Meds A-Z
Isoflurane
Detailed information about Isoflurane
Pet Owner Quick Guide
Start here: what this medicine is for, what it does, and when it's usually needed.
Usually used for:
For induction and maintenance of general anesthesia.
What it does:
For induction and maintenance of surgical anesthesia. For induction and maintenance of general anesthesia.
When it's needed:
Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxant...
Call your vet sooner if you notice:
- Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Commonly reported reactions:
- (2 reports)
- (1 reports)
- (1 reports)
What to ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Isoflurane
Drug type: Generic ingredient • Branded profile • FDA branded products available
Species: Both
Manufacturer: MSK
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200821 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200141 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source
Warnings / Contraindications
Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- High: Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Tap or hover a reaction to see what it means in plain language.
Most Reported Reactions
| Reaction | Cases | Species | Serious cases |
|---|---|---|---|
| 2 | Cat, Dog | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Cat | 1 | |
| 1 | Dog | 1 | |
| 1 | Cat | 1 | |
| 1 | Dog | 1 |
Species coverage: Dog (17) Cat (15)
View detailed reaction table
| Reaction | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Dog | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Serious | - | 1 | |
| Cat | Non-serious | - | 1 | |
| Dog | Non-serious | - | 1 | |
| Cat | Serious | - | 1 |
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case DEU-USFDACVM-2025-DE-000039
Storage & Handling
No storage/handling guidance is linked yet.
Documents
Official label facts are separated from secondary summaries.
Official documents: 11 • Secondary summaries: 0
- FOI Summary oA 200-821 Approved August 28, 2025.pdf · FOI
- Isoflurane · SPL
- A200141_Orig_07_26_1994.pdf · FOI
- ATTANE™ · SPL
- A200237_Orig_12_19_1997.pdf · FOI
- Isoflurane, USP · SPL
- A200129_Orig_06_29_1995.pdf · FOI
- Isospire™ · SPL
- A200070_Org_3_11_1993.pdf · FOI
- IsoFlo™ · SPL
- Aerrane® · SPL
No source yet.
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/17356 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/17696/Isoflurane · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1956 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/304/ATTANE%E2%84%A2 · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1914 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/137/Isoflurane%2C%20USP · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/3642 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/338/Isospire%E2%84%A2 · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1390 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/440/IsoFlo%E2%84%A2 · document · SPL
Promotional Materials (Marketing)
This content is marketing material and not clinical guidance.
No marketing assets are linked yet.
No source yet.
Technical appendix (vet reference)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
- Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
-
Animal Drugs @ FDA:
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Applications/products are imported from FDA export data.
-
Animal Drugs @ FDA previews:
Source FDA
| Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:02 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC
Diagnosis-code mappings are not available for this medication yet.
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
- Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Identifiers & Packages
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 11695-6777-1 | 11695 | - | |
| 11695-6777-2 | 11695 | - | |
| 13985-528-40 | 13985 | - | |
| 13985-528-60 | 13985 | - | |
| 17033-091-25 | 17033 | - | |
| 46066-115-03 | 46066 | - | |
| 46066-115-04 | 46066 | - | |
| 50989-150-12 | 50989 | - | |
| 50989-150-15 | 50989 | - | |
| 66794-013-10 | 66794 | - | |
| 66794-013-25 | 66794 | - | |
| 68504-010-01 | 68504 | - |
Enriched Documents
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
-
FOI Summary oA 200-821 Approved August 28, 2025.pdf
• FOI summary • Official
• Sept. 2, 2025
FDA FOI summary for application 200821
-
A200237_Orig_12_19_1997.pdf
• FOI summary • Official
• March 14, 2024
FDA FOI summary for application 200237
-
A200141_Orig_07_26_1994.pdf
• FOI summary • Official
• March 14, 2024
FDA FOI summary for application 200141
-
A200129_Orig_06_29_1995.pdf
• FOI summary • Official
• Nov. 16, 2022
FDA FOI summary for application 200129
-
A200070_Org_3_11_1993.pdf
• FOI summary • Official
• May 17, 2017
FDA FOI summary for application 200070
Data Sources & Revision History
Every non-trivial field is expected to include provenance and update timestamps.
- contraindications: Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depres… (Official, 2026-02-12)
- side_effects: Top reported reactions (openFDA): Vomiting, Death, Bradycardia, Lack of efficacy - NOS, Lethargy (see also Central nervous system depression in 'Neurological')… (Official, 2026-02-12)
- usage: For induction and maintenance of surgical anesthesia. For induction and maintenance of general anesthesia. (Official, 2026-02-12)
- side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
Official sponsor/proprietary-name/application-status records linked by active ingredient.
| Product | Sponsor | Application | Status | Published |
|---|---|---|---|---|
|
Isoflurane
RX
Isoflurane
Liquid
• Inhalation
|
Parnell Technologies Pty. Ltd. | ANADA 200-821 | Approved | Sep 2, 2025 |
|
ATTANE™
RX
Isoflurane
Liquid
• Inhalation
|
Piramal Pharma Ltd. | ANADA 200-141 | Approved | Mar 14, 2024 |
|
Isoflurane, USP
RX
Isoflurane
Liquid
• Inhalation
|
Piramal Pharma Ltd. | ANADA 200-237 | Approved | Mar 14, 2024 |
|
Isospire™
RX
Isoflurane
Liquid
• Inhalation
|
Dechra Veterinary Products LLC | ANADA 200-129 | Approved | Nov 16, 2022 |
|
IsoFlo™
RX
Isoflurane
Liquid
• Inhalation
|
Zoetis Inc. | ANADA 200-070 | Approved | May 17, 2017 |
|
Aerrane®
RX
Isoflurane
Liquid
• Inhalation
|
Baxter Healthcare Corp. | NADA 135-773 | W | Apr 4, 2017 |
Data source: FDA Animal Drugs @ FDA (public search export).
What It's For (FDA Label Highlights)
Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.
Composition / specifications
For induction and maintenance of general anesthesia.
For induction of surgical anesthesia: 3 to 5 percent isoflurane (with oxygen) for 5 to 10 minutes, For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
For induction and maintenance of general anesthesia.
For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 to 1.8 percent isoflurane (with oxygen).
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Composition / specifications
FDA page: Open in Animal Drugs @ FDA
Official Documents (FDA)
Direct links to FDA-hosted PDFs and SPL packages (when available).
-
Summary
For induction and maintenance of general anesthesia in horses and dogs.
- Isoflurane (ZIP)
FDA page: Open in Animal Drugs @ FDA
-
Summary
Isoflurane, USP is used for induction and maintenance of general anesthesia in horses and dogs.
- ATTANE™ (ZIP)
FDA page: Open in Animal Drugs @ FDA
-
Summary
Isoflurane, USP is used for induction and maintenance of general anesthesia in horses and dogs.
- Isoflurane, USP (ZIP)
FDA page: Open in Animal Drugs @ FDA
-
Summary
Isoflurane, USP is used for induction and maintenance of general anesthesia in dogs and horses.
- Isospire™ (ZIP)
FDA page: Open in Animal Drugs @ FDA
-
Summary
IsoFlo (isoflurane, USP) is used for induction and maintenance of general anesthesia in horses and dogs.
- IsoFlo™ (ZIP)
FDA page: Open in Animal Drugs @ FDA
- Aerrane® (ZIP)
FDA page: Open in Animal Drugs @ FDA
Usage
For induction and maintenance of surgical anesthesia. For induction and maintenance of general anesthesia.
Source: FDA Animal Drugs @ FDA • Reference
Contraindications
Administer by inhalation. Not for use in horses sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Not for use in dogs sensitive to halogenated agents. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Administer by inhalation. Increasing depth of anesthesia may increase hypotension and respiratory depression. Use less than usual amounts of nondepolarizing relaxants. Use with vaporizers producing predictable percentage concentrations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Side Effects
No approved side-effect narrative is linked yet.
openFDA reaction signals are available for Dog 56 and Cat 56 (view top reported reactions).
Top Reported Reactions (openFDA)
Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Cat, Domestic Shorthair, Male, 5 year, 8.61 kilogram • Drug: MSK, Unknown • Reactions: Hyperthermia, Hyperactivity • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-055972
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 5.00 Year
- Weight: 8.610 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, ['Shepherd Dog - German', 'Dog (unknown)'], Female, 2.5 year • Drug: MSK, Respiratory (Inhalation) • Reactions: Neutropenia, Eosinophilia, Lymphocytosis, Enamel disorder, Tooth disorder • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-055809
- Serious AE: Yes
- Treated For AE: No
- Sex: Female
- Age: 2.50 Year
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Respiratory (Inhalation)
Cat, Domestic Shorthair, Female, 10 month, 3.629 kilogram • Drug: MSK, Solution, Respiratory (Inhalation) • Reactions: Shaking, Overdose, Medication error NOS, Increased heart rate, Intentional misuse • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-054487
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 10.00 Month
- Weight: 3.629 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Respiratory (Inhalation)
- Form: Solution
Cat, Cat (other), Male, 13 year, 3.49 kilogram • Drug: MSK, Unknown • Reactions: Slow heart rate, Recovery prolonged • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-055510
- Serious AE: No
- Treated For AE: Yes
- Sex: Male
- Age: 13.00 Year
- Weight: 3.490 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Cat, Maine Coon, Female, 11 year, 4.58 kilogram • Drug: MSK, Unknown • Reactions: Recovery prolonged • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-055867
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 11.00 Year
- Weight: 4.580 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Cat, Domestic Mediumhair, Female, 19 week, 2.06 kilogram • Drug: MSK, Unknown • Reactions: Sleepiness - neurological disorder, Temporary blindness, Tiredness (lethargy), Reduced responses, Mydriasis… • Outcome: Euthanized
- Report ID: USA-USFDACVM-2025-US-055689
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 19.00 Week
- Weight: 2.060 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, Sheepdog - Old English (Bobtail), Male, 4 year, 37.8 kilogram • Drug: MSK, Solution, Unknown • Reactions: Malaise, Gastric ulcer, Peritonitis, Fluid in abdomen NOS, Fluid in abdomen NOS… • Outcome: Euthanized
- Report ID: DEU-USFDACVM-2025-DE-000039
- Serious AE: Yes
- Treated For AE: No
- Sex: Male
- Age: 4.00 Year
- Weight: 37.800 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Solution
Dog, ['Chihuahua', 'Mixed (Dog)'], Female, 9 year, 5.534 kilogram • Drug: MSK, Solution, Respiratory (Inhalation) • Reactions: Tachycardia, Hypotension • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-055949
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 9.00 Year
- Weight: 5.534 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Respiratory (Inhalation)
- Form: Solution
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.
Share Your Thoughts
Let others know your experience or advice regarding this medication.
This medication has not been reviewed by a veterinarian yet.