Meds A-Z
Buprenorphine
Detailed information about Buprenorphine
Pet Owner Quick Guide
Start here: what this medicine is for, what it does, and when it's usually needed.
Usually used for:
For the control of postoperative pain associated with surgical procedures in cats.
What it does:
For the control of postoperative pain associated with surgical procedures in cats.
When it's needed:
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Call your vet sooner if you notice:
- Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Commonly reported reactions:
- (1 reports)
- (1 reports)
- (1 reports)
What to ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Buprenorphine
Drug type: Generic ingredient • Branded profile • FDA branded products available
Species: Both
Manufacturer: MSK
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141434 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141547 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source
Warnings / Contraindications
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- High: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Tap or hover a reaction to see what it means in plain language.
Most Reported Reactions
| Reaction | Cases | Species | Serious cases |
|---|---|---|---|
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 |
Species coverage: Dog (24) Cat (8)
View detailed reaction table
| Reaction | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 |
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-056125
Storage & Handling
No storage/handling guidance is linked yet.
Documents
Official label facts are separated from secondary summaries.
Official documents: 4 • Secondary summaries: 0
- UCM408852.pdf · FOI
- Simbadol® · SPL
- FOI Summary oN 141-547 Approved January 20, 2022.pdf · FOI
- Zorbium™ · SPL
No source yet.
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/926 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2294/Simbadol%C2%AE · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/11847 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/11955/Zorbium%E2%84%A2 · document · SPL
Promotional Materials (Marketing)
This content is marketing material and not clinical guidance.
No marketing assets are linked yet.
No source yet.
Technical appendix (vet reference)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
- Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
-
Animal Drugs @ FDA:
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Applications/products are imported from FDA export data.
-
Animal Drugs @ FDA previews:
Source FDA
| Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:02 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC
Diagnosis-code mappings are not available for this medication yet.
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
- Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Identifiers & Packages
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 54771-4131-1 | 54771 | - | |
| 58198-0078-1 | 58198 | - | |
| 58198-0078-2 | 58198 | - | |
| 86084-100-30 | 86084 | - |
Enriched Documents
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
-
UCM408852.pdf
• FOI summary • Official
• Feb. 8, 2023
FDA FOI summary for application 141434
-
FOI Summary oN 141-547 Approved January 20, 2022.pdf
• FOI summary • Official
• Feb. 1, 2022
FDA FOI summary for application 141547
Data Sources & Revision History
Every non-trivial field is expected to include provenance and update timestamps.
- contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Official, 2026-02-12)
- side_effects: Top reported reactions (openFDA): Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), Diarrhoea, Death, Death by euthanasia, Ano… (Official, 2026-02-12)
- usage: For the control of postoperative pain associated with surgical procedures in cats. (Official, 2026-02-12)
- side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
Official sponsor/proprietary-name/application-status records linked by active ingredient.
| Product | Sponsor | Application | Status | Published |
|---|---|---|---|---|
|
Simbadol®
RX
Buprenorphine
Injectable Solution
• Subcutaneous
|
Zoetis Inc. | NADA 141-434 | Approved | Feb 8, 2023 |
|
Zorbium™
RX
Buprenorphine
Transdermal Solution
• Topical
|
Elanco US Inc. | NADA 141-547 | Approved | Feb 1, 2022 |
Data source: FDA Animal Drugs @ FDA (public search export).
What It's For (FDA Label Highlights)
Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
For the control of postoperative pain associated with surgical procedures in cats.
Administer topically to the dorsal cervical area at the base of the skull a single dose of 1.2 to 3.1 mg/lb (2.7 to 6.7 mg/kg) approximately 1 to 2 hours before surgery.
FDA page: Open in Animal Drugs @ FDA
Official Documents (FDA)
Direct links to FDA-hosted PDFs and SPL packages (when available).
-
FOI UCM408852.pdf
Summary
For the control of postoperative pain associated with surgical procedures in cats.
- Simbadol® (ZIP)
FDA page: Open in Animal Drugs @ FDA
-
Summary
For the control of postoperative pain associated with surgical procedures in cats
- Zorbium™ (ZIP)
FDA page: Open in Animal Drugs @ FDA
Usage
For the control of postoperative pain associated with surgical procedures in cats.
Source: FDA Animal Drugs @ FDA • Reference
Contraindications
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Side Effects
No approved side-effect narrative is linked yet.
openFDA reaction signals are available for Dog 56 and Cat 56 (view top reported reactions).
Top Reported Reactions (openFDA)
Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Cat, Domestic Longhair, Male, 6 month, 2.631 kilogram • Drug: MSK, Injection, solution, Subcutaneous, Dose: 0.36 mL per animal • Reactions: Hyperthermia, Underdose • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-056102
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 6.00 Month
- Weight: 2.631 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Subcutaneous
- Form: Injection, solution
- Dose: 0.36 mL per animal
Cat, Cat (unknown), Unknown • Drug: MSK, Solution, Unknown • Reactions: Dysphoria, Agitation, Behavioral disorder (unspecified) • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-056125
- Serious AE: No
- Treated For AE: No
- Sex: Unknown
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Solution
Cat, Siamese, Female, 6 year, 3.44 kilogram • Drug: MSK, Solution, Transdermal, Dose: 1 tube per animal • Reactions: Inappropriate urination, Not drinking, Reluctant to move, Not eating, Hiding… • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-055785
- Serious AE: No
- Treated For AE: Yes
- Sex: Female
- Age: 6.00 Year
- Weight: 3.440 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Transdermal
- Form: Solution
- Dose: 1 tube per animal
Cat, Domestic Shorthair, Male, 5 year, 8.61 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Hyperthermia, Hyperactivity • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-055972
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 5.00 Year
- Weight: 8.610 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Topical
- Form: Solution
- Dose: 1 tube per animal
Cat, Domestic Shorthair, Female, 18 year, 2.51 kilogram • Drug: MSK, Solution, Topical, Dose: 0.20 mL per animal • Reactions: Not sleeping, Dysphoria • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-056122
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 18.00 Year
- Weight: 2.510 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Topical
- Form: Solution
- Dose: 0.20 mL per animal
Dog, ['Collie (unspecified)', 'Dog (unknown)'], Female, 11 year, 18.234 kilogram • Drug: MSK, Unknown • Reactions: Decreased activity, Otitis NOS, Mucous stool, Bloody diarrhoea, Loss of hearing • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-055634
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 11.00 Year
- Weight: 18.234 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, ['Shepherd Dog - German', 'Dog (unknown)'], Female, 2.5 year • Drug: MSK, Intramuscular, Dose: 0.48 mL per animal • Reactions: Neutropenia, Eosinophilia, Lymphocytosis, Enamel disorder, Tooth disorder • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-055809
- Serious AE: Yes
- Treated For AE: No
- Sex: Female
- Age: 2.50 Year
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Intramuscular
- Dose: 0.48 mL per animal
Dog, Shepherd Dog - German, Female, 3 year, 39.463 kilogram • Drug: MSK, Unassigned, Unknown, Dose: 1.30 mL per animal • Reactions: Tiredness (lethargy), Drooling, Restlessness, Groaning • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-054508
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 3.00 Year
- Weight: 39.463 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Unassigned
- Dose: 1.30 mL per animal
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.
Share Your Thoughts
Let others know your experience or advice regarding this medication.
This medication has not been reviewed by a veterinarian yet.