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Pyrantel Pamoate

Detailed information about Pyrantel Pamoate

Official label facts Owner quick guide first Marketing clearly labeled
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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of adult hookworm ( Ancylostoma caninum , Ancylostoma braziliense , and Uncinaria stenocephala ) and roundworm ( Tox...

What it does:

For the removal and control of infections from the following mature parasites: Large strongyles ( Strongylus vulgaris , Strongylus edentatus , Strongylus equinus ), small strongyles pinworms ( Oxyuris ), and large roundw...

When it's needed:

Administered as a single dose mixed with the usual grain ration, or by stomach tube, or by dose syringe. Not for use in horses and ponies to be slaughtered for food purposes. When the drug is for administration by stomac...

Call your vet sooner if you notice:

  • Administered as a single dose mixed with the usual grain ration, or by stomach tube, or by dose syringe. Not for use in horses and ponies to be slaughtered for food purposes. When the drug is for administration by stomach tube, it shall be labeled: "Federal law restricts this drug to use by or on the order of a licensed veterinarian.'' When the drug is not for administration by stomach tube, it shall be labeled: ``Consult your veterinarian for in the diagnosis, control, and treatment of parasitism.'' Administer in the animal's feed bowl as a single dose by itself or mixed in a small quantity of food. Additional treatment may be required and should be confirmed by examination within 2 to 4 weeks. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

Commonly reported reactions:

  • (2 reports)
  • (2 reports)
  • (1 reports)

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
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Pyrantel Pamoate

Pyrantel Pamoate

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Elanco US Inc.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Elanco US Inc.
Form: Chewable Tablets, Flavored Tablets, Liquid (Suspension), Paste, Tablet, Tablet (Chewable)
Identifiers:
ANADA: 200007 ANADA: 200028 ANADA: 200246 ANADA: 200248 ANADA: 200281 ANADA: 200338 ANADA: 200342 ANADA: 200350 ANADA: 200352 ANADA: 200353 ANADA: 200445 ANADA: 200600 NADA: 100237 NADA: 101331 NADA: 129831 NADA: 139191 NADA: 140971 NADA: 141007 NADA: 141008 NADA: 141257
Source metadata:

Warnings / Contraindications

Administered as a single dose mixed with the usual grain ration, or by stomach tube, or by dose syringe. Not for use in horses and ponies to be slaughtered for food purposes. When the drug is for administration by stomach tube, it shall be labeled: "Federal law restricts this drug to use by or on the order of a licensed veterinarian.'' When the drug is not for administration by stomach tube, it shall be labeled: ``Consult your veterinarian for in the diagnosis, control, and treatment of parasitism.'' Administer in the animal's feed bowl as a single dose by itself or mixed in a small quantity of food. Additional treatment may be required and should be confirmed by examination within 2 to 4 weeks. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

  • High: Administered as a single dose mixed with the usual grain ration, or by stomach tube, or by dose syringe. Not for use in horses and ponies to be slaughtered for food purposes. When the drug is for administration by stomach tube, it shall be labeled: "Federal law restricts this drug to use by or on the order of a licensed veterinarian.'' When the drug is not for administration by stomach tube, it shall be labeled: ``Consult your veterinarian for in the diagnosis, control, and treatment of parasitism.'' Administer in the animal's feed bowl as a single dose by itself or mixed in a small quantity of food. Additional treatment may be required and should be confirmed by examination within 2 to 4 weeks. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
23
Serious reports
6
Species represented
2
Most Reported Reactions
Reaction Cases Species Serious cases
2 Cat, Dog 1
2 Cat, Dog 0
1 Cat 1
1 Cat 1
1 Cat 1
1 Cat 1
1 Dog 1
1 Cat 0

Species coverage: Cat (22) Dog (10)

View detailed reaction table
Reaction Species Seriousness Frequency Reports
Cat Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Dog Serious - 1
Cat Non-serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Dog Serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Cat Non-serious - 1
Cat Serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Cat Non-serious - 1
Cat Unknown - -
Cat Unknown - -
Cat Unknown - -
Dog Unknown - -
Dog Unknown - -
Dog Unknown - -
Dog Unknown - -
Dog Unknown - -
Cat Unknown - -
Source metadata:

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 80 • Secondary summaries: 0

Official label facts
Secondary summaries

No source yet.

Source metadata:

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.
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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 12, 2026, 10:42 PM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Anthelban V Credelio Quattro™ Credelio Quattro™-CA1 Dog Wormer Chewable Tablets D-Worm™ Adams™ Dog Wormer Tablets Drontal™ Plus Taste Tabs™ Drontal™ Plus Quad Dewormer Drontal™ Tablets Evict® Exodus™ Paste Exodus® Multi Dose Heartgard® Plus IVERHART MAX® Chew Iverhart Max® Liqui-Vict 2X™ Nemex-2 Nemex RFD Liquid Wormer NexGard® PLUS Primex® Primex® Canine Primex® 2-X Primex™ Equine Pyrantel Pamoate Chewable Tablets Pyrantel Pamoate Paste Pyrantel Pamoate Suspension-2.27mg Pyrantel Pamoate Suspension-4.54mg Pyrantel Pamoate Suspension Simparica TRIO® Strongid® Paste Banminth®-P Paste Strongid® T Tri-Heart Plus Chewable Tablets Virbantel® Worm X Plus® WormX®
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat And Kitten, Dog, Dog And Puppy, Dogs And Puppies, Horse, No Use Class Stated Or Implied, Pony
Rx/OTC: OTC, RX, RX/OTC
Form/route: Chewable Tablets, Flavored Tablets, Liquid (Suspension), Paste, Tablet, Tablet (Chewable) • Nasogastric, Oral
Applications: NADA 141-554 • NADA 141-619 • NADA 141-581 • NADA 141-521 • ANADA 200-338 • NADA 141-261 • NADA 141-007 • NADA 141-008 • NADA 141-441 • ANADA 200-350 • ANADA 200-600 • ANADA 200-342 • ANADA 200-246 • ANADA 200-007 • ANADA 200-248 • NADA 101-331 • ANADA 200-028 • NADA 129-831 • NADA 139-191 • NADA 140-971 • NADA 141-257 • NADA 100-237 • ANADA 200-445 • ANADA 200-352 • ANADA 200-353 • ANADA 200-281 • NADA 91739
Documents: 41 (FOI: 41) • SPL: 39 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 56 • Cat 8 • View
Case summaries: 11 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: B74.8 ICD10_CM: B88.1
Other filariases

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Administered as a single dose mixed with the usual grain ration, or by stomach tube, or by dose syringe. Not for use in horses and ponies to be slaughtered for food purposes. When the drug is for administration by stomach tube, it shall be labeled: "Federal law restricts this drug to use by or on the order of a licensed veterinarian.'' When the drug is not for administration by stomach tube, it shall be labeled: ``Consult your veterinarian for in the diagnosis, control, and treatment of parasitism.'' Administer in the animal's feed bowl as a single dose by itself or mixed in a small quantity of food. Additional treatment may be required and should be confirmed by examination within 2 to 4 weeks. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism. (Contraindication, High)
Top reaction signals
Abnormal cytology (1) Administration error NOS (1) Application site hair loss (1) Bacterial skin infection NOS (1) Death (1) Distension of abdomen (1) Hyperglycaemia (1) Hypotension (1) Injection site sarcoma (1) Itching (1) Lack of efficacy (endoparasite) - hookworm (1) Lack of efficacy (endoparasite) - tapeworm (1) Lack of efficacy (endoparasite) - tapeworm (1) Lack of efficacy - NOS (1) Lethargy (see also Central nervous system depression in Neurological) (1) Not drinking (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200007 ANADA: 200028 ANADA: 200246 ANADA: 200248 ANADA: 200281 ANADA: 200338 ANADA: 200342 ANADA: 200350 ANADA: 200352 ANADA: 200353 ANADA: 200445 ANADA: 200600 NADA: 100237 NADA: 101331 NADA: 129831 NADA: 139191 NADA: 140971 NADA: 141007 NADA: 141008 NADA: 141257 NADA: 141261 NADA: 141441 NADA: 141521 NADA: 141554
Package NDC Product NDC Form / Route Status
0010-4012-01 0010 -
0010-4012-02 0010 -
0010-4012-03 0010 -
0010-4012-04 0010 -
0010-4013-01 0010 -
0010-4013-02 0010 -
0010-4013-03 0010 -
0010-4013-04 0010 -
0010-4014-01 0010 -
0010-4014-02 0010 -
0010-4014-03 0010 -
0010-4014-04 0010 -
0061-1339-03 0061 -
0061-1346-04 0061 -
0061-1353-03 0061 -
21091-500-02 21091 -
21091-603-02 21091 -
21091-603-12 21091 -
21091-641-01 21091 -
21091-641-02 21091 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 44 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Administered as a single dose mixed with the usual grain ration, or by stomach tube, or by dose syringe. Not for use in horses and ponies to be slaughtered for… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Vomiting, Diarrhoea, Lethargy (see also Central nervous system depression in 'Neurological'), Emesis (multiple), Lack of effi… (Official, 2026-02-12)
  • usage: For the removal and control of infections from the following mature parasites: Large strongyles ( Strongylus vulgaris , Strongylus edentatus , Strongylus equin… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
NexGard® PLUS
RX
Afoxolaner Moxidectin Pyrantel Pamoate
Chewable Tablets • Oral
Label highlights
Official documents
Boehringer lngelheim Animal Health USA, Inc. NADA 141-554 Approved Feb 2, 2026
Credelio Quattro™-CA1
RX
Lotilaner Moxidectin Praziquantel Pyrantel Pamoate
Chewable Tablets • Oral
Label highlights
Official documents
Elanco US Inc. NADA 141-619 Approved Jan 5, 2026
Credelio Quattro™
RX
Lotilaner Moxidectin Praziquantel Pyrantel Pamoate
Chewable Tablets • Oral
Label highlights
Official documents
Elanco US Inc. NADA 141-581 Approved Nov 3, 2025
Simparica TRIO®
RX
Moxidectin Pyrantel Pamoate Sarolaner
Chewable Tablets • Oral
Label highlights
Official documents
Zoetis Inc. NADA 141-521 Approved Jun 3, 2025
Tri-Heart Plus Chewable Tablets
RX
Ivermectin Pyrantel Pamoate
Tablet (Chewable) • Oral
Label highlights
Official documents
Diamond Animal Health, Inc. ANADA 200-338 Approved Feb 8, 2024
Virbantel® Worm X Plus®
OTC
Praziquantel Pyrantel Pamoate
Tablet (Chewable) • Oral
Label highlights
Official documents
Virbac AH, Inc. NADA 141-261 Approved Jul 13, 2023
Drontal™ Plus Taste Tabs™ Drontal™ Plus Quad Dewormer
RX
Febantel Praziquantel Pyrantel Pamoate
Tablet • Oral
Label highlights
Official documents
Elanco US Inc. NADA 141-007 Approved Jun 15, 2022
Drontal™ Tablets
OTC
Praziquantel Pyrantel Pamoate
Tablet • Oral
Label highlights
Official documents
Elanco US Inc. NADA 141-008 Approved May 10, 2022
IVERHART MAX® Chew
RX
Ivermectin Praziquantel Pyrantel Pamoate
Chewable Tablets • Oral
Label highlights
Official documents
Virbac AH, Inc. NADA 141-441 Approved Nov 19, 2020
Exodus™ Paste Exodus® Multi Dose
OTC
Pyrantel Pamoate
Paste • Oral
Label highlights
Official documents
Bimeda Animal Health Limited ANADA 200-350 Approved May 29, 2020
WormX®
OTC
Pyrantel Pamoate
Flavored Tablets • Oral
Label highlights
Official documents
Sergeant’s Pet Care Products Inc. ANADA 200-600 W Apr 1, 2019
Pyrantel Pamoate Paste
OTC
Pyrantel Pamoate
Paste • Oral
Label highlights
Official documents
Farnam Companies, Inc. ANADA 200-342 Approved Dec 27, 2017
Anthelban V
RX/OTC
Pyrantel Pamoate
Liquid (Suspension) • Oral
Label highlights
Official documents
Elanco US Inc. ANADA 200-246 Approved Dec 19, 2017
Liqui-Vict 2X™
OTC
Pyrantel Pamoate
Liquid (Suspension) • Oral
Label highlights
Official documents
Happy Jack, Inc. ANADA 200-007 Approved Dec 19, 2017
Pyrantel Pamoate Suspension-2.27mg Pyrantel Pamoate Suspension-4.54mg Pyrantel Pamoate Suspension
OTC
Pyrantel Pamoate
Liquid (Suspension) • Oral
Label highlights
Official documents
Cronus Pharma Specialities India Private Ltd. ANADA 200-248 Approved Jul 19, 2017
Dog Wormer Tablets
OTC
Pyrantel Pamoate
Tablet • Oral
Label highlights
Official documents
Farnam Companies, Inc. NADA 101-331 Approved Jul 12, 2017
Evict®
OTC
Pyrantel Pamoate
Liquid (Suspension) • Oral
Label highlights
Official documents
Pegasus Laboratories, Inc. ANADA 200-028 W Jul 11, 2017
Strongid® Paste Banminth®-P Paste
OTC
Pyrantel Pamoate
Paste • Oral
Label highlights
Official documents
Zoetis Inc. NADA 129-831 Approved Feb 23, 2017
Dog Wormer Chewable Tablets D-Worm™ Adams™
OTC
Pyrantel Pamoate
Tablet (Chewable) • Oral
Label highlights
Official documents
Farnam Companies, Inc. NADA 139-191 Approved Jun 1, 2016
Heartgard® Plus
RX
Ivermectin Pyrantel Pamoate
Tablet (Chewable) • Oral
Label highlights
Official documents
Boehringer lngelheim Animal Health USA, Inc. NADA 140-971 Approved Jun 1, 2016
Iverhart Max®
RX
Ivermectin Praziquantel Pyrantel Pamoate
Tablet (Chewable) • Oral
Label highlights
Official documents
Virbac AH, Inc. NADA 141-257 Approved Jun 1, 2016
Nemex-2 Nemex RFD Liquid Wormer
OTC
Pyrantel Pamoate
Liquid (Suspension) • Oral
Label highlights
Official documents
Zoetis Inc. NADA 100-237 Approved Jun 1, 2016
Primex®
OTC
Pyrantel Pamoate
Liquid (Suspension) • Oral
Label highlights
Official documents
First Priority, Inc. ANADA 200-445 Approved Jun 1, 2016
Primex® Canine Primex® 2-X
OTC
Pyrantel Pamoate
Liquid (Suspension) • Oral
Label highlights
Official documents
First Priority, Inc. ANADA 200-352 Approved Jun 1, 2016
Primex™ Equine
RX
Pyrantel Pamoate
Liquid (Suspension) • Oral
Label highlights
Official documents
First Priority, Inc. ANADA 200-353 Approved Jun 1, 2016
Pyrantel Pamoate Chewable Tablets
OTC
Pyrantel Pamoate
Tablet (Chewable) • Oral
Label highlights
Official documents
Virbac AH, Inc. ANADA 200-281 Approved Jun 1, 2016
Strongid® T
RX/OTC
Pyrantel Pamoate
Liquid (Suspension) • Oral, Nasogastric
Label highlights
Official documents
Zoetis Inc. NADA 91739 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains 9.375 mg afoxolaner, 45 mcg moxidectin, and 18.75 mg pyrantel; 18.75 mg afoxolaner, 90 mcg moxidectin, and 37.5 mg pyrantel; 37.5 mg afoxolaner, 180 mcg moxidectin, and 75 mg pyrantel; 75 mg afoxolaner, 360 mcg moxidectin, and 150 mg pyrantel; or 150 mg afoxolaner, 720 mcg moxidectin, and 300 mg pyrantel.
Dogs
Indication

For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of adult hookworm (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala) and roundworm (Toxocara canis and Toxascaris leonina) infections. Kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of Ixodes scapularis (blacklegged tick), Rhipicephalus sanguineus (brown dog tick), Dermacentor variabilis (American dog tick), Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), and Haemaphysalis longicornis (longhorned tick) infestations for one month in dogs and puppies eight weeks of age and older, weighing four pounds of body weight or greater. For the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

Dosage

Administer orally once a month at the minimum dose of 1.14 mg/lb (2.5 mg/kg) afoxolaner, 5.45 mcg/lb (12 mcg/kg) moxidectin, and 2.27 mg/lb (5.0 mg/kg) pyrantel (as pamoate salt). For heartworm disease prevention, give once monthly for at least six months after last exposure to mosquitoes.

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
Each chewable tablet contains: 56.25 mg lotilaner, 0.056 mg moxidectin, 14.25 mg praziquantel, and 14.25 mg pyrantel* 112.5 mg lotilaner, 0.113 mg moxidectin, 28.5 mg praziquantel, and 28.5 mg pyrantel* 225 mg lotilaner, 0.225 mg moxidectin, 57 mg praziquantel, and 57 mg pyrantel* 450 mg lotilaner, 0.45 mg moxidectin, 114 mg praziquantel, and 114 mg pyrantel* 900 mg lotilaner, 0.9 mg moxidectin, 228 mg praziquantel, and 228 mg pyrantel* *As pamoate salt
Dogs
Indication

For the treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.

Dosage

Administer orally at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt).

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
56.25 mg lotilaner, 0.056 mg moxidectin, 14.25 mg praziquantel, and 14.25 mg pyrantel; 112.5 mg lotilaner, 0.113 mg moxidectin, 28.5 mg praziquantel, and 28.5 mg pyrantel; 225 mg lotilaner, 0.225 mg moxidectin, 57 mg praziquantel, and 57 mg pyrantel; 450 mg lotilaner, 0.45 mg moxidectin, 114 mg praziquantel, and 114 mg pyrantel; 900 mg lotilaner, 0.9 mg moxidectin, 228 mg praziquantel, and 228 mg pyrantel
Dogs
Indication

Credelio Quattro™ is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina), hookworm (fourth stage larvae, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala), and tapeworm (Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus) infections. Credelio Quattro™ kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma Americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (longhorned tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater. Credelio Quattro™ is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

Dosage

Administer orally once a month, at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt).

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains either: 3.0 mg sarolaner / 0.06 mg moxidectin / 12.5 mg pyrantel (as pamoate salt), 6.0 mg sarolaner / 0.12 mg moxidectin / 25.0 mg pyrantel (as pamoate salt), 12.0 mg sarolaner / 0.24 mg moxidectin / 50.0 mg pyrantel (as pamoate salt), 24.0 mg sarolaner / 0.48 mg moxidectin / 100 mg pyrantel (as pamoate salt), 48.0 mg sarolaner / 0.96 mg moxidectin / 200 mg pyrantel (as pamoate salt) or 72.0 mg sarolaner / 1.44 mg moxidectin / 300 mg pyrantel (as pamoate salt)
Dogs
Indication

Simparica TRIO® is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections. Simparica TRIO® kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated dog, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (Asian longhorned tick) for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater. Simparica TR O® is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

Dosage

SimparicaTRIO® is given orally, once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt).

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains either 68 micrograms of ivermectin and 57 milligrams of pyrantel (as pamoate salt), or 136 micrograms ivermectin and 114 milligrams pyrantel, or 272 micrograms and 227 milligrams, respectively.
Dogs
Indication
Ivermectin: to prevent canine heartworm diseases by eliminating the tissue larval stage of Dirofilaria immitis for a month (30 days) after infection. Pyrantel pamoate: for the treatment and control of adult Toxocara canis, Toxascaris leonina, Ancylostoma caninum, A braziliense, and Uncinaria stenocephala.
Dosage
A minimum of 6 micrograms of ivermectin and 5 milligrams of pyrantel (as pamoate salt) per kilogram (2.72 micrograms and 2.27 milligrams per pound) of body weight. up to 25 pounds: 68 micrograms ivermectin and 57 milligrams pyrantel pamoate 26 to 50 pounds: 136 micrograms ivermectin and 114 milligrams pyrantel pamoate 51 to 100 pounds: 272 micrograms ivermectin and 227 milligrams pyrantel pamoate
Limitations
Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dogs And Puppies
Composition / specifications
Each chewable tablet contains: 30 mg praziquantel and 30 mg pyrantel pamoate (For Small Dogs and Puppies) or 114 mg praziquantel and 114 mg pyrantel pamoate (For Medium and Large Dogs).
Dogs (Puppies and Small Dogs 6.0-25 Lbs)
Indication
For the treatment and control of roundworms (Toxocara canis and Toxascaris leonine), hookworms (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala), and tapeworms (Dipylidium caninum and Taenia pisiformis) in dogs and puppies.
Dosage
Administer a minimum dose of 5 milligrams praziquantel and 5 milligrams pyrantel pamoate per kilogram body weight (2.27 milligrams praziquantel and 2.27 milligrams pyrantel pamoate per pound body weight) according to the dosing tables on labeling.
Limitations

Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.Do not de-worm a dog or puppy that is sick. Consult a veterinarian for diagnosis of the illness. VIRBANTEL® Flavored Chewables are safe for use in puppies 12 weeks or older and adult dogs. Safety in breeding dogs and pregnant bitches has not been tested.

Dogs (Medium and Large Dogs- Greater than 25 Lbs)
Indication
For the treatment and control of roundworms (Toxocara canis and Toxascaris leonine), hookworms (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala), and tapeworms (Dipylidium caninum and Taenia pisiformis) in dogs and puppies.
Dosage
Administer a minimum dose of 5 milligrams praziquantel and 5 milligrams pyrantel pamoate per kilogram body weight (2.27 milligrams praziquantel and 2.27 milligrams pyrantel pamoate per pound body weight) according to the dosing tables on labeling.
Limitations

Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.Do not de-worm a dog or puppy that is sick. Consult a veterinarian for diagnosis of the illness. VIRBANTEL® Flavored Chewables are safe for use in puppies 12 weeks or older and adult dogs. Safety in breeding dogs and pregnant bitches has not been tested.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, Restricted During Pregnancy • Dog, Excluding Under 2 Pounds • Dog And Puppy, Excluding Under 3 Weeks Age
Composition / specifications
Each tablet contains either:
1) 22.7 milligrams praziquantel, 22.7 milligrams pyrantel base, and 113.4 milligrams febantel
2) 68 milligrams praziquantel, 68 milligrams pyrantel base, and 340.2 milligrams febantel
or
3) 136 milligrams praziquantel, 136 milligrams pyrantel base, and 680.4 milligrams febantel
Dogs: Weighing 2 to 4 pounds (0.9 to 1.8 kilograms)
Indication
For the removal of tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus); hookworms (Ancylostoma caninum, Uncinaria stenocephala); ascarids (Toxocara canis, Toxascaris leonina); and whipworms (Trichuris vulpis) and for removal and control of tapeworm (Echinococcus multilocularis).
Dosage
0.5 Tablet No.1
Limitations
Do not use in pregnant animals. Do not use in dogs weighing less than 2 pounds (0.9 kilogram) or in puppies less than 3 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian
Dogs: Weighing 5 to 7 pounds (2.3 to 3.2 kilograms):
Indication
For the removal of tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus); hookworms (Ancylostoma caninum, Uncinaria stenocephala); ascarids (Toxocara canis, Toxascaris leonina); and whipworms (Trichuris vulpis) and for removal and control of tapeworm (Echinococcus multilocularis).
Dosage
1 tablet No.1
Limitations
Do not use in pregnant animals. Do not use in dogs weighing less than 2 pounds (0.9 kilogram) or in puppies less than 3 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian
Dogs: Weighing 8 to 12 pounds (3.6 to 5.4 kilograms)
Indication
For the removal of tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus); hookworms (Ancylostoma caninum, Uncinaria stenocephala); ascarids (Toxocara canis, Toxascaris leonina); and whipworms (Trichuris vulpis) and for removal and control of tapeworm (Echinococcus multilocularis).
Dosage
1.5 tablet No.1
Limitations
Do not use in pregnant animals. Do not use in dogs weighing less than 2 pounds (0.9 kilogram) or in puppies less than 3 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian
Dogs: Weighing 13 to 18 pounds (5.9 to 8.2 kilograms)
Indication
For the removal of tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus); hookworms (Ancylostoma caninum, Uncinaria stenocephala); ascarids (Toxocara canis, Toxascaris leonina); and whipworms (Trichuris vulpis) and for removal and control of tapeworm (Echinococcus multilocularis).
Dosage
2 tablets No.1
Limitations
Do not use in pregnant animals. Do not use in dogs weighing less than 2 pounds (0.9 kilogram) or in puppies less than 3 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian
Dogs: Weighing 19 to 25 pounds (8.6 to 11.4 kilograms)
Indication
For the removal of tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus); hookworms (Ancylostoma caninum, Uncinaria stenocephala); ascarids (Toxocara canis, Toxascaris leonina); and whipworms (Trichuris vulpis) and for removal and control of tapeworm (Echinococcus multilocularis).
Dosage
2.5 tablets No.1
Limitations
Do not use in pregnant animals. Do not use in dogs weighing less than 2 pounds (0.9 kilogram) or in puppies less than 3 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian
Dogs: Weighing 26 to 30 pounds (11.8 to 13.6 kilograms)
Indication
For the removal of tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus); hookworms (Ancylostoma caninum, Uncinaria stenocephala); ascarids (Toxocara canis, Toxascaris leonina); and whipworms (Trichuris vulpis) and for removal and control of tapeworm (Echinococcus multilocularis).
Dosage
1 tablet No.2
Limitations
Do not use in pregnant animals. Do not use in dogs weighing less than 2 pounds (0.9 kilogram) or in puppies less than 3 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian
Dogs: Weighing 31 to 44 pounds (14.1 to 20.0 kilograms)
Indication
For the removal of tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus); hookworms (Ancylostoma caninum, Uncinaria stenocephala); ascarids (Toxocara canis, Toxascaris leonina); and whipworms (Trichuris vulpis) and for removal and control of tapeworm (Echinococcus multilocularis).
Dosage
1.5 tablets No.2
Limitations
Do not use in pregnant animals. Do not use in dogs weighing less than 2 pounds (0.9 kilogram) or in puppies less than 3 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian
Dogs: Weighing 45 to 60 pounds (20.4 to 27.2 kilograms)
Indication
For the removal of tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus); hookworms (Ancylostoma caninum, Uncinaria stenocephala); ascarids (Toxocara canis, Toxascaris leonina); and whipworms (Trichuris vulpis) and for removal and control of tapeworm (Echinococcus multilocularis).
Dosage
2.0 tablets No.2 or 1.0 Tablet No. 3
Limitations
Do not use in pregnant animals. Do not use in dogs weighing less than 2 pounds (0.9 kilogram) or in puppies less than 3 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian
Dogs: Weighing 61 to 90 pounds (27.7 to 40.9 kilograms)
Indication
For the removal of tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus); hookworms (Ancylostoma caninum, Uncinaria stenocephala); ascarids (Toxocara canis, Toxascaris leonina); and whipworms (Trichuris vulpis) and for removal and control of tapeworm (Echinococcus multilocularis).
Dosage
1.5 tablets No. 3
Limitations
Do not use in pregnant animals. Do not use in dogs weighing less than 2 pounds (0.9 kilogram) or in puppies less than 3 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian
Dogs: Weighing 91 to 120 pounds (41.3 to 54.5 kilograms)
Indication
For the removal of tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus); hookworms (Ancylostoma caninum, Uncinaria stenocephala); ascarids (Toxocara canis, Toxascaris leonina); and whipworms (Trichuris vulpis) and for removal and control of tapeworm (Echinococcus multilocularis).
Dosage
2 tablets No. 3
Limitations
Do not use in pregnant animals. Do not use in dogs weighing less than 2 pounds (0.9 kilogram) or in puppies less than 3 weeks of age. Federal law restricts this drug to use by or on the order of a licensed veterinarian

FDA page: Open in Animal Drugs @ FDA

Species: Cat And Kitten, Excluding Under 2 Months Of Age Or Under 2 Pounds Weight
Composition / specifications
Each tablet contains 18.2 mg praziquantel and 72.6 mg pyrantel base as pyrantel pamoate.
Cats and Kittens (Greater Than 2 Months of Age Or At Least 2 Lbs)
Indication
For removal of the common parasites of cats and kittens including tapeworms (Dipylidium caninum, Taenia taeniaeformis), hookworms (Ancylostoma tubaeforme), and large roundworms (Toxocara cati).
Dosage
Administer a minimum dose of 2.27 mg praziquantel and 9.2 pyrantel pamoate per pound of bodyweight according to the dosing tables on labeling.
Limitations

May be given directly by mouth or in a small amount of food. Do not withhold food prior to or after treatment. If reinfection occurs, treatment may be repeated. Consult your veterinarian before giving to sick or pregnant animals. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Not for use in kittens less than 2 months of age or weighing less than 2.0 pounds.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains either: 1) 34 micrograms (mcg) ivermectin, 28.5 milligrams (mg) pyrantel pamoate, and 28.5 mg praziquantel; 2) 68 mcg ivermectin, 57 mg pyrantel pamoate, and 57 mg praziquantel; 3) 136 mcg ivermectin, 114 mg pyrantel pamoate, and 114 mg praziquantel; or 4) 272 mcg ivermectin, 228 mg pyrantel pamoate, and 228 mg praziquantel.
Dogs
Indication

For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense), and tapeworms (Dipylidium caninum, Taenia pisiformis).

Dosage

Administer orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb), and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight, as follows:

  1. 6.0 to 12 pounds- one tablet containing 34 micrograms (mcg) ivermectin, 28.5 milligrams (mg) pyrantel pamoate, and 28.5 mg praziquantel
  2. 12.1 to 25 pounds- one tablet containing 68 mcg ivermectin, 57 mg pyrantel pamoate, and 57 mg praziquantel
  3. 25.1 to 50 pounds- one tablet containing 136 mcg ivermectin, 114 mg pyrantel pamoate, and 114 mg praziquantel 
  4. 50.1 to 100 one tablet containing 272 mcg ivermectin, 228 mg pyrantel pamoate, and 228 mg praziquantel
Limitations

Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: No Use Class Stated Or Implied
Composition / specifications
Each milliliter of paste contains 171 milligrams of pyrantel base (as pyrantel pamoate).
Horses and ponies
Indication

For removal and control of infections from the following mature parasites: large strongyles (Strongylus vulgaris, S. edentatus, S. equinus); small strongyles; pinworms (Oxyuris equi); and large roundworms (Parascaris equorum).

Dosage

Administer as single dose by depositing paste on dorsum of the tongue using the dose syringe. Equivalent of 3 milligrams pyrantel base per pound of body weight.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each tablet contains pyrantel pamoate equivalent to 22.7 mg or 113.5 mg pyrantel base
Label highlights
Indication

For removal of ascarids (Toxocara canis; Toxascaris leonina), and hookworms (Ancylostoma caninum; Uncinaria stenocephala) in dogs and puppies. To prevent reinfection of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping

Dosage

22.7 mg tablet in puppies and small dogs

For the removal of large roundworms (Ascarids) and hookworms, give 1 tablet for each 10 lb of body weight. Dosage is designed to provide at least 2.27 mg per pound body weight for dogs weighing over 5 lb, and at least 4.54 mg per pound of body weight for dogs weighing 5 lb or less. For dogs weighing more than 10 lb, tablets may be broken in half to provide ½ tablet for each additional 5 lb of body weight.

113.5 mg tablet in large dogs

For the removal of large roundworms (Ascarids) and hookworms in adult dogs or young dogs weighing more than 25 lb, administer tablets according to the weight of the animal.

Limitations

Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Retreatment of adult dogs may be necessary at monthly intervals as determined by laboratory fecal examinations. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production • Pony, Not For Food
Composition / specifications
Each milliliter of paste contains 226 milligrams of pyrantel base (as pyrantel pamoate).
Horses (and ponies)
Indication
For the removal and control of mature infections of tapeworms (Anoplocephala perfoliata).
Dosage
Equivalent of 6 milligrams pyrantel base per pound of body weight.
Limitations
Administer as single oral dose. Not for use in horses intended for food.
Indication
For removal and control of infections from the following mature parasites: large strongyles (Strongylus vulgaris, S. edentatus, S. equinus); small strongyles; pinworms (Oxyuris equi); and large roundworms (Parascaris equorum).
Dosage
Equivalent of 3 milligrams pyrantel base per pound of body weight.
Limitations
Administer as single dose by depositing paste on dorsum of the tongue using the dose syringe. Not for use in horses intended for food. It is recommended that severely debilitated animals not be treated with this preparation. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production
Composition / specifications
Pyrantel pamoate suspension contains pyrantel pamoate equivalent to 50 milligrams of pyrantel base per milliliter.
Horses (ponies)
Indication
For the removal and control of infections from the following mature parasites: Large strongyles (Strongylus vulgaris Strongylus edentatus, Strongylus equinus), small strongyles pinworms (Oxyuris), and large roundworms (Parascaris).
Dosage
Equivalent of 3 milligrams pyrantel base per pound of body weight.
Limitations
Administered as a single dose mixed with the usual grain ration, or by stomach tube, or by dose syringe. Not for use in horses and ponies to be slaughtered for food purposes. When the drug is for administration by stomach tube, it shall be labeled: "Federal law restricts this drug to use by or on the order of a licensed veterinarian.” When the drug is not for administration by stomach tube, it shall be labeled: “Consult your veterinarian for in the diagnosis, control, and treatment of parasitism.”

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Pyrantel pamoate suspension contains pyrantel pamoate equivalent to 4.54 milligrams of pyrantel base per milliliter.
Dogs (and puppies)
Indication
For the removal of large roundworms (Toxocara canis and Toxascaris leonina) and hookworms (Ancylostoma caninum and Uncinaria stenocephala)
Dosage
Equivalent of 2.27 milligrams of pyrantel base per pound of body weight.
Limitations
Administer in the animal's feed bowl as a single dose by itself or mixed in a small quantity of food. Additional treatment may be required and should be confirmed by examination within 2 to 4 weeks. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism
Dogs (puppies, adults, lactating bitches after whelping)
Indication
To prevent reinfections of Toxocara canis
Dosage
Equivalent to 2.27 milligrams of pyrantel base per pound of body weight.
Limitations
Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Pyrantel pamoate suspension contains pyrantel pamoate equivalent to 2.27 or 4.54 milligrams of pyrantel base per milliliter.
Dogs (and puppies)
Indication
For the removal of large roundworms (Toxocara canis and Toxascarias leonina) and hookworms (Ancylostoma caninum and Uncinaria stenocephala).
Dosage
Equivalent of 2.27 milligrams of pyrantel base per pound of body weight.
Limitations
Administer in the animal's feed bowl as a single dose by itself or mixed in a small quantity of food. Additional treatment may be required and should be confirmed by examination within 2 to 4 weeks. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.
Dogs (puppies, adults, and in lactating bitches after whelping)
Indication
To prevent reinfections of Toxocara canis.
Dosage
Equivalent to 2.27 milligrams of pyrantel base per pound of body weight.
Limitations
Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each tablet contains pyrantel pamoate equivalent to 22.7, 45.4, or 113.5 milligrams of pyrantel base.
Dogs
Indication
For removal and control of large roundworms (ascarids) (Toxocara canis and Toxascaris leonina), and hookworms (Ancylostoma caninum and Uncinaria stenocephala).
Dosage
For dogs weighing over 5 pounds, use at least 2.27 milligrams of pyrantel base per pound of body weight. For dogs weighing 5 pounds or less, use at least 4.54 milligrams of pyrantel base per pound of body weight.
Limitations
Administer orally directly or in a small amount of food. To prevent reinfection of T. canis in puppies, lactating bitches after whelping, and adult dogs; treat puppies 2, 3, 4, 6, 8, and 10 weeks of age; treat lactating bitches 2 to 3 weeks after whelping; routinely treat adult dogs monthly. Do not withhold food prior to or after treatment. The presence of these parasites should be confirmed by laboratory fecal examination. A followup fecal examination should be conducted 2 to 4 weeks after first treatment regimen to determine the need for re-treatment. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Dog, Restricted During Pregnancy
Composition / specifications
Pyrantel pamoate suspension contains pyrantel pamoate equivalent to 2.27 or 4.54 milligrams of pyrantel base per milliliter.
Dogs (and puppies)
Indication
For removal of large roundworms (T. canis and Toxascaris leonina) and hookworms (Ancylostoma caninum and Uncinaria stenocephala).
Dosage
Administer in the animal's feed bowl as a single dose by itself or mixed in a small quantity of food.
Limitations
Additional treatment may be required and should be confirmed by examination within 2 to 4 weeks. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.
Dogs (adults, puppies, and lactating bitches)
Indication
To prevent reinfections of Toxocara canis.
Dosage
Equivalent to 2.27 or 4.54 milligrams of pyrantel base per pound of body weight.
Limitations
Administer to puppies at 2,3,4,6,8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism. For use of 2.27 and 4.54 milligrams per milliliter product. See No. 023851 for use of 4.54 milligrams per milliliter product

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production • Pony, Not For Food
Composition / specifications
Each milliliter of paste contains 180 milligrams of pyrantel base (as pyrantel pamoate).
Horses (and ponies)
Indication
For removal and control of infections from the following mature parasites: large strongyles (Strongylus vulgaris, S. edentatus, S. equinus); small strongyles; pinworms (Oxyuris equi); and large roundworms (Parascaris equorum).
Dosage
Equivalent of 3 milligrams pyrantel base per pound of body weight.
Limitations

Administer as single dose by depositing paste on dorsum of the tongue using the dose syringe. Do not use in horses intended for human consumption. It is recommended that severely debilitated animals not be treated with this preparation. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each tablet contains pyrantel pamoate equivalent to 22.7 or 113.5 milligrams pyrantel base.
Dogs
Indication
For removal of ascarids (Toxocara canis; Toxascaris leonine), and hookworms (Ancylostoma caninum; Uncinaria stenocephala) in dogs and puppies. To prevent reinfection of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping
Dosage
Provides at least 2.27 milligrams of pyrantel base per pound of body weight for dogs weighing more than 5 pounds, and at least 4.54 milligrams of pyrantel base per pound body weight for dogs weighing 5 pounds or less
Limitations
Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Retreatment of adult dogs may be necessary at monthly intervals as determined by laboratory fecal examination. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, Excluding Under 6 Weeks Age
Composition / specifications
Each chewable tablet contains either 68 micrograms of ivermectin and 57 milligrams of pyrantel (as pamoate salt), or 136 micrograms ivermectin and 114 milligrams pyrantel, or 272 micrograms and 227 milligrams, respectively.
Dogs
Indication
To prevent canine heartworm diseases by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection. For the treatment and control of ascarids (Toxocara canis, Toxascaris leonine), and hookworms (Ancylostoma caninum, A braziliense, and Uncinaria stenocephala).
Dosage
A minimum of 6 micrograms of ivermectin and 5 milligrams of pyrantel (as pamoate salt) per kilogram (2.72 micrograms and 2.27 milligrams per pound) of body weight. up to 25 pounds: 68 micrograms ivermectin and 57 milligrams pyrantel pamoate 26 to 50 pounds: 136 micrograms ivermectin and 114 milligrams pyrantel pamoate 51 to 100 pounds: 272 micrograms ivermectin and 227 milligrams pyrantel pamoate
Limitations
Use monthly. Recommended for dogs 6 weeks of age or older. Federal law restricts this drug to use by or on the order of a veterinarian. All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains:
(1) 34 micrograms (mcg) ivermectin, 28.5 milligrams (mg) pyrantel pamoate, and 28.5 mg praziquantel;
(2) 68 mcg ivermectin, 57 mg pyrantel pamoate, and 57 mg praziquantel;
(3) 136 mcg ivermectin, 114 mg pyrantel pamoate, and 114 mg praziquantel; or
(4) 272 mcg ivermectin, 228 mg pyrantel pamoate, and 228 mg praziquantel.
Dogs (12.1 - 25 Lbs)
Indication
Prevents canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for 1 month (30 days) after infection and for the treatment and control of roundworm (Toxocara canis, Toxascaris leonine), hookworm (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) and tapeworm (Dipylidium caninum, Taenia pisiformis) infections.
Dosage
Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight. (One table monthly containing 68 mcg ivermectin, 57 mg pyrantel pamoate, and 57 mg praziquantel)
Limitations
For oral use in dogs only. IVERHART MAX Chewable Tablets are recommended for dogs 8 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these Chewable Tablets. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs (6.0 - 12 Lbs)
Indication
Prevents canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for 1 month (30 days) after infection and for the treatment and control of roundworm (Toxocara canis, Toxascaris leonine), hookworm (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) and tapeworm (Dipylidium caninum, Taenia pisiformis) infections.
Dosage
Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight. (One tablet monthly containing 34 micrograms (mcg) ivermectin, 28.5 milligrams (mg) pyrantel pamoate, and 28.5 mg praziquantel)
Limitations
For oral use in dogs only. IVERHART MAX Chewable Tablets are recommended for dogs 8 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these Chewable Tablets. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs (50.1 - 100 Lbs)
Indication
Prevents canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for 1 month (30 days) after infection and for the treatment and control of roundworm (Toxocara canis, Toxascaris leonine), hookworm (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) and tapeworm (Dipylidium caninum, Taenia pisiformis) infections.
Dosage
Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight. (One tablet monthly containing 272 mcg ivermectin, 228 mg pyrantel pamoate, and 228 mg praziquantel)
Limitations
For oral use in dogs only. IVERHART MAX Chewable Tablets are recommended for dogs 8 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these Chewable Tablets. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs (25.1 - 50 Lbs)
Indication
Prevents canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for 1 month (30 days) after infection and for the treatment and control of roundworm (Toxocara canis, Toxascaris leonine), hookworm (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) and tapeworm (Dipylidium caninum, Taenia pisiformis) infections.
Dosage
Administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight. (One tablet monthly containing 136 mcg ivermectin, 114 mg pyrantel pamoate, and 114 mg praziquantel)
Limitations
For oral use in dogs only. IVERHART MAX Chewable Tablets are recommended for dogs 8 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these Chewable Tablets. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Pyrantel pamoate suspension contains pyrantel pamoate equivalent to 2.27 or 4.54 milligrams of pyrantel base per milliliter.
Dogs (and puppies)
Indication
Equivalent of 2.27 milligrams of pyrantel base per pound of body weight.
Dosage
Equivalent of 2.27 milligrams of pyrantel base per pound of body weight.
Limitations
Administer in the animal's feed bowl as a single dose by itself or mixed in a small quantity of food. Additional treatment may be required and should be confirmed by examination within 2 to 4 weeks. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.
Dogs (puppies, adult dogs, and lactating bitches after whelping)
Indication
To prevent reinfections of Toxocara canis.
Dosage
Equivalent to 2.27 milligrams of pyrantel base per pound of body weight.
Limitations
Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production • Pony, Not For Food
Composition / specifications
Pyrantel pamoate suspension contains pyrantel pamoate equivalent to 50 milligrams of pyrantel base per milliliter.
Horses and ponies
Indication
For the removal and control of mature infections of large strongyles (Strongylus vulgaris, S. edentatus, S. equinus); pinworms (Oxyuris equi); large roundworms (Parascaris equorum); and small strongyles.
Dosage
Equivalent of 3 milligrams pyrantel base per pound of body weight
Limitations
Not for use in horses and ponies to be slaughtered for food purposes.

FDA page: Open in Animal Drugs @ FDA

Species: Dogs And Puppies
Composition / specifications
Pyrantel pamoate suspension contains pyrantel pamoate equivalent to 2.27 or 4.54 milligrams of pyrantel base per milliliter.
Dogs (and puppies)
Indication
For the removal of large roundworms (Toxocara canis and Toxascaris leonine) and hookworms (Ancylostoma caninum and Uncinaria stenocephala).
Dosage
Equivalent of 2.27 milligrams of pyrantel base per pound of body weight.
Limitations
Administer in the animal's feed bowl as a single dose by itself or mixed in a small quantity of food. Additional treatment may be required and should be confirmed by examination within 2 to 4 weeks. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, No Use Class Stated Or Implied • Pony, No Use Class Stated Or Implied
Composition / specifications
Pyrantel pamoate suspension contains pyrantel pamoate equivalent to 50 milligrams of pyrantel base per milliliter.
Horses (and ponies)
Indication
For the removal and control of infections from the following mature parasites: Large strongyles (Strongylus vulgaris Strongylus edentatus, Strongylus equinus), small strongyles pinworms (Oxyuris), and large roundworms (Parascaris).
Dosage
Equivalent of 3 milligrams pyrantel base per pound of body weight.
Limitations
Administered as a single dose mixed with the usual grain ration, or by stomach tube, or by dose syringe. Not for use in horses and ponies to be slaughtered for food purposes. When the drug is for administration by stomach tube, it shall be labeled: "Federal law restricts this drug to use by or on the order of a licensed veterinarian.'' When the drug is not for administration by stomach tube, it shall be labeled: ``Consult your veterinarian for in the diagnosis, control, and treatment of parasitism.''

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each tablet contains pyrantel pamoate equivalent to 22.7 or 113.5 milligrams pyrantel base.
Dogs
Indication
For removal of ascarids (Toxocara canis; Toxascaris leonina), and hookworms (Ancylostoma caninum; Uncinaria stenocephala) in dogs and puppies. To prevent reinfection of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping.
Dosage
Provides at least 2.27 milligrams of pyrantel base per pound of body weight for dogs weighing more than 5 pounds, and at least 4.54 milligrams of pyrantel base per pound body weight for dogs weighing 5 pounds or less.
Limitations
Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Retreatment of adult dogs may be necessary at monthly intervals as determined by laboratory fecal examination. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production • Pony, Not For Food
Composition / specifications
Pyrantel pamoate suspension contains pyrantel pamoate equivalent to 50 milligrams of pyrantel base per milliliter.
Horses (and ponies)
Indication
For the removal and control of infections from the following mature parasites: Large strongyles (Strongylus vulgaris, Strongylus edentatus, Strongylus equinus), small strongyles pinworms (Oxyuris), and large roundworms (Parascaris).
Dosage
Equivalent of 3 milligrams pyrantel base per pound of body weight.
Limitations
Administered as a single dose mixed with the usual grain ration, or by stomach tube, or by dose syringe. Not for use in horses and ponies to be slaughtered for food purposes. When the drug is for administration by stomach tube, it shall be labeled: "Federal law restricts this drug to use by or on the order of a licensed veterinarian.'' When the drug is not for administration by stomach tube, it shall be labeled: ``Consult your veterinarian for in the diagnosis, control, and treatment of parasitism.''

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary

    This supplement provides for the addition of the indication for the treatment and control of Amblyomma maculatum (Gulf Coast tick) infestations for one month in dogs and puppies eight weeks of age and older, weighing four pounds of body weight or greater.

  • Summary

    This supplement provides for the addition of the indication for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

  • Summary

    This supplement provides for the addition of the indication for the treatment and control of Haemaphysalis longicornis (longhorned tick) infestations in dogs and puppies eight weeks of age and older, weighing four pounds of body weight or greater, for one month. This supplement also provides for the addition of label language regarding the results of a second flea field study and improvement of erythema, alopecia, papules, scales, crusts, and excoriation in dogs with flea infestations and signs of Flea Allergy Dermatitis following treatment with afoxolaner alone, as a direct result of eliminating fleas.

  • Summary

    For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of adult hookworm (Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala) and roundworm (Toxocara canis and Toxascaris leonina) infections. Kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), Dermacentor variabilis (American dog tick), and Amblyomma americanum (lone star tick) infestations for one month in dogs and puppies eight weeks of age and older, weighing four pounds of body weight or greater.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    This supplement provides for the addition of the indication for the treatment and control of Haemaphysalis longicornis (longhorned tick) tick infestations for one month in dogs and puppies 8 weeks of age and older, weighing 3.3 pounds or greater, and for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

  • Summary

    This supplement provides for the addition of the indication for the treatment and control of hookworm (fourth stage larvae, immature adult, and adult Ancylostoma caninum) infections in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.

  • Summary

    For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina), hookworm (adult Uncinaria stenocephala), and tapeworm (Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus) infections. Kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), and Rhipicephalus sanguineus (brown dog tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    This supplement provides for the addition of the indication for the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated dog for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.

  • Summary

    This supplement provides for the addition of the indication for the treatment and control of Haemaphysalis longicornis (Asian longhorned tick) infestations for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.

  • Summary

    This supplement provides for the addition of the indications, for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks and for the treatment and control of L4 and immature adult Ancylostoma caninum.

  • Summary

    Simparica Trio® is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections. Simparica Trio® kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), and Rhipicephalus sanguineus (brown dog tick) for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    Prevents heartworm disease by eliminating the tissue stage of heartworm (Dirofilaria immitis) larvae for a month after infection and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense).
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For the treatment and control of roundworms (Toxocara canis, Toxascaris leonina); hookworms (Ancylostoma caninum, Ancylostoma braziliense, Uncinaria stenocephala); and tapeworms (Dipylidium caninum, Taenia pisiformis) in dogs and puppies.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    This supplement amends the approved NADA by adding a flavored tablet formulation with the same indications.
  • Summary
    Effect of Supplement: This supplement amends the NADA to provide for a larger tablet containing 136.0 mg praziquantel, 136.0 mg pyrantel base as pyrantel pamoate and 680.4 mg febantel and the associated label changes.
  • Summary

    This supplemental application amends NADA 141-007, Drontal™ Plus Broad Spectrum Anthelmintic Tablets, by adding the tape-worm Echinococcus multilocularis claim to the label.

  • Summary

    Drontalâ¿¢ Plus Broad Spectrum Anthelmintic Tablets are indicated for the removal of the following intestinal parasites in dogs:

    Tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus)

    Hookworms (Ancylostoma caninum, Incinaria stenocephala)

    Ascarids (Toxocara canis, Toxascaris leonina)

    Whipworms (Trichuris vulpis)

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    Drontal Tablets will remove Tapeworms ( Dipylidium caninum, Taenia taeniaeformis ), Hookworms ( Ancylostoma tubaeforme ) and Large Roundworms ( Toxocara cati ) in kittens and cats.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense), and tapeworms (Dipylidium caninum, Taenia pisiformis).

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    Pyrantel pamoate paste is indicated for the removal and control of mature infections of large strongyles (Strongylus vulgaris, S. edentatus, S. equinus); small strongyles; pinworms (Oxyuris equi); and large roundworms (Parascaris equorum) in horses and ponies.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For removal of ascarids ( Toxocara canis; Toxascaris leonina), and hookworms ( Ancylostoma caninum; Uncinaria stenocephala) in dogs and puppies. To prevent reinfection of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    The supplement to NADA 200-342 provides revisions to 21 CFR 520.2044: Addition of label claim for the removal and control of mature infections of tapeworms (Anoplocephala perfoliata) in horses and ponies, with a single oral dose of 6 milligrams pyrantel base per pound of body weight. The sponsor conducted effectiveness and target animal safety studies in support of this label claim; thus, this supplemental application is a submission under section 512(b)(1) of the Federal Food, Drug, and Cosmetic Act. As a result, the application status of this supplemental approval for Pyrantel Pamoate Paste is designated NADA 200-342.

  • Summary
    For the removal and control of mature infections of the following parasites: Large strongyles: Strongylus vulgaris, S. edentatus, S. equinus: Small strongyles; Pinworms: Oxyuris equi; Large roundworms; Parascaris equorum
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    For the removal and control of mature infections of large strongyles (Strongylus vulgaris, S. edentatus, S. equinus); pinworms (Oxyuris equi); large roundworms (Parascaris equorum); and small strongyles in horses and ponies.

  • Summary
    For the removal and control of matureinfections of large strongyles ( Strongylus vulgaris, S.edentatus, S. equinus); pinworms ( Oxyuris equi); large roundworms ( Parascarisequorum); and small strongyles in horses and ponies.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    To prevent reinfection of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping.
    For removal of large roundworms (Toxocara canis and Toxascaris leonina) and hookworms (Ancylostoma caninum and Uncinaria stenocephala) in dogs and puppies.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    To prevent reinfection of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping. For the removal of large roundworms (Toxocara canis and Toxascaris leonina) and hookworms (Ancylostoma caninum and Uncinaria stenocephala) in dogs and puppies. The presence of these parasites should be confirmed by laboratory fecal examination.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    Will provide for repeat treatment of puppies, lactating bitches and adult dogs for control of T. canis.
  • Summary

    For the removal of large roundworms (ascarids), Toxocara canis and Toxascaris leonina and hookworms, Anyclostoma caninum and Uncinaria stenocephala in dogs.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    To provide for a double strength pyrantel pamoate suspension.

  • Summary
    Evict® should be used to prevent reinfection of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping and for removal of large roundworms and hookworms in dogs and puppies.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For removal of ascarids ( Toxocara canis; Toxascaris leonina) and hookworms ( Ancylostoma caninum; Uncinaria stenocephala) in dogs and puppies. To prevent reinfection of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    This supplement expands the indications to include the treatment and control of adult hookworms ( Ancylostoma braziliense).
  • Summary
    Ivermectin (To prevent canine heartworm disease by eliminating the tissue larval stages of Dirofilaria immitis for a month (30 days) after infection), pyrantel pamoate (for the treatment and control of adult Toxocara canis, Toxascaris leonina, Ancylostoma caninum and Uncinaria stenocephala) in dogs.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    This supplement provides for removal of the following statement from the Precautions section of the package insert: “The effective use of this drug for the treatment and control of tapeworms has not been evaluated in dogs less than 15 pounds.”
  • Summary
    For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae ( Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms ( Toxocara canis, Toxascaris leonina), hookworms ( Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense) and tapeworms ( Dipylidium caninum, Taenia pisiformis).
SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For the removal and control of mature infections of large strongyles (Strongylus vulgaris, S. edentatus, S. equinus); pinworms (Oxyuris equi); large roundworms (Parascaris equorum) and small strongyles in horses and ponies.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For the removal of large roundworms (Toxocara canis and Toxascaris leonina) and hookworms (Ancylostoma caninum and Uncinaria stenocephala) in dogs and puppies. To prevent reinfestation of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For the removal and control of mature large strongyles (Strongylus vulgaris, S. edentatus, S. equinus); pin worms (Oxyuris equi); large roundworms (Parascaris equorum) and small strongyles in horses and ponies.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For the removal of large roundworms (ascarids) (Toxocara canis; Toxascaris leonina) and hookworms (Ancylostoma caninum; Uncinaria stenocephala) in dogs and puppies. To prevent reinfection of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

For the removal and control of infections from the following mature parasites: Large strongyles ( Strongylus vulgaris , Strongylus edentatus , Strongylus equinus ), small strongyles pinworms ( Oxyuris ), and large roundworms ( Parascaris ). Equivalent of 2.27 milligrams of pyrantel base per pound of body weight. To prevent reinfections of Toxocara canis.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Administered as a single dose mixed with the usual grain ration, or by stomach tube, or by dose syringe. Not for use in horses and ponies to be slaughtered for food purposes. When the drug is for administration by stomach tube, it shall be labeled: "Federal law restricts this drug to use by or on the order of a licensed veterinarian.'' When the drug is not for administration by stomach tube, it shall be labeled: ``Consult your veterinarian for in the diagnosis, control, and treatment of parasitism.'' Administer in the animal's feed bowl as a single dose by itself or mixed in a small quantity of food. Additional treatment may be required and should be confirmed by examination within 2 to 4 weeks. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 56 and Cat 8 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog
Digestive
Vomiting (2574) Diarrhea (928) Vomiting (652) Vomiting (515) Vomiting (15) Vomiting (15) Vomiting (15) Vomiting (15) Vomiting (15) Vomiting (12) Diarrhea (4) Diarrhea (4) Diarrhea (4) Diarrhea (4) Diarrhea (4) Vomiting (4) Vomiting (4) Vomiting (4) Vomiting (4) Vomiting (4) Vomiting (4) Diarrhea (3)
Neurologic
Tiredness (lethargy) (858) Tiredness (lethargy) (5) Tiredness (lethargy) (5) Tiredness (lethargy) (5) Tiredness (lethargy) (5) Tiredness (lethargy) (5) Tiredness (lethargy) (5)
Effectiveness
Lack of efficacy (endoparasite) - heartworm (608) Lack of efficacy (endoparasite) - hookworm (356) Lack of efficacy (endoparasite) - tapeworm (326) Lack of efficacy (endoparasite) - hookworm (18) Lack of efficacy (endoparasite) - hookworm (18) Lack of efficacy (endoparasite) - hookworm (18) Lack of efficacy (endoparasite) - hookworm (18) Lack of efficacy (endoparasite) - hookworm (17) Lack of efficacy (endoparasite) - hookworm (17) Lack of efficacy (endoparasite) - heartworm (6) Lack of efficacy (endoparasite) - heartworm (6) Lack of efficacy (endoparasite) - heartworm (6) Lack of efficacy (endoparasite) - heartworm (6) Lack of efficacy (endoparasite) - heartworm (6) Lack of efficacy (endoparasite) - heartworm (6) Lack of efficacy (endoparasite) - roundworm NOS (4) Lack of efficacy (endoparasite) - roundworm NOS (4) Lack of efficacy (endoparasite) - roundworm NOS (4) Lack of efficacy (endoparasite) - roundworm NOS (4) Lack of efficacy (endoparasite) - roundworm NOS (4)
Other
Death (9) Death (9) Death (9) Death (9) Death (8) Death (7) Other abnormal test result NOS (3)
Cat
Digestive
Vomiting (29) Loss of appetite (16) Diarrhea (13)
Neurologic
Tiredness (lethargy) (33)
Behavior
Behavioral disorder (unspecified) (14)
Other
Death (13) Fever (13) Weight loss (13)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Newfoundland, Female, 10.66 year, 61.24 kilogram • Drug: MSK, Tablet, Oral, Dose: 2.25 tablet per animal • Reactions: Death • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-056128
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 10.66 Year
  • Weight: 61.240 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 2.25 tablet per animal
Reactions Reported:
Death
Outcomes: Died

Dog, Crossbred Canine/dog, Female, 3 month, 15.195 kilogram • Drug: MSK, Tablet, Oral • Reactions: Lack of efficacy (endoparasite) - hookworm, Other abnormal test result NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055641
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 3.00 Month
  • Weight: 15.195 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
Reactions Reported:
Lack of efficacy (endoparasite) - hookworm Other abnormal test result NOS
Outcomes: Outcome Unknown

Dog, ['Dachshund (unspecified)', 'Terrier - Fox Smooth'], Male, 12 week, 5 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy (endoparasite) - tapeworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-056092
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 12.00 Week
  • Weight: 5.000 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Lack of efficacy (endoparasite) - tapeworm
Outcomes: Outcome Unknown

Dog, Retriever - Labrador, Female, 2.5 year, 26.21 kilogram • Drug: MSK, Tablet, Unknown • Reactions: Lack of efficacy (endoparasite) - hookworm, Other abnormal test result NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055796
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 2.50 Year
  • Weight: 26.210 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Tablet
Reactions Reported:
Lack of efficacy (endoparasite) - hookworm Other abnormal test result NOS
Outcomes: Outcome Unknown

Dog, Dog (unknown), Female, 13 week • Drug: MSK, Tablet, Oral • Reactions: Vomiting • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055397
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 13.00 Week
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal

Dog, 8 week • Drug: MSK, Suspension • Reactions: Death • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-053969
  • Serious AE: Yes
  • Treated For AE: No
  • Age: 8.00 Week
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Form: Suspension
Reactions Reported:
Death
Outcomes: Outcome Unknown

Cat, Cat (unknown), Male, 3.85 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal • Reactions: Tiredness (lethargy), Vomiting, Distension of abdomen, Not himself/herself, Not drinking… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-034225
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Weight: 3.850 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per animal
Reactions Reported:
Tiredness (lethargy) Vomiting Distension of abdomen Not himself/herself Not drinking Lack of efficacy - NOS Unclassifiable adverse event
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 3 year, 4.45 kilogram • Drug: MSK, Oral • Reactions: Sneezing, Hypotension, Hyperglycaemia, Injection site sarcoma • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-033869
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 3.00 Year
  • Weight: 4.450 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
Reactions Reported:
Sneezing Hypotension Hyperglycaemia Injection site sarcoma
Outcomes: Recovered/Normal

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

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