Meds A-Z

Butorphanol

Detailed information about Butorphanol

Official label facts Owner quick guide first Marketing clearly labeled

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Pet Owner Quick Guide

Start here: what this medicine is for, what it does, and when it's usually needed.

Usually used for:

For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.

What it does:

When it's needed:

Call your vet sooner if you notice:

Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Commonly reported reactions:

(2 reports)
(2 reports)
(2 reports)

What to ask your vet today:

Is this medicine the right fit for my pet’s current symptoms?
Which warning signs mean I should call back right away?
How should I handle missed doses or refusal to take the medicine?

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Butorphanol

Drug type: Generic ingredient • Branded profile • FDA branded products available

Species: Both

Manufacturer: Zoetis Inc.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both

Manufacturer: Zoetis Inc.

Form: Liquid (Solution), Tablet

Identifiers:

ANADA: 200239 ANADA: 200322 ANADA: 200332 ANADA: 200408 ANADA: 200446 NADA: 102990 NADA: 103390 NADA: 135780 NADA: 141047 NDC Package: 17033-097-01 NDC Package: 17033-097-05 NDC Package: 54771-2033-1 NDC Package: 54771-2033-2 NDC Package: 57926-722-66 NDC Package: 69043-064-02 NDC Package: 69043-064-05 NDC Package: 73377-107-01 NDC Product: 17033 NDC Product: 54771 NDC Product: 57926

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200332 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200322 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source

Warnings / Contraindications

Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

High: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Source metadata:

https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals

Reported cases

Serious reports

Species represented

Most Reported Reactions

Cases	Species	Serious cases
2	Cat, Dog	2
2	Cat, Dog	2
2	Cat, Dog	2
1	Dog	1
1	Cat	1
1	Dog	1
1	Cat	1
1	Cat	1

Species coverage: Cat (17) Dog (15)

View detailed reaction table

Species	Seriousness	Frequency	Reports
Dog	Serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Dog	Non-serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Cat	Non-serious	-	1
Cat	Non-serious	-	1
Dog	Non-serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1
Dog	Serious	-	1
Dog	Serious	-	1
Cat	Serious	-	1

Source metadata:

https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-054275

Storage & Handling

No storage/handling guidance is linked yet.

Source metadata: No source yet.

Documents

Official label facts are separated from secondary summaries.

Official documents: 15 • Secondary summaries: 0

Official label facts

Secondary summaries

No source yet.

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1080 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/170/Butorphic%E2%84%A2%20Injection · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1073 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/90/Torphadine%C2%AE · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1168 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/2027/Butorphine%E2%84%A2 · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1145 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/204/Butorphanol%20Tartrate%20Injection · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1010 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/153/Dolorex%C2%AE · document · SPL

Promotional Materials (Marketing)

This content is marketing material and not clinical guidance.

No marketing assets are linked yet.

No source yet.

Source metadata: No source yet.

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Technical appendix (vet reference)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness

Medication catalog: Source PetWisePlus | Refreshed Feb 12, 2026, 10:44 PM UTC
Animal Drugs @ FDA: Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Feb 16, 2026, 11:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
openFDA reaction terms: Source FDA openFDA | Refreshed Feb 16, 2026, 11:03 AM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Feb 9, 2026, 3:20 AM UTC

Official (FDA)

Identity: Generic ingredient • FDA branded products available

Official FDA brands: Butorphanol Tartrate Injection Butorphic™ Injection Butorphine™ Dolorex® Torbugesic-SA® Torbugesic® Torbutrol® Injection Torbutrol® Tablets Torphadine®

Case-reported brands (openFDA): MSK

Catalog species: Both • FDA-labeled species: Cat, Dog, Horse, No Use Class Stated Or Implied

Rx/OTC: RX

Form/route: Liquid (Solution), Tablet • Intravenous, Oral, Subcutaneous

Applications: ANADA 200-332 • ANADA 200-322 • ANADA 200-446 • ANADA 200-408 • ANADA 200-239 • NADA 135-780 • NADA 141-047 • NADA 102-990 • NADA 103-390

Documents: 6 (FOI: 6) • SPL: 9 • Label highlights • Official documents

Safety (openFDA)

Top reactions: Dog 56 • Cat 56 • View

Case summaries: 10 (showing 8) • View

openFDA reports are unverified and do not prove causation.

Explore

Related conditions: Cough (acute/chronic) Pain (acute, chronic) Tracheitis (non-kennel cough) Trauma (HBC, falls, bite wounds)

Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)

Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points

Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)

Top reaction signals

Anorexia (1) Application site pain (1) Aspiration pneumonia (1) Bradycardia (1) Cardiac arrest (1) Death (1) Death by euthanasia (1) Depression (1) Emesis (multiple) (1) Faecal incontinence (1) Haematuria (1) Hyperactivity (1) Hyperthermia (1) Hypotension (1) Lack of efficacy - NOS (1) Lack of efficacy - NOS (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers

Package NDC	Product NDC	Status
17033-097-01	17033	-
17033-097-05	17033	-
54771-2033-1	54771	-
54771-2033-2	54771	-
57926-722-66	57926	-
69043-064-02	69043	-
69043-064-05	69043	-
73377-107-01	73377	-

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

ucm061797.pdf • FOI summary • Official • June 13, 2024
FDA FOI summary for application 200332
ucm061785.pdf • FOI summary • Official • Oct. 7, 2022
FDA FOI summary for application 200322
UCM214392.pdf • FOI summary • Official • April 26, 2022
FDA FOI summary for application 200446
ucm061350.pdf • FOI summary • Official • Oct. 28, 2021
FDA FOI summary for application 200408
UCM061667.pdf • FOI summary • Official • June 1, 2016
FDA FOI summary for application 200239
UCM490962.pdf • FOI summary • Official • June 1, 2016
FDA FOI summary for application 141047

Data Sources & Revision History

Every non-trivial field is expected to include provenance and update timestamps.

Official 9 Clinical 0 Manufacturer 0 Marketing 0

Current Field Facts

contraindications: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not norma… (Official, 2026-02-12)
side_effects: Top reported reactions (openFDA): Lack of efficacy - NOS, Vomiting, Death, Diarrhoea, Bradycardia, Lethargy (see also Central nervous system depression in 'Neu… (Official, 2026-02-12)
usage: For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammat… (Official, 2026-02-12)

Recent Revisions

side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product	Sponsor	Application	Status	Published
Butorphic™ Injection RX Butorphanol Tartrate Liquid (Solution) • Intravenous Label highlights Official documents	Cronus Pharma Specialities India Private Ltd.	ANADA 200-332	Approved	Jun 13, 2024
Torphadine® RX Butorphanol Tartrate Liquid (Solution) • Intravenous Label highlights Official documents	Dechra Veterinary Products LLC	ANADA 200-322	Approved	Oct 7, 2022
Butorphine™ RX Butorphanol Tartrate Liquid (Solution) • Subcutaneous Label highlights Official documents	Modern Veterinary Therapeutics, LLC	ANADA 200-446	W	Apr 26, 2022
Butorphanol Tartrate Injection RX Butorphanol Tartrate Liquid (Solution) • Subcutaneous Label highlights Official documents	Dechra Veterinary Products LLC	ANADA 200-408	Approved	Oct 28, 2021
Dolorex® RX Butorphanol Tartrate Liquid (Solution) • Intravenous Label highlights Official documents	Intervet, Inc.	ANADA 200-239	Approved	Jun 1, 2016
Torbugesic® RX Butorphanol Tartrate Liquid (Solution) • Intravenous Label highlights Official documents	Zoetis Inc.	NADA 135-780	Approved	Jun 1, 2016
Torbugesic-SA® RX Butorphanol Tartrate Liquid (Solution) • Subcutaneous Label highlights Official documents	Zoetis Inc.	NADA 141-047	Approved	Jun 1, 2016
Torbutrol® Injection RX Butorphanol Tartrate Liquid (Solution) • Subcutaneous Label highlights Official documents	Zoetis Inc.	NADA 102-990	Approved	Jun 1, 2016
Torbutrol® Tablets RX Butorphanol Tartrate Tablet • Oral Label highlights Official documents	Zoetis Inc.	NADA 103-390	Approved	Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: No Use Class Stated Or Implied

Composition / specifications

Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).

Horses

Indication

For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.

Dosage

0.05 milligram of butorphanol per pound of body weight (0.1 milligram per kilogram of body weight). Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours.

Limitations

Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Horse, No Use Class Stated Or Implied

Composition / specifications

Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).

Horses

Indication

For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.

Dosage

0.05 milligram of butorphanol base activity per pound of body weight (0.1 milligram/kilogram) using 10 milligrams per milliliter solution. For intravenous use.

Limitations

Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied

Composition / specifications

Each mL contains 2 mg butorphanol base (as butorphanol tartrate, USP).

Cats

Indication

For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.

Dosage

Administer 0.4 mg of butorphanol per kilogram body weight (0.2 mg/lb). This is equivalent to 1.0 mL solution per 10 lbs body weight.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied

Composition / specifications

Each milliliter of aqueous solution contains 2 milligrams of butorphanol (as butorphanol tartrate).

Cats

Indication

For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures

Dosage

0.2 milligram of butorphanol base activity per pound of body weight (0.4 milligrams per kilogram), using 2 milligrams per milliliter solution. For subcutaneous injection.

Limitations

Dose may be repeated up to 4 times per day. Do not treat for more than 2 days. Safety for use in pregnant female cats, breeding male cats of kittens less than 4 months of age has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production

Composition / specifications

Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).

Horses

Indication

For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.

Dosage

0.05 milligram of butorphanol base activity per pound of body weight (0.1 milligram/kilogram) using 10 milligrams per milliliter solution. For intravenous use.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Horse, Not For Meat Production

Composition / specifications

Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).

Horses

Indication

For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.

Dosage

0.05 milligram of butorphanol base activity per pound of body weight (0.1 milligram/kilogram) using 10 milligrams per milliliter solution. For intravenous use.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied

Composition / specifications

Each milliliter of aqueous solution contains 2 milligrams of butorphanol (as butorphanol tartrate).

Cats

Indication

For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.

Dosage

0.2 milligram of butorphanol base activity per pound of body weight (0.4 milligrams per kilogram)

Limitations

For subcutaneous injection. Dose may be repeated up to 4 times per day. Do not treat for more than 2 days. Safety for use in pregnant female cats, breeding male cats of kittens less than 4 months of age has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied

Composition / specifications

Each milliliter of aqueous solution contains either 0.5 of butorphanol (as butorphanol tartrate).

Dogs

Indication

Dosage

0.025 milligram of butorphanol base activity per pound of body weight (equivalent to 0.5 milliliter per 10 pounds), using 0.5 milligram per milliliter solution. For subcutaneous injection.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied

Composition / specifications

Each tablet contains 1, 5, or 10 milligrams of butorphanol base activity as butorphanol tartrate.

Dogs

Indication

Dosage

0.25 milligram of butorphanol base activity per pound of body weight.

Limitations

For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Official Documents (FDA)

Direct links to FDA-hosted PDFs and SPL packages (when available).

Documents

FOI ucm061797.pdf

Summary

Butorphic Injection is indicated for relief of pain associated with colic in adult horses and yearlings. Clinical studies in the horse have shown that Butorphic Injection alleviates abdominal pain associated with torsion, impaction, intussusception, and tympanic colic, and postpartum pain.

SPL Packages

Butorphic™ Injection (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI ucm061785.pdf

Summary

Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings.

SPL Packages

Torphadine® (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM214392.pdf

Summary

Indicated for the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.

SPL Packages

Butorphine™ (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI ucm061350.pdf

Summary

Indicated for the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.

SPL Packages

Butorphanol Tartrate Injection (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM061667.pdf

Summary

For the relief of pain associated with colic in adult horses and yearlings and postpartum pain in mares.

SPL Packages

Dolorex® (ZIP)

FDA page: Open in Animal Drugs @ FDA

SPL Packages

Torbugesic® (ZIP)

FDA page: Open in Animal Drugs @ FDA

Documents

FOI UCM490962.pdf

Summary

Torbugesic-SA (butorphanol tartrate, USP) is indicated for the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.

SPL Packages

Torbugesic-SA® (ZIP)

FDA page: Open in Animal Drugs @ FDA

SPL Packages

Torbutrol® Injection (ZIP)

FDA page: Open in Animal Drugs @ FDA

SPL Packages

Torbutrol® Tablets (ZIP)

FDA page: Open in Animal Drugs @ FDA

Usage

For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammatory conditions of the upper respiratory tract. For the relief of pain associated with colic and postpartum pain in adult horses and yearlings. For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Side Effects

No approved side-effect narrative is linked yet.

openFDA reaction signals are available for Dog 56 and Cat 56 (view top reported reactions).

Top Reported Reactions (openFDA)

Aggregated reaction terms from FDA openFDA reports (not verified; does not prove causation).

Dog

Digestive

Vomiting (272) Diarrhea (173)

Skin & allergy

Injection site swelling (152)

Neurologic

Tiredness (lethargy) (157) Tiredness (lethargy) (136) Tiredness (lethargy) (6) Tiredness (lethargy) (6) Tiredness (lethargy) (6) Tiredness (lethargy) (6) Tiredness (lethargy) (5) Tiredness (lethargy) (5)

Effectiveness

Lack of efficacy - NOS (336) Lack of efficacy - NOS (3)

Other

Death (180) Bradycardia (160) Death (4) Death (4) Death (4) Death (4) Death (4) Hypotension (4) Hypotension (4) Hypotension (4) Hypotension (4) Hypotension (4) Hypotension (4) Tachycardia (4) Tachycardia (4) Tachycardia (4) Tachycardia (4) Tachycardia (4) Tachycardia (4) Anaphylaxis (3) Anaphylaxis (3) Anaphylaxis (3) Anaphylaxis (3) Death (3) Elevated alanine aminotransferase (3) Elevated alanine aminotransferase (3) Elevated alanine aminotransferase (3) Elevated alanine aminotransferase (3) Elevated alanine aminotransferase (3) Elevated alanine aminotransferase (3) Elevated creatinine (3) Elevated creatinine (3) Elevated creatinine (3) Elevated creatinine (3) Elevated creatinine (3) Elevated creatinine (3) Hyperphosphataemia (3) Hyperphosphataemia (3) Hyperphosphataemia (3) Hyperphosphataemia (3) Hyperphosphataemia (3) Hyperphosphataemia (3) Intentional misuse (3)

Cat

Digestive

Loss of appetite (71)

Skin & allergy

Application site hair loss (1) Application site hair loss (1)

Neurologic

Unsteady walking (ataxia) (1) Unsteady walking (ataxia) (1)

Behavior

Behavioral disorder (unspecified) (100)

Effectiveness

Lack of efficacy - NOS (95)

Other

Death (135) Dilated pupils (80) Not eating (80) Hyperactivity (67) Death by euthanasia (64) Anaphylaxis (2) Anaphylaxis (2) Anaphylaxis (2) Anaphylaxis (2) Death (2) Death (2) Death (2) Death (2) Death by euthanasia (2) Death by euthanasia (2) Death by euthanasia (2) Death by euthanasia (2) Death by euthanasia (2) Death by euthanasia (2) Intentional misuse (2) Intentional misuse (2) Intentional misuse (2) Intentional misuse (2) Intentional misuse (2) Intentional misuse (2) Pale mucous membrane (2) Pale mucous membrane (2) Pale mucous membrane (2) Pale mucous membrane (2) Underdose (2) Underdose (2) Underdose (2) Underdose (2) Underdose (2) Underdose (2) Abdominal effusion (1) Abdominal effusion (1) Abdominal effusion (1) Abdominal effusion (1) Abnormal posture NOS (1) Abnormal posture NOS (1) Abnormal posture NOS (1) Abnormal posture NOS (1) Anaphylaxis (1) Anaphylaxis (1) Aspiration pneumonia (1) Aspiration pneumonia (1) Cardiac arrest (1) Cardiac arrest (1)

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Shorthair, Male, 5 year, 8.61 kilogram • Drug: MSK, Unknown • Reactions: Hyperthermia, Hyperactivity • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-055972
Serious AE: No
Treated For AE: No
Sex: Male
Age: 5.00 Year
Weight: 8.610 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown

Reactions Reported:

Hyperthermia Hyperactivity

Outcomes: Ongoing

Dog, Poodle (unspecified), Male, 4 year, 9.5 kilogram • Drug: MSK, Unassigned, Intramuscular • Reactions: Vomiting, Pain NOS, Whining, Lack of efficacy - NOS • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-054507
Serious AE: Yes
Treated For AE: Yes
Sex: Male
Age: 4.00 Year
Weight: 9.500 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Intramuscular
Form: Unassigned

Reactions Reported:

Vomiting Pain NOS Whining Lack of efficacy - NOS

Outcomes: Ongoing

Cat, Domestic Mediumhair, Female, 19 week, 2.06 kilogram • Drug: MSK, Unknown • Reactions: Sleepiness - neurological disorder, Temporary blindness, Tiredness (lethargy), Reduced responses, Mydriasis… • Outcome: Euthanized

Report ID: USA-USFDACVM-2025-US-055689
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 19.00 Week
Weight: 2.060 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown

Reactions Reported:

Sleepiness - neurological disorder Temporary blindness Tiredness (lethargy) Reduced responses Mydriasis Death by euthanasia

Outcomes: Euthanized

Cat, Domestic Shorthair, Male, 13 year, 6.804 kilogram • Drug: MSK, Injection, Intravenous, Dose: 0.30 Milligram per kilogram • Reactions: Nausea, Prolonged one stage prothrombin time, Prolonged activated partial thrombin time, Cardiac arrest, Death • Outcome: Died

Report ID: USA-USFDACVM-2025-US-055853
Serious AE: Yes
Treated For AE: Yes
Sex: Male
Age: 13.00 Year
Weight: 6.804 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Intravenous
Form: Injection
Dose: 0.30 Milligram per kilogram

Reactions Reported:

Nausea Prolonged one stage prothrombin time Prolonged activated partial thrombin time Cardiac arrest Death

Outcomes: Died

Dog, ['Crossbred Canine/dog', 'Retriever - Labrador', 'Poodle - Medium size'], Female, 3 year, 12.338 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy - NOS, Rubbing, Application site pain • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-056018
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 3.00 Year
Weight: 12.338 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown

Reactions Reported:

Lack of efficacy - NOS Rubbing Application site pain

Outcomes: Ongoing

Dog, Crossbred Canine/dog, Male, 10 year, 33.112 kilogram • Drug: MSK, Injection, solution, Intramuscular, Dose: 2 Milligram per animal • Reactions: Urinary incontinence, Faecal incontinence, Tiredness (lethargy), Tremors, Loss of appetite… • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-054275
Serious AE: Yes
Treated For AE: Yes
Sex: Male
Age: 10.00 Year
Weight: 33.112 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Intramuscular
Form: Injection, solution
Dose: 2 Milligram per animal

Reactions Reported:

Urinary incontinence Faecal incontinence Tiredness (lethargy) Tremors Loss of appetite Sedation prolonged Leucopenia NOS Lymphopenia Lack of efficacy - NOS Unable to walk Pyuria Haematuria Urinary tract infection

Outcomes: Ongoing

Dog, ['Chihuahua', 'Mixed (Dog)'], Female, 9 year, 5.534 kilogram • Drug: MSK, Unknown • Reactions: Tachycardia, Hypotension • Outcome: Recovered/Normal

Report ID: USA-USFDACVM-2025-US-055949
Serious AE: No
Treated For AE: No
Sex: Female
Age: 9.00 Year
Weight: 5.534 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown

Reactions Reported:

Tachycardia Hypotension

Outcomes: Recovered/Normal

Dog, ['Doberman Pinscher', 'Dog (unknown)'], Female, 5 year, 26.354 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Tachycardia, Bradycardia, Shaking • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-053766
Serious AE: No
Treated For AE: No
Sex: Female
Age: 5.00 Year
Weight: 26.354 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Form: Unassigned

Reactions Reported:

Tachycardia Bradycardia Shaking

Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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Butorphanol

Pet Owner Quick Guide

Butorphanol

Quick Facts

Warnings / Contraindications

Adverse Reactions

Most Reported Reactions

Storage & Handling

Documents

Promotional Materials (Marketing)

At a Glance

Counseling and Monitoring Highlights

Identifiers & Packages

Enriched Documents

Data Sources & Revision History

FDA Products & Applications (Animal Drugs @ FDA)

What It's For (FDA Label Highlights)

Butorphic™ Injection • Liquid (Solution) • Intravenous

Torphadine® • Liquid (Solution) • Intravenous

Butorphine™ • Liquid (Solution) • Subcutaneous

Butorphanol Tartrate Injection • Liquid (Solution) • Subcutaneous

Dolorex® • Liquid (Solution) • Intravenous

Torbugesic® • Liquid (Solution) • Intravenous

Torbugesic-SA® • Liquid (Solution) • Subcutaneous

Torbutrol® Injection • Liquid (Solution) • Subcutaneous

Torbutrol® Tablets • Tablet • Oral

Official Documents (FDA)

Butorphic™ Injection • 200332

Torphadine® • 200322

Butorphine™ • 200446

Butorphanol Tartrate Injection • 200408

Dolorex® • 200239

Torbugesic® • 135780

Torbugesic-SA® • 141047

Torbutrol® Injection • 102990

Torbutrol® Tablets • 103390

Usage

Contraindications

Side Effects

Top Reported Reactions (openFDA)

Adverse Event Case Summaries (openFDA)

Sep 23, 2025 • Cat • Domestic Shorthair • Hyperthermia, Hyperactivity • Ongoing

Sep 18, 2025 • Dog • Poodle (unspecified) • Vomiting, Pain NOS • Ongoing

Sep 17, 2025 • Cat • Domestic Mediumhair • Sleepiness - neurological disorder, Temporary blindness • Euthanized

Sep 16, 2025 • Cat • Domestic Shorthair • Nausea, Prolonged one stage prothrombin time • Died

Sep 16, 2025 • Dog • ['Crossbred Canine/dog', 'Retriever - Labrador', 'Poodle - Medium size'] • Lack of efficacy - NOS, Rubbing • Ongoing

Sep 16, 2025 • Dog • Crossbred Canine/dog • Urinary incontinence, Faecal incontinence • Ongoing

Sep 15, 2025 • Dog • ['Chihuahua', 'Mixed (Dog)'] • Tachycardia, Hypotension • Recovered/Normal

Sep 12, 2025 • Dog • ['Doberman Pinscher', 'Dog (unknown)'] • Tachycardia, Bradycardia • Ongoing

Overdose Information

Storage & Handling

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