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Emodepside

Detailed information about Emodepside

Official label facts Owner quick guide first Marketing clearly labeled
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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

For the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and...

What it does:

For the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and...

When it's needed:

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Safe use of this product has not been evaluated in cats less that 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used fo...

Call your vet sooner if you notice:

  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. Safe use of this product has not been evaluated in cats less that 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy, or in lactating queens. Oral ingestion or exposure should be avoided.

Commonly reported reactions:

  • (1 reports)
  • (1 reports)
  • (1 reports)

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
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Emodepside

Emodepside

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: MSK

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: MSK
Form: Liquid
Identifiers:
NADA: 141275 NDC Package: 58198-0059-1 NDC Package: 58198-0059-2 NDC Package: 58198-0059-3 NDC Package: 58198-0060-1 NDC Package: 58198-0060-2 NDC Package: 58198-0060-3 NDC Package: 58198-0061-1 NDC Package: 58198-0061-2 NDC Package: 58198-0061-3 NDC Package: 58198-0062-1 NDC Product: 58198
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Safe use of this product has not been evaluated in cats less that 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy, or in lactating queens. Oral ingestion or exposure should be avoided.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Safe use of this product has not been evaluated in cats less that 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy, or in lactating queens. Oral ingestion or exposure should be avoided.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
19
Serious reports
0
Species represented
2
Most Reported Reactions
Reaction Cases Species Serious cases
1 Cat 0
1 Cat 0
1 Cat 0
1 Dog 0
1 Cat 0
1 Dog 0
1 Cat 0
1 Cat 0

Species coverage: Dog (17) Cat (15)

View detailed reaction table
Reaction Species Seriousness Frequency Reports
Dog Non-serious - 1
Dog Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Cat Non-serious - 1
Dog Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Cat Non-serious - 1
Dog Unknown - -
Dog Unknown - -
Dog Unknown - -
Dog Unknown - -
Dog Unknown - -
Dog Unknown - -
Dog Unknown - -
Cat Unknown - -
Dog Unknown - -
Dog Unknown - -
Dog Unknown - -
Dog Unknown - -
Dog Unknown - -
Source metadata:

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 2 • Secondary summaries: 0

Official label facts
Secondary summaries

No source yet.

Source metadata:

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.
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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 12, 2026, 10:42 PM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Profender™
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat
Rx/OTC: RX
Form/route: Liquid • Topical
Applications: NADA 141-275
Documents: 1 (FOI: 1) • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 38 • Cat 56 • View
Case summaries: 11 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Pica
Linked using: Fda_Label (0.95)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. Safe use of this product has not been evaluated in cats less that 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy, or in lactating queens. Oral ingestion or exposure should be avoided. (Contraindication, High)
Top reaction signals
Administration error NOS (1) Application site dermatitis (1) Application site hair loss (1) Application site inflammation (1) Application site irritation (1) Application site reddening (1) Application site scratching (1) Application site weeping (see also Skin) (1) Behavioural disorder NOS (1) Ear twitching (1) Hypersalivation (1) Hypersensitivity NOS (1) Irritability (1) Lack of efficacy (endoparasite) - roundworm NOS (1) Lack of efficacy (endoparasite) - tapeworm (1) Lack of efficacy - NOS (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141275 NDC Package: 58198-0059-1 NDC Package: 58198-0059-2 NDC Package: 58198-0059-3 NDC Package: 58198-0060-1 NDC Package: 58198-0060-2 NDC Package: 58198-0060-3 NDC Package: 58198-0061-1 NDC Package: 58198-0061-2 NDC Package: 58198-0061-3 NDC Package: 58198-0062-1 NDC Product: 58198
Package NDC Product NDC Form / Route Status
58198-0059-1 58198 -
58198-0059-2 58198 -
58198-0059-3 58198 -
58198-0060-1 58198 -
58198-0060-2 58198 -
58198-0060-3 58198 -
58198-0061-1 58198 -
58198-0061-2 58198 -
58198-0061-3 58198 -
58198-0062-1 58198 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • ucm062332.pdf • FOI summary • Official • April 29, 2021
    FDA FOI summary for application 141275

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 4 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Safe use of this product has not been evaluated in cats less that 8 weeks… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - hookworm, Incorrect route of drug administration, Vomiting, Accidental exposure, Administra… (Official, 2026-02-12)
  • usage: For the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections … (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Profender™
RX
Emodepside Praziquantel
Liquid • Topical
Label highlights
Official documents
Elanco US Inc. NADA 141-275 Approved Apr 29, 2021

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
Each mL contains 21.4 mg emodepside and 85.7 mg praziquantel
Cats
Indication
For the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and tapeworm infections caused by Dipylidium caninum (adults) and Taenia taeniaeformis (adults).
Dosage
The recommended minimum dose is 1.36 mg/pound (lb) (3 mg/kilogram (kg)) emodepside and 5.45 mg/ lb (12 mg/kg) praziquantel applied as a single topical dose.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Safe use of this product has not been evaluated in cats less that 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy, or in lactating queens. Oral ingestion or exposure should be avoided.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary
    PROFENDER Topical Solution is indicated for the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and tapeworm infections caused by Dipylidium caninum (adults) and Taenia taeniaeformis (adults) in cats.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

For the treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae), roundworm infections caused by Toxocara cati (adults and fourth stage larvae), and tapeworm infections caused by Dipylidium caninum (adults) and Taenia taeniaeformis (adults).

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Safe use of this product has not been evaluated in cats less that 8 weeks of age or weighing less than 2.2 lbs (1 kg), in cats used for breeding, during pregnancy, or in lactating queens. Oral ingestion or exposure should be avoided.

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 38 and Cat 56 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog
Digestive
Vomiting (3) Diarrhea (2) Drooling (1) Drooling (1) Drooling (1) Drooling (1) Drooling (1) Drooling (1)
Behavior
Behavioral disorder (unspecified) (2)
Effectiveness
Lack of efficacy (endoparasite) - hookworm (7) Lack of efficacy - NOS (2) Lack of efficacy - NOS (2) Lack of efficacy - NOS (2) Lack of efficacy - NOS (2) Lack of efficacy - NOS (2) Lack of efficacy - NOS (2) Lack of efficacy (endoparasite) - roundworm NOS (1) Lack of efficacy (endoparasite) - roundworm NOS (1) Lack of efficacy (endoparasite) - roundworm NOS (1) Lack of efficacy (endoparasite) - roundworm NOS (1) Lack of efficacy (endoparasite) - roundworm NOS (1) Lack of efficacy (endoparasite) - roundworm NOS (1)
Other
Incorrect route of drug administration (4) Accidental exposure (2) Administration error NOS (2) Administration error NOS (2) Administration error NOS (2) Administration error NOS (2) Administration error NOS (2) Administration error NOS (2) Administration error NOS (2) Drug administration error (2) Application site dermatitis (1) Application site dermatitis (1) Application site dermatitis (1) Application site dermatitis (1) Application site dermatitis (1) Application site dermatitis (1)
Cat
Digestive
Drooling (462) Vomiting (215)
Skin & allergy
Hair loss at application site (627) Application site hair loss (2) Application site hair loss (2) Application site hair loss (2) Application site hair loss (2) Application site hair loss (2) Application site hair loss (2)
Neurologic
Tiredness (lethargy) (320) Unsteady walking (ataxia) (212)
Behavior
Behavioral disorder (unspecified) (217) Behavioral disorder (unspecified) (1) Behavioral disorder (unspecified) (1) Behavioral disorder (unspecified) (1) Behavioral disorder (unspecified) (1)
Effectiveness
Lack of efficacy (endoparasite) - tapeworm (358) Lack of efficacy (endoparasite) - tapeworm (3) Lack of efficacy (endoparasite) - tapeworm (3) Lack of efficacy (endoparasite) - tapeworm (3) Lack of efficacy (endoparasite) - tapeworm (3) Lack of efficacy (endoparasite) - tapeworm (2) Lack of efficacy (endoparasite) - tapeworm (2)
Other
Licking at application site (201) Application site irritation (2) Application site irritation (2) Application site irritation (2) Application site irritation (2) Application site irritation (2) Application site irritation (2) Application site inflammation (1) Application site inflammation (1) Application site inflammation (1) Application site inflammation (1) Application site inflammation (1) Application site inflammation (1) Application site reddening (1) Application site reddening (1) Application site reddening (1) Application site reddening (1) Application site reddening (1) Application site reddening (1) Application site scratching (1) Application site scratching (1) Application site scratching (1) Application site scratching (1) Application site scratching (1) Application site scratching (1) Application site weeping (1) Application site weeping (1) Application site weeping (1) Application site weeping (1) Application site weeping (1) Application site weeping (1) Irritability (1) Irritability (1)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Shorthair, Male, 1.66 year, 4.536 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Application site scratching, Application site hair loss, Application site irritation, Application site reddening, Application site inflammation… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-055503
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 1.66 Year
  • Weight: 4.536 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 dose per animal
Reactions Reported:
Application site scratching Application site hair loss Application site irritation Application site reddening Application site inflammation Irritability
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 14.5 week, 1.87 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Lack of efficacy (endoparasite) - tapeworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055700
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 14.50 Week
  • Weight: 1.870 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 dose per animal
Reactions Reported:
Lack of efficacy (endoparasite) - tapeworm
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 7 week, 0.73 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal, Frequency: 1 per month • Reactions: Lack of efficacy (endoparasite) - tapeworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055999
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 7.00 Week
  • Weight: 0.730 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 dose per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (endoparasite) - tapeworm
Outcomes: Outcome Unknown

Dog, Mixed (Dog), Mixed, 1.6 year, 19.7 kilogram • Drug: MSK, Solution, Topical, Dose: 3 Milligram per kilogram • Reactions: Application site dermatitis, Administration error NOS • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055792
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Mixed
  • Age: 1.60 Year
  • Weight: 19.700 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 3 Milligram per kilogram
Reactions Reported:
Application site dermatitis Administration error NOS
Outcomes: Recovered/Normal

Dog, Mixed (Dog), Mixed, 1.6 year, 19.7 kilogram • Drug: MSK, Solution, Oral, Dose: 1 Milligram per kilogram • Reactions: Drooling • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055777
  • Serious AE: No
  • Treated For AE: No
  • Sex: Mixed
  • Age: 1.60 Year
  • Weight: 19.700 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Dose: 1 Milligram per kilogram
Reactions Reported:
Drooling
Outcomes: Recovered/Normal

Dog, Dog (unknown), Male • Drug: MSK, Solution, Oral • Reactions: Lack of efficacy - NOS, Administration error NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-055779
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
Reactions Reported:
Lack of efficacy - NOS Administration error NOS
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 4.33 year, 6.5 kilogram • Drug: MSK, Solution, Topical, Dose: 1 tube per animal • Reactions: Application site hair loss, Application site irritation, Moist dermatitis, Application site weeping • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-050212
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 4.33 Year
  • Weight: 6.500 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Form: Solution
  • Dose: 1 tube per animal
Reactions Reported:
Application site hair loss Application site irritation Moist dermatitis Application site weeping
Outcomes: Ongoing

Dog, Foxhound - American, Mixed, 1 year • Drug: MSK, Solution, Oral, Dose: 1 dose per animal • Reactions: Lack of efficacy - NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-051638
  • Serious AE: No
  • Treated For AE: No
  • Sex: Mixed
  • Age: 1.00 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Dose: 1 dose per animal
Reactions Reported:
Lack of efficacy - NOS
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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