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Lotilaner

Detailed information about Lotilaner

Official label facts Owner quick guide first Marketing clearly labeled
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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in dogs and puppies.

What it does:

For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in dogs and puppies. For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax...

When it's needed:

For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in dogs and puppies.

Commonly reported reactions:

  • (2 reports)
  • (2 reports)
  • (1 reports)

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
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Lotilaner

Lotilaner

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Elanco US Inc.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Elanco US Inc.
Form: Chewable Tablets
Identifiers:
NADA: 141494 NADA: 141528 NADA: 141581 NADA: 141619 NADA: 6662 NADA: 6664 NDC Package: 58198-5451-1 NDC Package: 58198-5451-2 NDC Package: 58198-5451-3 NDC Package: 58198-5451-4 NDC Package: 58198-5451-6 NDC Package: 58198-5451-7 NDC Package: 58198-5452-1 NDC Package: 58198-5452-2 NDC Package: 58198-5452-3 NDC Package: 58198-5452-4 NDC Package: 58198-5452-5 NDC Package: 58198-5452-6 NDC Package: 58198-5452-7 NDC Package: 58198-5454-1
Source metadata:

Warnings / Contraindications

No contraindication summary is linked yet.

No owner-focused warning rows are linked yet.

Source metadata: No source yet.

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
18
Species represented
2
Most Reported Reactions
Reaction Cases Species Serious cases
2 Cat, Dog 1
2 Cat, Dog 0
1 Cat 1
1 Cat 1
1 Cat 1
1 Cat 1
1 Cat 1
1 Cat 1

Species coverage: Cat (25) Dog (7)

View detailed reaction table
Reaction Species Seriousness Frequency Reports
Cat Non-serious - 1
Dog Non-serious - 1
Cat Serious - 1
Dog Non-serious - 1
Cat Serious - 1
Cat Serious - 1
Dog Non-serious - 1
Cat Serious - 1
Cat Non-serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Dog Non-serious - 1
Cat Serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Dog Non-serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Non-serious - 1
Cat Serious - 1
Cat Non-serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Non-serious - 1
Cat Serious - 1
Dog Non-serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Source metadata:

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 17 • Secondary summaries: 0

Official label facts
Secondary summaries

No source yet.

Source metadata:

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.
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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 12, 2026, 10:42 PM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Credelio Quattro™ Credelio Quattro™-CA1 Credelio™ Credelio™ CAT
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat, Dog
Rx/OTC: RX
Form/route: Chewable Tablets • Oral
Applications: E 6662 • E 6664 • NADA 141-619 • NADA 141-494 • NADA 141-581 • NADA 141-528
Documents: 11 (FOI: 11) • SPL: 6 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 56 • Cat 56 • View
Case summaries: 12 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: B74.8 ICD10_CM: B88.1
Other filariases

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Agitation (1) Cyst NOS (1) Death (1) Diarrhoea (1) Elevated blood urea nitrogen (BUN) (1) Elevated creatinine (1) Emesis (1) Haematuria (1) Hiding (1) Hyperkalaemia (1) Hypersalivation (1) Hyponatremia (1) Inappropriate defecation (1) Increased bowel movements (frequency) (1) Itching (1) Lack of efficacy (ectoparasite) - flea (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141494 NADA: 141528 NADA: 141581 NADA: 141619 NADA: 6662 NADA: 6664 NDC Package: 58198-5451-1 NDC Package: 58198-5451-2 NDC Package: 58198-5451-3 NDC Package: 58198-5451-4 NDC Package: 58198-5451-6 NDC Package: 58198-5451-7 NDC Package: 58198-5452-1 NDC Package: 58198-5452-2 NDC Package: 58198-5452-3 NDC Package: 58198-5452-4 NDC Package: 58198-5452-5 NDC Package: 58198-5452-6 NDC Package: 58198-5452-7 NDC Package: 58198-5454-1 NDC Package: 58198-5454-2 NDC Package: 58198-5454-3 NDC Package: 58198-5454-4 NDC Package: 58198-5454-6
Package NDC Product NDC Form / Route Status
58198-5451-1 58198 -
58198-5451-2 58198 -
58198-5451-3 58198 -
58198-5451-4 58198 -
58198-5451-6 58198 -
58198-5451-7 58198 -
58198-5452-1 58198 -
58198-5452-2 58198 -
58198-5452-3 58198 -
58198-5452-4 58198 -
58198-5452-5 58198 -
58198-5452-6 58198 -
58198-5452-7 58198 -
58198-5454-1 58198 -
58198-5454-2 58198 -
58198-5454-3 58198 -
58198-5454-4 58198 -
58198-5454-6 58198 -
58198-5454-7 58198 -
58198-5456-1 58198 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 13 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Vomiting, Diarrhoea, Lack of efficacy (ectoparasite) - tick NOS, Other abnormal test result NOS, Lethargy (see also Central n… (Official, 2026-02-12)
  • usage: For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in dogs and puppies. For the treatment of infestat… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Credelio™
RX
Lotilaner
Chewable Tablets • Oral
Label highlights
Official documents
Elanco US Inc. E 6662 G Jan 26, 2026
Credelio™ CAT
RX
Lotilaner
Chewable Tablets • Oral
Label highlights
Official documents
Elanco US Inc. E 6664 G Jan 26, 2026
Credelio Quattro™-CA1
RX
Lotilaner Moxidectin Praziquantel Pyrantel Pamoate
Chewable Tablets • Oral
Label highlights
Official documents
Elanco US Inc. NADA 141-619 Approved Jan 5, 2026
Credelio™
RX
Lotilaner
Chewable Tablets • Oral
Label highlights
Official documents
Elanco US Inc. NADA 141-494 Approved Nov 3, 2025
Credelio Quattro™
RX
Lotilaner Moxidectin Praziquantel Pyrantel Pamoate
Chewable Tablets • Oral
Label highlights
Official documents
Elanco US Inc. NADA 141-581 Approved Nov 3, 2025
Credelio™ CAT
RX
Lotilaner
Chewable Tablets • Oral
Label highlights
Official documents
Elanco US Inc. NADA 141-528 Approved May 3, 2021

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Composition / specifications
Each chewable tablet contains 56.25 mg, 112.5 mg, 225 mg, 450 mg, or 900 mg lotilaner
Dogs
Indication

For the treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) in dogs and puppies.

Dosage

Administer orally at the minimum dosage of 9 mg/lb (20 mg/kg) with food.

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
Each chewable tablet contains 12 mg or 48 mg lotilaner
Cats
Indication

For the treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) in cats and kittens.

Dosage

Administer orally at the minimum dosage of 2.7 mg/lb (6 mg/kg) with food.

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
Each chewable tablet contains: 56.25 mg lotilaner, 0.056 mg moxidectin, 14.25 mg praziquantel, and 14.25 mg pyrantel* 112.5 mg lotilaner, 0.113 mg moxidectin, 28.5 mg praziquantel, and 28.5 mg pyrantel* 225 mg lotilaner, 0.225 mg moxidectin, 57 mg praziquantel, and 57 mg pyrantel* 450 mg lotilaner, 0.45 mg moxidectin, 114 mg praziquantel, and 114 mg pyrantel* 900 mg lotilaner, 0.9 mg moxidectin, 228 mg praziquantel, and 228 mg pyrantel* *As pamoate salt
Dogs
Indication

For the treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.

Dosage

Administer orally at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt).

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains 56.25 mg, 112.5 mg, 225 mg, 450 mg, or 900 mg lotilaner.
Dogs
Indication

Credelio™ kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (longhorned tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater. Credelio™ is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

Dosage

Credelio™ chewable tablets are given orally once a month at the recommended minimum dosage of 9 mg/lb (20 mg/kg). Credelio™ must be administered with food.

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
56.25 mg lotilaner, 0.056 mg moxidectin, 14.25 mg praziquantel, and 14.25 mg pyrantel; 112.5 mg lotilaner, 0.113 mg moxidectin, 28.5 mg praziquantel, and 28.5 mg pyrantel; 225 mg lotilaner, 0.225 mg moxidectin, 57 mg praziquantel, and 57 mg pyrantel; 450 mg lotilaner, 0.45 mg moxidectin, 114 mg praziquantel, and 114 mg pyrantel; 900 mg lotilaner, 0.9 mg moxidectin, 228 mg praziquantel, and 228 mg pyrantel
Dogs
Indication

Credelio Quattro™ is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina), hookworm (fourth stage larvae, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala), and tapeworm (Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus) infections. Credelio Quattro™ kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma Americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (longhorned tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater. Credelio Quattro™ is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

Dosage

Administer orally once a month, at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt).

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains 12 mg or 48 mg lotilaner.
Cats
Indication

Kills adult fleas, and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) for one month in cats and kittens 8 weeks of age and older and weighing 2.0 pounds or greater. It also indicated for the treatment and control of Ixodes scapularis (black-legged tick) infestations for one month in cats and kittens 6 months of age and older, and weighing 2.0 pounds or greater.

Dosage

Administer orally once a month at the minimum dosage of 2.7 mg/lb (6 mg/kg). Must be administered with food.

Limitations

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    This supplement provides for the addition of the indication for the treatment and control of Haemaphysalis longicornis (longhorned tick) tick infestations for one month in dogs and puppies 8 weeks of age and older, weighing 4.4 pounds or greater, and for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

  • Summary

    This supplement provides for the addition of the indication for the prevention of flea
    infestations (Ctenocephalides felis) for one month in dogs and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater.

  • Summary

    Credelio™ kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick) and Rhipicephalus sanguineus (brown dog tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    This supplement provides for the addition of the indication for the treatment and control of Haemaphysalis longicornis (longhorned tick) tick infestations for one month in dogs and puppies 8 weeks of age and older, weighing 3.3 pounds or greater, and for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

  • Summary

    This supplement provides for the addition of the indication for the treatment and control of hookworm (fourth stage larvae, immature adult, and adult Ancylostoma caninum) infections in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.

  • Summary

    For the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina), hookworm (adult Uncinaria stenocephala), and tapeworm (Dipylidium caninum, Taenia pisiformis, and Echinococcus granulosus) infections. Kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), and Rhipicephalus sanguineus (brown dog tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    This supplement provides for the addition of the indication for the treatment and control of Ixodes scapularis (black-legged tick) infestations for one month in cats and kittens 6 months of age and older, and weighing 2.0 pounds or greater.

  • Summary

    Kills adult fleas, and for the treatment and prevention of flea infestation (Ctenocephalides felis) for one month in cats and kittens 8 weeks of age and older and weighing 2.0 pounds or greater.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in dogs and puppies. For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in cats and kittens. Credelio™ kills adult fleas and is indicated for the treatment and prevention of flea infestations ( Ctenocephalides felis ) and the treatment and control of tick infestations [ Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (longhorned tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater. Credelio™ is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

No approved contraindication text is linked yet. Review FDA label highlights and openFDA safety reports before making treatment decisions.

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 56 and Cat 56 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog
Digestive
Vomiting (2558) Diarrhea (1068) Vomiting (27) Vomiting (27) Vomiting (27) Vomiting (27) Vomiting (26) Vomiting (26) Diarrhea (20) Diarrhea (20) Diarrhea (20) Diarrhea (20) Diarrhea (20) Diarrhea (19)
Neurologic
Tiredness (lethargy) (624) Seizure NOS (593) Tiredness (lethargy) (9) Tiredness (lethargy) (9) Tiredness (lethargy) (9) Tiredness (lethargy) (9) Tiredness (lethargy) (8) Seizure NOS (7)
Effectiveness
Lack of efficacy (ectoparasite) - tick NOS (717) Lack of efficacy (bacteria) - Borrelia (588) Lack of efficacy (endoparasite) - heartworm (424) Lack of efficacy (bacteria) - Anaplasma (11) Lack of efficacy (bacteria) - Anaplasma (11) Lack of efficacy (bacteria) - Anaplasma (11) Lack of efficacy (bacteria) - Anaplasma (11) Lack of efficacy (bacteria) - Anaplasma (11) Lack of efficacy (bacteria) - Anaplasma (11) Lack of efficacy (endoparasite) - hookworm (11) Lack of efficacy (endoparasite) - hookworm (11) Lack of efficacy (bacteria) - Borrelia (10) Lack of efficacy (bacteria) - Borrelia (10) Lack of efficacy (bacteria) - Borrelia (10) Lack of efficacy (bacteria) - Borrelia (10) Lack of efficacy (bacteria) - Borrelia (10) Lack of efficacy (ectoparasite) - flea (10) Lack of efficacy (ectoparasite) - flea (10) Lack of efficacy (ectoparasite) - flea (10) Lack of efficacy (ectoparasite) - flea (10) Lack of efficacy (ectoparasite) - flea (10) Lack of efficacy (endoparasite) - hookworm (10) Lack of efficacy (endoparasite) - hookworm (10) Lack of efficacy (endoparasite) - hookworm (10) Lack of efficacy (endoparasite) - hookworm (10) Lack of efficacy (bacteria) - Borrelia (9) Lack of efficacy (endoparasite) - heartworm (7)
Other
Other abnormal test result NOS (635) Other abnormal test result NOS (10) Other abnormal test result NOS (10) Other abnormal test result NOS (10) Other abnormal test result NOS (10) Other abnormal test result NOS (8) Other abnormal test result NOS (8)
Cat
Digestive
Vomiting (131) Vomiting (11) Vomiting (11) Vomiting (11) Vomiting (11) Vomiting (11) Vomiting (11) Decreased appetite (5) Decreased appetite (5) Decreased appetite (5) Decreased appetite (5) Decreased appetite (5) Decreased appetite (5) Diarrhea (3) Diarrhea (3) Diarrhea (3) Diarrhea (3) Diarrhea (3) Diarrhea (3)
Neurologic
Tiredness (lethargy) (68) Tiredness (lethargy) (10) Tiredness (lethargy) (10) Tiredness (lethargy) (10) Tiredness (lethargy) (10) Tiredness (lethargy) (9) Tiredness (lethargy) (9)
Behavior
Behavioral disorder (unspecified) (88) Behavioral disorder (unspecified) (5) Behavioral disorder (unspecified) (5) Behavioral disorder (unspecified) (5) Behavioral disorder (unspecified) (5) Behavioral disorder (unspecified) (5) Behavioral disorder (unspecified) (4)
Effectiveness
Lack of efficacy (ectoparasite) - flea (127) Lack of efficacy (ectoparasite) - flea (6) Lack of efficacy (ectoparasite) - flea (6) Lack of efficacy (ectoparasite) - flea (6) Lack of efficacy (ectoparasite) - flea (6) Lack of efficacy (ectoparasite) - flea (6) Lack of efficacy (ectoparasite) - flea (6)
Other
Panting (95) Scratching (62) Hyperactivity (50) Not eating (45) Panting (8) Panting (8) Panting (8) Panting (8) Panting (8) Panting (8) Licking (4) Licking (4) Licking (4) Licking (4) Licking (4) Licking (4)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Havanese, Male, 12 year, 7.711 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Diarrhea, Inappropriate defecation • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055917
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 7.711 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Diarrhea Inappropriate defecation
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 9.41 year, 5.724 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Panting, Uncomfortable, Itching • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055819
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 9.41 Year
  • Weight: 5.724 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Panting Uncomfortable Itching
Outcomes: Recovered/Normal

Cat, Siberian, Male, 11 month, 5.352 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Not eating, Tiredness (lethargy), Sleepiness - systemic disorder, Vomiting bile, Increased bowel movements… • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-055971
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 11.00 Month
  • Weight: 5.352 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Not eating Tiredness (lethargy) Sleepiness - systemic disorder Vomiting bile Increased bowel movements Elevated blood urea nitrogen Elevated creatinine Drooling Renal failure White blood cell disorder NOS Vomiting Hyponatremia Hyperkalaemia Haematuria Weakness Leukocyturia Leucocytosis NOS Death
Outcomes: Died

Dog, Retriever - Labrador, Female, 1 year, 25.85 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Vomiting • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055920
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 1.00 Year
  • Weight: 25.850 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal

Dog, Bulldog - French, Female, 3 year, 15.42 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Cyst NOS, Lack of efficacy (endoparasite) - heartworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055991
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 3.00 Year
  • Weight: 15.420 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Cyst NOS Lack of efficacy (endoparasite) - heartworm
Outcomes: Outcome Unknown

Dog, Retriever - Golden, Female, 13 week, 6.8 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Vomiting • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-056124
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 13.00 Week
  • Weight: 6.800 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal

Dog, Setter (unspecified), Male, 6.91 year, 36.28 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Vomiting • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055625
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 6.91 Year
  • Weight: 36.280 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal

Dog, Irish Wolfhound, Male, 6 year, 63.5 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal, Frequency: 1 per month • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055993
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 6.00 Year
  • Weight: 63.500 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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