Meds A-Z
Eprinomectin
Detailed information about Eprinomectin
Pet Owner Quick Guide
Start here: what this medicine is for, what it does, and when it's usually needed.
Usually used for:
For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi) , lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy...
What it does:
The drug is used in beef and dairy cattle for treatment and control of gastrointestinal roundworms ( Haemonchus placei (adult and L4), Ostertagia ostertagi (adult and L4, including inhibited L4), Trichostrongylus axei (a...
When it's needed:
Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Do not use in calves to be processed for veal. Federal law restric...
Call your vet sooner if you notice:
- Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Do not use in calves to be processed for veal. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal. Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal.Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing.
Commonly reported reactions:
- (2 reports)
- (1 reports)
- (1 reports)
What to ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Eprinomectin
Drug type: Generic ingredient • Branded profile • FDA branded products available
Species: Both
Manufacturer: MSK
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200626 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200741 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source
Warnings / Contraindications
Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Do not use in calves to be processed for veal. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal. Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal.Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing.
- High: Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Do not use in calves to be processed for veal. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal. Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal.Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing.
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Tap or hover a reaction to see what it means in plain language.
Most Reported Reactions
| Reaction | Cases | Species | Serious cases |
|---|---|---|---|
| 2 | Cat, Dog | 0 | |
| 1 | Cat | 1 | |
| 1 | Dog | 1 | |
| 1 | Dog | 0 | |
| 1 | Dog | 0 | |
| 1 | Cat | 0 | |
| 1 | Dog | 0 | |
| 1 | Cat | 0 |
Species coverage: Cat (20) Dog (12)
View detailed reaction table
| Reaction | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Cat | Unknown | - | - | |
| Dog | Unknown | - | - | |
| Dog | Unknown | - | - |
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-055900
Storage & Handling
No storage/handling guidance is linked yet.
Documents
Official label facts are separated from secondary summaries.
Official documents: 18 • Secondary summaries: 0
- FOI Summary oA 200-626 Approved January 13, 2025.pdf · FOI
- Eprimectin™ Pour-On · SPL
- FOI Summary oA 200-741 Approved February 24, 2023.pdf · FOI
- EpriGard® · SPL
- UCM409097.pdf · FOI
- N-141327-Q-0106-OT-AA_foi.pdf · FOI
- 141-327 · EA
- 141-327 · FONSI
- Longrange® · SPL
- N141079_Supp_8_9_1998.pdf · FOI
- N141079_Orig_4_16_1997.pdf · FOI
- 141-079 · EA
- 141-079 · FONSI
- Eprinex® · SPL
- FOI Summary oN 141-492 Approved March 8, 2018.pdf · FOI
- Centragard® · SPL
- FOI Summary oA 200-563 Approved January 16, 2018.pdf · FOI
- Eprizero® · SPL
No source yet.
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/16468 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/16787/Eprimectin%E2%84%A2%20Pour-On · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/13514 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/13692/EpriGard%C2%AE · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/885 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/884 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadEA/94 · document · EA
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFonsi/94 · document · FONSI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2222/Longrange%C2%AE · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/2082 · document · FOI
Promotional Materials (Marketing)
This content is marketing material and not clinical guidance.
No marketing assets are linked yet.
No source yet.
Technical appendix (vet reference)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
- Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
-
Animal Drugs @ FDA:
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Applications/products are imported from FDA export data.
-
Animal Drugs @ FDA previews:
Source FDA
| Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:02 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
- Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Do not use in calves to be processed for veal. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal. Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal.Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing. (Contraindication, High)
Identifiers & Packages
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 0010-4120-01 | 0010 | - | |
| 0010-4120-02 | 0010 | - | |
| 0010-4120-03 | 0010 | - | |
| 0010-4121-01 | 0010 | - | |
| 0010-4121-02 | 0010 | - | |
| 0010-4121-03 | 0010 | - | |
| 0010-4251-01 | 0010 | - | |
| 0010-4251-02 | 0010 | - | |
| 0010-4751-01 | 0010 | - | |
| 0010-4751-02 | 0010 | - | |
| 0010-4751-03 | 0010 | - | |
| 0010-4751-04 | 0010 | - | |
| 0010-4751-05 | 0010 | - | |
| 0010-4751-06 | 0010 | - | |
| 0010-7216-02 | 0010 | - | |
| 0010-7216-03 | 0010 | - | |
| 0010-7216-04 | 0010 | - | |
| 51072-109-01 | 51072 | - | |
| 51072-109-02 | 51072 | - | |
| 51072-109-03 | 51072 | - |
Enriched Documents
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
-
FOI Summary oA 200-626 Approved January 13, 2025.pdf
• FOI summary • Official
• Feb. 5, 2025
FDA FOI summary for application 200626
-
FOI Summary oA 200-741 Approved February 24, 2023.pdf
• FOI summary • Official
• Nov. 12, 2024
FDA FOI summary for application 200741
-
N-141327-Q-0106-OT-AA_foi.pdf
• FOI summary • Official
• April 30, 2024
FDA FOI summary for application 141327
-
UCM409097.pdf
• FOI summary • Official
• April 30, 2024
FDA FOI summary for application 141327
-
N141079_Orig_4_16_1997.pdf
• FOI summary • Official
• March 18, 2024
FDA FOI summary for application 141079
-
N141079_Supp_8_9_1998.pdf
• FOI summary • Official
• March 18, 2024
FDA FOI summary for application 141079
-
FOI Summary oN 141-492 Approved March 8, 2018.pdf
• FOI summary • Official
• March 16, 2023
FDA FOI summary for application 141492
-
FOI Summary oA 200-563 Approved January 16, 2018.pdf
• FOI summary • Official
• July 2, 2018
FDA FOI summary for application 200563
Data Sources & Revision History
Every non-trivial field is expected to include provenance and update timestamps.
- contraindications: Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Do no… (Official, 2026-02-12)
- side_effects: Top reported reactions (openFDA): Accidental exposure, Ataxia, Dilated pupils, Vomiting, Impaired vision, Anorexia. (Official, 2026-02-12)
- usage: The drug is used in beef and dairy cattle for treatment and control of gastrointestinal roundworms ( Haemonchus placei (adult and L4), Ostertagia ostertagi (ad… (Official, 2026-02-12)
- side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
Official sponsor/proprietary-name/application-status records linked by active ingredient.
| Product | Sponsor | Application | Status | Published |
|---|---|---|---|---|
|
Eprimectin™ Pour-On
OTC
Eprinomectin
Topical Solution
• Topical
|
Bimeda Animal Health Limited | ANADA 200-626 | Approved | Feb 5, 2025 |
|
EpriGard®
OTC
Eprinomectin
Topical Solution
• Topical
|
Aurora Pharmaceutical, Inc. | ANADA 200-741 | Approved | Nov 12, 2024 |
|
Longrange®
RX
Eprinomectin
Liquid (Solution)
• Subcutaneous
|
Boehringer lngelheim Animal Health USA, Inc. | NADA 141-327 | Approved | Apr 30, 2024 |
|
Eprinex®
OTC
Eprinomectin
Liquid
• Topical
|
Boehringer lngelheim Animal Health USA, Inc. | NADA 141-079 | Approved | Mar 18, 2024 |
|
Centragard®
RX
Eprinomectin Praziquantel
Transdermal Solution
• Transdermal
|
Boehringer lngelheim Animal Health USA, Inc. | NADA 141-492 | Approved | Mar 16, 2023 |
|
Eprizero®
OTC
Eprinomectin
Topical Solution
• Topical
|
Norbrook Laboratories, Ltd. | ANADA 200-563 | Approved | Jul 2, 2018 |
Data source: FDA Animal Drugs @ FDA (public search export).
What It's For (FDA Label Highlights)
Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.
Composition / specifications
For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle.
Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight, Eprimectin™ Pour-On is indicated for the effective treatment and control of the following parasites:
Gastrointestinal Roundworms
Haemonchus placei (adults and L4)
Ostertagia ostertagi (adults and L4) (including inhibited L4)
Trichostrongylus axei (adults and L4)
Trichostrongylus colubriformis (adults and L4)
Trichostrongylus longispicularis (adults only)
Cooperia oncophora (adults and L4)
Cooperia punctata (adults and L4)
Cooperia surnabada (adults and L4)
Nematodirus helvetianus (adults and L4)
Oesophagostomum radiatum (adults and L4)
Bunostomum phlebotomum (adults and L4)
Strongyloides papillosus (adults only)
Trichuris spp. (adults only)
Lungworms
Dictyocaulus viviparus (adults and L4)
Cattle Grubs (all parasitic stages)
Hypoderma lineatum
Hypoderma bovis
Lice
Damalinia bovis
Linognathus vituli
Haematopinus eurysternus
Solenopotes capillatus
Mange Mites
Chorioptes bovis
Sarcoptes scabiei
Horn Flies
Haematobia irritans
Persistent Activity
Eprinomectin pour-on for beef and dairy cattle has been proved to effectively control infections and to protect cattle from re-infection with Dictyocaulus viviparus for 21 days after treatment and Haematobia irritans for 7 days after treatment.
The dose rate is 1 mL/10 kg (22 lb) of body weight. The product should be applied topically along the backline in a narrow strip extending from the withers to the tail head.
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle.
Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight, it is indicated for the effective treatment and control of the following parasites:
Gastrointestinal Roundworms
Haemonchus placei (adults and L4)
Ostertagia ostertagi (adults and L4)
(including inhibited L4)
Trichostrongylus axei (adults and L4)
Trichostrongylus colubriformis (adults and L4)
Trichostrongylus longispicularis (adults only)
Cooperia oncophora (adults and L4)
Cooperia punctata (adults and L4)
Cooperia surnabada (adults and L4)
Nematodirus helvetianus (adults and L4)
Oesophagostomum radiatum (adults and L4)
Bunostomum phlebotomum (adults and L4)
Strongyloides papillosus (adults only)
Trichuris spp. (adults only)
Lungworms
Dictyocaulus viviparus (adults and L4)
Cattle Grubs (all parasitic stages)
Hypoderma lineatum
Hypoderma bovis
Lice
Damalinia bovis
Linognathus vituli
Haematopinus eurysternus
Solenopotes capillatus
Mange Mites
Chorioptes bovis
Sarcoptes scabiei
Horn Flies
Haematobia irritans
Persistent Activity
EpriGard™ (eprinomectin) Pour-On for Beef and Dairy Cattle has been proved to effectively control infections and to protect cattle from re-infection with Dictyocaulus viviparus for 21 days after treatment and Haematobia irritans for 7 days after treatment.
The dose rate is 1 mL/10 kg (22 lb) of body weight. The product should be applied topically along the backline in a narrow strip extending from the withers to the tailhead.
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
Persistent Activity LONGRANGE® (eprinomectin) has been proven to effectively protect cattle from reinfection with the following parasites for the indicated amounts of time following treatment:Parasites Duration of Persistent Effectiveness Gastrointestinal Roundworms Bunostomum phlebotomum 150 daysCooperia oncophora 100 days Cooperia punctata 100 days Haemonchus placei 120 days Oesophagostomum radiatum 120 days Ostertagia lyrata 120 days Ostertagia ostertagi 120 days Trichostrongylus axei 100 days Lungworms Dictyocaulus viviparous 150 days
Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal.Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing.
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
For the prevention of heartworm disease caused by Dirofilaria immitis, and for the treatment and control of roundworms (adult and fourth stage larval Toxocara cati), hookworms (adult and fourth stage larval Ancylostoma tubaeforme; adult Ancylostoma braziliense), and tapeworms (adult Dipylidium caninum and Echinococcus multilocularis), in cats and kittens 7 weeks of age and older and 1.8 lbs or greater.
Centragard™ is dosed at a minimum of 0.055 mL/lb (0.12 mL/kg), which delivers a minimum dose of 0.23 mg/lb eprinomectin and 4.55 mg/lb praziquantel.
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle. Eprizero™ Pour-On is indicated for the effective treatment and control of the following parasites:
Gastrointestinal Roundworms
- Haemonchus placei (adults and L4)
- Ostertagia ostertagi (adults and L4) (including inhibited L4)
- Trichostrongylus axei (adults and L4)
- Trichostrongylus colubriformis (adults and L4)
- Trichostrongylus longispicularis (adults only)
- Cooperia onchophora (adults and L4)
- Cooperia punctata (adults and L4)
- Cooperia surnabada (adults and L4)
- Nematodirus helvetianus (adults and L4)
- Oesophagostomum radiatum (adults and L4)
- Bunostomum phlebotomum (adults and L4)
- Strongyloides papillosus (adults only)
- Trichuris spp. (adults only)
Lungworms
- Dictyocaulus viviparus (adults and L4)
- Hypoderma lineatum
- Hypoderma bovis
- Damalinia bovis
- Linognathus vituli
- Haematopinus eurysternus
- Solenopotes capillatus
- Chorioptes bovis
- Sarcoptes scabiei
- Haematobia irritans
1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight.
FDA page: Open in Animal Drugs @ FDA
Official Documents (FDA)
Direct links to FDA-hosted PDFs and SPL packages (when available).
-
Summary
For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle.
- Eprimectin™ Pour-On (ZIP)
FDA page: Open in Animal Drugs @ FDA
-
Summary
For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies
- EpriGard® (ZIP)
FDA page: Open in Animal Drugs @ FDA
-
FOI UCM409097.pdf
Summary
This supplement provides for the approval of a new indication for the treatment and control of Bunostomum phlebotomum (adults and L4s) and for the protection of cattle from reinfection with Bunostomum phlebotomum for 150 days following treatment. -
Summary
 For the treatment and control of the following parasites:
Gastrointestinal Roundworms
Cooperia oncophora â Adults and L4
Cooperia punctata â Adults and L4
Cooperia surnabada â Adults and L4
Haemonchus placei â Adults
Oesophagostomum radiatum â Adults
Ostertagia lyrata â Adults
Ostertagia ostertagi â Adults, L4, and inhibited L4
Trichostrongylus axei â Adults and L4
Trichostrongylus colubriformis â Adults
 Lungworms
Dictyocaulus viviparus â Adults
Grubs
Hypoderma bovis
Mites
Sarcoptes scabiei var. bovis
Persistent Activity
LONGRANGE⢠(eprinomectin) has been proven to effectively protect cattle from reinfection with the following parasites for the indicated amounts of time following treatment:
Parasites - Duration of Persistent Effectiveness
Gastrointestinal RoundwormsÂ
Cooperia oncophora - 100 days
Cooperia punctata - 100 days
Haemonchus placei - 120 days
Oesophagostomum radiatum -Â 120 days
Ostertagia lyrata - 120 days
Ostertagia ostertagi - 120 days
Trichostrongylus axei - 100 days
Lungworms
Dictyocaulus viviparous - 150 days -
EA 141-327
-
FONSI 141-327
- Longrange® (ZIP)
FDA page: Open in Animal Drugs @ FDA
-
Summary
This supplemental application adds indications for the treatment and control of adult Strongyloides papillosus and adult Trichostrongylus longispicularis and removes the age restriction for use in cattle under 8 weeks of age.
-
Summary
IVOMEC EPRINEX Pour-On for Beef and Dairy Cattle is indicated for treatment and control of:
Gastrointestinal nematodes (adults and fourth-stage larvae, L4): Haemonchus placei Ostertagia ostertagi (including inhibited L4), Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia oncophora, Cooperia punctate, Cooperia surnabada, Nematodirus helvetianus, Bunostomum phlebotomum, Oesophagostomum radiatum, Trichuris spp. (adults)
Lungworms (adults and L4): Dictyocaulus viviparus
Cattle grubs (all parasitic stages): Hypoderma lineatum, Hypoderma bovis
Lice: Damalinia bovis, Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus
Mange Mites: Chorioptes bovis, Sarcoptes scabiei
Flies: Haematobia irritans
IVOMEC EPRINEX (eprinomectin) Pour-On for Beef and Dairy Cattle has been proved to control infections of Dictyocaulus viviparus for 21 days after treatment and Haematobia irritans for 7 days after treatment.
-
EA 141-079
-
FONSI 141-079
- Eprinex® (ZIP)
FDA page: Open in Animal Drugs @ FDA
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Summary
For the prevention of heartworm disease caused by Dirofilaria immitis, and for the treatment and control of roundworms (adult and fourth stage larval Toxocara cati), hookworms (adult and fourth stage larval Ancylostoma tubaeforme; adult Ancylostoma braziliense), and tapeworms (adult Dipylidium caninum and Echinococcus multilocularis), in cats and kittens 7 weeks of age and older and 1.8 lbs or greater.
- Centragard® (ZIP)
FDA page: Open in Animal Drugs @ FDA
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Summary
For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle.
- Eprizero® (ZIP)
FDA page: Open in Animal Drugs @ FDA
Usage
The drug is used in beef and dairy cattle for treatment and control of gastrointestinal roundworms ( Haemonchus placei (adult and L4), Ostertagia ostertagi (adult and L4, including inhibited L4), Trichostrongylus axei (adult and L4), T. colubriformis (adult and L4), T. longispicularis (adult), Cooperia oncophora (adult and L4), C. punctate (adult and L4), C. surnabada (adult and L4), Nematodirus helvetianus (adult and L4), Bunostomum phlebotomum (adult and L4), Oesophagostomum radiatum (adult and L4), Strongyloides papillosus (adults), Trichuris species (adults)); lungworms ( Dictyocaulus viviparous , adult and L4); cattle grubs (all parasitic stages Hypoderma lineatum , H. bovis ); lice ( Damalinia bovis , Linognathus vituli , Haematopinus eurysternus , Solenopotes capillatus ); mange mites ( Chorioptes bovis , Sarcoptes scabiei ); and horn flies ( Haematobia irritans ). Controls and protects from reinfection of D. viviparous for 21 days after treatment and H. irritans for 7 days after treatment. Persistent Activity LONGRANGE ® (eprinomectin) has been proven to effectively protect cattle from reinfection with the following parasites for the indicated amounts of time following treatment:Parasites Duration of Persistent Effectiveness Gastrointestinal Roundworms Bunostomum phlebotomum 150 days Cooperia oncophora 100 days Cooperia punctata 100 days Haemonchus placei 120 days Oesophagostomum radiatum 120 days Ostertagia lyrata 120 days Ostertagia ostertagi 120 days Trichostrongylus axei 100 days Lungworms Dictyocaulus viviparous 150 days For the treatment and control of the following parasites: Gastrointestinal Roundworms Bunostomum phlebotomum : Adults and L4 Cooperia oncophora : Adults and L4 Cooperia punctata : Adults and L4 Cooperia surnabada : Adults and L4 Haemonchus placei : Adults Oesophagostomum radiatum : Adults Ostertagia lyrata : Adults Ostertagia ostertagi : Adults, L4, and inhibited L4 Trichostrongylus axei : Adults and L4 Trichostrongylus colubriformis : Adults Lungworms Dictyocaulus viviparus : Adults Grubs Hypoderma bovis Mites Sarcoptes scabiei var. bovis
Source: FDA Animal Drugs @ FDA • Reference
Contraindications
Apply topically along backbone from withers to tailhead. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Do not use in calves to be processed for veal. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal. Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing. Federal law restricts this drug to use by or on the order of a licensed veterinarian. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. Do not use in calves to be processed for veal.Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing.
Side Effects
No approved side-effect narrative is linked yet.
openFDA reaction signals are available for Dog 8 and Cat 56 (view top reported reactions).
Top Reported Reactions (openFDA)
Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Cat, Domestic Shorthair, Male, 3 month, 1.95 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Lack of efficacy (endoparasite) - hookworm • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-056138
- Serious AE: No
- Treated For AE: Yes
- Sex: Male
- Age: 3.00 Month
- Weight: 1.950 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Topical
- Form: Solution
- Dose: 1 dose per animal
Cat, Cat (unknown), Unknown • Drug: MSK, Solution, Unknown • Reactions: Lack of efficacy (endoparasite) - roundworm NOS • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-056147
- Serious AE: No
- Treated For AE: No
- Sex: Unknown
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Solution
Cat, Domestic Shorthair, Female, 10 week, 0.757 kilogram • Drug: MSK, Solution, Topical • Reactions: Death • Outcome: Died
- Report ID: USA-USFDACVM-2025-US-056167
- Serious AE: Yes
- Treated For AE: No
- Sex: Female
- Age: 10.00 Week
- Weight: 0.757 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Topical
- Form: Solution
Cat, Domestic Shorthair, Male, 3 month, 1.633 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Head bobbing, Unsteady walking (ataxia), Abnormal posture NOS • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-056135
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 3.00 Month
- Weight: 1.633 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Topical
- Form: Solution
- Dose: 1 dose per animal
Cat, Siamese, Female, 12 year, 3.992 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Loss of appetite, Unsteady walking (ataxia), Loose stool, Abnormal movement NOS, Abnormal posture NOS • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-055900
- Serious AE: No
- Treated For AE: Yes
- Sex: Female
- Age: 12.00 Year
- Weight: 3.992 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Topical
- Form: Solution
- Dose: 1 dose per animal
Dog, Shih Tzu, Female, 10 month, 3.629 kilogram • Drug: MSK, Solution, Oral, Dose: 1 dose per animal • Reactions: Vomiting • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-046628
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 10.00 Month
- Weight: 3.629 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Solution
- Dose: 1 dose per animal
Dog, ['Shih Tzu', 'Maltese'], Female, 7 year, 4.536 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Itching • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-033763
- Serious AE: No
- Treated For AE: Yes
- Sex: Female
- Age: 7.00 Year
- Weight: 4.536 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Topical
- Form: Solution
- Dose: 1 dose per animal
Dog, Dog (unknown), Unknown • Drug: MSK, Solution, Oral • Reactions: Dilated pupils • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-025469
- Serious AE: No
- Treated For AE: No
- Sex: Unknown
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Solution
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.
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