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Ketamine Hydrochloride

Detailed information about Ketamine Hydrochloride

Official label facts Owner quick guide first Marketing clearly labeled
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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

It is used for restraint.

What it does:

It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation. It is used for restraint. It is used in cats as the sole anesthet...

When it's needed:

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the orde...

Call your vet sooner if you notice:

  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Commonly reported reactions:

  • (1 reports)
  • (1 reports)
  • (1 reports)

What to ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
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Ketamine Hydrochloride

Ketamine Hydrochloride

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: MSK

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: MSK
Form: Liquid (Solution)
Identifiers:
ANADA: 200029 ANADA: 200042 ANADA: 200055 ANADA: 200073 ANADA: 200257 ANADA: 200279 NADA: 45290 NADA: 92116 NDC Package: 11695-0703-1 NDC Package: 13985-584-10 NDC Package: 17033-101-10 NDC Package: 54771-2013-1 NDC Package: 69043-063-01 NDC Product: 11695 NDC Product: 13985 NDC Product: 17033 NDC Product: 54771 NDC Product: 69043
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
29
Species represented
2
Most Reported Reactions
Reaction Cases Species Serious cases
1 Cat 1
1 Cat 1
1 Cat 1
1 Dog 1
1 Cat 1
1 Cat 1
1 Cat 1
1 Dog 1

Species coverage: Cat (21) Dog (11)

View detailed reaction table
Reaction Species Seriousness Frequency Reports
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Dog Serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Dog Serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Non-serious - 1
Cat Serious - 1
Dog Serious - 1
Cat Serious - 1
Dog Non-serious - 1
Cat Serious - 1
Cat Serious - 1
Dog Non-serious - 1
Dog Serious - 1
Cat Serious - 1
Cat Serious - 1
Cat Serious - 1
Source metadata:

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 14 • Secondary summaries: 0

Official label facts
Secondary summaries

No source yet.

Source metadata:

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.
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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
  • Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:02 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: KetaFlo™ Ketamine HCL Ketamine Hydrochloride Injection Ketamine Hydrochloride Injection, USP Ketaset® Plus VetaKet® Vetalar®
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat, Primates
Rx/OTC: RX
Form/route: Liquid (Solution) • Intramuscular
Applications: ANADA 200-257 • ANADA 200-055 • NADA 45290 • ANADA 200-029 • ANADA 200-042 • ANADA 200-073 • ANADA 200-279 • NADA 92116
Documents: 6 (FOI: 6) • SPL: 8 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 56 • Cat 56 • View
Case summaries: 10 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Abdominal effusion (1) Adipsia (1) Anaemia NOS (1) Anorexia (1) Bilirubinuria (1) Breathing difficulty (1) Cardiac disorder NOS (1) Cardiorespiratory arrest (1) Death (1) Dehydration (1) Elevated alanine aminotransferase (ALT) (1) Elevated aspartate aminotransferase (AST) (1) Elevated creatinine (1) Elevated gamma-glutamyl transferase (GGT) (1) Elevated serum alkaline phosphatase (ALP) (1) Elevated symmetrical dimethylarginine (SDMA) (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200029 ANADA: 200042 ANADA: 200055 ANADA: 200073 ANADA: 200257 ANADA: 200279 NADA: 45290 NADA: 92116 NDC Package: 11695-0703-1 NDC Package: 13985-584-10 NDC Package: 17033-101-10 NDC Package: 54771-2013-1 NDC Package: 69043-063-01 NDC Product: 11695 NDC Product: 13985 NDC Product: 17033 NDC Product: 54771 NDC Product: 69043
Package NDC Product NDC Form / Route Status
11695-0703-1 11695 -
13985-584-10 13985 -
17033-101-10 17033 -
54771-2013-1 54771 -
69043-063-01 69043 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 9 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appe… (Official, 2026-02-12)
  • side_effects: Top reported reactions (openFDA): Seizure NOS, INEFFECTIVE, ANESTHESIA, Death, Cardiac arrest, Drug administration error, Vomiting. (Official, 2026-02-12)
  • usage: It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation. It i… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Ketamine HCL
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Mylan Institutional LLC, a Viatris Company ANADA 200-257 W Jan 21, 2025
VetaKet®
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Cronus Pharma Specialities India Private Ltd. ANADA 200-055 Approved Jun 13, 2024
Vetalar®
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Boehringer lngelheim Animal Health USA, Inc. NADA 45290 Approved Jan 8, 2024
Ketamine Hydrochloride Injection
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Cronus Pharma Specialities India Private Ltd. ANADA 200-029 Approved Feb 1, 2018
Ketamine Hydrochloride Injection, USP
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Elanco US Inc. ANADA 200-042 Approved Aug 4, 2017
Ketamine Hydrochloride Injection, USP
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Dechra Veterinary Products LLC ANADA 200-073 Approved May 19, 2017
KetaFlo™
RX
Ketamine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Abbott Laboratories ANADA 200-279 W Jun 1, 2016
Ketaset® Plus
RX
Aminopentamide Hydrogen Sulfate Ketamine Hydrochloride Promazine Hydrochloride
Liquid (Solution) • Intramuscular
Label highlights
Official documents
Zoetis Inc. NADA 92116 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Primates, Non-Human Primates • Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter contains ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Primates, Non-Human Primates • Cat, Restricted During Pregnancy
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

FDA page: Open in Animal Drugs @ FDA

Species: Primates, Non-Human Primates • Cat, No Use Class Stated Or Implied
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

FDA page: Open in Animal Drugs @ FDA

Species: Primates, Non-Human Primates • Cat, No Use Class Stated Or Implied
Composition / specifications
Each milliliter contains ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Primates, Non-Human Primates • Cat, No Use Class Stated Or Implied
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

FDA page: Open in Animal Drugs @ FDA

Species: Primates, Non-Human Primates • Cat, No Use Class Stated Or Implied
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity.
Cats
Indication
It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 5 to 15 milligrams per pound of body weight depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Subhuman primates
Indication
It is used for restraint.
Dosage
It is administered intramuscularly at a recommended dose that ranges from 3 to 15 milligrams per kilogram of body weight depending upon the species, general condition and age of the subject.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
The drug is a sterile aqueous solution and each milliliter contains: Ketamine hydrochloride equivalent to 100 milligrams ketamine base activity, 7.5 milligrams of promazine hydrochloride, and 0.0625 milligram of aminopentamide hydrogen sulfate, with 1:10,000 benzethonium chloride.
Cats
Indication
It is used in cats as the sole anesthetic agent for ovariohysterectomy and general surgery.
Dosage
It is administered intramuscularly at a recommended dose from 15 to 20 milligrams ketamine base per pound of body weight, depending on the effect desired.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents
  • Summary
    Used in cats for restraint or as the sole anesthetic agent for diagnostic or minor, brief, surgical procedures that do not require skeletal muscle relaxation. Used in subhuman primates for restraint.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    VetaKetâ¿¢ may be used in cats for restraint or as the sole anesthetic agent for diagnostic or minor, brief, surgical procedures that do not require skeletal muscle relaxation. It may be used in subhuman primates for restraint.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    Ketamine Hydrochloride Injection may be used in cats for restraint or as the sole anesthetic agent for diagnostic or minor, brief, surgical procedures that do not require skeletal muscle relaxation. It may be used in subhuman primates for restraint.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    Ketaject® (ketamine hydrochloride injection. USP) may be used in cats for restraint or as the sole anesthetic agent for diagnostic or minor brief, surgical procedures that do not require skeletal muscle relaxation. It may be used in subhuman primates for restraint.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary

    Ketamine hydrochloride injection, USP may be used in cats for restraint or as the sole anesthetic agent for diagnostic or minor, brief, surgical procedures that do not require skeletal muscle relaxation. It may be used in subhuman primates for restraint.

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Documents
  • Summary
    For restraint or as the sole anesthetic agent for diagnostic or minor, brief, surgical procedures that do not require skeletal muscle relaxation. It may be used in subhuman primates for restraint.
SPL Packages

FDA page: Open in Animal Drugs @ FDA

SPL Packages

FDA page: Open in Animal Drugs @ FDA

Usage

It is used for restraint or as the sole anesthetic agent in diagnostic or minor, brief surgical procedures that do not require skeletal muscle relaxation. It is used for restraint. It is used in cats as the sole anesthetic agent for ovariohysterectomy and general surgery.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Store in a cool place. Protect from light. Do not use if precipitate appears. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 56 and Cat 56 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog
Digestive
Vomiting (16)
Neurologic
Seizure NOS (43)
Effectiveness
Lack of efficacy - NOS (15)
Other
INEFFECTIVE, ANESTHESIA (35) Death (34) Cardiac arrest (20) Drug administration error (19) Bradycardia (13) Bilirubinuria (1) Bilirubinuria (1) Bilirubinuria (1) Bilirubinuria (1) Bilirubinuria (1) Bilirubinuria (1) Elevated alanine aminotransferase (1) Elevated alanine aminotransferase (1) Elevated alanine aminotransferase (1) Elevated alanine aminotransferase (1) Elevated alanine aminotransferase (1) Elevated alanine aminotransferase (1) Elevated aspartate aminotransferase (1) Elevated aspartate aminotransferase (1) Elevated aspartate aminotransferase (1) Elevated aspartate aminotransferase (1) Elevated aspartate aminotransferase (1) Elevated aspartate aminotransferase (1) Elevated creatinine (1) Elevated creatinine (1) Elevated creatinine (1) Elevated creatinine (1) Elevated creatinine (1) Elevated creatinine (1) Elevated gamma-glutamyl transferase (1) Elevated gamma-glutamyl transferase (1) Elevated gamma-glutamyl transferase (1) Elevated gamma-glutamyl transferase (1) Elevated gamma-glutamyl transferase (1) Elevated gamma-glutamyl transferase (1) Elevated serum alkaline phosphatase (1) Elevated serum alkaline phosphatase (1) Elevated serum alkaline phosphatase (1) Elevated serum alkaline phosphatase (1) Elevated serum alkaline phosphatase (1) Elevated serum alkaline phosphatase (1) Elevated symmetrical dimethylarginine (1) Elevated symmetrical dimethylarginine (1) Elevated symmetrical dimethylarginine (1) Elevated symmetrical dimethylarginine (1) Elevated symmetrical dimethylarginine (1) Elevated symmetrical dimethylarginine (1) Icterus (1) Icterus (1) Icterus (1) Icterus (1) Icterus (1) Icterus (1)
Cat
Digestive
Haemorrhagic diarrhoea (1) Haemorrhagic diarrhoea (1) Loss of appetite (1) Loss of appetite (1) Loss of appetite (1) Loss of appetite (1) Loss of appetite (1) Loss of appetite (1)
Neurologic
Seizure NOS (19)
Effectiveness
Lack of efficacy - NOS (31)
Other
Death (72) Cardiac arrest (44) Hyperthermia (32) INEFFECTIVE, ANESTHESIA (29) Bradycardia (16) Death by euthanasia (15) Death (2) Death (2) Death (2) Death (2) Abdominal effusion (1) Abdominal effusion (1) Abdominal effusion (1) Abdominal effusion (1) Adipsia (1) Adipsia (1) Adipsia (1) Adipsia (1) Adipsia (1) Adipsia (1) Anaemia NOS (1) Anaemia NOS (1) Anaemia NOS (1) Anaemia NOS (1) Anaemia NOS (1) Anaemia NOS (1) Breathing difficulty (1) Breathing difficulty (1) Breathing difficulty (1) Breathing difficulty (1) Cardiac disorder NOS (1) Cardiac disorder NOS (1) Cardiac disorder NOS (1) Cardiac disorder NOS (1) Cardiorespiratory arrest (1) Cardiorespiratory arrest (1) Cardiorespiratory arrest (1) Cardiorespiratory arrest (1) Death (1) Death (1) Dehydration (1) Dehydration (1) Elevated thyroxine (1) Elevated thyroxine (1) Haematemesis (1) Haematemesis (1)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Cat (unknown), Female, 4.05 kilogram • Drug: MSK, Solution, Unknown, Dose: 6.67 Milligram per kilogram • Reactions: Hyperglycaemia • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-054116
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Weight: 4.050 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution
  • Dose: 6.67 Milligram per kilogram
Reactions Reported:
Hyperglycaemia
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 16 year, 4.36 kilogram • Drug: MSK, Solution, Intramuscular, Dose: 1.15 Milligram per kilogram • Reactions: Lack of efficacy - NOS • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-055487
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 16.00 Year
  • Weight: 4.360 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Solution
  • Dose: 1.15 Milligram per kilogram
Reactions Reported:
Lack of efficacy - NOS
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Female, 15 year • Drug: MSK, Unknown • Reactions: Inappropriate defecation, Hyperthermia, Dehydration, Weight loss, Adipsia… • Outcome: Ongoing

  • Report ID: GBR-USFDACVM-2025-GB-000057
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 15.00 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Inappropriate defecation Hyperthermia Dehydration Weight loss Adipsia Loss of appetite Polyuria Urine abnormalities NOS Elevated thyroxine Neutrophilia Anaemia NOS Nausea Stomatitis Lip disorder NOS Haemorrhagic diarrhoea Haematemesis
Outcomes: Ongoing

Dog, Retriever - Labrador, Female, 9 year, 24.7 kilogram • Drug: MSK, Solution, Intramuscular, Dose: 0.20 mL per animal • Reactions: Elevated serum alkaline phosphatase, Elevated aspartate aminotransferase, Elevated alanine aminotransferase, Monocytosis, Elevated symmetrical dimethylarginine… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-054322
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 9.00 Year
  • Weight: 24.700 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Solution
  • Dose: 0.20 mL per animal
Reactions Reported:
Elevated serum alkaline phosphatase Elevated aspartate aminotransferase Elevated alanine aminotransferase Monocytosis Elevated symmetrical dimethylarginine Elevated creatinine Proteinuria Bilirubinuria Icterus Elevated gamma-glutamyl transferase
Outcomes: Ongoing

Cat, Cat (unknown), Male, 6 month, 2.3 kilogram • Drug: MSK, Solution, Intramuscular • Reactions: Shaking, Seizure NOS, Head bobbing, Death • Outcome: Recovered/Normal, Died

  • Report ID: USA-USFDACVM-2025-US-054096
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 6.00 Month
  • Weight: 2.300 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Solution
Reactions Reported:
Shaking Seizure NOS Head bobbing Death
Outcomes: Recovered/Normal, Died

Cat, Mixed (Cat), Male, 4 month, 2.331 kilogram • Drug: MSK, Injection, Intramuscular, Dose: 0.15 mL per animal • Reactions: Pale mucous membrane, Breathing difficulty, Death, Cardiac disorder NOS, Pericarditis… • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-049823
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 4.00 Month
  • Weight: 2.331 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Injection
  • Dose: 0.15 mL per animal
Reactions Reported:
Pale mucous membrane Breathing difficulty Death Cardiac disorder NOS Pericarditis Cardiorespiratory arrest Pericardial effusion Pulmonary congestion Oedema NOS Pleural effusion Necropsy performed Abdominal effusion
Outcomes: Died

Dog, ['Poodle - Toy', 'Chihuahua'], Unknown, 3 year, 1 kilogram • Drug: MSK, Solution, Unknown, Dose: 4.40 Milligram per kilogram • Reactions: Seizure NOS • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-045387
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Unknown
  • Age: 3.00 Year
  • Weight: 1.000 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution
  • Dose: 4.40 Milligram per kilogram
Reactions Reported:
Seizure NOS
Outcomes: Recovered/Normal

Dog, ['Retriever - Labrador', 'Corso Dog', 'Dog (unknown)'], Unknown • Drug: MSK, Solution, Unknown, Dose: 3 Milligram per kilogram • Reactions: Seizure NOS • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-045388
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Unknown
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution
  • Dose: 3 Milligram per kilogram
Reactions Reported:
Seizure NOS
Outcomes: Recovered/Normal

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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