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Sarolaner

Detailed information about Sarolaner

Official label facts Owner quick guide first Marketing clearly labeled
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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

Simparica TRIO® is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina ) an...

What it does:

SIMPARICA® kills adult fleas, and is indicated for the treatment and prevention of flea infestations ( Ctenocephalides felis ), and the treatment and control of tick infestations [ Amblyomma americanum (lone star tick),...

When it's needed:

Simparica TRIO® is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina ) an...

Commonly reported reactions:

  • (2 reports)
  • (2 reports)
  • (2 reports)

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
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Sarolaner

Sarolaner

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: MSK

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: MSK
Form: Chewable Tablets, Topical Solution
Identifiers:
NADA: 141452 NADA: 141502 NADA: 141521 NDC Package: 54771-0411-1 NDC Package: 54771-0411-2 NDC Package: 54771-0411-3 NDC Package: 54771-0412-1 NDC Package: 54771-0412-2 NDC Package: 54771-0412-3 NDC Package: 54771-0416-1 NDC Package: 54771-0416-2 NDC Package: 54771-0416-3 NDC Package: 54771-2015-1 NDC Package: 54771-2015-2 NDC Package: 54771-2015-3 NDC Package: 54771-2016-1 NDC Package: 54771-2016-2 NDC Package: 54771-2016-3 NDC Package: 54771-2017-1 NDC Package: 54771-2017-2
Source metadata:

Warnings / Contraindications

No contraindication summary is linked yet.

No owner-focused warning rows are linked yet.

Source metadata: No source yet.

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
23
Species represented
2
Most Reported Reactions
Reaction Cases Species Serious cases
2 Cat, Dog 2
2 Cat, Dog 2
2 Cat, Dog 2
2 Cat, Dog 1
1 Cat 1
1 Cat 1
1 Cat 1
1 Cat 1

Species coverage: Cat (22) Dog (10)

View detailed reaction table
Reaction Species Seriousness Frequency Reports
Cat Serious - 1
Cat Serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Dog Serious - 1
Cat Serious - 1
Cat Non-serious - 1
Cat Serious - 1
Cat Non-serious - 1
Cat Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Cat Non-serious - 1
Dog Serious - 1
Cat Serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Serious - 1
Cat Non-serious - 1
Cat Serious - 1
Dog Non-serious - 1
Cat Serious - 1
Cat Serious - 1
Dog Serious - 1
Cat Serious - 1
Cat Serious - 1
Dog Non-serious - 1
Cat Serious - 1
Cat Non-serious - 1
Source metadata:

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 14 • Secondary summaries: 0

Official label facts
Secondary summaries

No source yet.

Source metadata:

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.
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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: SIMPARICA® Simparica TRIO® revolution® PLUS
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat, Dog
Rx/OTC: RX
Form/route: Chewable Tablets, Topical Solution • Oral, Topical
Applications: NADA 141-521 • NADA 141-502 • NADA 141-452
Documents: 11 (FOI: 11) • SPL: 3 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 56 • Cat 56 • View
Case summaries: 10 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: B74.8 ICD10_CM: B88.1
Other filariases

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Accidental exposure (1) Agitation (1) Application site irritation (1) Application site scratching (1) Ataxia (1) Ataxia (1) Behavioural disorder NOS (1) Clumsy (1) Decreased appetite (1) Dilated pupils (1) Disorientation (1) Dysphoria (1) Epilepsy (1) Excessive chewing, licking and/or grooming (1) Foam in the mouth (1) Increased seizure frequency (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141452 NADA: 141502 NADA: 141521 NDC Package: 54771-0411-1 NDC Package: 54771-0411-2 NDC Package: 54771-0411-3 NDC Package: 54771-0412-1 NDC Package: 54771-0412-2 NDC Package: 54771-0412-3 NDC Package: 54771-0416-1 NDC Package: 54771-0416-2 NDC Package: 54771-0416-3 NDC Package: 54771-2015-1 NDC Package: 54771-2015-2 NDC Package: 54771-2015-3 NDC Package: 54771-2016-1 NDC Package: 54771-2016-2 NDC Package: 54771-2016-3 NDC Package: 54771-2017-1 NDC Package: 54771-2017-2 NDC Package: 54771-2017-3 NDC Package: 54771-2018-1 NDC Package: 54771-2018-2 NDC Package: 54771-2018-3
Package NDC Product NDC Form / Route Status
54771-0411-1 54771 -
54771-0411-2 54771 -
54771-0411-3 54771 -
54771-0412-1 54771 -
54771-0412-2 54771 -
54771-0412-3 54771 -
54771-0416-1 54771 -
54771-0416-2 54771 -
54771-0416-3 54771 -
54771-2015-1 54771 -
54771-2015-2 54771 -
54771-2015-3 54771 -
54771-2016-1 54771 -
54771-2016-2 54771 -
54771-2016-3 54771 -
54771-2017-1 54771 -
54771-2017-2 54771 -
54771-2017-3 54771 -
54771-2018-1 54771 -
54771-2018-2 54771 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 13 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Vomiting, Seizure NOS, Lethargy (see also Central nervous system depression in 'Neurological'), Tremor, Diarrhoea, Lack of ef… (Official, 2026-02-12)
  • usage: SIMPARICA® kills adult fleas, and is indicated for the treatment and prevention of flea infestations ( Ctenocephalides felis ), and the treatment and control o… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Simparica TRIO®
RX
Moxidectin Pyrantel Pamoate Sarolaner
Chewable Tablets • Oral
Label highlights
Official documents
Zoetis Inc. NADA 141-521 Approved Jun 3, 2025
revolution® PLUS
RX
Sarolaner Selamectin
Topical Solution • Topical
Label highlights
Official documents
Zoetis Inc. NADA 141-502 Approved Dec 2, 2024
SIMPARICA®
RX
Sarolaner
Chewable Tablets • Oral
Label highlights
Official documents
Zoetis Inc. NADA 141-452 Approved Dec 2, 2024

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains either: 3.0 mg sarolaner / 0.06 mg moxidectin / 12.5 mg pyrantel (as pamoate salt), 6.0 mg sarolaner / 0.12 mg moxidectin / 25.0 mg pyrantel (as pamoate salt), 12.0 mg sarolaner / 0.24 mg moxidectin / 50.0 mg pyrantel (as pamoate salt), 24.0 mg sarolaner / 0.48 mg moxidectin / 100 mg pyrantel (as pamoate salt), 48.0 mg sarolaner / 0.96 mg moxidectin / 200 mg pyrantel (as pamoate salt) or 72.0 mg sarolaner / 1.44 mg moxidectin / 300 mg pyrantel (as pamoate salt)
Dogs
Indication

Simparica TRIO® is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections. Simparica TRIO® kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated dog, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (Asian longhorned tick) for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater. Simparica TR O® is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

Dosage

SimparicaTRIO® is given orally, once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt).

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
60 mg/mL selamectin; 10 mg/mL sarolaner
Cats
Indication

revolution® PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis, the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections, and the treatment and control of ear mite (Otodectes cynotis) infestations. revolution® PLUS kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated cat, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Ixodes scapularis (black-legged tick) for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

Dosage

The recommended minimum dosage is 2.7 mg selamectin per pound (6.0 mg/kg) of body weight in combination with 0.45 mg sarolaner per pound (1.0 mg/kg) of body weight administered monthly.


Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
5 mg, 10 mg, 20 mg, 40 mg, 80 mg, and 120 mg
Dogs
Indication

SIMPARICA® kills adult fleas, and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus
sanguineus (brown dog tick), and Haemaphysalis longicornis (Asian longhorned tick)] for one month in dogs 6 months of age or older and weighing 2.8 pounds or greater. SIMPARICA® is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

Dosage
0.91 mg/lb (2 mg/kg body weight), one per month.
Limitations

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary

    This supplement provides for the addition of the indication for the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated dog for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.

  • Summary

    This supplement provides for the addition of the indication for the treatment and control of Haemaphysalis longicornis (Asian longhorned tick) infestations for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.

  • Summary

    This supplement provides for the addition of the indications, for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks and for the treatment and control of L4 and immature adult Ancylostoma caninum.

  • Summary

    Simparica Trio® is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections. Simparica Trio® kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), and Rhipicephalus sanguineus (brown dog tick) for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    This supplement provides for the addition of the indication for the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated cat for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

  • Summary

    This supplement provides for the addition of the indication for the treatment and control of tick infestations with Amblyomma americanum (lone star tick) for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

  • Summary

    revolution® PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. revolution® PLUS kills adult fleas (Ctenocephalides felis)and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations with Ixodes scapularis (black-legged tick), Amblyomma maculatum (Gulf Coast tick) and Dermacentor variabilis (American dog tick), the treatment and control of ear mite (Otodectes cynotis) infestations, and the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    This supplement provides for the addition of the indication for the treatment and control of Haemaphysalis longicornis (Asian longhorned tick) infestations for one month in dogs 6 months of age or older and weighing 2.8 pounds or greater.

  • Summary

    This supplement provides for the addition of the indication, "for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks."

  • Summary

    The effect of this supplement is to provide for the treatment and control of tick infestations [Ixodes scapularis (black-legged tick)] for one month in dogs 6 months of age or older and weighing 2.8 pounds or greater.

  • Summary
    Simparica™ kills adult fleas and is indicated for the treatment and prevention of flea infestations ( Ctenocephalides felis) and the treatment and control of tick infestations [ Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for one month in dogs 6 months of age or older and weighing 2.8 pounds or more.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

SIMPARICA® kills adult fleas, and is indicated for the treatment and prevention of flea infestations ( Ctenocephalides felis ), and the treatment and control of tick infestations [ Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (Asian longhorned tick)] for one month in dogs 6 months of age or older and weighing 2.8 pounds or greater. SIMPARICA® is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks. revolution® PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis , the treatment and control of roundworm ( Toxocara cati ) and intestinal hookworm ( Ancylostoma tubaeforme ) infections, and the treatment and control of ear mite ( Otodectes cynotis ) infestations. revolution® PLUS kills adult fleas ( Ctenocephalides felis ) and is indicated for the treatment and prevention of flea infestations, the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated cat, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Ixodes scapularis (black-legged tick) for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater. Simparica TRIO® is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina ) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala ) infections. Simparica TRIO® kills adult fleas ( Ctenocephalides felis ) and is indicated for the treatment and prevention of flea infestations, the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated dog, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (Asian longhorned tick) for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater. Simparica TR O® is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

No approved contraindication text is linked yet. Review FDA label highlights and openFDA safety reports before making treatment decisions.

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 56 and Cat 56 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog
Digestive
Vomiting (3703) Diarrhea (1307) Vomiting (11) Vomiting (11) Vomiting (10) Vomiting (10) Vomiting (10) Diarrhea (9) Diarrhea (9) Vomiting (8) Diarrhea (7) Diarrhea (7) Diarrhea (7)
Neurologic
Seizure NOS (2716) Tiredness (lethargy) (1567) Tremors (1316) Unsteady walking (ataxia) (991) Seizure NOS (10) Seizure NOS (10) Seizure NOS (10) Seizure NOS (10) Seizure NOS (10) Seizure NOS (10) Tiredness (lethargy) (7) Tiredness (lethargy) (7) Tiredness (lethargy) (7) Tiredness (lethargy) (7) Tiredness (lethargy) (7) Tiredness (lethargy) (6)
Effectiveness
Lack of efficacy (ectoparasite) - tick NOS (1179) Lack of efficacy (ectoparasite) - flea (1029) Lack of efficacy (bacteria) - Borrelia (7) Lack of efficacy (bacteria) - Borrelia (7) Lack of efficacy (bacteria) - Borrelia (7) Lack of efficacy (bacteria) - Borrelia (7) Lack of efficacy (bacteria) - Borrelia (7) Lack of efficacy (bacteria) - Borrelia (7) Lack of efficacy (ectoparasite) - flea (6)
Other
Overdose (11) Overdose (11) Overdose (11) Overdose (11) Overdose (11) Overdose (10) Intentional misuse (9) Intentional misuse (9) Intentional misuse (9) Intentional misuse (9) Intentional misuse (9) Intentional misuse (7) Medication error NOS (7) Medication error NOS (7) Medication error NOS (7) Medication error NOS (7) Shaking (7) Shaking (7)
Cat
Digestive
Vomiting (70) Drooling (23) Drooling (20)
Skin & allergy
Twitching (47)
Neurologic
Seizure NOS (98) Tremors (47) Tiredness (lethargy) (17) Seizure NOS (1) Seizure NOS (1) Seizure NOS (1) Seizure NOS (1) Seizure NOS (1) Seizure NOS (1) Tiredness (lethargy) (1) Tiredness (lethargy) (1) Tiredness (lethargy) (1) Tiredness (lethargy) (1) Tiredness (lethargy) (1) Tiredness (lethargy) (1)
Other
Accidental exposure (87) Accidental exposure (1) Accidental exposure (1) Accidental exposure (1) Accidental exposure (1) Accidental exposure (1) Accidental exposure (1) Dilated pupils (1) Dilated pupils (1) Dilated pupils (1) Dilated pupils (1) Dilated pupils (1) Dilated pupils (1) Dysphoria (1) Dysphoria (1) Dysphoria (1) Dysphoria (1) Dysphoria (1) Dysphoria (1) Intentional misuse (1) Intentional misuse (1) Intentional misuse (1) Intentional misuse (1) Intentional misuse (1) Intentional misuse (1) Overdose (1) Overdose (1) Overdose (1) Overdose (1) Overdose (1) Overdose (1) Panting (1) Panting (1) Panting (1) Panting (1) Panting (1) Panting (1)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Chihuahua, Male, 4 year, 6.441 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 dose per animal • Reactions: Unsteady walking (ataxia), Vomiting, Disorientation, Foam in the mouth, Loss of bowel control… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054762
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 4.00 Year
  • Weight: 6.441 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 dose per animal
Reactions Reported:
Unsteady walking (ataxia) Vomiting Disorientation Foam in the mouth Loss of bowel control Epilepsy
Outcomes: Ongoing

Dog, Dog (unknown), Male, 33.112 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 80 Milligram per animal • Reactions: Vomiting • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055274
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Weight: 33.112 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 80 Milligram per animal
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal

Dog, ['Terrier (unspecified)', 'Poodle (unspecified)'], Female, 6 year, 5.216 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 80 Milligram per animal • Reactions: Tremors, Overdose • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055305
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 6.00 Year
  • Weight: 5.216 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 80 Milligram per animal
Reactions Reported:
Tremors Overdose
Outcomes: Ongoing

Dog, ['Spaniel (unspecified)', 'Dog (unknown)'], Female, 3 year, 14.061 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 dose per animal, Frequency: 1 per month • Reactions: Lack of efficacy (bacteria) - Borrelia, Intentional misuse • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054869
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 3.00 Year
  • Weight: 14.061 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 dose per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (bacteria) - Borrelia Intentional misuse
Outcomes: Ongoing

Dog, ['Retriever - Golden', 'Poodle (unspecified)'], Male, 11 year, 34.019 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 80 Milligram per animal • Reactions: Seizure NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055086
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 11.00 Year
  • Weight: 34.019 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 80 Milligram per animal
Reactions Reported:
Seizure NOS
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 14 year, 4.581 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 80 Milligram per animal • Reactions: Tiredness (lethargy), Accidental exposure, Overdose, Intentional misuse, Seizure NOS… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-051479
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 14.00 Year
  • Weight: 4.581 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 80 Milligram per animal
Reactions Reported:
Tiredness (lethargy) Accidental exposure Overdose Intentional misuse Seizure NOS Dilated pupils Panting Dysphoria Shaking
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 9 month, 4.309 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 80 Milligram per animal • Reactions: Seizure NOS, Agitation, Accidental exposure, Overdose • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-036409
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 9.00 Month
  • Weight: 4.309 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 80 Milligram per animal
Reactions Reported:
Seizure NOS Agitation Accidental exposure Overdose
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Male, 3 month, 1.134 kilogram • Drug: MSK, Tablet, chewable, Oral • Reactions: Not himself/herself, Clumsy, Seizure NOS, Increased seizure frequency, Accidental exposure… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-032655
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 3.00 Month
  • Weight: 1.134 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
Reactions Reported:
Not himself/herself Clumsy Seizure NOS Increased seizure frequency Accidental exposure Overdose Unsteady walking (ataxia) Intentional misuse Twitching
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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