Meds A-Z

Praziquantel

Detailed information about Praziquantel

Official label facts Owner quick guide first Marketing clearly labeled

Talk to a Vet / Find a Vet Near You Start Symptom Intake

Showing simplified owner view. Switch to Vet View for full technical detail.

Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.

What it does:

When it's needed:

Call your vet sooner if you notice:

Not intended for use in puppies less than 4 weeks of age. Federal law restricts the drug to use by or on the order of a licensed veterinarian. Not intended for use in kittens less than 6 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer directly by mouth or crumbled and in feed. Not intended for use in puppies less than 4 weeks of age.

Commonly reported reactions:

(2 reports)
(2 reports)
(1 reports)

What to ask your vet today:

Is this medicine the right fit for my pet’s current symptoms?
Which warning signs mean I should call back right away?
How should I handle missed doses or refusal to take the medicine?

Talk to a Vet / Find a Vet Near You

Image coming soon

Praziquantel

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Elanco US Inc.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both

Manufacturer: Elanco US Inc.

Form: Chewable Tablets, Gel, Injectable Solution, Liquid, Liquid (Solution), Paste

Identifiers:

ANADA: 200176 ANADA: 200501 ANADA: 200734 ANADA: 200834 NADA: 111607 NADA: 111798 NADA: 133953 NADA: 141007 NADA: 141008 NADA: 141214 NADA: 141215 NADA: 141216 NADA: 141257 NADA: 141261 NADA: 141275 NADA: 141333 NADA: 141338 NADA: 141421 NADA: 141441 NADA: 141492

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141619 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200834 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source

Warnings / Contraindications

Not intended for use in puppies less than 4 weeks of age. Federal law restricts the drug to use by or on the order of a licensed veterinarian. Not intended for use in kittens less than 6 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer directly by mouth or crumbled and in feed. Not intended for use in puppies less than 4 weeks of age.

High: Not intended for use in puppies less than 4 weeks of age. Federal law restricts the drug to use by or on the order of a licensed veterinarian. Not intended for use in kittens less than 6 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer directly by mouth or crumbled and in feed. Not intended for use in puppies less than 4 weeks of age.

Source metadata:

https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals

Reported cases

Serious reports

Species represented

Most Reported Reactions

Cases	Species	Serious cases
2	Cat, Dog	0
2	Cat, Dog	0
1	Dog	1
1	Dog	0
1	Dog	0
1	Cat	0
1	Cat	0
1	Cat	0

Species coverage: Cat (23) Dog (9)

View detailed reaction table

Species	Seriousness	Frequency	Reports
Cat	Non-serious	-	1
Cat	Non-serious	-	1
Cat	Non-serious	-	1
Cat	Non-serious	-	1
Cat	Non-serious	-	1
Cat	Non-serious	-	1
Dog	Non-serious	-	1
Dog	Serious	-	1
Dog	Non-serious	-	1
Cat	Non-serious	-	1
Dog	Non-serious	-	1
Dog	Non-serious	-	1
Cat	Non-serious	-	1
Dog	Non-serious	-	1
Dog	Non-serious	-	1
Cat	Non-serious	-	1
Cat	Non-serious	-	1
Cat	Non-serious	-	1
Cat	Non-serious	-	1
Dog	Non-serious	-	1
Dog	Non-serious	-	1
Cat	Unknown	-	-
Cat	Unknown	-	-
Cat	Unknown	-	-
Cat	Unknown	-	-
Cat	Unknown	-	-
Cat	Unknown	-	-
Cat	Unknown	-	-
Cat	Unknown	-	-
Cat	Unknown	-	-
Cat	Unknown	-	-
Cat	Unknown	-	-

Source metadata:

https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-055503

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 68 • Secondary summaries: 0

Official label facts

FOI Summary o 141-619 Approved December 17, 2025 (2).pdf · FOI
Credelio Quattro™-CA1 · SPL
FOI Summary oA 200-834 Approved December 22, 2025.pdf · FOI
Praziquantel Tablets · SPL
FOI Summary sN 141-581 Approved October 20, 2025.pdf · FOI
FOI Summary sN 141-581 Approved May 21, 2025.pdf · FOI
FOI Summary oN 141-581 Approved October 7, 2024.pdf · FOI
Credelio Quattro™ · SPL
UCM408781.pdf · FOI
Duocare™ · SPL
UCM457309.pdf · FOI
ucm118023.pdf · FOI
ucm118021.pdf · FOI
ucm118019.pdf · FOI
Quest® Plus Gel · SPL
UCM050062.pdf · FOI
Virbantel® · SPL
Worm X Plus® · SPL
FOI Summary oN 141-492 Approved March 8, 2018.pdf · FOI
Centragard® · SPL
FOI Summary oA 200-734 Approved January 12, 2023.pdf · FOI
Praziquantel Tablets · SPL
UCM181521.pdf · FOI
Droncit™ 5.68% Injectible Solution · SPL
ucm116081.pdf · FOI
ucm116050.pdf · FOI
N141007_Supp_03-28-1996.pdf · FOI
N141007_Orig_5_19_1994.pdf · FOI
Drontal™ Plus Taste Tabs™ · SPL
Drontal™ Plus · SPL
Quad Dewormer · SPL
UCM487815.pdf · FOI
Drontal™ Tablets · SPL
N111798_Supp_7_16_1993.pdf · FOI
N111798_Orig_1_11_1993(2).pdf · FOI
N111798_Supp_1_18_1990.pdf · FOI
Droncit® Feline Cestocide Tablets · SPL
Praziquantel 34 (Rx) · SPL
Droncit® Canine Cestocide Tablets · SPL
Tapeworm Dewormer for Dogs (OTC) · SPL
Tapeworm Dewormer for Cats (OTC) · SPL
ucm118012.pdf · FOI
ucm118011.pdf · FOI
ucm118009.pdf · FOI
ZIMECTERIN® Gold Paste · SPL
ucm062332.pdf · FOI
Profender™ · SPL
FOI Summary oN 141-441 Approved December 11, 2017.pdf · FOI
IVERHART MAX® Chew · SPL
FOI Summary sN-141-333 Approved September 28, 2017.pdf · FOI
UCM292003.pdf · FOI
Sentinel® Spectrum® · SPL
UCM514664.pdf · FOI
Praziquantel Injection · SPL
ucm061606.pdf · FOI
Prazitech™ · SPL
FOI Summary sN 141-338 Approved June 21, 2017.pdf · FOI
UCM318617.pdf · FOI
INTERCEPTOR™ PLUS · SPL
ucm118017.pdf · FOI
ucm118016.pdf · FOI
ucm118014.pdf · FOI
Equimax® · SPL
N133953_Supp_09_12_1991.pdf · FOI
Vercom Paste Anthelmintic · SPL
ucm051414.pdf · FOI
UCM051416.pdf · FOI
Iverhart Max® · SPL

Secondary summaries

No source yet.

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/17789 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/18151/Credelio%20Quattro%E2%84%A2-CA1 · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/17826 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/18161/Praziquantel%20Tablets · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/17690 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/16986 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/15966 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/16306/Credelio%20Quattro%E2%84%A2 · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/919 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2257/Duocare%E2%84%A2 · document · SPL

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.

Talk to a Vet / Find a Vet Near You

Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness

Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:02 AM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Feb 12, 2026, 10:42 PM UTC

Official (FDA)

Identity: Generic ingredient • FDA branded products available

Official FDA brands: Centragard® Credelio Quattro™ Credelio Quattro™-CA1 Droncit® Feline Cestocide Tablets Praziquantel 34 (Rx) Droncit® Canine Cestocide Tablets Tapeworm Dewormer for Dogs (OTC) Tapeworm Dewormer for Cats (OTC) Droncit™ 5.68% Injectible Solution Drontal™ Plus Taste Tabs™ Drontal™ Plus Quad Dewormer Drontal™ Tablets Duocare™ Equimax® INTERCEPTOR™ PLUS IVERHART MAX® Chew Iverhart Max® Praziquantel Injection Praziquantel Tablets Prazitech™ Profender™ Quest® Plus Gel Sentinel® Spectrum® Vercom Paste Anthelmintic Virbantel® Worm X Plus® ZIMECTERIN® Gold Paste

Case-reported brands (openFDA): MSK

Catalog species: Both • FDA-labeled species: Cat, Cat And Kitten, Cats and kittens, Dog, Dog And Puppy, Dogs And Puppies, Dogs and puppies, Horse, No Use Class Stated Or Implied

Rx/OTC: OTC, RX

Form/route: Chewable Tablets, Gel, Injectable Solution, Liquid, Liquid (Solution), Paste, Tablet, Tablet (Chewable), Transdermal Solution • Intramuscular, Oral, Subcutaneous, Topical, Transdermal

Applications: NADA 141-619 • ANADA 200-834 • NADA 141-581 • NADA 141-421 • NADA 141-216 • NADA 141-261 • NADA 141-492 • ANADA 200-734 • NADA 111-607 • NADA 141-007 • NADA 141-008 • NADA 111-798 • NADA 141-214 • NADA 141-275 • NADA 141-441 • NADA 141-333 • ANADA 200-501 • ANADA 200-176 • NADA 141-338 • NADA 141-215 • NADA 133-953 • NADA 141-257

Documents: 39 (FOI: 39) • SPL: 29 • Label highlights • Official documents

Safety (openFDA)

Top reactions: Dog 56 • Cat 56 • View

Case summaries: 11 (showing 8) • View

openFDA reports are unverified and do not prove causation.

Explore

Related conditions: Fleas (Flea Infestation) Heartworm Disease Myiasis (fly strike) Pica Tick infestation

Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)

Diagnosis Codes

ICD10_CM: B74.8 ICD10_CM: B88.1

Other filariases

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points

Not intended for use in puppies less than 4 weeks of age. Federal law restricts the drug to use by or on the order of a licensed veterinarian. Not intended for use in kittens less than 6 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer directly by mouth or crumbled and in feed. Not intended for use in puppies less than 4 weeks of age. (Contraindication, High)

Top reaction signals

Application site hair loss (1) Application site inflammation (1) Application site irritation (1) Application site reddening (1) Application site scratching (1) Cough (1) Cyst NOS (1) Death (1) Diarrhoea (1) Emesis (multiple) (1) Emesis (multiple) (1) Inappropriate defecation (1) Irritability (1) Lack of efficacy (endoparasite) - heartworm (1) Lack of efficacy (endoparasite) - hookworm (1) Lack of efficacy (endoparasite) - hookworm (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers

Package NDC	Product NDC	Status
0010-4120-01	0010	-
0010-4120-02	0010	-
0010-4120-03	0010	-
0010-4121-01	0010	-
0010-4121-02	0010	-
0010-4121-03	0010	-
0010-4251-01	0010	-
0010-4251-02	0010	-
0010-6001-03	0010	-
0010-6001-04	0010	-
0061-5354-01	0061	-
0061-5354-02	0061	-
0061-5355-01	0061	-
0061-5355-02	0061	-
0061-5356-01	0061	-
0061-5356-02	0061	-
0061-5357-01	0061	-
0061-5357-02	0061	-
17163-015-16	17163	-
17163-016-17	17163	-

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

FOI Summary oA 200-834 Approved December 22, 2025.pdf • FOI summary • Official • Jan. 5, 2026
FDA FOI summary for application 200834
FOI Summary o 141-619 Approved December 17, 2025 (2).pdf • FOI summary • Official • Jan. 5, 2026
FDA FOI summary for application 141619
FOI Summary oN 141-581 Approved October 7, 2024.pdf • FOI summary • Official • Nov. 3, 2025
FDA FOI summary for application 141581
FOI Summary sN 141-581 Approved May 21, 2025.pdf • FOI summary • Official • Nov. 3, 2025
FDA FOI summary for application 141581
FOI Summary sN 141-581 Approved October 20, 2025.pdf • FOI summary • Official • Nov. 3, 2025
FDA FOI summary for application 141581
UCM408781.pdf • FOI summary • Official • May 15, 2024
FDA FOI summary for application 141421
ucm118019.pdf • FOI summary • Official • Sept. 19, 2023
FDA FOI summary for application 141216
ucm118021.pdf • FOI summary • Official • Sept. 19, 2023
FDA FOI summary for application 141216
ucm118023.pdf • FOI summary • Official • Sept. 19, 2023
FDA FOI summary for application 141216
UCM457309.pdf • FOI summary • Official • Sept. 19, 2023
FDA FOI summary for application 141216
UCM050062.pdf • FOI summary • Official • July 13, 2023
FDA FOI summary for application 141261
FOI Summary oN 141-492 Approved March 8, 2018.pdf • FOI summary • Official • March 16, 2023
FDA FOI summary for application 141492
FOI Summary oA 200-734 Approved January 12, 2023.pdf • FOI summary • Official • Feb. 1, 2023
FDA FOI summary for application 200734
N141007_Orig_5_19_1994.pdf • FOI summary • Official • June 15, 2022
FDA FOI summary for application 141007
N141007_Supp_03-28-1996.pdf • FOI summary • Official • June 15, 2022
FDA FOI summary for application 141007
ucm116050.pdf • FOI summary • Official • June 15, 2022
FDA FOI summary for application 141007
ucm116081.pdf • FOI summary • Official • June 15, 2022
FDA FOI summary for application 141007
UCM181521.pdf • FOI summary • Official • June 15, 2022
FDA FOI summary for application 111607
UCM487815.pdf • FOI summary • Official • May 10, 2022
FDA FOI summary for application 141008
N111798_Supp_1_18_1990.pdf • FOI summary • Official • April 26, 2022
FDA FOI summary for application 111798
N111798_Orig_1_11_1993(2).pdf • FOI summary • Official • April 26, 2022
FDA FOI summary for application 111798
N111798_Supp_7_16_1993.pdf • FOI summary • Official • April 26, 2022
FDA FOI summary for application 111798
ucm118009.pdf • FOI summary • Official • July 26, 2021
FDA FOI summary for application 141214
ucm118011.pdf • FOI summary • Official • July 26, 2021
FDA FOI summary for application 141214
ucm118012.pdf • FOI summary • Official • July 26, 2021
FDA FOI summary for application 141214
ucm062332.pdf • FOI summary • Official • April 29, 2021
FDA FOI summary for application 141275
FOI Summary oN 141-441 Approved December 11, 2017.pdf • FOI summary • Official • Nov. 19, 2020
FDA FOI summary for application 141441
UCM292003.pdf • FOI summary • Official • Aug. 3, 2020
FDA FOI summary for application 141333
FOI Summary sN-141-333 Approved September 28, 2017.pdf • FOI summary • Official • Aug. 3, 2020
FDA FOI summary for application 141333
UCM514664.pdf • FOI summary • Official • Oct. 2, 2018
FDA FOI summary for application 200501
ucm061606.pdf • FOI summary • Official • Oct. 2, 2018
FDA FOI summary for application 200176
UCM318617.pdf • FOI summary • Official • Jan. 10, 2018
FDA FOI summary for application 141338
FOI Summary sN 141-338 Approved June 21, 2017.pdf • FOI summary • Official • Jan. 10, 2018
FDA FOI summary for application 141338
ucm118014.pdf • FOI summary • Official • Dec. 18, 2017
FDA FOI summary for application 141215
ucm118016.pdf • FOI summary • Official • Dec. 18, 2017
FDA FOI summary for application 141215
ucm118017.pdf • FOI summary • Official • Dec. 18, 2017
FDA FOI summary for application 141215
N133953_Supp_09_12_1991.pdf • FOI summary • Official • July 10, 2017
FDA FOI summary for application 133953
UCM051416.pdf • FOI summary • Official • June 1, 2016
FDA FOI summary for application 141257
ucm051414.pdf • FOI summary • Official • June 1, 2016
FDA FOI summary for application 141257

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 42 Clinical 0 Manufacturer 0 Marketing 0

Current Field Facts

contraindications: Not intended for use in puppies less than 4 weeks of age. Federal law restricts the drug to use by or on the order of a licensed veterinarian. Not intended for… (Official, 2026-02-12)
side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (endoparasite) - heartworm, Diarrhoea, INEFFECTIVE, HOOKS, Lethargy (see also Central nervous syst… (Official, 2026-02-12)
usage: For removal of canine cestodes: Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus, and removal and control of canine cestode Echinococcus mult… (Official, 2026-02-12)

Recent Revisions

side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product	Sponsor	Application	Status	Published
Credelio Quattro™-CA1 RX Lotilaner Moxidectin Praziquantel Pyrantel Pamoate Chewable Tablets • Oral Label highlights Official documents	Elanco US Inc.	NADA 141-619	Approved	Jan 5, 2026
Praziquantel Tablets RX Praziquantel Chewable Tablets • Oral Label highlights Official documents	Felix Pharmaceuticals Pvt. Ltd.	ANADA 200-834	Approved	Jan 5, 2026
Credelio Quattro™ RX Lotilaner Moxidectin Praziquantel Pyrantel Pamoate Chewable Tablets • Oral Label highlights Official documents	Elanco US Inc.	NADA 141-581	Approved	Nov 3, 2025
Duocare™ OTC Ivermectin Praziquantel Paste • Oral Label highlights Official documents	Boehringer lngelheim Animal Health USA Inc.	NADA 141-421	W	May 15, 2024
Quest® Plus Gel OTC Moxidectin Praziquantel Gel • Oral Label highlights Official documents	Zoetis Inc.	NADA 141-216	Approved	Sep 19, 2023
Virbantel® Worm X Plus® OTC Praziquantel Pyrantel Pamoate Tablet (Chewable) • Oral Label highlights Official documents	Virbac AH, Inc.	NADA 141-261	Approved	Jul 13, 2023
Centragard® RX Eprinomectin Praziquantel Transdermal Solution • Transdermal Label highlights Official documents	Boehringer lngelheim Animal Health USA, Inc.	NADA 141-492	Approved	Mar 16, 2023
Praziquantel Tablets RX Praziquantel Chewable Tablets • Oral Label highlights Official documents	Felix Pharmaceuticals Pvt. Ltd.	ANADA 200-734	Approved	Feb 1, 2023
Droncit™ 5.68% Injectible Solution RX Praziquantel Liquid (Solution) • Subcutaneous, Intramuscular Label highlights Official documents	Elanco US Inc.	NADA 111-607	Approved	Jun 15, 2022
Drontal™ Plus Taste Tabs™ Drontal™ Plus Quad Dewormer RX Febantel Praziquantel Pyrantel Pamoate Tablet • Oral Label highlights Official documents	Elanco US Inc.	NADA 141-007	Approved	Jun 15, 2022
Drontal™ Tablets OTC Praziquantel Pyrantel Pamoate Tablet • Oral Label highlights Official documents	Elanco US Inc.	NADA 141-008	Approved	May 10, 2022
Droncit® Feline Cestocide Tablets Praziquantel 34 (Rx) Droncit® Canine Cestocide Tablets Tapeworm Dewormer for Dogs (OTC) Tapeworm Dewormer for Cats (OTC) RX Praziquantel Tablet • Oral Label highlights Official documents	Elanco US Inc.	NADA 111-798	Approved	Apr 26, 2022
ZIMECTERIN® Gold Paste OTC Ivermectin Praziquantel Paste • Oral Label highlights Official documents	Boehringer lngelheim Animal Health USA, Inc.	NADA 141-214	Approved	Jul 26, 2021
Profender™ RX Emodepside Praziquantel Liquid • Topical Label highlights Official documents	Elanco US Inc.	NADA 141-275	Approved	Apr 29, 2021
IVERHART MAX® Chew RX Ivermectin Praziquantel Pyrantel Pamoate Chewable Tablets • Oral Label highlights Official documents	Virbac AH, Inc.	NADA 141-441	Approved	Nov 19, 2020
Sentinel® Spectrum® RX Lufenuron Milbemycin Oxime Praziquantel Chewable Tablets • Oral Label highlights Official documents	Intervet, Inc.	NADA 141-333	Approved	Aug 3, 2020
Praziquantel Injection Praziquantel Injectable Solution • Intramuscular, Subcutaneous Label highlights Official documents	Bimeda Animal Health Limited	ANADA 200-501	Approved	Oct 2, 2018
Prazitech™ RX Praziquantel Liquid (Solution) • Intramuscular, Subcutaneous Label highlights Official documents	Bimeda Animal Health Limited	ANADA 200-176	Approved	Oct 2, 2018
INTERCEPTOR™ PLUS RX Milbemycin Oxime Praziquantel Chewable Tablets • Oral Label highlights Official documents	Elanco US Inc.	NADA 141-338	Approved	Jan 10, 2018
Equimax® OTC Ivermectin Praziquantel Paste • Oral Label highlights Official documents	Virbac AH, Inc.	NADA 141-215	Approved	Dec 18, 2017
Vercom Paste Anthelmintic RX Febantel Praziquantel Paste • Oral Label highlights Official documents	Elanco US Inc.	NADA 133-953	Approved	Jul 10, 2017
Iverhart Max® RX Ivermectin Praziquantel Pyrantel Pamoate Tablet (Chewable) • Oral Label highlights Official documents	Virbac AH, Inc.	NADA 141-257	Approved	Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Composition / specifications

Each chewable tablet contains: 56.25 mg lotilaner, 0.056 mg moxidectin, 14.25 mg praziquantel, and 14.25 mg pyrantel* 112.5 mg lotilaner, 0.113 mg moxidectin, 28.5 mg praziquantel, and 28.5 mg pyrantel* 225 mg lotilaner, 0.225 mg moxidectin, 57 mg praziquantel, and 57 mg pyrantel* 450 mg lotilaner, 0.45 mg moxidectin, 114 mg praziquantel, and 114 mg pyrantel* 900 mg lotilaner, 0.9 mg moxidectin, 228 mg praziquantel, and 228 mg pyrantel* *As pamoate salt

Dogs

Indication

For the treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.

Dosage

Administer orally at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt).

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications

Each chewable tablet contains 23 mg praziquantel.

Cats

Indication

For removal of feline cestodes Dipylidium caninum and Taenia taeniaeformis.

Dosage

Cats 4 pounds and under, 11.5 mg; 5 to 11 pounds, 23 mg; over 11 pounds, 34.5 mg.

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications

56.25 mg lotilaner, 0.056 mg moxidectin, 14.25 mg praziquantel, and 14.25 mg pyrantel; 112.5 mg lotilaner, 0.113 mg moxidectin, 28.5 mg praziquantel, and 28.5 mg pyrantel; 225 mg lotilaner, 0.225 mg moxidectin, 57 mg praziquantel, and 57 mg pyrantel; 450 mg lotilaner, 0.45 mg moxidectin, 114 mg praziquantel, and 114 mg pyrantel; 900 mg lotilaner, 0.9 mg moxidectin, 228 mg praziquantel, and 228 mg pyrantel

Dogs

Indication

Credelio Quattro™ is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina), hookworm (fourth stage larvae, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala), and tapeworm (Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus) infections. Credelio Quattro™ kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma Americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (longhorned tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater. Credelio Quattro™ is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

Dosage

Administer orally once a month, at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt).

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: No Use Class Stated Or Implied

Composition / specifications

Each milligram of Duocare™ paste contains 0.0187 mg (1.87%) ivermectin and 0.2338 mg (23.38%) praziquantel. Each syringe contains 113.75 mg of ivermectin and 1421.5 mg of praziquantel.

Horses

Indication

For the treatment and control of the following parasites in horses over 5 months of age: Tapeworms Anoplocephala perfoliata; Large Strongyles (adults) - Strongylus vulgaris (also early forms in blood vessels), S. edentatus (also tissue stages), S. equinus, Triodontophorus spp. including T. brevicauda and T. serratus, and Craterostomum acuticaudatum; Small Strongyles (adults, including those resistant to some benzimidazole class compounds) - Coronocyclus spp. including C. coronatus, C. labiatus and C. labratus; Cyathostomum spp. including C. catinatum and C. pateratum; Cylicocyclus spp. including C. insigne, C. leptostomum, C. nassatus and C. brevicapsulatus; Cylicodontophorus spp. Cylicostephanus spp. including C. calicatus, C. goldi, C. longibursatus and C. minutus, and Petrovinema poculatum; Small Strongyles - Fourth-stage larvae; Pinworms (adults and fourth-stage larvae)- Oxyuris equi; Ascarids (adults and third- and fourth-stage larvae) - Parascaris equorum; Hairworms (adults) - Trichostrongylus axei; Large-mouth Stomach Worms (adults) - Habronema muscae; Bots (oral and gastric stages) - Gasterophilus spp. including G. intestinalis and G. nasalis; Lungworms (adults and fourth-stage larvae) - Dictyocaulus arnfieldi; Intestinal Threadworms (adults) - Strongyloides westeri; Summer Sores caused by Habronema and Draschia spp. cutaneous third-stage larvae; Dermatitis caused by neck threadworm microfilariae, Onchocerca sp.

Dosage

200 mcg/kg ivermectin (91 mcg/lb) and 2.5 mg/kg praziquantel (1.14 mg/lb).

Limitations

Do not use in horses intended for human consumption.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Six Months And Older Not For Food

Composition / specifications

Each milliliter of gel contains 20 milligrams (2.0 percent) moxidectin and 125 milligrams (12.5 percent) praziquantel.

Horses and Ponies

Indication

For the treatment and control of large strongyles: Strongylus vulgaris (adults and L4/L5 arterial stages), S. edentatus (adult and tissue stages), Triodontophorus brevicauda (adults), and T. serratus (adults); small strongyles (adults): (Cyathostomum species, including C. catinatum and C. pateratum; Cylicocyclus species, including C. insigne, C. leptostomum, C. nassatus and Cylicocyclus radiatus; Cylicostephanus species, including C. calicatus, C. goldi, C. longibursatus, and C. minutus; Coronocyclus species, including C. coronatus, C. labiatus, and C. labratus; Gyalocephalus capitatus; and Petrovinema poculatus; small strongyles: undifferentiated luminal larvae; encysted cyathostomes (late L3 and L4 mucosal cyathostome larvae); ascarids: Parascaris equorum (adults and L4 larval stages); pinworms: Oxyuris equi (adults and L4 larval stages); hairworms: Trichostrongylus axei (adults); large-mouth stomach worms: Habronema muscae (adults); horse stomach bots: Gasterophilus intestinalis (2nd and 3rd instars) and G. nasalis (3rd instars); and tapeworms: Anoplocephala perfoliata (adults). One dose also suppresses strongyle egg production for 84 days.

Dosage

Administer by mouth as a single dose: 0.4 milligram moxidectin per kilogram and 2.5 milligrams praziquantel per kilogram (2.2 pounds) body weight.

Limitations

For oral use in horses and ponies 6 months of age and older. Do not use in horses intended for human consumption.QUEST PLUS Gel has been formulated specifically for use in horses and ponies only.Reproductive safety studies on breeding stallions have not been conducted.This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result.Extreme caution should be used when administering the product to foals, young and miniature horses, as overdosage may result in serious adverse reactions. Do not use in sick, debilitated, or underweight animals.

FDA page: Open in Animal Drugs @ FDA

Species: Dogs And Puppies

Composition / specifications

Each chewable tablet contains: 30 mg praziquantel and 30 mg pyrantel pamoate (For Small Dogs and Puppies) or 114 mg praziquantel and 114 mg pyrantel pamoate (For Medium and Large Dogs).

Dogs (Puppies and Small Dogs 6.0-25 Lbs)

Indication

For the treatment and control of roundworms (Toxocara canis and Toxascaris leonine), hookworms (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala), and tapeworms (Dipylidium caninum and Taenia pisiformis) in dogs and puppies.

Dosage

Administer a minimum dose of 5 milligrams praziquantel and 5 milligrams pyrantel pamoate per kilogram body weight (2.27 milligrams praziquantel and 2.27 milligrams pyrantel pamoate per pound body weight) according to the dosing tables on labeling.

Limitations

Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.Do not de-worm a dog or puppy that is sick. Consult a veterinarian for diagnosis of the illness. VIRBANTEL® Flavored Chewables are safe for use in puppies 12 weeks or older and adult dogs. Safety in breeding dogs and pregnant bitches has not been tested.

Dogs (Medium and Large Dogs- Greater than 25 Lbs)

Indication

Dosage

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied

Composition / specifications

Eprinomectin – 4 mg/mL; Praziquantel – 83 mg/mL

Cats

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis, and for the treatment and control of roundworms (adult and fourth stage larval Toxocara cati), hookworms (adult and fourth stage larval Ancylostoma tubaeforme; adult Ancylostoma braziliense), and tapeworms (adult Dipylidium caninum and Echinococcus multilocularis), in cats and kittens 7 weeks of age and older and 1.8 lbs or greater.

Dosage

Centragard™ is dosed at a minimum of 0.055 mL/lb (0.12 mL/kg), which delivers a minimum dose of 0.23 mg/lb eprinomectin and 4.55 mg/lb praziquantel.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied

Composition / specifications

34 mg per tablet

Dogs

Indication

For the removal of the following canine cestodes: Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus and for the removal and control of Echinococcus multilocularis.

Dosage

Dogs 5 pounds (lb) and under, 1/2 tablet (17 mg); 6 to 10 lb, 1 tablet (34 mg); 11 to 15 lb, 1 1/2tablets (51 mg); 16 to 30 lb, 2 tablets (68 mg); 31 to 45 lb, 3 tablets (102 mg); 46 to 60 lb, 4 tablets (136mg); over 60 lb, 5 tablets maximum (170 mg). Administer directly by mouth or crumbled and in feed.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dogs and puppies, excluding puppies under 4 weeks age • Cats and kittens, excluding kittens under 6 weeks age

Composition / specifications

Each milliliter contains 56.8 milligrams of praziquantel.

Dogs

Indication

For removal of canine cestodes: Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus, and removal and control of canine cestode Echinococcus multilocularis.

Dosage

For dogs 5 pounds and under, 0.3 milliliter (17.0 milligrams); for 6 to 10 pounds, 0.5 milliliter (28.4 milligrams); for 11 to 25 pounds, 1.0 milliliter (56.8 milligrams); if over 25 Pounds, 0.2 milliliter (11.4 milligrams) per 5 pounds body weight to a maximum of 3 milliliters (170.4 milligrams). For subcutaneous or intramuscular use.

Limitations

Not intended for use in puppies less than 4 weeks of age. Federal law restricts the drug to use by or on the order of a licensed veterinarian.

Cats

Indication

For removal of feline cestodes Dipylidium caninum and Taenia taeniaeformis.

Dosage

For cats under 5 pounds, 0.2 milliliter (11.4 milligrams); 5 to 10 pounds, 0.4 milliliter (22.7 milligrams); 11 pounds and over, 0.6 milliliter (34.1 milligrams) maximum. For subcutaneous or intramuscular injection.

Limitations

Not intended for use in kittens less than 6 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, Restricted During Pregnancy • Dog, Excluding Under 2 Pounds • Dog And Puppy, Excluding Under 3 Weeks Age

Composition / specifications

Each tablet contains either:
1) 22.7 milligrams praziquantel, 22.7 milligrams pyrantel base, and 113.4 milligrams febantel
2) 68 milligrams praziquantel, 68 milligrams pyrantel base, and 340.2 milligrams febantel
or
3) 136 milligrams praziquantel, 136 milligrams pyrantel base, and 680.4 milligrams febantel

Dogs: Weighing 2 to 4 pounds (0.9 to 1.8 kilograms)

Indication

For the removal of tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus); hookworms (Ancylostoma caninum, Uncinaria stenocephala); ascarids (Toxocara canis, Toxascaris leonina); and whipworms (Trichuris vulpis) and for removal and control of tapeworm (Echinococcus multilocularis).

Dosage

0.5 Tablet No.1

Limitations

Do not use in pregnant animals. Do not use in dogs weighing less than 2 pounds (0.9 kilogram) or in puppies less than 3 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian

Dogs: Weighing 5 to 7 pounds (2.3 to 3.2 kilograms):

Indication

Dosage

1 tablet No.1

Limitations

Dogs: Weighing 8 to 12 pounds (3.6 to 5.4 kilograms)

Indication

Dosage

1.5 tablet No.1

Limitations

Dogs: Weighing 13 to 18 pounds (5.9 to 8.2 kilograms)

Indication

Dosage

2 tablets No.1

Limitations

Dogs: Weighing 19 to 25 pounds (8.6 to 11.4 kilograms)

Indication

Dosage

2.5 tablets No.1

Limitations

Dogs: Weighing 26 to 30 pounds (11.8 to 13.6 kilograms)

Indication

Dosage

1 tablet No.2

Limitations

Dogs: Weighing 31 to 44 pounds (14.1 to 20.0 kilograms)

Indication

Dosage

1.5 tablets No.2

Limitations

Dogs: Weighing 45 to 60 pounds (20.4 to 27.2 kilograms)

Indication

Dosage

2.0 tablets No.2 or 1.0 Tablet No. 3

Limitations

Dogs: Weighing 61 to 90 pounds (27.7 to 40.9 kilograms)

Indication

Dosage

1.5 tablets No. 3

Limitations

Dogs: Weighing 91 to 120 pounds (41.3 to 54.5 kilograms)

Indication

Dosage

2 tablets No. 3

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Cat And Kitten, Excluding Under 2 Months Of Age Or Under 2 Pounds Weight

Composition / specifications

Each tablet contains 18.2 mg praziquantel and 72.6 mg pyrantel base as pyrantel pamoate.

Cats and Kittens (Greater Than 2 Months of Age Or At Least 2 Lbs)

Indication

For removal of the common parasites of cats and kittens including tapeworms (Dipylidium caninum, Taenia taeniaeformis), hookworms (Ancylostoma tubaeforme), and large roundworms (Toxocara cati).

Dosage

Administer a minimum dose of 2.27 mg praziquantel and 9.2 pyrantel pamoate per pound of bodyweight according to the dosing tables on labeling.

Limitations

May be given directly by mouth or in a small amount of food. Do not withhold food prior to or after treatment. If reinfection occurs, treatment may be repeated. Consult your veterinarian before giving to sick or pregnant animals. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Not for use in kittens less than 2 months of age or weighing less than 2.0 pounds.

FDA page: Open in Animal Drugs @ FDA

Species: Dogs and puppies, excluding puppies under 4 weeks age

Composition / specifications

Each dog tablet contains 34 milligrams of praziquantel

Dogs

Indication

For removal of the canine cestode Echinococcus granulosus, and for removal and control of the canine cestode Echinococcus multilocularis. For removal of canine cestodes Dipylidium caninum and Taenia pisiformis.

Dosage

5 pounds and under, 1/2 tablet (17 milligrams); 6 to 10 pounds, 1 tablet (34 milligrams); 11 to 15 pounds, 1 1/2 tablets (51 milligrams); 16 to 30 pounds, 2 tablets (68 milligrams); 31 to 45 pounds, 3 tablets (102 milligrams); 46 to 60 pounds, 4 tablets (136 milligrams); over 60 pounds, 5 tablets maximum (170 milligrams).

Limitations

Administer directly by mouth or crumbled and in feed. Not intended for use in puppies less than 4 weeks of age.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Foals 2 Months And Older, Not For Food

Composition / specifications

Each milligram of paste contains 0.0155 milligram (1.55 percent) ivermectin and 0.0775 milligram (7.75 percent) praziquantel.

Horses

Indication

For treatment and control of the following parasites in horses: tapeworms--Anoplocephala perfoliata; large strongyles (adults)-- Strongylus vulgaris (also early forms in blood vessels), S. edentates (also tissue stages), S. equinus, Triodontophorus species including T. brevicauda and T. serratus, and Craterostomum acuticaudatum; small strongyles (adults, including those resistant to some benzimidazole class compounds)--Coronocyclus species including C. coronatus, C. labiatus, and C. labratus, Cyathostomum species including C. catinatum and C. pateratum, Cylicocyclus species including C. insigne, C. leptostomum, C. nassatus, and C. brevicapsulatus, Cylicodontophorus species, Cylicostephanus species including C. calicatus, C. goldi, C. longibursatus, and C. minutus, and Petrovinema poculatum; small strongyles-fourth-stage larvae; pinworms (adults and fourth stage larvae)--Oxyuris equi; Ascarids (adults and third- and fourth-stage larvae)--Parascaris equorum; hairworms (adults)--Trichostrongylus axei; large-mouth stomach worms (adults)--Habronema muscae; bots (oral and gastric stages)--Gasterophilus species including G. intestinalis and G. nasalis; lungworms (adults and fourth-stage larvae)--Dictyocaulus arnfieldi; intestinal threadworms (adults)--Strongyloides westeri; summer sores caused by Habronema and Draschia species cutaneous third-stage larvae; Dermatitis caused by neck threadworm microfilariae, Onchocerca species.

Dosage

200 microgram per kilogram ivermectin (91 microgram per pound) and 1 milligram per kilogram praziquantel (454 micrograms per pound) body weight.

Limitations

For oral use only. Do not use in horses intended for human consumption. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result.

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied

Composition / specifications

Each mL contains 21.4 mg emodepside and 85.7 mg praziquantel

Cats

Indication

For the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and tapeworm infections caused by Dipylidium caninum (adults) and Taenia taeniaeformis (adults).

Dosage

The recommended minimum dose is 1.36 mg/pound (lb) (3 mg/kilogram (kg)) emodepside and 5.45 mg/ lb (12 mg/kg) praziquantel applied as a single topical dose.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Safe use of this product has not been evaluated in cats less that 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy, or in lactating queens. Oral ingestion or exposure should be avoided.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied

Composition / specifications

Each chewable tablet contains either: 1) 34 micrograms (mcg) ivermectin, 28.5 milligrams (mg) pyrantel pamoate, and 28.5 mg praziquantel; 2) 68 mcg ivermectin, 57 mg pyrantel pamoate, and 57 mg praziquantel; 3) 136 mcg ivermectin, 114 mg pyrantel pamoate, and 114 mg praziquantel; or 4) 272 mcg ivermectin, 228 mg pyrantel pamoate, and 228 mg praziquantel.

Dogs

Indication

For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense), and tapeworms (Dipylidium caninum, Taenia pisiformis).

Dosage

Administer orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb), and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight, as follows:

6.0 to 12 pounds- one tablet containing 34 micrograms (mcg) ivermectin, 28.5 milligrams (mg) pyrantel pamoate, and 28.5 mg praziquantel
12.1 to 25 pounds- one tablet containing 68 mcg ivermectin, 57 mg pyrantel pamoate, and 57 mg praziquantel
25.1 to 50 pounds- one tablet containing 136 mcg ivermectin, 114 mg pyrantel pamoate, and 114 mg praziquantel
50.1 to 100 one tablet containing 272 mcg ivermectin, 228 mg pyrantel pamoate, and 228 mg praziquantel

Limitations

Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied

Composition / specifications

Each chewable tablet contains: 2.3 mg milbemycin oxime/46 mg lufenuron/22.8 mg praziquantel; 5.75 mg milbemycin oxime/115 mg lufenuron/57 mg praziquantel; 11.5 mg milbemycin oxime/230 mg lufenuron/114 mg praziquantel; 23.0 mg milbemycin oxime/460 mg lufenuron/228 mg praziquantel

Dogs

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis), and adult tapeworm (Dipylidium caninum,Taenia pisiformis, Echinococcus multilocularis and Echinococcus granulosus) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.

Dosage

SENTINEL SPECTRUM is given orally, once a month, at the minimum dosage of 0.23 mg/pound body weight (0.5 mg/kg) of milbemycin oxime, 4.55 mg/pound (10 mg/kg) of lufenuron, and 2.28 mg/pound (5 mg/kg) of praziquantel. For heartworm prevention, give once monthly beginning within 1 month of the dog’s first seasonal exposure to mosquitoes and continuing until at least 6 months after the dog’s last seasonal exposure.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dogs and puppies, excluding puppies under 4 weeks age • Cats and kittens, excluding kittens under 6 weeks age

Composition / specifications

56.8 mg/mL

Cats

Indication

For removal of feline cestodes Dipylidium caninum and Taenia taeniaeformis.

Dosage

May be administered by either the subcutaneous or intramuscular route to cats utilizing the following dosage schedule: Under 5 lbs.—0.2 mL; 5-10 lbs.—0.4 mL; 11 lbs. and over—0.6 mL maximum.

Limitations

Not intended for use in kittens less than six (6) weeks of age. Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

Dogs

Indication

For removal of canine cestodes Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus, and removal and control of canine cestode Echinococcus multilocularis.

Dosage

May be administered by either the subcutaneous or intramuscular route to dogs utilizing the following dosage schedule: 5 lbs. and under—0.3 mL; 6-10 lbs.—0.5 mL; 11-25 lbs.—1.0 mL; over 25 lbs.—0.2 mL per 5 lbs. body weight to a maximum of 3 mL.

Limitations

Not intended for use in puppies less than four (4) weeks of age. Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dogs and puppies, excluding puppies under 4 weeks age • Cats and kittens, excluding kittens under 6 weeks age

Composition / specifications

Each milliliter contains 56.8 milligrams of praziquantel.

Cats

Indication

For removal of feline cestodes Dipylidium caninum and Taenia taeniaeformis.

Dosage

Limitations

Not intended for use in kittens less than 6 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Dogs

Indication

For removal of canine cestodes: Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus, and removal and control of canine cestode Echinococcus multilocularis.

Dosage

Limitations

Not intended for use in puppies less than 4 weeks of age. Federal law restricts the drug to use by or on the order of a licensed veterinarian

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied

Composition / specifications

Each chewable tablet contains:
2.3 mg milbemycin oxime/22.8 mg praziquantel
5.75 mg milbemycin oxime/57 mg praziquantel
11.5 mg milbemycin oxime/114 mg praziquantel
23 mg milbemycin oxime/228 mg praziquantel

Dogs (2 lbs or greater and 6 weeks or older)

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis), and adult tapeworm (Taenia pisiformis, Echinococcus multilocularis, and Echinococcus granulosus) and Dipylidium caninum infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.

Dosage

Administer orally, once a month, a minimum dosage of 0.23 mg per pound (mg/lb) of body weight (0.5 mg per kilogram (mg/kg)) milbemycin oxime and 2.28 mg/lb of body weight (5 mg/kg) praziquantel.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, No Use Class Stated Or Implied

Composition / specifications

Each milligram of paste contains 0.0187 mg (1.87 percent) ivermectin and 0.1403 mg (14.03 percent) praziquantel.

Horses

Indication

For treatment and control of the following parasites in horses: Tapeworms--Anoplocephala perfoliata; Large Strongyles (adults)--Strongylus vulgaris (also early forms in blood vessels), S.edentatus (also tissue stages), S. equinus, Triodontophorus spp.; Small Strongyles (adults, including those resistant to some benzimidazole class compounds)--Cyathostomum species, Cylicocyclus species, Cylicostephanus species, Cylicodontophorus species; Small Strongyles--fourth-stage larvae; Pinworms (adults and fourth-stage larvae)--Oxyuris equi; Ascarids (adults and third- and fourth-stage larvae)--Parascaris equorum; Hairworms (adults)--Trichostrongylus axei; Large-mouth Stomach Worms (adults)--Habronema muscae; Bots (oral and gastric stages)--Gasterophilus species; Lungworms (adults and fourth-stage larvae)--Dictyocaulus arnfieldi; Intestinal Threadworms (adults)--Strongyloides westeri; Summer Sores caused by Habronema and Draschia spp. cutaneous third-stage larvae; Dermatitis caused by neck threadworm microfilariae, Onchocerca species.

Dosage

200 microgram per kilogram ivermectin (91 microgram per pound) and 1.5 milligram per kilogram praziquantel (.68 milligram per pound) body weight.

Limitations

For oral use in horses only. Do not use in horses intended for human consumption. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result

FDA page: Open in Animal Drugs @ FDA

Species: Dog, Restricted During Pregnancy • Cat, Restricted During Pregnancy

Composition / specifications

Each gram of paste contains 34 milligrams of febantel and 3.4 milligrams of praziquantel.

Dogs (over 6 months of age)

Indication

For removal of hookworms (Ancylostoma caninum and Uncinaria stenocephala), whipworms (Trichuris vulpis), ascarids (Toxocara canis and Toxascaris leonina), and tapeworms (Dipylidium caninum and Taenia pisiformis).

Dosage

10 milligrams of febantel and 1 milligram of praziquantel per kilogram of body weight (1 gram of paste per 7.5 pounds body weight) administered by mouth or in the food once daily for 3 days.

Limitations

Do not use in pregnant animals. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Consider alternative therapy or use with caution in animals with pre-existing liver or kidney dysfunction.

Dogs (puppies less than 6 months of age)

Indication

Dosage

15 milligrams of febantel and 1.5 milligrams of praziquantel per kilogram of body weight (1 gram of paste per 5 pounds body weight) administered by mouth on a full stomach once daily for 3 days.

Limitations

Cats (over 6 months of age)

Indication

For removal of hookworms (Ancylostoma tubaeforme), ascarids (Toxocara cati) and tapeworms (Dipylidium caninum and Taenia taeniaeformis).

Dosage

10 milligrams of febantel and 1 milligram of praziquantel per kilogram of body weight (1 gram of paste per 7.5 pounds body weight) administered by mouth or in the food once daily for 3 days.

Limitations

Cats (kittens under 6 months of age)

Indication

For removal of hookworms (Ancylostoma tubaeforme), ascarids (Toxocara cati) and tapeworms (Dipylidium caninum and Taenia taeniaeformis).

Dosage

15 milligrams of febantel and 1.5 milligrams of praziquantel per kilogram of body weight (1 gram of paste per 5 pounds body weight) administered by mouth on a full stomach once daily for 3 days.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied

Composition / specifications

Each chewable tablet contains:
(1) 34 micrograms (mcg) ivermectin, 28.5 milligrams (mg) pyrantel pamoate, and 28.5 mg praziquantel;
(2) 68 mcg ivermectin, 57 mg pyrantel pamoate, and 57 mg praziquantel;
(3) 136 mcg ivermectin, 114 mg pyrantel pamoate, and 114 mg praziquantel; or
(4) 272 mcg ivermectin, 228 mg pyrantel pamoate, and 228 mg praziquantel.

Dogs (12.1 - 25 Lbs)

Indication

Prevents canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for 1 month (30 days) after infection and for the treatment and control of roundworm (Toxocara canis, Toxascaris leonine), hookworm (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) and tapeworm (Dipylidium caninum, Taenia pisiformis) infections.

Dosage

Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight. (One table monthly containing 68 mcg ivermectin, 57 mg pyrantel pamoate, and 57 mg praziquantel)

Limitations

For oral use in dogs only. IVERHART MAX Chewable Tablets are recommended for dogs 8 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these Chewable Tablets. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Dogs (6.0 - 12 Lbs)

Indication

Dosage

Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight. (One tablet monthly containing 34 micrograms (mcg) ivermectin, 28.5 milligrams (mg) pyrantel pamoate, and 28.5 mg praziquantel)

Limitations

Dogs (50.1 - 100 Lbs)

Indication

Dosage

Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight. (One tablet monthly containing 272 mcg ivermectin, 228 mg pyrantel pamoate, and 228 mg praziquantel)

Limitations

Dogs (25.1 - 50 Lbs)

Indication

Dosage

Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight. (One tablet monthly containing 136 mcg ivermectin, 114 mg pyrantel pamoate, and 114 mg praziquantel)

Limitations

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents

FOI FOI Summary o 141-619 Approved December 17, 2025 (2).pdf

Summary

For the treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.

SPL Packages

Credelio Quattro™-CA1 (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI FOI Summary oA 200-834 Approved December 22, 2025.pdf

Summary

For the removal of the following feline cestodes: Dipylidium caninum and Taenia taeniaeformis.

SPL Packages

Praziquantel Tablets (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI FOI Summary sN 141-581 Approved October 20, 2025.pdf

Summary

This supplement provides for the addition of the indication for the treatment and control of Haemaphysalis longicornis (longhorned tick) tick infestations for one month in dogs and puppies 8 weeks of age and older, weighing 3.3 pounds or greater, and for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.
FOI FOI Summary sN 141-581 Approved May 21, 2025.pdf

Summary

This supplement provides for the addition of the indication for the treatment and control of hookworm (fourth stage larvae, immature adult, and adult Ancylostoma caninum) infections in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.
FOI FOI Summary oN 141-581 Approved October 7, 2024.pdf

Summary

For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina), hookworm (adult Uncinaria stenocephala), and tapeworm (Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus) infections. Kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), and Rhipicephalus sanguineus (brown dog tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.

SPL Packages

Credelio Quattro™ (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM408781.pdf

Summary

For the treatment and control of the following parasites in horses over 5 months of age: TapewormsAnoplocephala perfoliata; Large Strongyles (adults) - Strongylus vulgaris (also early forms in blood vessels), S. edentatus (also tissue stages), S. equinus, Triodontophorus spp. including T. brevicauda and T. serratus, and Craterostomum acuticaudatum; Small Strongyles (adults, including those resistant to some benzimidazole class compounds) - Coronocyclus spp. including C. coronatus, C. labiatus and C. labratus; Cyathostomum spp. including C. catinatum and C. pateratum; Cylicocyclus spp. including C. insigne, C. leptostomum, C. nassatus and C. brevicapsulatus; Cylicodontophorus spp. Cylicostephanus spp. including C. calicatus, C. goldi, C. longibursatus and C. minutus, and Petrovinema poculatum; Small Strongyles - Fourth-stage larvae; Pinworms (adults and fourth-stage larvae)- Oxyuris equi; Ascarids (adults and third- and fourth-stage larvae) - Parascaris equorum; Hairworms (adults) - Trichostrongylus axei; Large-mouth Stomach Worms (adults) - Habronema muscae; Bots (oral and gastric stages) - Gasterophilus spp. including G. intestinalis and G. nasalis; Lungworms (adults and fourth-stage larvae) - Dictyocaulus arnfieldi; Intestinal Threadworms (adults) - Strongyloides westeri; Summer Sores caused by Habronema and Draschia spp. cutaneous third-stage larvae; Dermatitis caused by neck threadworm microfilariae, Onchocerca sp.

SPL Packages

Duocare™ (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM457309.pdf

Summary

This supplement supports the safe use in breeding, pregnant, or lactating mares.
FOI ucm118023.pdf

Summary

The supplement provides for the use of QUEST Plus gel for the treatment and control of adult Cylicocyclus radiatus and Petrovinema poculatus based on results from additional dose confirmation studies.
FOI ucm118021.pdf

Summary

For the treatment and control of the following stages of gastrointestinal parasites of horses and ponies
FOI ucm118019.pdf

Summary

For the treatment and control of the following stages of gastrointestinal parasites of horses and ponies six months of age and older and not to be used for food

SPL Packages

Quest® Plus Gel (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM050062.pdf

Summary

For the treatment and control of roundworms (Toxocara canis, Toxascaris leonina); hookworms (Ancylostoma caninum, Ancylostoma braziliense, Uncinaria stenocephala); and tapeworms (Dipylidium caninum, Taenia pisiformis) in dogs and puppies.

SPL Packages

Virbantel® (ZIP)
Worm X Plus® (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI FOI Summary oN 141-492 Approved March 8, 2018.pdf

Summary

For the prevention of heartworm disease caused by Dirofilaria immitis, and for the treatment and control of roundworms (adult and fourth stage larval Toxocara cati), hookworms (adult and fourth stage larval Ancylostoma tubaeforme; adult Ancylostoma braziliense), and tapeworms (adult Dipylidium caninum and Echinococcus multilocularis), in cats and kittens 7 weeks of age and older and 1.8 lbs or greater.

SPL Packages

Centragard® (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI FOI Summary oA 200-734 Approved January 12, 2023.pdf

Summary

For the removal of the following canine cestodes: Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus and for the removal and control of Echinococcus multilocularis.

SPL Packages

Praziquantel Tablets (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM181521.pdf

Summary

This Supplemental Application amends the NADA to provide for the use of Droncit Injectable Solution against Echinococcus multilocularis in dogs.

SPL Packages

Droncit™ 5.68% Injectible Solution (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI ucm116081.pdf

Summary

This supplement amends the approved NADA by adding a flavored tablet formulation with the same indications.
FOI ucm116050.pdf

Summary

Effect of Supplement: This supplement amends the NADA to provide for a larger tablet containing 136.0 mg praziquantel, 136.0 mg pyrantel base as pyrantel pamoate and 680.4 mg febantel and the associated label changes.
FOI N141007_Supp_03-28-1996.pdf

Summary

This supplemental application amends NADA 141-007, Drontal™ Plus Broad Spectrum Anthelmintic Tablets, by adding the tape-worm Echinococcus multilocularis claim to the label.
FOI N141007_Orig_5_19_1994.pdf

Summary

Drontalâ¿¢ Plus Broad Spectrum Anthelmintic Tablets are indicated for the removal of the following intestinal parasites in dogs:
Tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus)
Hookworms (Ancylostoma caninum, Incinaria stenocephala)
Ascarids (Toxocara canis, Toxascaris leonina)
Whipworms (Trichuris vulpis)

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM487815.pdf

Summary

Drontal Tablets will remove Tapeworms ( Dipylidium caninum, Taenia taeniaeformis ), Hookworms ( Ancylostoma tubaeforme ) and Large Roundworms ( Toxocara cati ) in kittens and cats.

SPL Packages

Drontal™ Tablets (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI N111798_Supp_7_16_1993.pdf

Summary

This Supplemental Application amends the NADA to provide for the use of Droncit Tablets against Echinococcus multilocularis in dogs. Droncit Tablets (NADA #111-798, 46 FR 60570 [December 11, 1981]) are currently approved for use in dogs and cats.
FOI N111798_Orig_1_11_1993(2).pdf

Summary

This supplement amends the NADA to provide for a 11.5 mg spherical tablet, which is half the concentration of the previously approved 23 mg tablet, for cats.
FOI N111798_Supp_1_18_1990.pdf

Summary

The purpose of the supplement is to provide for OTC marketing of praziquantel tablets for the indications listed below:
Dogs: CUTTER Tape-Tabs (praziquantel) Tapeworm Tablets will remove the common tapeworms, Dipylidium caninum and Taenia pisiformis, from dogs and puppies.
Cats: CUTTER Tape-Tabs (praziquantel) Tapeworm Tablets will remove the common tapeworms, Dipylidium caninum and Taenia taeniaeformis, from cats and kittens.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents

FOI ucm118012.pdf

Summary

This supplement amends the ZIMECTERIN Gold (ivermectin/praziquantel) Paste labeling to reflect the change in the age of treatment from “5 months of age and older” to “2 months of age and older.”
FOI ucm118011.pdf

Summary

This supplement amends the ZIMECTRIN Gold (ivermectin/praziquantel) Paste labeling to reflect a change in the indications section. Specifically, under the sub-heading Small Strongyles, the labeling has been revised to separate the listing of adult species from the fourth-stage larvae. The label language has also been revised for treatment frequency; removing the eight week intertreatment interval because treatment frequency should be based on a parasite control program designed specifically for each horse. A new precaution statement has also been added.
FOI ucm118009.pdf

Summary

For treatment and control of the following parasites in horses: Tapeworms: noplocephala perfoliata Large strongyles (adults):
Strongylus vulgaris (also early forms in blood vessels), Strongylus edentatus (also tissue stages), Strongylus equinus Triodontophorus spp. including: Triodontophorus brevicauda, Triodontophorus serratus,
Craterostomum acuticaudatum Small strongyles: Including those resistant to some benzimidazole class compounds (adults and 4th stage larvae)
Coronocyclus spp. including: Coronocyclus coronatus, Coronocyclus labiatus, Coronocyclus labratus, Cyathostomum spp. including:
Cyathostomum catinatum, Cyathostomum pateratum, Cylicocyclus spp. including: Cylicocyclus insigne, Cylicocyclus leptostomum, Cylicocyclus nassatus, Cylicocyclus brevicapsulatus, Cylicodontophorus spp.
Cylicostephanus spp. including: Cylicostephanus calicatus, Cylicostephanus goldi, Cylicostephanus longibursatus, Cylicostephanus minutus Petrovinema poculatum Pinworms (adults and 4th stage larvae) - Oxyuris equi Ascarids (adults and 3rd and 4th stage larvae) - Parascaris equorum Hairworms (adults) - Trichostrongylus axei Large-mouth stomach worms (adults) - Habronema muscae Bots (oral and gastric stages) – Gasterophilus spp. including G. intestinalis and G. nasalis
Lungworms (adults and 4th stage larvae) - Dictyocaulus arnfieldi
Intestinal threadworms (adults) - Strongyloides westeri Summer sores caused by Habronema and Draschia spp. cutaneous third-stage larvae; dermatitis caused by neck threadworm microfilariae, Onchocerca

SPL Packages

ZIMECTERIN® Gold Paste (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI ucm062332.pdf

Summary

PROFENDER Topical Solution is indicated for the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and tapeworm infections caused by Dipylidium caninum (adults) and Taenia taeniaeformis (adults) in cats.

SPL Packages

Profender™ (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI FOI Summary oN 141-441 Approved December 11, 2017.pdf

Summary

For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense), and tapeworms (Dipylidium caninum, Taenia pisiformis).

SPL Packages

IVERHART MAX® Chew (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI FOI Summary sN-141-333 Approved September 28, 2017.pdf

Summary

This supplement provides for the addition of the treatment and control of adult tapeworm (Dipylidium caninum) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.
FOI UCM292003.pdf

Summary

For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis), and adult tapeworm (Taenia pisiformis, Echinococcus multilocularis and Echinococcus granulosus) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.

SPL Packages

Sentinel® Spectrum® (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM514664.pdf

Summary

1) For the removal of canine cestodes Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus, and removal and control of canine cestode Echinococcus multilocularis; and 2) For removal of feline cestodes Dipylidium caninum and Taenia taeniaeformis.

SPL Packages

Praziquantel Injection (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI ucm061606.pdf

Summary

For the removal of the following cestodes: Dogs - Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus, and Echinococcus multilocularis. Cats - Taenia taeniaeformis and Dipylidium caninum.

SPL Packages

Prazitech™ (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI FOI Summary sN 141-338 Approved June 21, 2017.pdf

Summary

This supplement provides for the addition of the treatment and control of adult tapeworm (Dipylidium caninum) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.
FOI UCM318617.pdf

Summary

For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis), and adult tapeworm (Taenia pisiformis, Echinococcus multilocularis, and Echinococcus granulosus) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.

SPL Packages

INTERCEPTOR™ PLUS (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI ucm118017.pdf

Summary

This is a regulatory supplement requested by the Division of Surveillance to bring product labeling into compliance with the pioneer product. Therefore, this supplement provides for separation of small strongyle fourth-stage larvae from the small strongyle adults, which are speciated in the indication section of the product labeling. In addition, it revises the Warning statement to read “Do not use in horses intended for human consumption.”
FOI ucm118016.pdf

Summary

This supplement provides for the use of EQUIMAX Paste in breeding, pregnant or lactating mares without adverse effects on fertility.
FOI ucm118014.pdf

Summary

Indications: Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism. EQUIMAX™ (ivermectin/praziquantel) Paste is indicated for the treatment and control of the following parasites:
Tapeworms: Anoplocephala perfoliata
Large Strongyles (adults): Strongylus vulgaris (also early forms in blood vessels), S. edentatus (also tissue stages), S. equinus, Triodontophorus spp.
Small Strongyles including those resistant to some benzimidazole class compounds (adults and fourth-stage larvae): Cyathostomum spp., Cylicocyclus spp., Cylicostephanus spp., Cylicodontophorus spp.
Pinworms (adults and fourth-stage larvae): Oxyuris equi
Ascarids (adults and third- and fourth-stage larvae): Parascaris equorum
Hairworms (adults): Trichostrongylus axei
Large-mouth Stomach Worms (adults): Habronema muscae
Bots (oral and gastric stages): Gasterophilus spp.
Lungworms (adults and fourth-stage larvae): Dictyocaulus arnfieldi
Intestinal Threadworms (adults): Strongyloides westeri
Summer sores caused by Habronema and Draschia spp. cutaneous third- stage larvae.
Dermatitis caused by Neck threadworm microfilariae, Onchocerca

SPL Packages

Equimax® (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI N133953_Supp_09_12_1991.pdf

Summary

This supplement provides for the addition of the following warning statement to the label: "Warning: Consider alternative therapy or use with caution in animals with pre-existing liver or kidney dysfunction."

SPL Packages

Vercom Paste Anthelmintic (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI ucm051414.pdf

Summary

This supplement provides for removal of the following statement from the Precautions section of the package insert: “The effective use of this drug for the treatment and control of tapeworms has not been evaluated in dogs less than 15 pounds.”
FOI UCM051416.pdf

Summary

For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae ( Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms ( Toxocara canis, Toxascaris leonina), hookworms ( Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) and tapeworms ( Dipylidium caninum, Taenia pisiformis).

SPL Packages

Iverhart Max® (ZIP)

FDA page: Open in Animal Drugs @ FDA

Usage

For removal of canine cestodes: Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus, and removal and control of canine cestode Echinococcus multilocularis. For removal of feline cestodes Dipylidium caninum and Taenia taeniaeformis. For removal of the canine cestode Echinococcus granulosus , and for removal and control of the canine cestode Echinococcus multilocularis . For removal of canine cestodes Dipylidium caninum and Taenia pisiformis .

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 56 and Cat 56 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog

Digestive

Vomiting (8544) Diarrhea (3160) Vomiting (44) Vomiting (44) Vomiting (44) Vomiting (43) Vomiting (41) Vomiting (38) Diarrhea (28) Diarrhea (28) Diarrhea (28) Diarrhea (27) Diarrhea (25) Diarrhea (24)

Neurologic

Tiredness (lethargy) (2503) Tiredness (lethargy) (24) Tiredness (lethargy) (24) Tiredness (lethargy) (24) Tiredness (lethargy) (24) Tiredness (lethargy) (22) Tiredness (lethargy) (22) Seizure NOS (11) Seizure NOS (11) Seizure NOS (11) Seizure NOS (11) Seizure NOS (11) Seizure NOS (11)

Effectiveness

Lack of efficacy (endoparasite) - heartworm (7888) Lack of efficacy (endoparasite) - hookworm (2357) Lack of efficacy (1266) Lack of efficacy (endoparasite) - heartworm (56) Lack of efficacy (endoparasite) - heartworm (56) Lack of efficacy (endoparasite) - heartworm (56) Lack of efficacy (endoparasite) - heartworm (56) Lack of efficacy (endoparasite) - heartworm (52) Lack of efficacy (endoparasite) - heartworm (49) Lack of efficacy (endoparasite) - hookworm (45) Lack of efficacy (endoparasite) - hookworm (45) Lack of efficacy (endoparasite) - hookworm (44) Lack of efficacy (endoparasite) - hookworm (44) Lack of efficacy (endoparasite) - hookworm (43) Lack of efficacy (endoparasite) - hookworm (42)

Other

INEFFECTIVE, HOOKS (2951) Other abnormal test result NOS (1558) Other abnormal test result NOS (14) Other abnormal test result NOS (14) Other abnormal test result NOS (14) Other abnormal test result NOS (14) Other abnormal test result NOS (13) Other abnormal test result NOS (13) Death (12) Death (12) Death (12) Death (12) Death (11) Death (10)

Cat

Digestive

Drooling (895) Vomiting (861) Vomiting (11) Vomiting (11) Vomiting (11) Vomiting (11) Vomiting (11) Vomiting (11) Drooling (7) Drooling (7) Drooling (6)

Skin & allergy

Hair loss at application site (709) Application site hair loss (9) Application site hair loss (9) Application site hair loss (9) Application site hair loss (9) Application site hair loss (8) Application site hair loss (8)

Neurologic

Tiredness (lethargy) (586) Unsteady walking (ataxia) (520) Tiredness (lethargy) (513) Tiredness (lethargy) (16) Tiredness (lethargy) (16) Tiredness (lethargy) (16) Tiredness (lethargy) (16) Tiredness (lethargy) (15) Tiredness (lethargy) (15)

Behavior

Behavioral disorder (unspecified) (469)

Effectiveness

Lack of efficacy (endoparasite) - tapeworm (822) Lack of efficacy (endoparasite) - tapeworm (10) Lack of efficacy (endoparasite) - tapeworm (10) Lack of efficacy (endoparasite) - tapeworm (10) Lack of efficacy (endoparasite) - tapeworm (10) Lack of efficacy (endoparasite) - tapeworm (8) Lack of efficacy (endoparasite) - tapeworm (8) Lack of efficacy (endoparasite) - roundworm NOS (7) Lack of efficacy (endoparasite) - roundworm NOS (7) Lack of efficacy (endoparasite) - roundworm NOS (7) Lack of efficacy (endoparasite) - roundworm NOS (7) Lack of efficacy (endoparasite) - roundworm NOS (7)

Other

Foaming at the mouth (9) Foaming at the mouth (9) Foaming at the mouth (9) Foaming at the mouth (9) Foaming at the mouth (8) Foaming at the mouth (8) Not eating (8) Not eating (8) Not eating (8) Not eating (8) Not eating (8) Not eating (8) Application site reddening (6) Application site reddening (6) Application site reddening (6) Application site reddening (6)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Newfoundland, Female, 10.66 year, 61.24 kilogram • Drug: MSK, Tablet, Oral, Dose: 2.25 tablet per animal • Reactions: Death • Outcome: Died

Report ID: USA-USFDACVM-2025-US-056128
Serious AE: Yes
Treated For AE: No
Sex: Female
Age: 10.66 Year
Weight: 61.240 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Tablet
Dose: 2.25 tablet per animal

Reactions Reported:

Death

Outcomes: Died

Dog, Havanese, Male, 12 year, 7.711 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Diarrhea, Inappropriate defecation • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-055917
Serious AE: No
Treated For AE: No
Sex: Male
Age: 12.00 Year
Weight: 7.711 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Tablet, chewable
Dose: 1 tablet per animal

Reactions Reported:

Diarrhea Inappropriate defecation

Outcomes: Outcome Unknown

Dog, Bulldog - French, Female, 3 year, 15.42 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal, Frequency: 1 per month • Reactions: Cyst NOS, Lack of efficacy (endoparasite) - heartworm • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-055991
Serious AE: No
Treated For AE: Yes
Sex: Female
Age: 3.00 Year
Weight: 15.420 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Tablet, chewable
Dose: 1 tablet per animal
Frequency: 1 per month

Reactions Reported:

Cyst NOS Lack of efficacy (endoparasite) - heartworm

Outcomes: Outcome Unknown

Dog, Crossbred Canine/dog, Male, 8 year, 23.94 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 23 Milligram per animal, Frequency: 1 per month • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-055799
Serious AE: No
Treated For AE: No
Sex: Male
Age: 8.00 Year
Weight: 23.940 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Tablet, chewable
Dose: 23 Milligram per animal
Frequency: 1 per month

Reactions Reported:

Lack of efficacy (endoparasite) - heartworm

Outcomes: Outcome Unknown

Dog, ['Pit Bull', 'Dog (unknown)'], Male, 4.33 year, 23.59 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal, Frequency: 1 per month • Reactions: Weight loss, Lack of efficacy (endoparasite) - hookworm • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-056117
Serious AE: No
Treated For AE: No
Sex: Male
Age: 4.33 Year
Weight: 23.590 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Tablet, chewable
Dose: 1 tablet per animal
Frequency: 1 per month

Reactions Reported:

Weight loss Lack of efficacy (endoparasite) - hookworm

Outcomes: Outcome Unknown

Dog, ['Terrier - Yorkshire', 'Bichon Frise'], Female, 15 year, 4.536 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 5.75 Milligram per animal • Reactions: Diarrhea, Vomiting, Vomiting • Outcome: Recovered/Normal

Report ID: USA-USFDACVM-2025-US-055882
Serious AE: No
Treated For AE: No
Sex: Female
Age: 15.00 Year
Weight: 4.536 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Tablet, chewable
Dose: 5.75 Milligram per animal

Reactions Reported:

Diarrhea Vomiting Vomiting

Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Male, 3 year, 4.85 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal • Reactions: Vomiting, Not defecating • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-055563
Serious AE: No
Treated For AE: No
Sex: Male
Age: 3.00 Year
Weight: 4.850 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Oral
Form: Tablet
Dose: 1 tablet per animal

Reactions Reported:

Vomiting Not defecating

Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 3 month, 1.95 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Lack of efficacy (endoparasite) - hookworm • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-056138
Serious AE: No
Treated For AE: Yes
Sex: Male
Age: 3.00 Month
Weight: 1.950 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Topical
Form: Solution
Dose: 1 dose per animal

Reactions Reported:

Lack of efficacy (endoparasite) - hookworm

Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

Share Your Thoughts

Let others know your experience or advice regarding this medication.

No community reviews yet. Be the first to share your experience.

This medication has not been reviewed by a veterinarian yet.

Medical Disclaimer: The medication details provided on PetWisePlus are for informational purposes only and are not a substitute for professional veterinary advice. Always consult your veterinarian about your pet's specific needs.

Praziquantel

Pet Owner Quick Guide

Praziquantel

Quick Facts

Warnings / Contraindications

Adverse Reactions

Most Reported Reactions

Storage & Handling

Documents

Promotional Materials (Marketing)

At a Glance

Counseling and Monitoring Highlights

Identifiers & Packages

Enriched Documents

Data Sources & Revision History

FDA Products & Applications (Animal Drugs @ FDA)

What It's For (FDA Label Highlights)

Credelio Quattro™-CA1 • Chewable Tablets • Oral

Praziquantel Tablets • Chewable Tablets • Oral

Credelio Quattro™ • Chewable Tablets • Oral

Duocare™ • Paste • Oral

Quest® Plus Gel • Gel • Oral

Virbantel® Worm X Plus® • Tablet (Chewable) • Oral

Centragard® • Transdermal Solution • Transdermal

Praziquantel Tablets • Chewable Tablets • Oral

Droncit™ 5.68% Injectible Solution • Liquid (Solution) • Subcutaneous, Intramuscular

Drontal™ Plus Taste Tabs™ Drontal™ Plus Quad Dewormer • Tablet • Oral

Drontal™ Tablets • Tablet • Oral

Droncit® Feline Cestocide Tablets Praziquantel 34 (Rx) Droncit® Canine Cestocide Tablets Tapeworm Dewormer for Dogs (OTC) Tapeworm Dewormer for Cats (OTC) • Tablet • Oral

ZIMECTERIN® Gold Paste • Paste • Oral

Profender™ • Liquid • Topical

IVERHART MAX® Chew • Chewable Tablets • Oral

Sentinel® Spectrum® • Chewable Tablets • Oral

Praziquantel Injection • Injectable Solution • Intramuscular, Subcutaneous

Prazitech™ • Liquid (Solution) • Intramuscular, Subcutaneous

INTERCEPTOR™ PLUS • Chewable Tablets • Oral

Equimax® • Paste • Oral

Vercom Paste Anthelmintic • Paste • Oral

Iverhart Max® • Tablet (Chewable) • Oral

Official Documents (FDA)

Credelio Quattro™-CA1 • 141619

Praziquantel Tablets • 200834

Credelio Quattro™ • 141581

Duocare™ • 141421

Quest® Plus Gel • 141216

Virbantel® Worm X Plus® • 141261

Centragard® • 141492

Praziquantel Tablets • 200734

Droncit™ 5.68% Injectible Solution • 111607

Drontal™ Plus Taste Tabs™ Drontal™ Plus Quad Dewormer • 141007

Drontal™ Tablets • 141008

Droncit® Feline Cestocide Tablets Praziquantel 34 (Rx) Droncit® Canine Cestocide Tablets Tapeworm Dewormer for Dogs (OTC) Tapeworm Dewormer for Cats (OTC) • 111798

ZIMECTERIN® Gold Paste • 141214

Profender™ • 141275

IVERHART MAX® Chew • 141441

Sentinel® Spectrum® • 141333

Praziquantel Injection • 200501

Prazitech™ • 200176

INTERCEPTOR™ PLUS • 141338

Equimax® • 141215

Vercom Paste Anthelmintic • 133953

Iverhart Max® • 141257

Usage

Contraindications

Side Effects

Top Reported Reactions (openFDA)

Adverse Event Case Summaries (openFDA)

Sep 25, 2025 • Dog • Newfoundland • Death • Died

Sep 24, 2025 • Dog • Havanese • Diarrhea, Inappropriate defecation • Outcome Unknown

Sep 23, 2025 • Dog • Bulldog - French • Cyst NOS, Lack of efficacy (endoparasite) - heartworm • Outcome Unknown

Sep 23, 2025 • Dog • Crossbred Canine/dog • Lack of efficacy (endoparasite) - heartworm • Outcome Unknown

Sep 23, 2025 • Dog • ['Pit Bull', 'Dog (unknown)'] • Weight loss, Lack of efficacy (endoparasite) - hookworm • Outcome Unknown

Sep 23, 2025 • Dog • ['Terrier - Yorkshire', 'Bichon Frise'] • Diarrhea, Vomiting • Recovered/Normal

Sep 20, 2025 • Cat • Domestic Shorthair • Vomiting, Not defecating • Outcome Unknown

Sep 18, 2025 • Cat • Domestic Shorthair • Lack of efficacy (endoparasite) - hookworm • Outcome Unknown

Overdose Information

Storage & Handling

Share Your Thoughts