Meds A-Z
Grapiprant
Detailed information about Grapiprant
Pet Owner Quick Guide
Start here: what this medicine is for, what it does, and when it's usually needed.
Usually used for:
For the control of pain and inflammation associated with osteoarthritis in dogs.
What it does:
For the control of pain and inflammation associated with osteoarthritis in dogs.
When it's needed:
For oral use in dogs only.
Call your vet sooner if you notice:
- For oral use in dogs only.
Commonly reported reactions:
- (2 reports)
- (1 reports)
- (1 reports)
What to ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Grapiprant
Drug type: Generic ingredient • Branded profile • FDA branded products available
Species: Both
Manufacturer: MSK
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141455 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source
Warnings / Contraindications
For oral use in dogs only.
- High: For oral use in dogs only.
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Tap or hover a reaction to see what it means in plain language.
Most Reported Reactions
| Reaction | Cases | Species | Serious cases |
|---|---|---|---|
| 2 | Cat, Dog | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 |
Species coverage: Cat (25) Dog (7)
View detailed reaction table
| Reaction | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|
| Cat | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 |
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-052521
Storage & Handling
No storage/handling guidance is linked yet.
Documents
Official label facts are separated from secondary summaries.
Official documents: 4 • Secondary summaries: 0
- UCM494127.pdf · FOI
- N-141455-C-0045-NL-AA_CIS.pdf · Labeling
- N-141455-C-0055-CS-AA_PI.pdf · Labeling
- Galliprant™ · SPL
No source yet.
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/941 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadLabeling/1340 · document · Labeling
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadLabeling/1341 · document · Labeling
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2568/Galliprant%E2%84%A2 · document · SPL
Promotional Materials (Marketing)
This content is marketing material and not clinical guidance.
No marketing assets are linked yet.
No source yet.
Technical appendix (vet reference)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
- Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
-
Animal Drugs @ FDA:
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Applications/products are imported from FDA export data.
-
Animal Drugs @ FDA previews:
Source FDA
| Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:02 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
- For oral use in dogs only. (Contraindication, High)
Identifiers & Packages
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 58198-5810-1 | 58198 | - | |
| 58198-5810-2 | 58198 | - | |
| 58198-5810-3 | 58198 | - | |
| 58198-5811-1 | 58198 | - | |
| 58198-5811-2 | 58198 | - | |
| 58198-5811-3 | 58198 | - | |
| 58198-5812-1 | 58198 | - | |
| 58198-5812-2 | 58198 | - | |
| 58198-5812-3 | 58198 | - |
Enriched Documents
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
-
N-141455-C-0055-CS-AA_PI.pdf
• Official label • Official
• July 15, 2025
FDA official labeling for application 141455
-
N-141455-C-0045-NL-AA_CIS.pdf
• Official label • Official
• July 15, 2025
FDA official labeling for application 141455
-
UCM494127.pdf
• FOI summary • Official
• July 15, 2025
FDA FOI summary for application 141455
Data Sources & Revision History
Every non-trivial field is expected to include provenance and update timestamps.
- contraindications: For oral use in dogs only. (Official, 2026-02-12)
- side_effects: Top reported reactions (openFDA): Vomiting, Diarrhoea, Lack of efficacy - NOS, Lethargy (see also Central nervous system depression in 'Neurological'), Elevate… (Official, 2026-02-12)
- usage: For the control of pain and inflammation associated with osteoarthritis in dogs. (Official, 2026-02-12)
- side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
Official sponsor/proprietary-name/application-status records linked by active ingredient.
| Product | Sponsor | Application | Status | Published |
|---|---|---|---|---|
|
Galliprant™
RX
Grapiprant
Tablet
• Oral
|
Elanco US Inc. | NADA 141-455 | Approved | Jul 15, 2025 |
Data source: FDA Animal Drugs @ FDA (public search export).
What It's For (FDA Label Highlights)
Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Official Documents (FDA)
Direct links to FDA-hosted PDFs and SPL packages (when available).
-
FOI UCM494127.pdf
Summary
For the control of pain and inflammation associated with osteoarthritis in dogs. -
Labeling N-141455-C-0045-NL-AA_CIS.pdf
-
Labeling N-141455-C-0055-CS-AA_PI.pdf
- Galliprant™ (ZIP)
FDA page: Open in Animal Drugs @ FDA
Usage
For the control of pain and inflammation associated with osteoarthritis in dogs.
Source: FDA Animal Drugs @ FDA • Reference
Contraindications
For oral use in dogs only.
Side Effects
No approved side-effect narrative is linked yet.
openFDA reaction signals are available for Dog 56 and Cat 20 (view top reported reactions).
Top Reported Reactions (openFDA)
Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Dog, Dog (unknown), Unknown, 15 year, 27.66 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal, Frequency: 1 per day • Reactions: Arthritis, Dental discolouration, Elevated alanine aminotransferase, Elevated serum alkaline phosphatase • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-055864
- Serious AE: No
- Treated For AE: No
- Sex: Unknown
- Age: 15.00 Year
- Weight: 27.660 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 1 tablet per animal
- Frequency: 1 per day
Dog, Retriever - Labrador, Male, 12 year, 34.292 kilogram • Drug: MSK, Tablet, Unknown • Reactions: Horner's syndrome • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-055778
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 12.00 Year
- Weight: 34.292 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Tablet
Dog, ['Retriever - Labrador', 'Dog (unknown)'], Male, 14 year, 15.876 kilogram • Drug: MSK, Tablet, Oral • Reactions: Seizure NOS, Inappropriate urination, Walking difficulty, Urinary incontinence, Swelling NOS… • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-056004
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Male
- Age: 14.00 Year
- Weight: 15.876 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
Dog, Crossbred Canine/dog, Female, 7 year, 14.061 kilogram • Drug: MSK, Tablet, Oral, Frequency: 1 per day • Reactions: Vomiting • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-055518
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 7.00 Year
- Weight: 14.061 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Frequency: 1 per day
Dog, ['Weimaraner', 'Retriever - Labrador'], Male, 14 year, 26.3 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal • Reactions: Gait abnormality, Walking difficulty, Unsteady gait, Product label issues • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-054553
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 14.00 Year
- Weight: 26.300 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 1 tablet per animal
Cat, Domestic Shorthair, Male, 4 year, 7.257 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal, Frequency: 1 per day • Reactions: Accidental exposure, Hiding • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-052521
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 4.00 Year
- Weight: 7.257 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 1 tablet per animal
- Frequency: 1 per day
Cat, Cat (unknown), Male, 12 week, 0.998 kilogram • Drug: MSK, Tablet, Unknown • Reactions: Lack of efficacy - NOS, Intentional misuse, Weight loss, Anaemia NOS, Leucocytosis NOS… • Outcome: Euthanized
- Report ID: USA-USFDACVM-2024-US-076581
- Serious AE: Yes
- Treated For AE: No
- Sex: Male
- Age: 12.00 Week
- Weight: 0.998 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Tablet
Cat, Domestic Shorthair, Male, 17 year, 6.53 kilogram • Drug: MSK, Tablet, Oral, Dose: 0.50 tablet per animal • Reactions: Agitation, Not sleeping, Hiding, Not eating, Enlarged pupils… • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2024-US-027068
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Male
- Age: 17.00 Year
- Weight: 6.530 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 0.50 tablet per animal
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.
Share Your Thoughts
Let others know your experience or advice regarding this medication.
This medication has not been reviewed by a veterinarian yet.