (Sarcoptes scabiei ) and control of tick infestations due to Dermacentor variabilis.

    For cats 8 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and treatment and control of ear mite (Otodectes cynotis ) infestations. Treatment and control of intestinal hookworm (Ancylostoma tubaeforme) and roundworm (Toxocara cati ) infections.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    For use in dogs six weeks of age or older and cats eight weeks of age and older for the following parasites and indications: 

    Dogs: Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.

    Cats: Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    Provide additional indication for control of intestinal hookworm (Ancylostoma tubaeforme) and roundworm(Toxocara cati) infections in cats.
  • Summary
    Provides for the additional indication for control of tick infestations in dogs
  • Summary
    Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations in dogs and cats. Revolution also is indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) in dogs, and the treatment of intestinal hookworm (Ancylostoma tubaeforme) and roundworm (Toxocara cati) infections in cats. Revolution is recommended for use in dogs and cats six weeks of age and older.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    For use in dogs six weeks of age or older and cats eight weeks of age and older for the following parasites and indications:

    Dogs: Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.

    Cats: Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the preventionand control of flea infestations ( Ctenocephalides felis ), prevention of heartworm disease caused by Dirofilariaimmitis, and the treatment and control of ear mite ( Otodectes cynotis ) infestations. Revolution is also indicatedfor the treatment and control of roundworm ( Toxocara cati ) and intestinal hookworm ( Ancylostoma tubaeforme )infections in cats. Revolution kills adult fleas and prevents flea eggs from hatching for one month andis indicated for the prevention and control of flea infestations ( Ctenocephalidesfelis ), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment andcontrol of ear mite ( Otodectes cynotis ) infestations. Revolution also is indicated forthe treatment and control of sarcoptic mange ( Sarcoptes scabiei ) and for the controlof tick infestations due to Dermacentor variabilis. revolution® PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis , the treatment and control of roundworm ( Toxocara cati ) and intestinal hookworm ( Ancylostoma tubaeforme ) infections, and the treatment and control of ear mite ( Otodectes cynotis ) infestations. revolution® PLUS kills adult fleas ( Ctenocephalides felis ) and is indicated for the treatment and prevention of flea infestations, the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated cat, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Ixodes scapularis (black-legged tick) for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 56 and Cat 56 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog
Digestive
Vomiting (562) Diarrhea (346) Vomiting (4) Vomiting (4) Vomiting (4) Vomiting (4) Vomiting (4) Vomiting (4)
Neurologic
Tiredness (lethargy) (494) Seizure NOS (323) Tiredness (lethargy) (6) Tiredness (lethargy) (6) Tiredness (lethargy) (6) Tiredness (lethargy) (6) Tiredness (lethargy) (6) Tiredness (lethargy) (6)
Behavior
Behavioral disorder (unspecified) (4) Behavioral disorder (unspecified) (4) Behavioral disorder (unspecified) (4) Behavioral disorder (unspecified) (4) Behavioral disorder (unspecified) (4) Behavioral disorder (unspecified) (4)
Effectiveness
Lack of efficacy (ectoparasite) - flea (707) Lack of efficacy (endoparasite) - heartworm (586) Lack of efficacy (endoparasite) - hookworm (249) Lack of efficacy (ectoparasite) - flea (13) Lack of efficacy (ectoparasite) - flea (13) Lack of efficacy (ectoparasite) - flea (13) Lack of efficacy (ectoparasite) - flea (13) Lack of efficacy (ectoparasite) - flea (12) Lack of efficacy (ectoparasite) - flea (11) Lack of efficacy (endoparasite) - heartworm (6) Lack of efficacy (endoparasite) - heartworm (6) Lack of efficacy (endoparasite) - heartworm (6) Lack of efficacy (endoparasite) - heartworm (6) Lack of efficacy (endoparasite) - hookworm (6) Lack of efficacy (endoparasite) - hookworm (6) Lack of efficacy (endoparasite) - hookworm (6) Lack of efficacy (endoparasite) - hookworm (6) Lack of efficacy (endoparasite) - hookworm (6) Lack of efficacy (endoparasite) - hookworm (6) Lack of efficacy (endoparasite) - heartworm (5) Lack of efficacy (endoparasite) - heartworm (4)
Other
INEFFECTIVE, HEARTWORM LARVAE (420) Medication error NOS (8) Medication error NOS (8) Medication error NOS (8) Medication error NOS (8) Medication error NOS (8) Medication error NOS (8) Intentional misuse (5) Intentional misuse (5) Intentional misuse (5) Intentional misuse (5) Intentional misuse (5) Intentional misuse (5)
Cat
Digestive
Vomiting (673) Loss of appetite (351)
Skin & allergy
Application site hair loss (1547) Hair loss at application site (894) Application site hair loss (3) Application site hair loss (3) Application site hair loss (3) Application site hair loss (3) Application site hair loss (3) Application site hair loss (3) Hair loss NOS (2) Hair loss NOS (2) Hair loss NOS (2) Hair loss NOS (2) Hair loss NOS (2) Hair loss NOS (2) Itching (2) Itching (2) Itching (2) Itching (2) Itching (2) Itching (2)
Neurologic
Tiredness (lethargy) (743)
Effectiveness
Lack of efficacy (ectoparasite) - flea (1049) Lack of efficacy (ectoparasite) - flea (10) Lack of efficacy (ectoparasite) - flea (10) Lack of efficacy (ectoparasite) - flea (10) Lack of efficacy (ectoparasite) - flea (10) Lack of efficacy (ectoparasite) - flea (10) Lack of efficacy (ectoparasite) - flea (10) Lack of efficacy (endoparasite) - tapeworm (4) Lack of efficacy (endoparasite) - tapeworm (4) Lack of efficacy (endoparasite) - tapeworm (4) Lack of efficacy (endoparasite) - tapeworm (4) Lack of efficacy (endoparasite) - tapeworm (3) Lack of efficacy (endoparasite) - tapeworm (3) Lack of efficacy (ectoparasite) - NOS (2) Lack of efficacy (ectoparasite) - NOS (2) Lack of efficacy (ectoparasite) - NOS (2) Lack of efficacy (ectoparasite) - NOS (2) Lack of efficacy (ectoparasite) - NOS (2) Lack of efficacy (ectoparasite) - NOS (2)
Other
Application site scab (489) Application site reddening (337) Application site lesion (3) Application site lesion (3) Application site lesion (3) Application site lesion (3) Application site lesion (3) Application site lesion (3) Application site irritation (2) Application site irritation (2) Application site irritation (2) Application site irritation (2) Application site irritation (2) Application site irritation (2)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Chihuahua, Unknown, 6 year, 2.722 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Lack of efficacy (ectoparasite) - flea, Underdose, Intentional misuse • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-054868
  • Serious AE: No
  • Treated For AE: No
  • Sex: Unknown
  • Age: 6.00 Year
  • Weight: 2.722 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 dose per animal
Reactions Reported:
Lack of efficacy (ectoparasite) - flea Underdose Intentional misuse
Outcomes: Outcome Unknown

Cat, Cat (other), Male, 13 year, 3.49 kilogram • Drug: MSK, Unknown • Reactions: Slow heart rate, Recovery prolonged • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055510
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 13.00 Year
  • Weight: 3.490 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Slow heart rate Recovery prolonged
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Male, 6 year, 9.525 kilogram • Drug: MSK, Solution, Topical, Dose: 60 Milligram per animal • Reactions: Hair loss at application site, Application site lesion • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055202
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 6.00 Year
  • Weight: 9.525 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 60 Milligram per animal
Reactions Reported:
Hair loss at application site Application site lesion
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Male, 14.5 week, 1.87 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy (endoparasite) - tapeworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055700
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 14.50 Week
  • Weight: 1.870 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Lack of efficacy (endoparasite) - tapeworm
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 7 week, 0.73 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy (endoparasite) - tapeworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055999
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 7.00 Week
  • Weight: 0.730 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Lack of efficacy (endoparasite) - tapeworm
Outcomes: Outcome Unknown

Dog, ['Retriever - Labrador', 'Dog (unknown)'], Male, 4 year, 36.287 kilogram • Drug: MSK, Solution, Topical, Dose: 240 Milligram per animal • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055014
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 4.00 Year
  • Weight: 36.287 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 240 Milligram per animal
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Cat, Domestic Longhair, Male, 14.2 year, 6.895 kilogram • Drug: MSK, Solution, Topical • Reactions: Skin scab, Itching, Abnormal cytology • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055194
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 14.20 Year
  • Weight: 6.895 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
Reactions Reported:
Skin scab Itching Abnormal cytology
Outcomes: Ongoing

Dog, Terrier (unspecified), Male, 9 month, 2.812 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Lack of efficacy (endoparasite) - hookworm, Intentional misuse • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055260
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 9.00 Month
  • Weight: 2.812 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 dose per animal
Reactions Reported:
Lack of efficacy (endoparasite) - hookworm Intentional misuse
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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