Meds A-Z
Polysulfated Glycosaminoglycan
Detailed information about Polysulfated Glycosaminoglycan
Pet Owner Quick Guide
Start here: what this medicine is for, what it does, and when it's usually needed.
Usually used for:
For control of signs associated with noninfectious degenerative and/or traumatic arthritis of canine synovial joints.
What it does:
Polysulfated glycosaminoglycan is for the treatment of noninfectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal joint in horses. Polysulfated glycosaminoglycan is for the treatm...
When it's needed:
Not for use in horses intended for food. Safe use in breeding animals has not been established. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for huma...
Call your vet sooner if you notice:
- Not for use in horses intended for food. Safe use in breeding animals has not been established. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption. Safe use in breeding animals or in lactating mares has not been established. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For Intramuscular use in horses only. Not for intra-articular use. Do not mix with other drugs or solvents. PSGAG is a synthetic heparinoid; do not use in dogs with known or suspected bleeding disorders. Do not exceed recommended dose or regimen. Do not mix with other drugs or solvents. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Commonly reported reactions:
- (2 reports)
- (1 reports)
- (1 reports)
What to ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Polysulfated Glycosaminoglycan
Drug type: Generic ingredient • Branded profile • FDA branded products available
Species: Both
Manufacturer: MSK
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141038 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/140901 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source
Warnings / Contraindications
Not for use in horses intended for food. Safe use in breeding animals has not been established. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption. Safe use in breeding animals or in lactating mares has not been established. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For Intramuscular use in horses only. Not for intra-articular use. Do not mix with other drugs or solvents. PSGAG is a synthetic heparinoid; do not use in dogs with known or suspected bleeding disorders. Do not exceed recommended dose or regimen. Do not mix with other drugs or solvents. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- High: Not for use in horses intended for food. Safe use in breeding animals has not been established. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption. Safe use in breeding animals or in lactating mares has not been established. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For Intramuscular use in horses only. Not for intra-articular use. Do not mix with other drugs or solvents. PSGAG is a synthetic heparinoid; do not use in dogs with known or suspected bleeding disorders. Do not exceed recommended dose or regimen. Do not mix with other drugs or solvents. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Tap or hover a reaction to see what it means in plain language.
Most Reported Reactions
| Reaction | Cases | Species | Serious cases |
|---|---|---|---|
| 2 | Cat, Dog | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Dog | 1 |
Species coverage: Dog (20) Cat (12)
View detailed reaction table
| Reaction | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 |
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-055636
Storage & Handling
No storage/handling guidance is linked yet.
Documents
Official label facts are separated from secondary summaries.
Official documents: 8 • Secondary summaries: 0
- N141038_Orig_7_15_1997.pdf · FOI
- Adequan® Canine · SPL
- N140901_Supp_9_12_1996.pdf · FOI
- N140901 Orig_11_11_1989.pdf · FOI
- Adequan® i.m. Multi-Dose · SPL
- Adequan® i.m. · SPL
- UCM367650.pdf · FOI
- Adequan® Injectable · SPL
No source yet.
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/3696 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1867/Adequan%C2%AE%20Canine · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/2489 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/2487 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1205/Adequan%C2%AE%20i.m.%20Multi-Dose · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1204/Adequan%C2%AE%20i.m. · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/413 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1446/Adequan%C2%AE%20Injectable · document · SPL
Promotional Materials (Marketing)
This content is marketing material and not clinical guidance.
No marketing assets are linked yet.
No source yet.
Technical appendix (vet reference)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
- Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
-
Animal Drugs @ FDA:
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Applications/products are imported from FDA export data.
-
Animal Drugs @ FDA previews:
Source FDA
| Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:02 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC
Diagnosis-code mappings are not available for this medication yet.
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
- Not for use in horses intended for food. Safe use in breeding animals has not been established. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption. Safe use in breeding animals or in lactating mares has not been established. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For Intramuscular use in horses only. Not for intra-articular use. Do not mix with other drugs or solvents. PSGAG is a synthetic heparinoid; do not use in dogs with known or suspected bleeding disorders. Do not exceed recommended dose or regimen. Do not mix with other drugs or solvents. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Identifiers & Packages
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 10797-959-01 | 10797 | - | |
| 10797-975-01 | 10797 | - | |
| 10797-975-02 | 10797 | - | |
| 10797-995-01 | 10797 | - | |
| 10797-995-70 | 10797 | - |
Enriched Documents
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
-
N141038_Orig_7_15_1997.pdf
• FOI summary • Official
• June 28, 2018
FDA FOI summary for application 141038
-
N140901 Orig_11_11_1989.pdf
• FOI summary • Official
• Dec. 7, 2017
FDA FOI summary for application 140901
-
N140901_Supp_9_12_1996.pdf
• FOI summary • Official
• Dec. 7, 2017
FDA FOI summary for application 140901
-
UCM367650.pdf
• FOI summary • Official
• June 1, 2016
FDA FOI summary for application 136383
Data Sources & Revision History
Every non-trivial field is expected to include provenance and update timestamps.
- contraindications: Not for use in horses intended for food. Safe use in breeding animals has not been established. Federal law restricts this drug to use by or on the order of a … (Official, 2026-02-12)
- side_effects: Top reported reactions (openFDA): Vomiting, Diarrhoea, Lack of efficacy - NOS, Lethargy (see also Central nervous system depression in 'Neurological'), Not eat… (Official, 2026-02-12)
- usage: Polysulfated glycosaminoglycan is for the treatment of noninfectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal join… (Official, 2026-02-12)
- side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
Official sponsor/proprietary-name/application-status records linked by active ingredient.
| Product | Sponsor | Application | Status | Published |
|---|---|---|---|---|
|
Adequan® Canine
RX
Polysulfated Glycosaminoglycan
Liquid (Solution)
• Intramuscular
|
American Regent, Inc. | NADA 141-038 | Approved | Jun 28, 2018 |
|
Adequan® i.m. Multi-Dose Adequan® i.m.
RX
Polysulfated Glycosaminoglycan
Liquid (Solution)
• Intramuscular
|
American Regent, Inc. | NADA 140-901 | Approved | Dec 7, 2017 |
|
Adequan® Injectable
RX
Polysulfated Glycosaminoglycan
Liquid (Solution)
• Intra-Articular
|
American Regent, Inc. | NADA 136-383 | Approved | Jun 1, 2016 |
Data source: FDA Animal Drugs @ FDA (public search export).
What It's For (FDA Label Highlights)
Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Official Documents (FDA)
Direct links to FDA-hosted PDFs and SPL packages (when available).
-
Summary
Adequan® Canine is recommended for intramuscular injection for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints.
- Adequan® Canine (ZIP)
FDA page: Open in Animal Drugs @ FDA
-
Summary
This supplemental application amends the NADA to provide for the use of Adequan® i.m. in the treatment of noninfectious degenerative and/or traumatic joint dysfunction and associated lameness of the hock joint in horses.
-
Summary
Adequan® i.m. is recommended for the intramuscular treatment of noninfectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal joint in horses.
- Adequan® i.m. Multi-Dose (ZIP)
- Adequan® i.m. (ZIP)
FDA page: Open in Animal Drugs @ FDA
-
FOI UCM367650.pdf
Summary
Adequan is recommended for the treatment of noninfectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal joint in horses.
- Adequan® Injectable (ZIP)
FDA page: Open in Animal Drugs @ FDA
Usage
Polysulfated glycosaminoglycan is for the treatment of noninfectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal joint in horses. Polysulfated glycosaminoglycan is for the treatment of noninfectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses. For control of signs associated with noninfectious degenerative and/or traumatic arthritis of canine synovial joints.
Source: FDA Animal Drugs @ FDA • Reference
Contraindications
Not for use in horses intended for food. Safe use in breeding animals has not been established. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in horses intended for human consumption. Safe use in breeding animals or in lactating mares has not been established. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For Intramuscular use in horses only. Not for intra-articular use. Do not mix with other drugs or solvents. PSGAG is a synthetic heparinoid; do not use in dogs with known or suspected bleeding disorders. Do not exceed recommended dose or regimen. Do not mix with other drugs or solvents. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Side Effects
No approved side-effect narrative is linked yet.
openFDA reaction signals are available for Dog 56 and Cat 56 (view top reported reactions).
Top Reported Reactions (openFDA)
Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Dog, Shepherd Dog - German, Male, 5.8 year, 40.82 kilogram • Drug: MSK, Unknown • Reactions: Sneezing, Listless, Not eating, Reduced responses, Difficulty standing… • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-055636
- Serious AE: No
- Treated For AE: Yes
- Sex: Male
- Age: 5.80 Year
- Weight: 40.820 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Cat, Cat (unknown), Female, 20.5 year • Drug: MSK, Unassigned, Unknown • Reactions: General illness, Hiding, Joint pain, Elevated creatinine, Elevated symmetrical dimethylarginine… • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-055646
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 20.50 Year
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Unassigned
Dog, ['Chihuahua', 'Dog (unknown)'], Male, 10.75 year, 5.715 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 0.25 mL per dose • Reactions: Anaphylaxis, Swollen face, Itching, Swollen feet • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-055955
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Male
- Age: 10.75 Year
- Weight: 5.715 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Subcutaneous
- Form: Solution
- Dose: 0.25 mL per dose
Cat, Domestic Shorthair, Male, 13 year, 6.804 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 0.50 mL per dose, Frequency: 1 per week • Reactions: Nausea, Prolonged one stage prothrombin time, Prolonged activated partial thrombin time, Cardiac arrest, Death • Outcome: Died
- Report ID: USA-USFDACVM-2025-US-055853
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Male
- Age: 13.00 Year
- Weight: 6.804 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Subcutaneous
- Form: Solution
- Dose: 0.50 mL per dose
- Frequency: 1 per week
Dog, Crossbred Canine/dog, Male, 8 year, 10.569 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Shaking, Seizure NOS, Diarrhea, Vomiting • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-054899
- Serious AE: Yes
- Treated For AE: No
- Sex: Male
- Age: 8.00 Year
- Weight: 10.569 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Unassigned
Dog, Bulldog - English, Male, 6 year, 32.659 kilogram • Drug: MSK, Injection, solution, Unknown • Reactions: Partial lack of efficacy • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-053131
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 6.00 Year
- Weight: 32.659 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Injection, solution
Dog, ['Bulldog - English', 'Retriever - Labrador'], Male, 11 year, 30.844 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 1.40 mL per dose • Reactions: Anaphylaxis, Facial oedema, Hives • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-052943
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Male
- Age: 11.00 Year
- Weight: 30.844 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Subcutaneous
- Form: Solution
- Dose: 1.40 mL per dose
Cat, Domestic Shorthair, Male, 12 year, 6.35 kilogram • Drug: MSK, Parenteral • Reactions: Vomiting • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-051052
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 12.00 Year
- Weight: 6.350 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Parenteral
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.
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Let others know your experience or advice regarding this medication.
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